Agomelatine poda mugadziri CAS Nha.: 138112-76-2 99% kuchena min.zvekuwedzera zvinhu
Product Parameters
| Product name | Agomelatine |
| Rimwe zita | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS Nha. | 138112-76-2 |
| Molecular formula | C15H17NO2 |
| Molecular uremu | 243.3082 |
| Kuchena | 99.0% |
| Chitarisiko | Upfu chena |
| Packing | 1kg/bhegi 25kg/drum |
| Application | Utano chigadzirwa mbishi zvinhu |
Product sumo
Agomelatine rudzi rutsva rwemishonga inoderedza kuora mwoyo.Maitiro ayo ekuita anopwanya kuburikidza neyechinyakare monoamine transmitter system.Iyo inomutsa melatonin receptors, MT1 uye MT2, uye inopikisa 5-HT2C receptors.Inogona kuvandudza kunaka kwekurara uye kudzoreredza biological rhythm uku uine antidepressant maitiro;pakati pavo, nekupikisa 5-HT2C receptor ye postsynaptic membrane, inogona kuwedzera kusunungurwa kweDA uye NE mu prefrontal cortex uye kutamba basa rekudzivirira.Kana MT agonism uye 5-HT2C receptor antagonism iripo panguva imwe chete, yakasarudzika synergistic mhedzisiro inogona kugadzirwa kukurudzira kuburitswa kweakawanda DA uye NE munzvimbo yeuropi yePFC, ichiwedzera kusimbisa iyo antidepressant mhedzisiro.Mukuwedzera, agomelatine inogonawo kukurudzira kusunungurwa kweuropi-yakatorwa neurotrophic factor muPFC uye kuvhara kushushikana-kunokonzerwa kusunungurwa kwe glutamate munharaunda yeuropi yeamygdala.
Feature
(1) Dual regulation: Haigoni kungogadzirisa kusunungurwa kwe melatonin, asiwo kugadzirisa kusunungurwa kwe5-hydroxytryptamine uye norepinephrine, nokudaro ichiita basa rekugadzirisa mafungiro, kurara, kurwadziwa nezvimwe zvakadaro.
(2) Kuvandudzwa kwekurara: Agomelatine inogona kuvandudza kushaya hope pasina kukonzera kukotsira kana coma.
(3) Kuvandudza cognitive basa: Agomelatine inogona kuvandudza cognitive basa nekuvandudza neuroplasticity muhippocampus.
(4) Kuchengetedzwa kwepamusoro: Kuenzaniswa nemamwe maantidepressants, mushonga wacho une zvishoma zvishoma kana uchirapa kuora mwoyo, uye hazvizokanganisa basa repabonde uye uremu hwemuviri.
Applications
Agomelatine ndeye antidepressant iyo zvakare inopikisa melatonin.Inoderedza kuora mwoyo zviratidzo nekugadzirisa mazinga e melatonin MT1 receptors (kuderedza cortical alarm signals) uye MT2 receptors (kune circadian rhythms yekurara) uye serotonin.Kutorwa husiku kutevedzera rhythm yechisikigo yekuburitswa kwe melatonin, inogona kuvandudza zvakanyanya kunaka kwekurara.
