YDL223C (HBT1) mugadziri weupfu Nhamba yeCAS: 489408-02-8 99% kuchena kwezvishandiso zvekuwedzera Mufananidzo Wakatariswa

YDL223C (HBT1) mugadziri weupfu Nhamba yeCAS: 489408-02-8 99% kuchena kweminiti yezvinongedzo zvekuwedzera

Tsananguro pfupi:

HBT1 inosunga kune ligand-binding domain ye α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) nenzira inoenderana ne glutamate.

Tumira email kwatiri

Ruzivo rweChigadzirwa

Matagi eChigadzirwa

Vhidhiyo yeChigadzirwa

Zvimiro zveChigadzirwa

Zita rechigadzirwa	HBT1
Rimwe zita	YDL223C
Nhamba yeCAS	489408-02-8
Fomura yemamorekuru	C16H17F3N4O2S
Kurema kwemasero	386.40
Kuchena	99.0%
Chitarisiko	Yakasimba yero yakajeka
Kurongedza	1kg pabhegi rimwe nerimwe 25kg padhiramu rimwe nerimwe
Kushandiswa	mishonga ye nootropic

Sumo yechigadzirwa

HBT1 inosungana nechikamu chinosunga ligand cheα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) nenzira inoenderana neglutamate. Izvi zvinoreva kuti HBT1 imorekuru inogona kungosungana panzvimbo chaiyo paAMPA-R protein kana glutamate iripo, uye kubatana uku kunobatsira kudzora mashandiro eprotein. AMPA receptors inoratidzwa muhurongwa hwese hwetsinga uye inoita basa rakakosha mukutaurirana kweneuron, kugadzirisa manzwiro, kudzidza, kurangarira, uye synapse plasticity. AMPA receptors inonyanya kubatsira mukufambiswa kweneuron, inotungamira kukurumidza, nekukurumidza kudzima kunzwa kwemanzwiro pa synapses dzakawanda, uye inobatanidzwa mukupindura kwekutanga ku glutamate munzvimbo dzesynaptic. AMPA receptors inowanzo ratidzwa pamwe chete neNMDA receptors pa synapses, uye pamwe chete inokurudzira maitiro e synapse plasticity anobatanidzwa mukudzidza, kurangarira, excitotoxicity, uye neuroprotection. Brain-derived neurotrophic factor (BDNF) chinhu chinokonzerwa ne neurotrophic chinoita basa rakakosha mukuchengetedza nekuwedzera kwe neuron uye chine simba uye mhedzisiro yakawanda pakuwanda, kusiyanisa, kupona uye kufa kwemasero e neuronal neesiri-neuronal. , neurotransmitter modulator inobatsira mukuvandudza neural mukudzidza nekurangarira. Nokudaro, zvakakosha pahutano uye kugara zvakanaka kwehurongwa hwe neural.

Chinhu

(1) Kuchena kwakanyanya: HBT1 inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nekugadzira zvinhu zvakacheneswa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu uye kushomeka kwemigumisiro yakaipa.

(2) Kuchengetedzeka: HBT1 yakaratidzwa kuti yakachengeteka mumuviri wemunhu.

(3) Kugadzikana: HBT1 ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.

Mashandisirwo

HBT1 imushonga mutsva weAMPA receptor enhancer une agonism shoma, iyo inokonzera kugadzirwa kwe brain-derived neurotrophic factor (BDNF) uye haina mhedzisiro yakawanda pa neurons dzekutanga. HBT1 inobatanidza ne ligand-binding domain ye AMPA-R nenzira inoenderana ne glutamate. Pamwe chete, vanokurudzira synaptic plasticity processes inobatanidzwa mukudzidza, kurangarira, kufara, uye kudzivirira tsinga. Inogona kuvandudza kugona kwehuropi nekurangarira, uye kuwedzera kugona kwevanhu kudzidza. Inowanzo wedzerwa mukudya kwezuva nezuva muchimiro chezvinowedzera zvekudya.