5-Amino-1-methylquinolinium chloride Nhamba yeCAS:42464-96-0 98.0% kuchena mugadziri wezvishandiso zvekuwedzera
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | 5-Amino-1-methylquinolinium chloride (5-amino-1MQ) |
| Rimwe zita | 5-amino-1MQ5-Amino-1-mq chloride 5-Amino-1-methylquinolinium chloride 5-Amino-1-methylquinolin-1-ium chloride 5-AMINO-1-METHYLQUINOLIN-1-IUM CHLOEIDE 5-Amino-1-methyl-1-quinolinium chloride |
| Nhamba yeCAS | 42464-96-0 |
| Fomura yemamorekuru | C₁₀H₁₁ClN₂ |
| Kurema kwemasero | 194.6 |
| Kuchena | 98% |
| Chitarisiko | brown kusvika kutsvuku brown yakasimba |
| Kurongedza | 1kg/bhegi, 25kg/bhareri |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
5-Amino-1-methylquinolinium chloride ienzyme inobuda zvakanyanya panguva yekukwegura kwetsandanyama dzemapfupa uye inobatanidzwa nekugadzirisa kukuvara kwenzira yeNAD+, kushanda kwesirtuin1 kusina kunaka, uye kuwedzera kwekukura kwemasero etsinga dzetsandanyama. 5-Amino-1-methylquinolinium chloride inokurudzira kusiyana kwemyoblast mu vitro uye inowedzera kubatanidzwa nekuvandudzwa kwemasero etsinga dzetsandanyama mumbeva dzakura. 5-Amino-1-methylquinolinium chloride inodzivirirawo nicotinamide N-methyltransferase (NNMT), inobatanidza zvakasara kune NNMT substrate binding site residues. 5-Amino-1-methylquinolinium chloride inokurudzira kusiyana kwemyoblast mu vitro uye inowedzera kubatanidzwa nekuvandudzwa kwemasero etsinga dzetsandanyama mumbeva dzakura. Pakati padzo, cytosolic enzyme nicotinamide N-methyltransferase (NNMT) yakawanikwa ichangobva kudzora mazinga e nicotinamide precursors anodiwa pakugadzira NAD+ biosynthesis, uye nekudaro inoita basa rakakosha mukudzora nzira yekuponesa NAD+ uye metabolism yemasero.
5-Amino-1-Methylquinolinium Chloride inoshanda mukati me microbiome yako kuderedza mafuta (mafuta) uye kukubatsira kuderedza huremu. Kana masero emafuta akawanda akaungana, muviri wako unogadzira enzyme inozivikanwa seNNMT (nicotinamide N-methyltransferase). Kana NNMT yakawanda, muviri wako unowedzera kuzvimba uye unochengeta mafuta. 5-Amino-1-Methylquinolinium Chloride inodzivirira NNMT, zvichiita kuti muviri wako uderedze huremu hwakawandisa.
Chinhu
(1) Kuchena kwakanyanya: 5-Amino-1-methylquinolinium chloride inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nemaitiro ekugadzira akacheneswa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu.
(2) Kutarisa: 5-Amino-1-methylquinolinium chloride inonyanya kunanga enzyme yeNNMT uye inogona kudzivirira kushanda kwayo zvinobudirira, nokudaro ichikanganisa nzira ye metabolism ye nicotinamide.
(3) Kugadzikana: 5-Amino-1-methylquinolinium chloride ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.
(4) Tarisiro yekukura: Nekuda kwehunhu hwakasiyana hwe5-Amino-1-methylquinolinium chloride, kukura kwayo kwave kucherechedzwa zvakanyanya uye kune mikana yakawanda yekutsvaga nekushandisa.
Mashandisirwo
5-Amino-1-methylquinolinium chloride inhibitor ye nicotinamide N-methyltransferase (NNMT) inokurudzira kusiyana kwe myoblast. 5-Amino-1-methylquinolinium chloride inogonawo kushandiswa sekuwedzera kubatsira kuderedza huremu nemafuta uye kuvandudza mafuta echiropa.
