Nhamba yeCAS yeSLU-PP-332: 303760-60-3
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | SLU-PP-332 |
| Rimwe zita | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide； |
| Nhamba yeCAS | 303760-60-3 |
| Fomura yemamorekuru | C18H14N2O2 |
| Kurema kwemasero | 290.32 |
| Kuchena | 98% |
| Chitarisiko | Upfu huchena kana husina kuchena |
| Kurongedza | 1kg/bhegi, 25kg/bhareri |
| Kushandiswa | Zvekudya Zvinowedzerwa Zvekudya Zvakagadzirwa |
Sumo yechigadzirwa
SLU-PP-332 imhando itsva yemamorekuru madiki anoshanda se perifollicle estrogen receptor (ERR) agonist, achinyanya kunanga ERRα, ERRβ, uye ERRγ, ine simba guru rekushanda paERRα (EC₅₀=98 nM). Iyi mhando inoita kuti ERR signaling pathway ishande nekutevedzera mashandiro ekurovedza muviri, nokudaro ichichinja simba rekushanda, mashandiro emitochondrial, uye kutsungirira kwetsandanyama.
Chinhu
(1) Maitiro ekushanda: kumutsa ERRα/β/γ, kuwedzera mafuta acid oxidation (FAO) uye majini ane chekuita nekufema kwemitochondrial, kukurudzira kuputsika kwemafuta kuti pave nesimba, kuderedza kuunganidzwa kwemafuta, kusimudzira mashandiro emitochondrial yetsandanyama dzemapfupa, kuvandudza kugona kweoxidative uye kutsungirira, zvakafanana nemhedzisiro yekurovedza muviri.
(2) Kushanda kwemuviri: a) Migumisiro yemuenzaniso wemhuka: Mbeva dzakafuta: mushure memazuva makumi maviri nemasere ekurapwa, huremu hwemuviri hwakaderera ne12%, uye mafuta echiropa, cholesterol, uye triglycerides zvakaderedzwa zvakanyanya; mbeva dzakajairika: nguva yekushanda yakawedzera ne70%, daro rakawedzera ne45%, pasina kukanganisa chishuwo chekudya kana kufamba kwekuzvidira. b) Kuchengeteka: hapana migumisiro yakakomba yakaonekwa muzvidzidzo zve preclinical.
(3) Hunhu hwemuviri nemakemikari: chena kusvika kuchena chakasimba, chinonyungudika muDMSO (75 mg/mL) uye ethanol, chisinganyungudike mumvura; chinofanira kuchengetwa murima.
Mashandisirwo
SLU-PP-332 inoita kuti mafuta adzike uye shuga yeropa idzoke zvakanaka nekukurudzira mafuta kuti adzike uye kuwedzera insulin; inovandudza chirwere chechiropa chine mafuta chisiri doro (NAFLD), inoderedza mafuta echiropa; inopa rutsigiro rwema metabolic kune vanhu vasingagoni kurovedza muviri, kuchengetedza tsandanyama nekushanda zvakanaka; inoderedza kurasikirwa kwetsandanyama panguva yekurasikirwa kwemafuta; uye ine mikana yakakura munzvimbo dzekurasikirwa nemafuta, kutsungirira, uye kuvandudzwa kwema metabolic process.
