O-304 CAS Nhamba.:1261289-04-6 Kuvaka tsandanyama uye kuderedza mafuta.
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | O-304 |
| Rimwe zita | 4-Chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]benzamide |
| Nhamba yeCAS | 1261289-04-6 |
| Fomura yemamorekuru | C16H11Cl2N3O2S |
| Kurema kwemasero | 380.25 |
| Kuchena | 98% |
| Chitarisiko | Upfu huchena kusvika huchena |
| Kurongedza | 1kg/bhegi, 25kg/bhareri |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
O-304 imushonga weAMPK une mamorekuru madiki unowedzera mashandiro eAMPK nekudzivisa dephosphorylation yeAMPK (pAMPK) ine phosphorylated, nokudaro uchiwedzera huwandu hwepAMPK pasina kuderedza huwandu hweadenosine triphosphate (ATP) mumasero. Ine nzira dzakawanda dzekushanda, dzinosanganisira kuvandudza metabolism yeglucose, kuderedza insulin resistance, uye kudzivirira hurongwa hwemwoyo.
Chinhu
(1) Kuchena kwakanyanya: O-304 inogadzirwa kuburikidza nekugadzirwa kwakanyatsogadzirwa, zvichiita kuti chigadzirwa chive chakachena kwazvo. Kuchena kwakanyanya kunoreva kuti chigadzirwa ichi chinowanikwa zviri nani.
(2) Mabasa Emuviri:O-304 imushonga unoshanda nemuromo weAMPK (AMP-activated protein kinase). Inowedzera mashandiro eAMPK nekudzivirira dephosphorylation yepAMPK.
Mashandisirwo
1. Kushanda kweAMPK: O-304 inowedzera mashandiro eAMPK nekudzivisa maitiro ekubvisa phosphorylation yeAMPK (pAMPK) ine phosphorylated, nokudaro ichidzora kuenzana kwesimba remagetsi.
2. Kuvandudza kushandiswa kweglucose mumuviri: Muzvidzidzo zvemhuka, dose ye100 mg/kg yeO-304 yakabatsira kuchengetedza huwandu hweglucose muropa rinotsanya uye insulin muropa, zvichideredza zvakanyanya mutoro wekushandiswa kweglucose mumuviri unokonzerwa nekudya kune mafuta akawanda, uye kudzivirira kuchinja-chinja kweglucose muropa uye kuwedzera kweinsulin kunokonzerwa nekusawirirana kwekudya.
3. Pkudzivirira kusimba kwetsinga dzeropa:O-304 inobatsira kuchengetedza BP iri padanho rakanaka, inoderedza kushushikana patsinga dzeropa, uye inopa dziviriro inononoka kwenguva refu yehurongwa hwemwoyo netsinga dzeropa, ichitsigira kugadzikana kwepfungwa uye simba rinogara riripo.
4.Kukurudzira hudiki hunogara kwenguva refu:O-304 inonyatsonanga nzira yekutumira masaini yeAMPK-mTOR, ichidzora nekuchenjera maitiro e autophagy yemasero, ichikurudzira catabolism yemapuroteni akwegura uye mafuta asina kujairika, uye ichichengetedza nharaunda yakachena uye ine simba yemasero, nokudaro ichinonotsa kukwegura kwemasero.
