Mugadziri weupfu weLemairamin (WGX-50) Nhamba yeCAS: 29946-61-0 98.0% kuchena kweminiti yezvinongedzo zvekuwedzera
Vhidhiyo yeChigadzirwa
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | Lemairamin |
| Rimwe zita | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| Nhamba yeCAS | 29946-61-0 |
| Fomura yemamorekuru | C19H21NO3 |
| Kurema kwemasero | 311.37 |
| Kuchena | 98.0% |
| Chitarisiko | Upfu huchena kusvika huchena |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
Lemairamin kana kuti Wgx50 chinhu chechisikigo chinotorwa kubva mumhiripiri dzine chili chakaratidza mhedzisiro yakanaka mukudzivirira chirwere cheAlzheimer. Zvidzidzo zvakawana kuti inogona kudzivirira Aβ-induced neuronal apoptosis, kuderedza chepfu ye calcium mu neuronal, uye kuderedza kuunganidzwa kweAβ oligomers mu cerebral cortex. Pamusoro pezvo, wgx50 yakaratidzwa kuti inovandudza mashandiro ekuziva mumakonzo. Tsvagiridzo inoratidza kuti wgx50 ine mukana wekudzivirira kusangana kwemapuroteni nemapuroteni pakati pemamorekuru e amyloid. Kazhinji, wgx50 ine mukana wekudzivirira chirwere cheAlzheimer uye inogona kupa nzira itsva dzekugadzira mishonga inotarisa maAβ oligomers. Pamusoro pezvo, WGX-50 inoratidza basa rakakosha rekudzivirira kuzvimba, izvo zvinoita kuti ive mukana wekurapa zvirwere zvinozvimba. WGX-50 yakawanikwa iine mhedzisiro yakakura paganda, senge kuderedza makwinya uye kuvandudza kusimba kweganda. Pamusoro pemakemikari echisikigo anotorwa kubva muchirimwa cheZanthoxylum bungeanum, parizvino kune mamwe makemikari ekugadzira anoshandiswa mukushandiswa kwakasiyana-siyana uye akakodzera kumusika.
Chinhu
(1) Kuchena kwakanyanya: Lemairamin inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nekubvisa zvakasikwa uye kugadzirisa maitiro ekugadzira. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu uye kushomeka kwemhedzisiro yakaipa.
(2) Kuchengetedzeka: Kuchengetedzwa kwakanyanya, kushomeka kwemigumisiro yakaipa, hapana migumisiro yakaipa inooneka kunyangwe ikashandiswa kwenguva refu.
(3) Kugadzikana: Lemairamin ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.
(4) Zviri nyore kunyudza: Lemairamin inogona kunyudzwa nekukurumidza nemuviri wemunhu uye kugoverwa kunhengo dzakasiyana dzemuviri.
Mashandisirwo
Lemairamin imusanganiswa weamide unotorwa kubva mugwati remuti weZanthoxylum bungeanum. Parizvino inoshandiswa sechikafu chekuwedzera, inoshandawo semushonga we alpha7 nicotinic acetylcholine receptor (α7nAChR), iyo inoderedza kuzvimba kweuropi muchirwere cheAlzheimer, uye inogadzirwa zvachose. Wgx50 yakaratidza mhedzisiro inokurudzira muzvidzidzo zve preclinical, zvinosanganisira kudzivirira Aβ-induced neuronal apoptosis, kuderedza neuronal calcium toxicity, kuderedza kuunganidzwa kweAβ oligomers mu cerebral cortex, uye kuvandudza mashandiro ekuziva mumakonzo.
