Mugadziri weupfu weCMS121 Nhamba yeCAS: 1353224-53-9 98.0% kuchena kweminiti yezvinongedzo zvekuwedzera
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | CMS121 |
| Rimwe zita | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase,chirwere,chinodzivirira tsinga dzemuviri,chinodzivisa,chinorwisa kuzvimba,mitochondrial,Alzheimer's,chinorwisa oxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| Nhamba yeCAS | 1353224-53-9 |
| Fomura yemamorekuru | C20H19NO3 |
| Kurema kwemasero | 321.37 |
| Kuchena | 98.0% |
| Chitarisiko | Upfu hweyero yakapfava |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol chinhu chinonziwo CMS121. Kuomarara kwechimiro chechinhu ichi kunoratidza kuti chingave nehunyanzvi hwakasiyana uye mashandisirwo aunogona kuita. Kuti unzwisise kukosha kwacho, zvinobatsira kuona mapoka anoshanda aripo uye kuongorora simba rawo. Kuvapo kweringi yequinoline kunoratidza kuti chinhu ichi chinogona kunge chichishanda muhupenyu. Mamorekuru anobva kuQuinoline anozivikanwa nehunyanzvi hwawo hwakasiyana hwehupenyu, kusanganisira mabasa ekurwisa mabhakitiriya uye ekudzivirira kuzvimba. Kubatanidzwa kweboka recyclopentyloxy kunogona kubatsira mukunyungudika kwechinhu ichi kana kuwedzera basa rayo rehupenyu kuburikidza nemhedzisiro yesteric. Muzvidzidzo pamasero eHT22, CMS-121 yakaratidza mhedzisiro yakakosha yekudzivirira tsinga, ichidzivirira masero aya kubva ku ischemia uye kukuvara kwe oxidative. Uyezve, CMS-121 ine hunyanzvi hwakakosha hwekudzivirira kuzvimba, zvichiratidza kugona kwayo kugadzirisa mhinduro dzekuzvimba. Nekuita izvi, CMS-121 ine mukana wekuderedza kuzvimba mumatishu akasiyana-siyana nenhengo. CMS-121 ine simba guru mukurapa semushonga unodzivirira acetyl-CoA carboxylase 1 (ACC1). Simba rayo guru rekudzivirira paACC1 rinoita kuti ive mushonga unovimbisa.
Chinhu
(1) Kuchena kwakanyanya: CMS-121 inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nemaitiro ekugadzira akacheneswa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu uye kushomeka kwemhedzisiro yakaipa.
(2) Kuchengetedzeka: Kuchengeteka kwakanyanya, kusawirirana kushoma.
(3) Kugadzikana: CMS-121 ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.
Mashandisirwo
CMS-121 inhibitor ye quinolone derivative uye inonwiwa nemuromo ine hunhu hwakanaka hwemishonga. Tsvagiridzo yakakura yakaitwa kuti iongorore mabhenefiti angangovepo eCMS-121 munzvimbo dzakasiyana-siyana, kusanganisira kudzivirira tsinga, mhedzisiro yekudzivirira kuzvimba, kushanda kweantioxidant, uye kukanganisa kwayo zviratidzo zvine chekuita nekukwegura kwakanaka.
