7,8-Dihydroxyflavone (7,8-DHF) iflavonoid inowanikwa zvakasikwa inoratidza kuvimbisa munzvimbo dzakasiyana dzehutano. Kana uchifarira zvekudya zvechisikigo kana zvinhu zvekudya zvinogona kutsigira hutano hwehuropi, manzwiro, uye hutano hwese, 7,8-DHF ingave yakakosha kuongorora. 7,8-Dihydroxyflavone Powder inopihwa naSuzhou Myland ine nhamba yeCAS ye38183-03-8 uye kuchena kusvika ku98%. Chigadzirwa ichi chakaongororwa zvakanyanya uye chinoenderana nezvinodiwa zvepasi rose, zvichiona kushanda zvakanaka uye kuchengetedzeka kwechigadzirwa. , chakakodzera kutsvagisa kwesainzi, kugadzira mishonga, kugadzirwa kwezvigadzirwa zvehutano nedzimwe nzvimbo, zvichikupa sarudzo yakavimbika.
7,8-Dihydroxyflavone (7,8-DHF)imusanganiswa weflavonoid usingawanzo kuwanikwa muzvisikwa. Wakaonekwa muAstragalus pumila, Primula grandifolia naHubei crabapple. Wakabuda semusanganiswa une tariro ye nootropic. Waratidza mhedzisiro dzakasiyana-siyana dze neuropharmacological muzvidzidzo zve preclinical,
Maflavonoids imhando yemakomichi epolyphenolic anowanikwa mumichero yakasiyana-siyana, miriwo, nezvimwe zvinomera. Mumakore achangopfuura, akanyanya kutariswa nekuda kwesimba rawo rekudzivirira muviri kubva pakukuvadza, kudzivirira kuzvimba, uye kudzivirira tsinga.
Mishonga iyi yakaratidzwa kuti ine mhedzisiro inobatsira pauropi, kusanganisira kusimudzira mashandiro epfungwa uye kudzivirira zvirwere zvinokanganisa tsinga. 7,8-DHF ndeimwe yemishonga inonyanya kuzivikanwa yepolyphenolic inogamuchira kutariswa kuri kuwedzera semushonga we nootropic. Yakadzidzwa nezvemhedzisiro yayo pamanzwiro, ndangariro, kudzidza, kuzvidya mwoyo, uye mamwe mabasa epfungwa.
Zvinofungidzirwa kuti mhedzisiro yetsinga dzeropa dze7,8-DHF inokonzerwa nekushanda kwayo nemareceptor chaiwo. Yakawanikwa kuti iTrkA, receptor inobatsira mukukura kwetsinga uye yakakosha pakurarama kwetsinga uye kuvandudza mashandiro etsinga.
7,8-DHF inoshanda nekudzora kutaurwa kwemareceptor akasiyana-siyana, kusanganisira glutamate receptor subunits uye BDNF. Inokanganisawo kuumbwa kwesynapse, kushandiswa kwesimba, uye kuburitswa kweacetylcholine mune dzimwe nzvimbo dzeuropi.
Pamusoro pezvo, osteoporosis inozivikanwa se "muurayi akanyarara" wemuviri wemunhu, ichityisidzira zvakanyanya hutano hwevanhu vezera repakati nepakati nevakwegura, kunyanya vakadzi vasvika panguva yekupedza kuenda kumwedzi. Mumamiriro ezvinhu akajairwa emuviri, kugadziriswa kwemapfupa kuri mumamiriro akaenzana; asi kana paine kusawirirana pakati pekuumbwa kwemapfupa anokonzerwa neosteoblast uye kusvetwa kwemapfupa anokonzerwa neosteoclast, uye huwandu hwemapfupa akaumbwa husina kukwana kuwedzera huwandu hwemapfupa anonyudzwa, huwandu hwemapfupa huchaderera. , chimiro chemapfupa chinoparadzwa, zvichikonzera osteoporosis.
7,8-Dihydroxyflavone (7,8-DHF) iflavonoid inobva mumiti inogona kutevedzera mashandiro europi-inobva kuuropi (BDNF), inokonzera dimerization yeTrkB receptors uye inoita kuti mamorekuru ayo ekutumira masaini ashande. Zvidzidzo zvakaratidza kuti BDNF inogona kukurudzira kusiyana kweosteoblast uye kufamba uye kukurumidzisa kuporesa kwekukuvara.
7,8-DHF inogona kukurudzira kuwanda nekusiyana kwemaosteoblast nekubatana neTrkB uye kuita kuti nzira yeWnt/β-catenin isinhike, uye inogona kudzivirira kugadzirwa kwemaosteoclast nekuderedza transcription factor c-fos; pamusoro pezvo, 7,8-DHF inogona kuvandudza osteoporosis phenotype mumakonzo ane ovariectomized.
Maumbirwo emakemikari uye hunhu hwe7,8-dihydroxyflavone
Ine mapoka maviri ehydroxyl pa ring yebenzene uye rimwe boka rehydroxyl pa pyrrolone ring. Ngatinyatsoongororai maumbirwo emakemikoro e7,8-dihydroxyflavone:
Fomura yemamorekuru ye7,8-DHF ndeye C15H10O5, zvichiratidza kuti ine maatomu ecarbon gumi nemashanu, maatomu ehydrogen gumi, uye maatomu mashanu eokisijeni.
7,8-Dihydroxyflavone ikristaro yero ine huremu hwemamorekuru hwe286.24 g/mol. Inonyungudika zvishoma mumvura nekuda kwemapoka akawanda ehydroxyl anogona kubatanidza hydrogen nemamorekuru emvura.
7,8-DHF maitiro ekuita: Mutemo weBDNF uye kushanda kweTrkb receptor
Panyaya yekushanda, 7,8-DHF inozivikanwa nekusimudzira kugadzirwa kweBDNF (neurotrophic factor inobva muuropi) nekusunga uye kuvhura receptor yayo TrkB. Pasina kunyanya kushandisa tekinoroji, izvi zvinotungamira mukuita mabasa akawanda emasero anobatsira kuchengetedza mashandiro akanaka etsinga dzeropa uye kukurudzira kugadzirwa kwetsinga dzeropa.
Ngatinyatsoongorora maitiro makuru e7,8-DHF pazasi.
Brain-derived neurotrophic factor (BDNF) uye basa rayo mu neuroplasticity
Nekuwanikwa kwekuti kutaura kweuropi kunobva kuuropi (BDNF) kunoderera muzvirwere zvinoderedza mashandiro etsinga, kunyanya chirwere cheAlzheimer's (AD), kukosha kwacho mukuchengetedza nekusimudzira hutano hwehuropi kuri kuramba kuchionekwa.
BDNF inokosha pamabasa akasiyana-siyana etsinga dzetsinga sezvo ichisimudzira kutapurirana kwesynaptic, synaptogenesis, uye synaptic plasticity kuburikidza nekutumira masaini nemaTrkB receptors. Izvi zvinoita kuti nzira yekutumira masaini yeBDNF-TrkB ive chinangwa chakanaka chekuvandudza nzira dzekurapa dzakanangana nekurwisa zvirwere zvinokanganisa tsinga dzetsinga.
Ongororo dzichangobva kuitwa dzakaongorora mabhenefiti angangowanikwa nemorekuru diki inonzi TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) mukuderedza migumisiro yekutanga yechirwere chinokonzerwa neAD. Mukudzidza kwemuenzaniso wembeva we5xFAD weAD, mbeva dzakarapwa ne7,8-DHF kwemwedzi miviri kutanga pamwedzi mumwe chete.
Zvakabuda mukuferefeta uku zvinoratidza kugona kwekurapa kwe7,8-DHF mukugadzirisa kuchinja kwemakemikari europi ane chekuita neAD uye zviratidzo zvezvirwere. Zvinonyanya kukosha ndezvekuti, kurapwa kwe7,8-DHF kwakaita kuti pave nekudzikira kweAβ plaque deposition mucortical, chiratidzo chikuru cheAD.
Uyezve, inodzivirira ma neuron e cortical kubva mukuderera kwekuomarara kwe dendritic arbor, zvichibatsira kuchengetedza chimiro che neuron yese. Zvisinei, haina kukanganisa zvakanyanya density ye dendritic spine.
Sekureva kwaAytan, Nurgul nevamwe, kurapwa uku kwakaratidzawo mhedzisiro yekudzivirira tsinga mu hippocampus, zvichidzivirira huwandu hwakakwira hwemakemikari ane choline uye kuderedza kurasikirwa kwe glutamate.
Nzira yekutumira chiratidzo cheTropomyosin receptor kinase B (Trkb)
Muna 2010, boka raProfessor Ye Keqiang weEmory University rakashuma kekutanga muProceedings of the National Academy of Sciences (PNAS) kuti 7,8-DHF inogona kushandiswa se molecule diki agonist ye tropomyosin receptor kinase B (TrkB), iyo inogona kutevedzera. Basa re brain-derived neurotrophic factor (BDNF) rinowedzera kushanda kwenzira dzekutumira zviratidzo pasi peTrkB, dzakadai seMAPK/ERK, PI3K/Akt nePKC. Uyezve, zvidzidzo zvakatevera zvakawana kuti 7,8-DHF inogona kuderedza kufutisa kunokonzerwa nekudya kwakawanda mumbeva dzechikadzi nekushandisa TrkB mutsandanyama dzemapfupa, zvichiratidza kusiyana kukuru pakati pevanhurume nevanhukadzi.
Brain-derived neurotrophic factor (BDNF) inogona kukurudzira osteoblast differentiation, facilitation uye break break. BDNF inhengo yemhuri yeneurotrophic factor uye inodzora maitiro akasiyana-siyana ehupenyu kunyanya nekubatana ne transmembrane receptor tyrosine kinase B (TrkB). Kunyange zvakadaro, chiratidzo cheBDNF-induced TrkB chaive chenguva pfupi pamaminitsi gumi uye chakasvika pamaminitsi makumi matanhatu. Zvisinei, BDNF ine hafu yehupenyu hupfupi uye haigone kuyambuka zviri nyore chipingamupinyi cheropa-uropi.
7,8-dihydroxyflavone (7,8-DHF) iflavonoid inobva mumiti inokwanisa kukunda zvipingamupinyi zvataurwa pamusoro apa zveBDNF uye yakaonekwa seBDNF mimetic inoshanda uye ikozvino inoshandiswa mumasisitimu akasiyana-siyana ebiochemical necellular. Zvakaonekwa kuti inogona kukonzera TrkB dimerization uye kumutsa mamorekuru ayo ekutumira masaini.
Iyo tropomyosin receptor kinase B (TrkB) receptor ine basa rakakosha mukugadzirisa mhedzisiro yeBDNF pama neuron. Semugamuchiri we transmembrane tyrosine kinase, TrkB ndiyo receptor huru yeBDNF uye inotanga kuwanda kwezviitiko zve intracellular signaling events kana zvabatana ne neurotrophic factors.
BDNF inoita kuti TrkB itange nzira dzakasiyana dzemukati memasero, dzinosanganisira phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), uye phospholipase Cγ (PLCγ)-protein kinase C (PKC). Imwe neimwe yenzira idzi inobatsira kune chimwe chinhu chakasiyana chekushanda kwetsinga uye kugara zvakanaka.
Nzira yePI3K-Akt yakakosha pakusimudzira kupona kwetsinga dzeropa uye kudzivirira apoptosis. BDNF-TrkB signaling inomutsa nzira iyi kuti iwedzere kupona kwemasero nekudzivisa zvinhu zvinosimudzira apoptosis uye kukurudzira zvinhu zvinorwisa apoptosis, nokudaro ichivimbisa kuchengetedzwa kwema neuron ane hutano.
Kune rumwe rutivi, nzira yeMAPK-ERK inoita basa rakakosha mukusiyana kwetsinga dzeropa uye kuwanda kwadzo. BDNF-TrkB signaling inokurudzira kushanda kwenzira yeMAPK-ERK, iyo inotsigira kukura kwetsinga dzeropa uye kusiyanisa kwadzo uye kubatanidzwa kwadzo mu network dzetsinga dzeropa dziripo.
Nzira yePLCγ-PKC yakakosha pakugadzirisa synaptic plasticity, iyo nzira huru yekudzidza nekuyeuka. BDNF-TrkB signaling inogadzirisa mashandiro enzira iyi, zvichizopedzisira zvaita kuti pave nekuchinja kwesimba resynaptic nekubatana.
Kuchinja uku kunokurudzira kugadziriswa uye kurongeka patsva kwemasero etsinga dzetsinga zvichienderana nezviitiko zvitsva uye zvinokurudzira zvakatipoteredza.
Zvimiro zvekudzivirira tsinga
Tsvagiridzo inoratidza kuti iyi flavonoid inodzivirira ma neuron kubva mukushushikana kwe oxidative uye apoptosis (kufa kwemasero kwakarongwa). Kushushikana kwe oxidative chinhu chakakosha muzvirwere zvinokanganisa mashandiro etsinga dzakadai seAlzheimer's neParkinson's disease. Nekubvisa ma free radicals uye kuderedza kukuvara kwe oxidative, 7,8-DHF inogona kubatsira kuchengetedza kushanda zvakanaka kwetsinga dzetsinga.
Muzvidzidzo zvemhuka, 7,8-DHF yakaratidzwa kuti inovandudza mashandiro ekuziva uye ndangariro. Semuenzaniso, mumhando dzechirwere cheAlzheimer, 7,8-DHF yakaratidzwa kuti inowedzera plasticity ye synaptic, iyo inokosha pakudzidza nekuyeuka.
Kurwisa kuzvimba
Kuwedzera pakudzivirira kwayo tsinga dzeuropi, 7,8-dihydroxyflavone inewo simba rekudzivirira kuzvimba. Kuzvimba kwenguva refu chinhu chinowanzoitika muzvirwere zvakawanda, kusanganisira zvirwere zvinoderedza kuzvimba kweuropi. Nekugadzirisa nzira dzekuzvimba, 7,8-DHF inogona kubatsira kuderedza kuzvimba kweuropi, izvo zvinowanzobatanidzwa nekuderera kwepfungwa.
Hunhu hweAntioxidant: Kubvisa ROS uye lipid peroxidation
7,8-DHF ine simba rekudzivirira muviri sezvinoratidzwa nekukwanisa kwayo kubvisa reactive oxygen species (ROS) uye kuderedza lipid peroxidation. Izvi zvinobatsira mukudzivirira tsinga dzetsinga nekuderedza kukuvara kwetsinga dzetsinga uye kusashanda zvakanaka kwetsinga dzetsinga.
Ongororo dzakaratidza kuti 7,8-DHF inodzivirira kugadzirwa kwema cytokines anokonzera kuzvimba uye inoderedza kushanda kwe microglia, masero ekudzivirira muviri mutsinga huru. Izvi zvinodzivirira kuzvimba hazvingodziviriri ma neuron chete asiwo zvinogadzira nzvimbo yakanaka yekushanda kwepfungwa.
Zvichienderana nekubatsira kwayo pahutano hwehuropi, 7,8-dihydroxyflavone inogona kushandiswa munzvimbo dzakasiyana dzehutano nemishonga. Mamwe emashandisirwo ayo anozivikanwa zvikuru anosanganisira:
Kubatanidzwa kwendangariro uye kudzoka kwadzo
7,8-DHF yakawanikwa ichivandudza kubatana kwendangariro nekutora zvinhu mumabasa akasiyana-siyana ekudzidza nekuyeuka anoenderana nehippocampal mumakonzo. Izvi zvakawanikwa zvinoratidza kuti 7,8-DHF inogona kunge iri nootropic inovimbisa yekuvandudza mashandiro endangariro muvanhu vane hutano neavo vane dambudziko rendangariro.
Synaptic plasticity: kugona kwenguva refu uye kuora mwoyo
Sezvambotaurwa, 7,8-DHF yakaratidzwa kuti inochinja plasticity yesynaptic nekusimudzira LTP uye kuderedza LTD mu hippocampus. Mhedzisiro iyi inofungidzirwa kuti inokonzerwa nekukwanisa kwayo kumutsa maTrkB receptors uye nekudaro inovandudza nzira yekutumira masaini yeBDNF.
Kuchinja uku kwe synaptic plasticity kunobatsira mukuvandudzwa kwebasa rekuziva rinoonekwa mushure mekupiwa kwe7,8-DHF.
Kuvandudza pfungwa
Sezvambotaurwa, 7,8-DHF inoratidza mukana wekuvandudza mashandiro epfungwa nekurangarira. Izvi zvinoita kuti ive mishonga yekuwedzera inovavarira kuvandudza mashandiro epfungwa, kunyanya kune vakwegura kana vanhu vane dambudziko rekushaya njere.
Kunyudzwa, Kugoverwa, Kugadzirwa kwemuviri, uye Kuburitswa kwemvura (ADME): 7,8-DHF ine hunhu hwakanaka hwe pharmacokinetic, kusanganisira kukurumidza kunyudzwa, kupararira kwakafara, uye kupinda kweuropi zvakanaka. Inonyanya kugayiwa nechiropa, chikamu chikuru chemushonga chichiburitswa mutsvina uye chikamu chidiki chichiburitswa muweti.
Kupinda kweropa muuropi uye kupinda kwemasero europi. Chimwe chezvinhu zvakakosha zve 7,8-DHFkugona kwayo kuyambuka chipingamupinyi cheropa-uropi (BBB) uye kupinda mumasero europi, izvo zvakakosha kuti ishande zvakanaka semushonga we nootropic.
Nhoroondo Yekuchengetedza Pamberi Pekiriniki - Zvidzidzo Zvehupfu Hwakanyanya Uye Husingaperi: Zvidzidzo zvekuchengetedza pamberi pekiriniki zvakaratidza kuti 7,8-DHF ine nhoroondo yakanaka yekuchengetedza, pasina migumisiro yakaipa yakaonekwa muzvidzidzo zvehupfu hwemakonzo. Zvisinei, kuongororwa kwakawanda kwekuchengetedza, kusanganisira zvidzidzo mumhuka dzakakwirira nevanhu, kunodiwa kuti uone kuchengetedzeka kwayo pakushandiswa mukiriniki.
Kunyangwe zvidzidzo zvepamberi pekiriniki zvakaratidza kuti 7,8-DHF ine hunhu hwakanaka hwekuchengetedza, migumisiro inogona kuitika muvanhu ichiri kuzivikanwa zvakanyanya. Sezvineiwo nechero mushonga mutsva, kungwarira kunofanira kuitwa uye migumisiro yakaipa inogona kutariswa pakuongorora kushandiswa kwayo muvanhu.
Zvichienderana nemaitiro e7,8-DHF uye mhedzisiro yema receptors eTrkB, mimwe migumisiro inogona kunge yakabatana ne7,8-DHF inogona kusanganisira:
Musoro: Kushanda kweBDNF neTrkB receptor kunodzora mashandiro etsinga dzetsinga uye kufara; kupiwa kwe7,8-DHF kunogona kukonzera misoro kune vamwe vanhu.
Kushaya hope: Kuwedzera kwekushanda kwetsinga dzeropa uye kugadzikana kwetsinga dzeropa (synaptic plasticity) zvinogona kukanganisa maitiro ekurara, zvichikonzera kushaya hope kana kukanganiswa kwehope.
Matambudziko emudumbu: Kufanana nezvinhu zvakawanda zvinoshanda mumuviri, 7,8-DHF inogona kukonzera migumisiro yakaipa mudumbu, yakadai sekusvotwa, kurutsa, kana manyoka mune vamwe vanhu.
Zvakakosha kuziva kuti migumisiro iyi inogona kuitika inofanira kudzidzwa zvakanyanya mumiedzo yekiriniki. Zvichienderana nekukwanisa kwayo kugadzirisa BDNF signaling uye TrkB receptor activation, kungwarira kunofanirawo kuitwa pakubatanidza 7,8-DHF nemimwe mishonga inotarisa nzira idzi kana ine nzira dzakafanana dzekushanda.
Semusanganiswa unokosha, 7,8-Dihydroxyflavone yakakwezva vanhu vakawanda nekuda kwemabasa ayo akasiyana ehupenyu. Kune vaongorori vesainzi nemabhizinesi, zvakakosha kuwana 7,8-Dihydroxyflavone Powder yemhando yepamusoro. 7,8-Dihydroxyflavone Powder inopihwa naSuzhou Myland ine nhamba yeCAS 38183-03-8 uye kuchena kwayo kusvika ku98%. Chigadzirwa ichi chakaongororwa zvakanyanya uye chinoenderana nezvinodiwa zvepasi rose, zvichiona kushanda zvakanaka uye kuchengetedzeka kwechigadzirwa ichi. , chakakodzera kutsvagisa kwesainzi, kugadzira mishonga, kugadzira zvigadzirwa zvehutano nedzimwe nzvimbo, zvichikupa sarudzo yakavimbika.
Simbiso yemhando yepamusoro
Tinoziva kuti mhando yezvigadzirwa zvedu inokanganisa zvakananga mhedzisiro yetsvakiridzo yevatengi vedu uye mashandisirwo azvo. Saka, Suzhou Myland inotevedzera zvakanyanya GMP (Good Manufacturing Practice) uye ISO certification standards panguva yekugadzira kuitira kuti ive nechokwadi chekugadzikana uye kugara kwenguva refu kwezvigadzirwa zvese. Pamusoro pezvo, timu yedu yeR&D inoramba ichiita tekinoroji itsva uye inoedza kuramba ichivandudza mhando yezvigadzirwa uye mashandiro azvo.
Mabatiro evatengi
Suzhou Myland haingopi zvigadzirwa zvemhando yepamusoro chete, asiwo inoteerera zvinodiwa nevatengi. Tine timu yehunyanzvi yekutsigira tekinoroji inogona kupa vatengi mazano ekushandisa chigadzirwa uye nhungamiro yehunyanzvi kubatsira vatengi kuwana mhedzisiro iri nani mukutsvagisa nekushandisa. Ingave kuyedza kudiki kana kugadzira kukuru, tinogona kupa mhinduro dzinochinjika kuti tisangane nezvinodiwa nevatengi vakasiyana.
Maitiro Ekuwana Powder ye7,8-Dihydroxyflavone
Kana uchitsvaga 7,8-Dihydroxyflavone Powder yemhando yepamusoro, Suzhou Myland ndiyo sarudzo yako yakanakira. Unogona kutibata ne:
Webhusaiti yepamutemo: Shanyira webhusaiti yepamutemo yeSuzhou Myland kuti udzidze zvakawanda nezveruzivo rwechigadzirwa uye rutsigiro rwehunyanzvi.
Kubvunzana paIndaneti: Kutaurirana zvakananga nechikwata chedu chebasa revatengi kuburikidza nebasa rekubvunzana paIndaneti rinopihwa newebhusaiti kuti uwane ruzivo rwechigadzirwa uye makotesheni aunoda.
Runhare: Fonera nhamba yedu yekutaurirana kuti utaure nevashandi vekutengesa vane hunyanzvi uye uwane ruzivo rwakadzama nezvechigadzirwa uye mazano ekutenga.
Kubvunza nezve email: Munogonawo kutibvunza nezveruzivo rwechigadzirwa kuburikidza neemail, uye tichakupindurai nekukurumidza sezvinobvira.
Mukupedzisa
Semusanganiswa unokosha une mabasa akasiyana-siyana ehupenyu, 7,8-Dihydroxyflavone iri kuva chikamu chakakosha mukutsvagisa kwesainzi uye mashandisirwo emaindasitiri. 7,8-Dihydroxyflavone Powder yakachena kwazvo inopihwa naSuzhou Myland ichapa rutsigiro rwakasimba pakutsvagisa kwako nekugadzirwa kwechigadzirwa chako nemhando yayo yepamusoro uye sevhisi yakavimbika. Tinotarisira kushanda nemi kuti tiongorore zvimwe zvinogoneka zvekushandisa zve7,8-Dihydroxyflavone.
Mubvunzo: Chii chinonzi 7,8-dihydroxyflavone?
A:7,8-Dihydroxyflavone iflavonoid inowanikwa zvakasikwa inozivikanwa nekuda kwesimba rayo rekudzivirira tsinga uye iri kuongororwa nezvemhedzisiro yayo pakushanda kwepfungwa uye kuvandudza mafungiro.
Mubvunzo: Ndezvipi zvakanakira zvinogona kuwanikwa ne7,8-dihydroxyflavone?
A: Tsvagiridzo inoratidza kuti 7,8-dihydroxyflavone inogona kubatsira kuvandudza ndangariro, kuderedza kuzvidya mwoyo, uye kudzivirira zvirwere zvinokanganisa tsinga. Hunhu hwayo hwekuchengetedza ma antioxidants hunogonawo kukurudzira hutano hwese nekurwisa kushushikana kwe oxidative.
Mubvunzo: Chii chinonzi bioavailability ye7,8-DHF?
A: Kuwanikwa kwe7,8-dihydroxyflavone (7,8-DHF) mumuviri muzvidzidzo zvemhuka kunosvika 5% (mumakonzo) nekuda kwekusanyunguduka kwayo zvakanaka uye kukurumidza kushandiswa kwayo mumuviri. Pasinei nekusawanikwa kwayo zvakanaka mumuviri, 7,8-DHF ichiri kukwanisa kuyambuka chipingamupinyi cheropa-uropi uye kukanganisa uropi. Tsvakurudzo yakawanda inodiwa kuti ione kuwanikwa kwayo mumuviri muvanhu uye kutsvaga nzira dzekuivandudza.
Mubvunzo: 7,8-DHF inoita kuti unzwe sei?
A:Semushonga we nootropic, 7,8-dihydroxyflavone (7,8-DHF) ine mhedzisiro yakanaka pakushanda kwepfungwa uye manzwiro. Vanhu vanowana ndangariro dziri nani, pfungwa dzakanyanya, uye hunyanzvi hwekudzidza huri nani.
Chiziviso: Chinyorwa ichi ndecheruzivo rwese chete uye hachifanirwe kutorwa semazano ekurapa. Mamwe emashoko eblog anobva paInternet uye haasi ehunyanzvi. Iyi webhusaiti ine basa rekugadzirisa, kuronga nekugadzirisa zvinyorwa chete. Chinangwa chekutumira rumwe ruzivo hazvirevi kuti unobvumirana nemaonero ayo kana kusimbisa chokwadi chezviri mukati mayo. Gara uchibvunza nyanzvi yehutano usati washandisa chero mishonga yekuwedzera kana kuita shanduko kuhurongwa hwako hwehutano.
Nguva yekutumira: Gumiguru-14-2024
