Mugadziri weupfu weOleoylethanolamide (OEA) Nhamba yeCAS: 111-58-0 98%,85% kuchena kweminiti yezvekuwedzera
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | Oleoyl ethanolamide |
| Rimwe zita | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide |
| Nhamba yeCAS | 111-58-0 |
| Fomura yemamorekuru | C20H39NO2 |
| Kurema kwemasero | 325.53 |
| Kuchena | 98.0% ，85.0% |
| Chitarisiko | Upfu hwekristaro chena hwakanaka |
| Kurongedza | 1kg/bhegi, 25kg/dhiramu |
| Kushandiswa | Mushonga wekurwadziwa, unodzivirira kuzvimba |
Sumo yechigadzirwa
Oleoylethanolamide imusanganiswa wechipiri weamide unoumbwa ne lipophilic oleic acid uye hydrophilic ethanolamine. Oleoylethanolamide zvakare imorekuru yemafuta inowanikwa mune dzimwe nyama dzemhuka nemiti. Inowanikwa zvakanyanya munyama dzemhuka nemiti dzakadai secocoa powder, soya, nenzungu, asi huwandu hwayo hwakaderera zvakanyanya. Kana nharaunda yekunze ikachinja kana chikafu chikakurudzirwa, ndipo chete panobva pagadzirwa zvimwe zvezvinhu izvi.
Pakupisa kwemumba, Oleoylethanolamide chinhu chichena chine poindi yekunyunguduka inosvika 50°C. Inonyunguduka zviri nyore muzvinonyunguduka zvine doro zvakaita semethanol neethanol, inonyunguduka zviri nyore muzvinonyunguduka zvisiri zvepolar zvakaita se n-hexane ne ether, uye hainyunguduke mumvura. OEA imorekuru ine amphiphilic inoshandiswa kare se surfactant uye sipo muindasitiri yemakemikari. Zvisinei, tsvakiridzo yakawedzerwa yakawana kuti OEA inogona kushanda semorekuru inoratidza lipid mugut-brain axis uye inoratidza mabasa akasiyana-siyana ehupenyu mumuviri, anosanganisira: kudzora chido chekudya, kuvandudza lipid metabolism, kusimudzira ndangariro nekuziva uye mamwe mabasa. Pakati pazvo, mabasa eOleoylethanolamide ekudzora chido chekudya uye kuvandudza lipid metabolism akanyanya kutariswa.
Oleoylethanolamide inogona kudzora kudya uye simba rehomeostasis nekushandisa peroxisome proliferator-activated receptor-α. Pamusoro pezvo, Oleoylethanolamide inoratidza zvimwe zviitiko zvine chekuita nehutano, zvinosanganisira kugadzirisa mashandiro ekushandura mu lysosomal-to-nuclear signaling pathway ine chekuita nekutonga kwenguva refu uye kudzivirira tsinga dzinodzora maitiro ekuora mwoyo. Tsvagiridzo inoratidzawo kuti Oleoylethanolamide inogona kuva nemhedzisiro yekudzivirira tsinga. Mumhando dzemhuka, yakawanikwa ichideredza kukuvara kunokonzerwa nesitiroko nekukuvara kweuropi. Mhedzisiro yekutonga yeOleoylethanolamide inokonzerwa nekusunga kwayo kuPPARα, iyo inodzikira ne retinoid X receptor (RXR) uye inoishanda sesimba rekunyora rinobatanidzwa mu combined energy homeostasis, lipid metabolism, autophagy, uye kuzvimba.
Chinhu
(1) Kuchena kwakanyanya: OEA inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nekugadzira zvinhu zvakacheneswa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwezvinhu zvipenyu uye kusaita zvinhu zvakaipa.
(2) Kuchengetedzeka: OEA yakaratidzwa kuti yakachengeteka kumuviri wemunhu.
(3) Kugadzikana: OEA ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi penzvimbo dzakasiyana uye mamiriro ekuchengetedza.
(4) Zviri nyore kunyudza: OEA inogona kunyudzwa nekukurumidza nemuviri wemunhu uye kugoverwa kune nhengo dzakasiyana dzemuviri.
Mashandisirwo
Oleoylethanolamide imafuta echisikigo eethanolamide anoshandiswa senzira yekuronga zvekudya uye kudzora uremu hwemuviri mumarudzi akasiyana-siyana emhuka dzine mapfupa anotenderera. I metabolite ye oleic acid inoumbwa muura hwemunhu. Oleylethanolamide (OEA) imorekuru inodzora metabolism yemafuta uye energy homeostasis. Inonamatira kuma PPAR Alpha receptors uye inobatsira kudzora zvinhu zvina: nzara, mafuta emuviri, cholesterol uye huremu. PPAR Alpha inomiririra peroxide proliferator-activated receptor alpha, uye bioactive lipid amide oleoylethanolamide (OEA) ine mhando dzakasiyana dzehomeostatic properties, dzinosanganisira anti-inflammatory activity, immune response modulation, uye antioxidant effects.
