BAM15A CAS Nhamba:210302-02-6 Kuvaka tsandanyama uye kuderedza mafuta.
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | BAM15A |
| Rimwe zita | N5,N6-Bis(2-Chlorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine |
| Nhamba yeCAS | 210302-02-6 |
| Fomura yemamorekuru | C16H10Cl2N6O |
| Kurema kwemasero | 373.2 |
| Kuchena | 98% |
| Chitarisiko | Upfu hwakachena kusvika hweyero yakapfava |
| Kurongedza | 1kg/bhegi, 25kg/bhareri |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
BAM15A imuchina mutsva wekugadzirisa mitochondrial. Semuchina wakanaka wekubvisa mapurotoni emumitochondrial, unodzora zvinyoro nyoro mafambiro eprotoni mukati memukati memitochondrial membrane, unowedzera kushanda zvakanaka kwesimba remuviri uye unokurumidzisa kuputsika kwemafuta, pasina kukanganisa tsandanyama kana chishuwo chekudya chakajairika.
Ongororo dzekutanga dzakaratidza kuti chinhu ichi chinobatsira kuvandudza kuzvimba kwemuviri, kuwedzera kunzwa kwe insulin, kuderedza kuunganidzwa kwemafuta muchiropa uye kuderedza kuzvimba mumuviri. Chine bioavailability yemuromo inosvika 67% uye chine hunhu husina kusimba uye chakachengeteka zvakanyanya. Kusiyana nezvinhu zvechinyakare zvakafanana, hachikonzeri kupisa kwemuviri kana kukuvara kwemasero, zvichiita kuti chive chinhu chepamusoro chekugadzirisa huremu uye kugadzirisa metabolic metabolic process.
Chinhu
(1) Kuchena kwakanyanya: BAM15Ainogona kugadzira zvigadzirwa zvine hutsanana hwakanyanya kuburikidza nekugadzirwa kwakanyatsogadzirwa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwechinhu ichi.
(2) Nzira yekusunungura inoshanda: Semutakuri wemaprotoni emumitochondrial, inokanganisa kutenderera kwemaprotoni emukati memitochondrial membrane, ichikurudzira kushandurwa kwesimba re oxidative kubva muzvinovaka muviri kuita simba rekupisa panzvimbo peATP, zvichiwedzera zvakanyanya kushandiswa kwesimba.
(3) Kurasikirwa nemafuta zvakachengeteka uye kuvandudzwa kwemetabolism: Mukuyedza kwemhuka, kuwanikwa kwemafuta nemuromo kwakasvika 67%, zvichideredza mafuta emuviri neanopfuura 20% pasina kuderedza tsandanyama, zvichikanganisa chishuwo chekudya kana tembiricha yemuviri, ukuwo zvichivandudza kunzwa kwe insulin, zvichideredza mafuta echiropa nekuzvimba.
(4) Kubatsira kushoma kwechepfu: Kana tichienzanisa nezvinhu zvechinyakare zvinosunungura, hapana njodzi yekupisa zvakanyanya kana kukuvadza nhengo dzemuviri. Hapana kukuvara kwenhengo kana mhedzisiro yetsinga..
Mashandisirwo
1. Kuderedza mafuta uye kuvandudza mashandiro emuviri: Kuburikidza nekusunungura mitochondrial, kunoderedza mafuta emuviri zvakanyanya (mumhuka, mafuta emuviri anoderera neanopfuura 20%), panguva imwe chete kunoderedza shuga muropa, kuramba insulin, uye kuunganidzwa kwemafuta echiropa, pasina kukanganisa kuda kudya kana tsandanyama;
2. Kudzivirira kukwegura: Kunowedzera huremu hwetsandanyama (ne8%) uye simba (ne40%) mumhuka dzakwegura, kuderedza mafuta uye kudzivirira kuzvimba kusingaperi, uye kurwisa kufutisa kunokonzerwa ne myogenic.
3. Kurwisa kuzvimba: Kunoderedza njodzi yekukuvara kweitsvo kunokonzerwa ne sepsis (AKI), uye kunoderedza kuzvimba kwemuviri nekudzivirira kugadzirwa kweROS yemitochondrial uye kuburitswa kwemtDNA.
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