5-Amino-1-methylquinolinium iodide（NNMTi） Nhamba yeCAS:42464-96-0 98.0% kuchena mugadziri wezvishandiso zvekuwedzera
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | 5-Amino-1-methylquinolinium iodide（NNMTi） |
| Rimwe zita | NMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODHIDE 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iodide 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| Nhamba yeCAS | 42464-96-0 |
| Fomura yemamorekuru | C10H11IN2 |
| Kurema kwemasero | 286.11 |
| Kuchena | 98.0% |
| Chitarisiko | brown kusvika kutsvuku brown yakasimba |
| Kurongedza | 1kg/bhegi, 25kg/bhareri |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
Iyi cytosolic enzyme nicotinamide N-methyltransferase (NNMT) yakawanikwa ichangobva kudzorwa kuti igadzirise huwandu hwe nicotinamide precursors hunodiwa pakugadzira NAD+ uye nekudaro inoita basa rakakosha mukugadzirisa nzira yekuponesa NAD+ uye metabolism yemasero. NNMT inoratidzwa mutsandanyama dzemapfupa, uye kuratidzwa kwayo kunowedzera zvishoma nezvishoma nekukwegura kwetsandanyama. Zvakakosha, NNMT chikamu chikuru che sarcopenic gene expression signature, uye kuratidzwa kwayo kwakanyanya kunogona kutungamira kudzikira kukuru kwemazinga eNAD+ uye kudzikira kwetsandanyama, simba, uye mashandiro anoperekedza kukwegura. Kurapa mbeva dzakwegura ne molecule diki NNMT inhibitor (NNMTTi) kwakasimbisa kuwanda, kubatanidzwa, uye kugona kwekuvandudza kwe muSCs, nokudaro zvichivandudza mashandiro etsandanyama dzemapfupa. Mhedzisiro yakafanana yakawanikwa mu vitro uchishandisa masero eC2C12, akafanana zvikuru ne muSCs, uko kurapwa kweNNMTTi kwakakurudzira kusiyana kwe myoblast uye kwakatsigira shanduko dze metabolic mu metabolites dzemasero dzine chekuita nenzira yeNAD + salvage.
NNMT ienzyme inobuda zvakanyanya panguva yekukwegura kwetsandanyama dzemapfupa uye inobatanidzwa nekukuvara kwenzira yeNAD+, kusagadzikana kwekushanda kwesirtuin1, uye kuwedzera kwekukura kwemasero etsinga dzetsandanyama. NNMT ienzyme yemetabolism inokonzeresa methylation ye nicotinamide (NAM) ichishandisa universal methyl donor S-adenosylmethionine (SAM), ichibatanidza mamiriro emetabolism yesero kune methylation balance uye intracellular NAD+ levels. NNMT inoratidzwa zvakanyanya muchiropa nemafuta, pamwe nemamiriro ezvinhu anoratidzwa nekuwedzera kwekuda kwemetabolism, senge mamwe mafuru echiropa nechirwere cheshuga. NNMT inobatanidzwa mumhando dzakasiyana dzekuchinja, kusanganisira naive to mature human embryonic stem cell transition, myogenesis, uye epithelial uye neuromesenchymal transitions mukenza dzakasiyana-siyana. Kutaurwa kweNNMT kunodzorwa nenzira yakanangana netishu uye mamiriro ezvinhu kwete nemaitiro ekutonga aripo.
Chinhu
(1) Kuchena kwakanyanya: NNMTi inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nemaitiro ekugadzira akacheneswa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu.
(2) Kutarisa: NNMTTi inonyanya kutarisa enzyme yeNNMT uye inogona kudzivirira kushanda kwayo, nokudaro ichikanganisa nzira ye metabolism ye nicotinamide.
(3) Kugadzikana: NNMTi ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.
(4) Tarisiro yebudiriro: Nekuda kwehunhu hwakasiyana hweNNMTi, budiriro yayo yakagamuchirwa zvakanyanya uye ine mikana yakawanda yekutsvaga nekushandisa.
Mashandisirwo
NNMT (CAS 42464-96-0) inhibitor ye nicotinamide N-methyltransferase (NNMT), inhibitor ine simba (IC50=1.2 μM) ye nicotinamide N-methyltransferase (NNMT) inokurudzira kusiyana kwe myoblast. NNMTTi inosarudza kubatana neNNMT substrate binding site residues. NNMTTi inokurudzira kusiyana kwe myoblast in vitro uye inowedzera muscle stem cell fusion uye regeneration mumakonzo akwegura. NNMT ienzyme ye cytosolic biotransformation iyo inokurudzira N-methylation ye endogenous uye exogenous xenobiotics. Zvichienzaniswa nekutsiva kudya kwakaderera chete, kurapwa kweNNMTTi pamwe chete nekutsiva kudya kwakaderera kwakakurudzira kuvandudzwa kwemafuta emuviri, kuwedzera muviri wese kurema kwehuremu hwemuviri, kuderedza uremu hwemafuta machena epididymal epididymal liver, kuderedza mafuta echiropa, uye kuvandudzwa kwe steatosis yechiropa. Pamusoro pezvo, NNMTTi inogona kuwedzera simba uye kukurudzira kugona kwekuvandudza kwetsandanyama dzakwegura, izvo zvinogona kubatsira pakurapa sarcopenia.
