1-Methylnicotinamide Chloride Nhamba yeCAS:1005-24-9
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | 1-Methylnicotinamide chloride |
| Rimwe zita | N-Methylnicotinamide chloride；NMN-Cl；1-MNA chloride；3-carbamoyl-1-methyl-pyridinium chloride |
| Nhamba yeCAS | 1005-24-9 |
| Fomura yemamorekuru | C7H9N2OCl |
| Kurema kwemasero | 172.61 |
| Kuchena | 98.5% |
| Chitarisiko | Chena - chakaita segirazi rakasimba, chisina kuchenaupfu |
| Kurongedza | 1kg/bhegi; 25kg/dhiramu |
| Kushandiswa | cchemicalezvekuyedzamterevhizheni |
Sumo yechigadzirwa
1-Methylnicotinamide chloride imhando ye nicotinamide ine methyl, inoratidzwa nechimiro chemunyu che quaternary ammonium salt chakasimba. Inoshanda sechikamu chakakosha mukudzidza metabolism ye nicotinamide. Kunyungudika kwayo mumvura uye kugadzikana kwayo kwemakemikari zvinoita kuti ive chinhu chakakosha chekuongorora biochemical.
1-MNA chinhu chinowanikwa mumuviri wemunhu, chinoshanda sechinhu chakajairika che metabolism ye niacin. Sechikamu chepakati che metabolism iyi, 1-MNA inogadziriswazve ne aldehyde oxidase kuti igadzire metabolites dziri pasi dzakadai seN-methyl-2-pyridone-5-carboxamide (2PY) uye N-methyl-4-pyridone-3-carboxamide (4PY), idzo dzinozoburitswa kuburikidza ne weti.
1-Methylnicotinamide chloride imhando ye nicotinamide ine methyl, inoratidzwa nechimiro chemunyu che quaternary ammonium salt chakasimba. Inoshanda sechikamu chakakosha mukudzidza metabolism ye nicotinamide. Kunyungudika kwayo mumvura uye kugadzikana kwayo kwemakemikari zvinoita kuti ive chinhu chakakosha chekuongorora biochemical.
1-MNA chinhu chinowanikwa mumuviri wemunhu, chinoshanda sechinhu chakajairika che metabolism ye niacin. Sechikamu chepakati che metabolism iyi, 1-MNA inogadziriswazve ne aldehyde oxidase kuti igadzire metabolites dziri pasi dzakadai seN-methyl-2-pyridone-5-carboxamide (2PY) uye N-methyl-4-pyridone-3-carboxamide (4PY), idzo dzinozoburitswa kuburikidza ne weti.
Chinhu
(1) Kunyungudika kwemvura: Inonyungudika nyore nyore mumvura uye mune zvinonyungudutsa zve polar organic.
(2) Kugadzikana: Kugadzikana kana tembiricha yemumba asi kunoda kuchengetwa munzvimbo dzisingapindi hunyoro.
(3) Kuchengetedzeka: European Union yakaita ongororo yesainzi ye1-MNA sechinhu chitsva chekudya. Zvichienderana neEU Regulation (EC) No 258/97, 1-MNA inoonekwa seyakachengeteka kudyiwa, uye inokurudzirwa kuti munhu mukuru adye 58 mg pazuva, kunyanya inoshandiswa muzvikafu zvinowedzera.
Mashandisirwo
1-Methylnicotinamide chloride (yakapfupikiswa seMNC) imhando ye methylated derivative ye nicotinamide. Kuwanikwa kwe 1-MNA kunogona kuitwa nenzira dzakadai se high-performance liquid chromatography (HPLC) uye enzyme-linked immunosorbent assay (ELISA). Inoratidza mukana wekushandiswa muzvikamu zvekudya uye zvigadzirwa zvehutano. Muindasitiri yezvikafu, inogona kushanda se antioxidant kunonotsa oxidation yemafuta uye kuchengetedza mhando yechikafu. Nekuda kwehunhu hwayo hwechimiro, inogona zvakare kushanda sechinhu chinoshanda muzvikafu zvakasimbiswa nekudya. Uyezve, 1-MNA inoratidza mabasa mukudzora metabolic uye kuvandudza mamiriro emuviri, ichiipa kukosha kwekuvandudzwa kwechikafu chinoshanda uye zvekudya zvinovaka muviri zvine hutano.
Ongororo yeEU yakagumisa kuti kunwa 58 mg ye1-MNA zuva nezuva kubva muzvikafu zvinovaka muviri hazvingangokonzere migumisiro yakaipa pahutano hwevanhu, uye zvakabatanidzwa zviri pamutemo mukatarogu itsva yezvekudya yeEU.
Senzira yakakosha yekuongorora mamorekuru anoshanda mumuviri uye chiyero chekutarisa, 1-methylnicotinamide chloride ine mikana yakawanda yekushandiswa mukutsvaga kwesainzi, kugadzira mishonga, uye indasitiri yekuwedzera chikafu. Kuongororwa kwayo kwakanyatsotsanangurwa uye mabasa akasiyana-siyana ehupenyu zvinoratidza kuti inokosha pakutsvagisa uye chikamu chekushandiswa kwakasiyana-siyana.
