7,8-Dihydroxyflavone (7,8-DHF) flavonoid inowanzoitika inoratidza vimbiso munzvimbo dzakasiyana dzehutano. Kana iwe uchifarira zvechisikigo zvekuwedzera kana zvekudya zvinongedzo zvinogona kutsigira hutano hwehuropi, manzwiro, uye kugara zvakanaka, 7,8-DHF inogona kunge yakakosha kuongorora. Iyo 7,8-Dihydroxyflavone Powder yakapihwa naSuzhou Myland ine nhamba yeCAS ye38183-03-8 uye kuchena kunosvika 98%. Chigadzirwa chacho chave chakanyatso kudzora mhando uye chinoenderana nemitemo yenyika, kuve nechokwadi chekushanda uye kuchengetedzeka kwechigadzirwa. , yakakodzera tsvakurudzo yesayenzi, kugadzirwa kwezvinodhaka, kugadzirwa kwehutano hwehutano uye mamwe minda, ichikupa iwe sarudzo yakavimbika.
7,8-Dihydroxyflavone (7,8-DHF)chinhu chisingawanikwe cheflavonoid chinongoitika muzvisikwa. Yakaonekwa muAstragalus pumila, Primula grandifolia uye Hubei crabapple. yakabuda sechinhu chinovimbisa nootropic compound. Yakaratidza huwandu hwehuropharmacological mhedzisiro mune preclinical zvidzidzo,
Flavonoids ikirasi yemapolyphenolic makomisheni anowanikwa mumhando dzakasiyana dzemichero, miriwo, uye zvimwe zvinorimwa. Mumakore achangopfuura, vakawana kutariswa kwakanyanya nekuda kweiyo antioxidant, anti-inflammatory, uye neuroprotective properties.
Aya makomisheni akaratidzwa kuve ane mhedzisiro inobatsira pahuropi, kusanganisira kuwedzera kugona kwekuziva uye kudzivirira neurodegenerative zvirwere. 7,8-DHF ndeimwe yemakomisheni ane mukurumbira epolyphenolic anogamuchira kuwedzera kutariswa seanotropic. Yakave ichidzidzwa nekuda kwezvinogona kuitika pamanzwiro, ndangariro, kudzidza, kunetseka, uye mamwe mabasa ekuziva.
Izvo zvinokonzerwa neurological ye7,8-DHF inofungidzirwa kuti inopindirana nekubatana kwayo nemamwe ma receptors. Yakawanikwa iri TrkA, receptor inobatanidzwa muhutano hwekukura kwechiratidzo uye yakakosha kune neuronal kupona uye plastiki.
7,8-DHF inoshanda nekugadzirisa kutaura kwezvakasiyana-siyana zvinogamuchirwa, kusanganisira glutamate receptor subunits uye BDNF. Inobatawo kuumbwa kwe synapse, simba metabolism, uye kusunungurwa kweacetylcholine mune dzimwe nzvimbo dzehuropi.
Mukuwedzera, osteoporosis inozivikanwa se "muurayi akanyarara" wemuviri wemunhu, achityisidzira zvakanyanya hutano hwevanhu vepakati-kati uye vakwegura, kunyanya vakadzi ve postmenopausal. Pasi pemamiriro ezvinhu ehutano hwepanyama, kugadziriswa kwepfupa kuri mumamiriro akaenzana; asi kana paine kusaenzana pakati peosteoblast-mediated bone formation uye osteoclast-mediated bone resorption, uye huwandu hwepfupa hwakaumbwa husina kukwana kuwedzera pfupa rakabatwa, mapfupa emapfupa achaderera. , iyo microstructure yemapfupa emapfupa inoparadzwa, zvichiita kuti osteoporosis.
7,8-Dihydroxyflavone (7,8-DHF) inonzi flavonoid inogadzirwa nemiti inogona kutevedzera basa reuropi-derived neurotrophic factor (BDNF), inokonzera dimerization yeTrkB receptors uye inomisa mamolekemu ayo ekudzika. Zvidzidzo zvakaratidza kuti BDNF inogona kukurudzira kusiyanisa kwe osteoblast uye kutama uye kukurumidza kuporesa kuputsika.
7,8-DHF inogona kukurudzira kupararira uye kusiyanisa kwemaosteoblasts kuburikidza nekubatana neTrkB nekugadzirisa nzira yeWnt / β-catenin yechiratidzo, uye inogona kudzivisa chizvarwa che osteoclasts nekuderedza zvinyorwa zvinyorwa c-fos; uyezve, 7,8-DHF inogona kuvandudza osteoporosis phenotype mumakonzo ane ovariectomized.
Chimiro chemakemikari uye zvivakwa zve7,8-dihydroxyflavone
Iine mapoka maviri e-hydroxyl pamhete yebenzene uye rimwe boka rehydroxyl pane pyrrolone ring. Ngatitarisei zvakanyanya kuumbwa kwemakemikari e7,8-dihydroxyflavone:
Iyo molecular formula ye7,8-DHF iC15H10O5, zvichiratidza kuti ine maatomu ecarbon 15, maatomu ehydrogen gumi, uye maatomu mashanu eokisijeni.
7,8-Dihydroxyflavone ikristaro yeyero ine huremu hwe286.24 g/mol. Inonyungudika zvishoma mumvura nekuda kwemapoka akawanda ehydroxyl anogona kubatanidza hydrogen kumamorekuru emvura.
7,8-DHF nzira yekuita: BDNF mutemo uye Trkb receptor activation
Mukutaura kwemaitiro ekuita, 7,8-DHF inozivikanwa kukurudzira kugadzirwa kweBDNF (brain-derived neurotrophic factor) nekusunga nekuita kuti receptor yayo TrkB. Pasina kuwana tekinoroji yakawandisa, izvi zvinotungamira kune kuwanda kwezviitiko zvemaserura zvinobatsira mukuchengetedza kwakaringana neuronal basa uye kusimudzira neurogenesis.
Ngatitarisei zvakanyanya pa7,8-DHF's main mode of action pazasi.
Brain-yakatorwa neurotrophic factor (BDNF) uye basa rayo mune neuroplasticity
Nekuwanikwa kwekuti brain-derived neurotrophic factor (BDNF) kutaura kwakaderedzwa muzvirwere zveurourodegenerative, kunyanya chirwere cheAlzheimer (AD), kukosha kwayo mukuchengetedza nekusimudzira hutano hwehuropi huri kuramba huchibuda pachena. .
BDNF yakakosha kune akasiyana-siyana neuronal mabasa sezvo ichikurudzira synaptic transmission, synaptogenesis, uye synaptic plasticity kuburikidza nekuisa chiratidzo neTrkB receptors. Izvi zvinoita kuti BDNF-TrkB isaina nzira ive inovimbisa chinangwa chekuvandudza kwekurapa kupindira kune chinangwa chekurwisa neurodegenerative zvirwere.
Zvidzidzo zvenguva pfupi yapfuura zvakaongorora zvingangobatsira zvemorekuru diki TrkB agonist 7,8-dihydroxyflavone (7,8-DHF) mukudzikisa mhedzisiro yekutanga yeAD-inoenderana pathology. Muchidzidzo che5xFAD mbeva modhi yeAD, mbeva dzakarapwa ne7,8-DHF kwemwedzi miviri kutanga nemwedzi mumwe wezera.
Mhedzisiro yeongororo iyi inoratidza kugona kwekurapa kwe7,8-DHF mukugadzirisa AD-ane chekuita neurochemical alterations uye pathological markers. Zvinonyanya kukosha, kurapwa kwe7,8-DHF kwakakonzera kuderedzwa kwecortical Aβ plaque deposition, chiratidzo chikuru cheAD.
Uyezve, inodzivirira cortical neurons kubva mukuderedza dendritic arbor kuoma, kubatsira kuchengetedza yakazara neuronal chimiro. Zvisinei, hazvina kukanganisa zvakanyanya dendritic spine density.
Sekureva kwaAytan, Nurgul nevamwe, kurapwa kwakaratidzawo neuroprotective mhedzisiro muhippocampus, kudzivirira yakakwira mazinga echoline-ine makomisheni uye attenuating glutamate kurasikirwa.
Tropomyosin receptor kinase B (Trkb) receptor chiratidzo nzira
Muna 2010, boka raProfessor Ye Keqiang weEmory University rakashuma kekutanga muProceedings of the National Academy of Sciences (PNAS) kuti 7,8-DHF inogona kushandiswa seyakanyanya diki molecule agonist ye tropomyosin receptor kinase B ( TrkB), iyo inogona kutevedzera Basa reuropi-derived neurotrophic factor (BDNF) rinowedzera kushandura nzira dzechiratidzo pasi peTrkB, dzakadai seMAPK/ERK, PI3K/Akt uye PKC. Uyezve, zvidzidzo zvakazotevera zvakawana kuti 7,8-DHF inogona kuderedza kufutisa-kunokonzerwa nekudya-kunokonzera kufutisa mumakonzo echikadzi kuburikidza nekuita skeletal muscle TrkB, kuratidza kusiyana kwakakura kwevakadzi.
Brain-derived neurotrophic factor (BDNF) inogona kukurudzira osteoblast kusiyanisa, kutama uye kuporesa kuputsika. BDNF inhengo yemhuri yeurourotrophic factor uye inoronga zvakasiyana-siyana zvehupenyu hwehupenyu kunyanya nekusunga kune transmembrane receptor tyrosine kinase B (TrkB). Zvakangodaro, iyo BDNF-induced TrkB siginecha yaive yenguva pfupi pa10 min uye yakakwira pa60 min. Nekudaro, BDNF ine hafu yehupenyu hupfupi uye haigone kuyambuka zviri nyore chipingamupinyi cheropa-uropi.
7,8-dihydroxyflavone (7,8-DHF) inonzi flavonoid inogadzirwa nechirimwa inokwanisa kukunda pamusoro pemiganhu yeBDNF uye yakaonekwa seBDNF mimetic inoshanda uye ikozvino inoshandiswa mumhando dzakasiyana-siyana dzebiochemical uye cellular systems Yakasimbiswa kuti inogona kupinza TrkB dimerization uye kumisa mamorekuru ayo ekudzika.
Iyo tropomyosin receptor kinase B (TrkB) receptor inoita basa rakakosha mukuyananisa mhedzisiro yeBDNF pane neuroni. Se transmembrane tyrosine kinase receptor, TrkB ndiyo yekutanga receptor yeBDNF uye inotanga kubuda kwezviitiko zvekusaina intracellular pakusunga kune neurotrophic factor.
BDNF inomutsa TrkB kuti itange nzira dzinoverengeka dzakakosha dzemukati, kusanganisira phosphatidylinositol 3-kinase (PI3K) -Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), uye phospholipase Cγ (PLCγ) -protein kinase ( PKC) nzira. Imwe neimwe yenzira idzi inobatsira kune imwe nzira yeurouronal basa uye kugara zvakanaka.
Iyo PI3K-Akt nzira yakakosha mukusimudzira kupona neuronal uye kuvharidzira apoptosis. BDNF-TrkB siginecha inomutsa nzira iyi kuti iwedzere kupona kwesero nekudzivisa pro-apoptotic zvinhu uye kukurudzira anti-apoptotic zvinhu, nokudaro kuve nechokwadi kuchengetedzwa kwehutano neuroni.
Kune rimwe divi, iyo MAPK-ERK nzira inoita basa rakakosha mukusiyanisa neuronal uye kuwanda. BDNF-TrkB siginecha inosimudzira activation yeMAPK-ERK nzira, iyo inotsigira neuronal maturation uye kusiyanisa uye kubatanidzwa kwavo mune iripo neuronal network.
Iyo PLCγ-PKC nzira yakakosha pakugadzirisa synaptic plasticity, yakakosha maitiro ekudzidza nekuyeuka. BDNF-TrkB siginecha inogadzirisa chiitiko cheiyi nzira, inozotungamira kune shanduko musimba re synaptic uye kubatana.
Iyi modulation inosimudzira kuchinjika uye kurongekazve kweneural maseketi mukupindura kune zvitsva zviitiko uye kwezvakatipoteredza zvinokurudzira.
Neuroprotective properties
Tsvagiridzo inoratidza kuti iyi flavonoid inodzivirira neurons kubva kune oxidative kusagadzikana uye apoptosis (yakarongwa sero kufa). Oxidative kusagadzikana chinhu chakakosha muzvirwere zveurourodegenerative senge Alzheimer's uye Parkinson's chirwere. Nekutsvaira mahara radicals uye kuderedza oxidative kukuvara, 7,8-DHF inogona kubatsira kuchengetedza neuronal kuperera uye kushanda.
Muzvidzidzo zvemhuka, 7,8-DHF yakaratidzwa kuvandudza basa rekuziva uye ndangariro. Semuenzaniso, mumhando dzechirwere cheAlzheimer, 7,8-DHF yakaratidzwa kuwedzera synaptic plasticity, iyo yakakosha pakudzidza nekuyeuka. Nzira yekuita
Anti-inflammatory effect
Pamusoro peiyo neuroprotector properties, 7,8-dihydroxyflavone inewo anti-inflammatory effects. Kuzvimba kusingaperi chinhu chakajairika chezvirwere zvakawanda, kusanganisira neurodegenerative zvirwere. Nekugadzirisa nzira dzekuzvimba, 7,8-DHF inogona kubatsira kuderedza neuroinflammation, iyo inowanzobatanidzwa nekuderera kwekuziva.
Antioxidant zvivakwa: ROS scavenging uye lipid peroxidation
7,8-DHF ine antioxidant properties sezvinoratidzwa nekukwanisa kwayo kutsvaira reactive oxygen marudzi (ROS) uye kuderedza lipid peroxidation. Izvi zvinokonzeresa mhedzisiro yayo neuroprotective nekudzikisa oxidative kusagadzikana-induced neuronal kukuvara uye kusashanda.
Zvidzidzo zvakaratidza kuti 7,8-DHF inhibits kugadzirwa kwepro-inflammatory cytokines uye inoderedza kushandiswa kwe microglia, masero ekudzivirira mukati mehutano hwehutano. Iyi anti-inflammatory effect haingodziviriri neurons chete asiwo inogadzira nzvimbo yakanaka yekuziva basa.
Tichifunga nezve mhedzisiro yayo pahutano hwehuropi, 7,8-dihydroxyflavone ine inogona kushandiswa munzvimbo dzakasiyana dzehutano nemishonga. Mamwe emaapplication anozivikanwa anosanganisira:
Kusimbisa ndangariro uye kudzoreredza
7,8-DHF yakawanikwa kuti iwedzere kubatanidzwa kwendangariro uye kudzoreredza mune dzakasiyana siyana-inotsamira hippocampal kudzidza uye ndangariro mabasa mumakonzo modhi. Izvi zvakawanikwa zvinoratidza kuti 7,8-DHF inogona kunge iri nootropic inovimbisa yekuvandudza ndangariro basa muvanhu vane hutano uye avo vane ndangariro.
Synaptic plastiki: kugona kwenguva refu uye kuora mwoyo
Sezvambotaurwa, 7,8-DHF yakaratidzwa kugadzirisa synaptic plasticity nekusimudzira LTP uye kuderedza LTD muhippocampus. Izvi zvinokonzeresa zvinofungidzirwa kuti zvinoyananiswa nekugona kwayo kumisa TrkB receptors uyezve kuwedzera iyo BDNF kusaina nzira.
Iyi modulation ye synaptic plasticity inobatsira mukuvandudzika kwekuita kwekuziva kunocherechedzwa kunotevera 7,8-DHF kutonga.
Kuwedzera kwekuziva
Sezvambotaurwa, 7,8-DHF inoratidza mukana wekusimudzira kugona kwekuziva uye ndangariro. Izvi zvinoita kuti ive mukwikwidzi wezvekuwedzera ane chinangwa chekuvandudza mashandiro epfungwa, kunyanya mukuchembera vanhu kana vanhu vane ruzivo rwekudzikira.
Kutora, Kugovera, Metabolism, uye Excretion (ADME): 7,8-DHF inoratidzira yakanaka pharmacokinetic zvinhu, kusanganisira kukurumidza kunyura, kugovera kwakafara, uye kupinza kwehuropi hunobudirira. Inonyanya kushandiswa nechiropa, nehuwandu hwehuwandu hunobudiswa mumarara uye shoma shoma inobudiswa muweti.
Ropa-uropi chinovharira permeability uye huropi tishu permeability. Imwe yeakakosha maitiro e 7,8-DHFiko kugona kwayo kuyambuka ropa-brain barriers (BBB) uye kupinda muuropi tishu, iyo yakakosha pakuita kwayo se nootropic.
Preclinical Safety Profile - Acute uye Chronic Toxicity Studies: Preclinical chengetedzo zvidzidzo zvakaratidza kuti 7,8-DHF ine yakanaka chengetedzo mbiri, isina yakakosha mhedzisiro inocherechedzwa mune acute uye asingaperi chepfu zvidzidzo mumakonzo. Nekudaro, kumwe kuongorora kwekuchengetedza, kusanganisira zvidzidzo mumhuka dzepamusoro uye zvidzidzo zvevanhu, zvinodikanwa kuona kuchengetedzeka kwayo pakushandiswa kwekiriniki.
Kunyange zvazvo zvidzidzo zvepreclinical zvakaratidza kuti 7,8-DHF ine chimiro chekuchengetedza chakanaka, zvinogona kuitika muzvidzidzo zvevanhu zvinoramba zvisingazivikanwe. Sezvinei nechero novel komputa, kungwarira kunofanirwa kuitwa uye zvinogona kukanganisa zvinotariswa kana uchiongorora kushandiswa kwayo muvanhu.
Zvichienderana ne7,8-DHF maitiro ekuita uye mhedzisiro paTrkB receptors, mamwe maitiro anogona kuve akabatana ne7,8-DHF anogona kusanganisira:
Musoro wemusoro: BDNF uye TrkB receptor activation inogadzirisa neuronal basa uye kufara; kutonga kwe7,8-DHF kunogona kukonzera misoro mune vamwe vanhu.
Insomnia: Kuwedzera neuronal chiitiko uye synaptic plasticity inogona kukanganisa maitiro ekurara, zvinogona kutungamirira kukushaya hope kana kukanganisa kurara.
Zvinetso zvomudumbu: Kungofanana nemishonga yakawanda yebioactive, 7,8-DHF inogona kukonzera migumisiro yomudumbu, zvakadai sokusvotwa, kurutsa, kana kuti manyoka mune vamwe vanhu.
Zvakakosha kuziva kuti izvi zvinogona kuitika zvinofanirwa kuenderera mberi nekudzidza mumakiriniki ekuedzwa. Zvichipa kukwanisa kwayo kugadzirisa zviratidzo zveBDNF uye TrkB receptor activation, kuchenjerera kunofanirawo kushandiswa pakubatanidza 7,8-DHF nemimwe mishonga inotarisa nzira idzi kana kuti dzine maitiro akafanana ekuita.
Semusanganiswa wakakosha, 7,8-Dihydroxyflavone yakakwezva kutarisisa zvakanyanya nekuda kweiyo yakasarudzika zviitiko zvebhaibheri. Kune vaongorori vesainzi nemabhizinesi, zvakakosha kuti uwane yepamusoro-mhando 7,8-Dihydroxyflavone Powder. Iyo 7,8-Dihydroxyflavone Powder yakapihwa naSuzhou Myland ine nhamba yeCAS ye38183-03-8 uye kuchena kunosvika 98%. Chigadzirwa chacho chave chakanyatso kudzora mhando uye chinoenderana nemitemo yenyika, kuve nechokwadi chekushanda uye kuchengetedzeka kwechigadzirwa. , yakakodzera tsvakurudzo yesayenzi, kugadzirwa kwezvinodhaka, kugadzirwa kwehutano hwehutano uye mamwe minda, ichikupa iwe sarudzo yakavimbika.
Kuvimbiswa kwehutano
Isu tinoziva kuti mhando yezvigadzirwa zvedu inobata zvakananga tsvakiridzo yevatengi vedu uye mhinduro dzekushandisa. Naizvozvo, Suzhou Myland inoteedzera GMP (Yakanaka Kugadzira Maitiro) uye ISO certification zviyero panguva yekugadzira maitiro kuti ive nechokwadi chekugadzikana uye kuenderana kwebatch yega yega yezvigadzirwa. Pamusoro pezvo, timu yedu yeR&D inoramba ichiita hunyanzvi hwekuvandudza tekinoroji uye inovavarira kuramba ichivandudza kunaka kwechigadzirwa uye kuita.
Mabatiro evatengi
Suzhou Myland haingopi zvigadzirwa zvemhando yepamusoro, asi zvakare inoteerera kune zvinodiwa nevatengi. Tine timu yehunyanzvi yekutsigira tekinoroji inogona kupa vatengi mazano ekushandiswa kwechigadzirwa uye kutungamira kwehunyanzvi kubatsira vatengi kuwana mhedzisiro iri nani mukutsvaga nekushandisa. Kunyangwe kuri kudiki-kuyedza kana kugadzirwa kwakakura, tinogona kupa mhinduro dzinochinjika kuzadzisa zvinodiwa nevatengi vakasiyana.
Nzira yekuwana 7,8-Dihydroxyflavone Powder
Kana iwe uchitsvaga yemhando yepamusoro 7,8-Dihydroxyflavone Powder, Suzhou Myland ndiyo sarudzo yako yakanaka. Unogona kutibata ne:
Webhusaiti yepamutemo: Shanyira webhusaiti yepamutemo yeSuzhou Myland kuti udzidze zvakawanda nezve ruzivo rwechigadzirwa uye rutsigiro rwehunyanzvi.
Kubvunzurudza pamhepo: Taurirana zvakananga neboka redu revashandi vevatengi kuburikidza nebasa rekubvunza pamhepo rinopihwa newebhusaiti kuti uwane ruzivo rwechigadzirwa uye makotesheni aunoda.
Kubata parunhare: Fonera nhamba yedu yekuonana kuti utaure nevashandi vekutengesa uye uwane ruzivo rwakadzama rwechigadzirwa uye mazano ekutenga.
Email kubvunza: Unogona zvakare kutikumbira ruzivo rwechigadzirwa kuburikidza neemail, uye isu tichakupindura iwe nekukurumidza sezvinobvira.
Mukupedzisa
Sechikamu chakakosha chine huwandu hwakawanda hwezviitiko zvehupenyu, 7,8-Dihydroxyflavone zvishoma nezvishoma inova chikamu chakakosha mukutsvaga kwesainzi uye kushandiswa kwemaindasitiri. Iyo yakakwirira-kuchena 7,8-Dihydroxyflavone Powder yakapihwa naSuzhou Myland ichapa rutsigiro rwakasimba rwekutsvagisa kwako nekuvandudzwa kwechigadzirwa nemhando yayo yakanakisa uye yakavimbika sevhisi. Isu tinotarisira kushanda newe kuti tiongorore zvimwe zvekushandisa zve7,8-Dihydroxyflavone.
Mubvunzo: Chii chinonzi 7,8-dihydroxyflavone?
A:7,8-Dihydroxyflavone iflavonoid inongoitika yega inozivikanwa nekugona kwayo kuchengetedzeka kweurouroprotective uye iri kudzidzwa nekuda kwemhedzisiro yayo pakuziva kwekuita uye kusimudzira mafungiro.
Mubvunzo:Ndedzipi mabhenefiti angangove e7,8-dihydroxyflavone?
A: Tsvakurudzo inoratidza kuti 7,8-dihydroxyflavone inogona kubatsira kuvandudza ndangariro, kuderedza kushushikana, uye kudzivirira neurodegenerative zvirwere. Iyo antioxidant zvimiro zvinogona zvakare kusimudzira hutano hwese nekurwisa oxidative kusagadzikana.
Q:Ndeipi bioavailability ye7,8-DHF?
A: The bioavailability ye7,8-dihydroxyflavone (7,8-DHF) muzvidzidzo zvemhuka inenge 5% (mumakonzo) nekuda kwekusagadzikana kwayo uye nekukurumidza metabolism. Pasinei nekushomeka kwayo kwebioavailability, 7,8-DHF inogona kuramba ichiyambuka chipingamupinyi cheropa-uropi uye kukanganisa uropi. Imwe tsvagiridzo inodiwa kuona bioavailability yayo muvanhu uye kuongorora nzira dzekusimudzira.
Mubvunzo: 7,8-DHF inoita kuti unzwe sei?
A: Se nootropic, 7,8-dihydroxyflavone (7,8-DHF) ine migumisiro yakanaka pakuziva basa uye mafungiro. Vanhu vanowana ndangariro dziri nani, kuwedzera kuisa pfungwa pachinhu chimwe, uye kugona kudzidza kwakawedzerwa.
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Nguva yekutumira: Oct-14-2024
