Agomelatine poda mugadziri CAS Nha.: 138112-76-2 99% kuchena min. zvekuwedzera zvinhu
Product Vhidhiyo
Product Parameters
| Product name | Agomelatine |
| Rimwe zita | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| CAS Nha. | 138112-76-2 |
| Molecular formula | C15H17NO2 |
| Molecular uremu | 243.3082 |
| Kuchena | 99.0% |
| Chitarisiko | Upfu chena |
| Packing | 1kg/bhegi 25kg/drum |
| Application | Utano chigadzirwa mbishi zvinhu |
Product sumo
Agomelatine yakatanga kuvhurwa muEurope muna 2009 uye yave kubvumidzwa kushandiswa munyika dzinopfuura makumi manomwe. Kusiyana nechinyakare antidepressants, agomelatine inoshanda nekunanga melatonin uye serotonin receptors muuropi. Nekuita seanopikisa pa melatonin receptors, agomelatine inobatsira kudzoreredza maitiro ekurara akakanganisika anowanzo sangana nekuora mwoyo. Iyi michina haingobatsiri kuvandudza kunaka kwekurara asiwo inobatsira kudzoreredza echisikigo circadian rhythms. Mukuwedzera, agomelatine inoita seanopikisa pane mamwe serotonin receptors (5-HT2C receptors). Ichi chakasarudzika chiito cheviri chinosimudzira kuwanikwa kweserotonin muuropi, neurotransmitter ine basa rekudzora manzwiro. Nokugadzirisa mazinga e serotonin, agomelatine inogona kuita seyakagadzirisa kuora mwoyo, kubvisa zviratidzo zvakadai sekusuruvara, kurasikirwa kwechido, kunzwa uine mhosva kana kusakosha. Uyezve, agomelatine inogona kupa mamwe mabhenefiti. Tsvagiridzo inoratidza kuti inogona kubatsira kuvandudza basa rekuziva Tsvagiridzo inoratidza kugona kwayo kusimudzira ndangariro, kutarisisa, uye basa rekutonga, zvichiita kuti ive nzvimbo inonakidza yekutsvaga ramangwana.
Feature
(1) Kuchena kwepamusoro: Agomelatine inogona kuwana zvigadzirwa zvakachena kuburikidza nekunatsa maitiro ekugadzira. Kuchena kwepamusoro kunoreva zvirinani bioavailability uye kushoma kwakashata maitiro.
(2) Kuchengeteka: Kuchengetedzeka kwepamusoro, maitiro mashoma asina kunaka.
(3) Kugadzikana: Agomelatine ine kugadzikana kwakanaka uye inogona kuchengetedza basa rayo nekuita pasi pemamiriro akasiyana-siyana uye kuchengetedza mamiriro.
Applications
Agomelatine is antidepressant uye melatonin anopikisa. Inoderedza kuora mwoyo zviratidzo nekugadzirisa melatonin MT1 receptors (inoderedza cortical alarm signals) uye MT2 receptors (circadian sleep rhythm) uye serotonin mazinga. Inotorwa husiku, inoteedzera rhythm yechisikigo yekuburitswa kwe melatonin uye inogona kuvandudza zvakanyanya kunaka kwekurara. Maitiro ayo ekuita anopwanya kuburikidza neyechinyakare monoamine transmitter system. Iyo inomutsa melatonin receptors MT1 uye MT2 uye inopikisa 5-HT2C receptors. Inovandudza kunaka kwekurara, inodzorera biological rhythm, uye ine antidepressant effect; pakati pavo, nekupikisa 5-HT2C receptors pane postsynaptic membrane, inogona kuwedzera kusunungurwa kweDA uye NE mu prefrontal cortex, ichiita antidepressant effect. Kana MT agonism uye 5-HT2C receptor antagonism iripo, yakasarudzika synergistic mhedzisiro inogona kugadzirwa, ichikurudzira kuburitswa kweakawanda DA uye NE munzvimbo yeuropi yePFC, ichiwedzera kusimbisa iyo antidepressant mhedzisiro. Mukuwedzera, agomelatine inogona kukurudzira kusunungurwa kweuropi-yakagadzirwa neurotrophic factor muPFC uye inodzivisa kushushikana-kunokonzerwa kusunungurwa kwe glutamate munharaunda yeuropi yeamygdala.
