Chii chinonzi NAD+ uye Nei Uchichida Kuti Uwane Hutano Hwako?

Munyika iri kukura yehutano nekugara zvakanaka, NAD+ yave izwi guru, richikwezva kutariswa kwevasayendisiti nevanofarira hutano zvakafanana. Asi chii chaizvo chinonzi NAD+? Sei ichikosha kuhutano hwako? Ngatidzidzei zvakawanda nezveruzivo rwakakodzera pazasi!

Chii chinonzi NAD+?

Zita resainzi reNAD ​​ndinicotinamide adenine dinucleotide. NAD+ iripo musero rega rega remuviri wedu. Ichinhu chakakosha mumetabolism uye coenzyme munzira dzakasiyana siyana dzemetabolism. Inobatsira uye inobata mabasa akasiyana-siyana ehupenyu. Maenzyme anopfuura mazana matatu anovimba neNAD+ kuti ishande.

NAD+ipfupiso yeChirungu yeNicotinamide adenine dinucleotide. Zita rayo rakazara muchiChinese ndinicotinamide adenine dinucleotide, kana kuti Coenzyme I muchidimbu. Se coenzyme inotumira ma hydrogen ions, NAD+ ine basa guru muzvinhu zvakawanda zve metabolism yemunhu, kusanganisira glycolysis, Gluconeogenesis, tricarboxylic acid cycle, nezvimwewo. Dzimwe ongororo dzakaratidza kuti kupera kweNAD+ kune chekuita nezera, uye mashandiro emuviri anokonzerwa neNAD+ ane chekuita nekukwegura, zvirwere zve metabolic, neuropathy nekenza, kusanganisira kudzora cell homeostasis, sirtuins inozivikanwa se "longevity genes", kugadzirisa DNA, maPARPs emhuri mapuroteni ane chekuita ne necroptosis uye CD38 inobatsira mu calcium signaling.

NAD+ inoshanda sebhazi rekufambisa, rinotakura maerekitironi kubva kune rimwe molecule kuenda kune rimwe. Pamwe chete neNADH, inobatanidzwa mukuita kwakasiyana-siyana kwemetabolism kuburikidza nekuchinjana kwemaerekitironi kunogadzira adenosine triphosphate (ATP), molecule ye "simba" yemuviri.

Zvichitaurwa zviri nyore, NAD+ inokosha pakuchengetedza hutano hwemuviri uye kuenzana. Kugadzira metabolism, redox, kuchengetedza nekugadzirisa DNA, kugadzikana kwemajini, epigenetic regulation, nezvimwewo zvese zvinoda kuti NAD+ itore chikamu.

Saka, muviri wedu unoda NAD+. NAD+ inogara ichigadzirwa, ichiputswa uye ichidzokororwa mumasero kuti irambe iine mazinga akasimba eNAD+.

NAD+ chinhu chakakosha pakushanda kwemasero uye chinobatanidzwa mukupa simba uye kugadzirisa DNA, zvose izvi zvine chekuita nekukwegura kwakanaka.

1) Inopararira zvakanyanya mumasero ese emuviri wemunhu uye inobata mabasa akawanda e biocatalytic. Inogona kukurudzira metabolism yeshuga, mafuta uye maamino acids, uye inobatawo mukugadzirwa kwesimba. I coenzyme inokosha inodiwa mumuviri wemunhu.

2) NAD+ ndiyo yega substrate yema enzymes anodya coI (iyo yega substrate yeDNA repair enzyme PARP, ndiyo yega substrate yeprotein yeSirtuins inorarama kwenguva refu, uye ndiyo yega substrate yecyclic ADP ribose synthase CD38/157).

Zvisinei, sezvo zera richikura, huwandu hweNAD+ mumuviri hunodzikira nekukurumidza. Hunodzikira ne50% makore makumi maviri ega ega. Pazera remakore angangoita makumi mana, huwandu hweNAD+ mumuviri wemunhu hunongova 25% chete yezvaiva muvana.

Kana masero evanhu asina NAD+, kusashanda zvakanaka kwemitochondrial kunodzikira, kugona kugadzirisa kukuvara kweDNA kunodzikira, uye mhuri yemapuroteni emagene ehupenyu hurefu yeSirtuin inodzikirawo, nezvimwewo. Zvinhu izvi zvakaipa zvinogona kutungamira kuapoptosis, chirwere chevanhu, kukwegura uye kunyange kufa.

Basa reNAD+ muhutano hwako hwese

Kudzivirira kukwegura

NAD+ inochengetedza kutaurirana kwemakemikari pakati penucleus ne mitochondria, uye kutaurirana kusina simba ndicho chikonzero chikuru chekukwegura kwemasero.

NAD+ inogona kubvisa huwandu huri kuwedzera hwemakodhi eDNA asina kururama panguva yekushandiswa kwemasero, kuchengetedza kuratidzwa kwemajini kwakajairika, kuchengetedza kushanda kwakajairika kwemasero, uye kunonotsa kukwegura kwemasero evanhu.

Gadzirisa kukuvara kweDNA

NAD+ chinhu chakakosha cheDNA repair enzyme PARP, iyo ine simba guru pakugadzirisa DNA, kugadzirwa kwemajini, kukura kwemasero, kupona kwemasero, kugadziriswazve kwemakromosomu, uye kugadzikana kwemajini.

Shandisa mapuroteni ehupenyu hurefu

MaSirtuin anowanzonzi mhuri yemapuroteni ehupenyu hurefu uye anoita basa rakakosha mukudzora mashandiro emasero, akadai sekuzvimba, kukura kwemasero, circadian rhythm, simba rekugadzirisa muviri, mashandiro etsinga dzeropa, uye kuramba kushushikana, uye NAD+ ienzyme inokosha pakugadzirwa kwemapuroteni ehupenyu hurefu.

Inoshanda nemapuroteni ese manomwe ehupenyu hurefu mumuviri wemunhu, ichiita basa rakakosha mukudzivirira kushushikana kwemasero, kushandiswa kwesimba mumuviri, kudzivirira kushanduka kwemasero, apoptosis uye kukwegura.

Ipa simba

Inobatsira kugadzirwa kweanopfuura 95% yesimba rinodiwa pakuita mabasa ehupenyu. Mitochondria mumasero evanhu ndiyo nzvimbo dzinoshandiswa simba mumasero. NAD+ i coenzyme inokosha mu mitochondria yekugadzira molekyuru yesimba ATP, ichishandura zvinovaka muviri kuita simba rinodiwa nemuviri wemunhu.

Kurudzira kugadzurwa kwetsinga dzeropa uye kuchengetedza kutwasuka kwetsinga dzeropa

Mitsipa yeropa inhengo dzinokosha zvikuru pakuita mabasa ehupenyu. Sezvatinokura, mitsipa yeropa inorasikirwa nekuchinjika kwayo zvishoma nezvishoma uye inova yakaoma, yakakora, uye yakatetepa, zvichikonzera "arteriosclerosis."

NAD+ inogona kuwedzera mashandiro e elastin mutsinga dzeropa, nokudaro ichichengetedza kusimba kwetsinga dzeropa uye kuchengetedza hutano hwetsinga dzeropa.

Kurudzira kushandiswa kwemagetsi mumuviri

Metabolism ihuwandu hwemaitiro akasiyana-siyana emakemikari mumuviri. Muviri ucharamba uchichinjana zvinhu nesimba. Kana kuchinjana uku kwamira, hupenyu hwemuviri huchaperawo.

Purofesa Anthony nechikwata chake chekutsvagisa paYunivhesiti yeCalifornia, USA, vakaona kuti NAD+ inogona kuvandudza kuderera kwekushandiswa kwemasero mumuviri kunokonzerwa nekukwegura, nokudaro ichivandudza hutano hwevanhu uye kuwedzera hupenyu hwavo.

Dzivirira hutano hwemwoyo

Mwoyo ndiwo nhengo inonyanya kukosha pavanhu, uye huwandu hweNAD+ mumuviri hunoita basa rakakosha mukuchengetedza kushanda zvakanaka kwemoyo.

Kuderedzwa kweNAD+ kunogona kunge kwakabatana nekukura kwezvirwere zvakawanda zvemwoyo, uye zvidzidzo zvakawanda zvakaratidzawo kuti kuwedzera NAD+ kunobatsira pazvirwere zvemwoyo.

Kudzivirira zvirwere zvemwoyo netsinga dzeropa

Ongororo dzakaratidza kuti mhando dzese nomwe dzesirtuins (SIRT1-SIRT7) dzine chekuita nekuitika kwezvirwere zvemwoyo. Sirtuins dzinoonekwa sedzinorapwa zvirwere zvemwoyo, kunyanya SIRT1.

NAD+ ndiyo chete substrate yeSirtuins. Kuwedzera NAD+ mumuviri wemunhu panguva yakakodzera kunogona kuita kuti basa remhando yega yega yeSirtuins rishande, nokudaro zvichidzivirira hutano hwemwoyo nekudzivirira zvirwere zvemwoyo.

Kurudzira kukura kwebvudzi

Chikonzero chikuru chekurasikirwa nebvudzi kurasikirwa nesimba remasero ebvudzi, uye kurasikirwa nesimba remasero ebvudzi kunokonzerwa nekuti huwandu hweNAD+ mumuviri wemunhu hunoderera. Masero emadzimai ebvudzi haana ATP yakakwana yekuita kuti puroteni yebvudzi iite, nokudaro achirasikirwa nesimba rebvudzi uye zvichikonzera kurasikirwa nesimba.

Saka, kuwedzera NAD+ kunogona kusimbisa acid cycle uye kugadzira ATP, kuitira kuti masero ebvudzi ave nekukwanisa kwakakwana kugadzira mapuroteni ebvudzi, nokudaro zvichivandudza kurasikirwa nebvudzi.

Kwekutenga Beta-NAD+ Supplement Zvakachengeteka Pamhepo

Suzhou Myland Pharm & Nutrition Inc. ikambani yakanyoreswa neFDA inopa hupfu hweNAD+ Supplement hwemhando yepamusoro uye hwakachena.

KuSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yepamusoro. Upfu hwedu hweNAD+ Supplement hwakaedzwa zvakasimba kuti huve hwakachena uye hune simba, zvichiita kuti uwane supplement yemhando yepamusoro yaunogona kuvimba nayo. Kunyangwe uchida kutsigira hutano hwemasero, kusimbisa masoja emuviri wako kana kusimudzira hutano hwese, upfu hwedu hweNAD+ Supplement ndiyo sarudzo yakakwana.

Nemakore makumi matatu eruzivo uye zvichitungamirirwa netekinoroji yepamusoro uye nzira dzeR&D dzakanyatsogadzirwa, Suzhou Myland Pharm yakagadzira zvigadzirwa zvakasiyana-siyana zvinokwikwidzana uye yakava kambani itsva yekuwedzera sainzi yehupenyu, kugadzira zvinhu zvakagadzirwa uye kugadzira zvinhu.

Pamusoro pezvo, Suzhou Myland Pharm ikambani yakanyoreswa neFDA. Zvishandiso zveR&D zvekambani, nzvimbo dzekugadzira, uye zvishandiso zvekuongorora ndezvemazuva ano uye zvinoshanda zvakawanda, uye zvinogona kugadzira makemikari kubva pamamirigiramu kusvika kumatani muhukuru, uye zvinoenderana neISO 9001 standards uye specifications dzekugadzira GMP.