Chii chinonzi NAD + uye Nei Uchichida kune Hutano Hwako?

Munyika inogara ichikura yehutano uye hutano, NAD + yave chirevo, ichikwezva kutariswa kwesainzi nevanofarira hutano zvakafanana. Asi chii chaizvo chinonzi NAD+? Sei zvakakosha kuhutano hwako? Ngatidzidze zvakawanda nezve ruzivo rwakakodzera pazasi!

Chii chinonzi NAD+?

Zita resainzi reNAD ​​ndinicotinamide adenine dinucleotide. NAD + iripo musero rega rega remuviri wedu. Iyo yakakosha metabolite uye coenzyme munzira dzakasiyana dzemetabolism. Inopindirana uye inobatanidzwa mune zvakasiyana-siyana zvehupenyu. Anopfuura mazana matatu ma enzymes anoenderana neNAD+ Kushanda.

NAD+ndicho chipfupiso cheChirungu cheNicotinamide adenine dinucleotide. Zita rayo rakazara muchiChinese ndinicotinamide adenine dinucleotide, kana kuti Coenzyme I kwenguva pfupi. Se coenzyme inotumira hydrogen ions, NAD + inobata chikamu mune zvakawanda zvemetabolism yevanhu, kusanganisira glycolysis, Gluconeogenesis, tricarboxylic acid cycle, etc. Zvimwe zvidzidzo zvakaratidza kuti kupera kweNAD + kune hukama nezera, uye nzira dzemuviri dzakapindirana. neNAD + zvine hukama nekuchembera, metabolic zvirwere, neuropathy uye kenza, kusanganisira kudzora cell homeostasis, sirtuins. inozivikanwa se "kureba kwemajini", kugadzirisa DNA, PARPs mapuroteni emhuri ane hukama necroptosis uye CD38 inobatsira mukusaina calcium.

NAD + inoita sebhazi rekufambisa, rinotakura maerekitironi kubva kune imwe sero molecule kuenda kune imwe. Pamwe chete neayo mamorekuru anoenderana NADH, inotora chikamu mukuchinja kwakasiyana-siyana kwemagetsi kuburikidza nekuchinjana kwemagetsi kunoburitsa adenosine triphosphate (ATP), "simba" remuviri.

Zvichitaurwa zviri nyore, NAD + yakakosha kuchengetedza hutano hwemuviri uye kuenzanisa. Metabolism, redox, DNA kuchengetedza uye kugadzirisa, kugadzikana kwemajini, epigenetic regulation, nezvimwe zvose zvinoda kubatanidzwa kweNAD +.

Naizvozvo, muviri wedu une kudiwa kwakanyanya kweNAD +. NAD + inoramba ichigadzirwa, yakaputsika uye inodzokororwa mumaseru kuchengetedza yakagadzikana cellular NAD + mazinga.

NAD + chinhu chakakosha chekuita kweserura uye inobatanidzwa mukupihwa kwesimba uye kugadzirisa kweDNA, zvese zviri zviviri zvine hukama nekuchembera kune hutano.

1) Inoparadzirwa zvakanyanya mumasero ese emuviri wemunhu uye inotora chikamu muzviuru zvebiocatalytic reactions. Inogona kusimudzira metabolism yeshuga, mafuta uye amino acids, uye kutora chikamu mukuumbwa kwesimba. Iyo yakakosha coenzyme inodiwa kumuviri wemunhu.

2) NAD+ ndiyo yega substrate yecoI-inopedza enzymes (iyo chete substrate yeDNA kugadzirisa enzyme PARP, iyo chete substrate yehupenyu hurefu protein Sirtuins, uye iyo chete substrate ye cyclic ADP ribose synthase CD38/157).

Nekudaro, nekukura kwezera, mwero weNAD + mumuviri unodzikira nekukurumidza. Ichadzikira ne50% makore ese makumi maviri. Paanenge makore makumi mana, iyo NAD + iri mumuviri wemunhu ingori makumi maviri neshanu muzana yezvaive muvana.

Kana masero evanhu akashaya NAD +, mitochondrial dysfunction yakaderedzwa, DNA kukanganisa kugadzirisa kukwanisa kunoderedzwa, uye hupenyu hurefu hwejena reprotein mhuri Sirtuin hainawo kushandiswa, nezvimwewo zvinhu izvi zvisina kunaka zvinogona kutungamirira kuapoptosis, chirwere chevanhu, kukwegura uye kunyange rufu.

Basa reNAD+ muHutano Hwako Hwakazara

Anti-kuchembera

NAD + inochengetedza kutaurirana kwekemikari pakati peiyo nucleus uye mitochondria, uye kutadza kutaurirana ndicho chikonzero chakakosha chekukwegura kweserura.

NAD + inogona kubvisa huwandu huri kuwedzera hweakakanganisa makodhi eDNA panguva yesero metabolism, chengetedza kutaridzika kwemajini, kuchengetedza kushanda kwakajairwa kwemaseru, uye kuderedza kuchembera kwemasero emunhu.

Gadzirisa DNA kukanganisa

NAD+ yakakosha substrate yeDNA kugadzirisa enzyme PARP, ine zvakakosha pakugadzirisa DNA, gene expression, kuvandudzwa kwesero, kupona kwesero, kuvakazve chromosome, uye kugadzikana kwemajini.

Activate longevity protein

Sirtuin inowanzonzi hupenyu hurefu hweprotein mhuri uye inoita basa rakakosha rekutonga mukushanda kwesero, senge kuzvimba, kukura kwesero, circadian rhythm, simba metabolism, neuronal basa, uye kusagadzikana kusagadzikana, uye NAD + yakakosha enzyme yekubatanidza kwehupenyu hurefu mapuroteni. .

Inomisikidza ese mapuroteni manomwe ehupenyu hurefu mumuviri wemunhu, achiita basa rakakosha muserura kusagadzikana kuramba, simba metabolism, kudzivirira sero shanduko, apoptosis uye kuchembera.

Ipa simba

Inokonzera kugadzirwa kweinopfuura 95% yesimba rinodiwa pamabasa ehupenyu. Mitochondria mumasero evanhu ndiwo masimba emagetsi emasero. NAD + yakakosha coenzyme mumitochondria kugadzira iyo molecule yesimba ATP, ichishandura chikafu kuita simba rinodiwa nemuviri wemunhu.

Kurudzira kuvandudzwa kwetsinga yeropa uye kuchengetedza tsinga yeropa elasticity

Mitsipa yeropa matishu akakosha pazviitiko zvehupenyu. Sezvatinokura, tsinga dzeropa zvishoma nezvishoma dzinorasikirwa nekushanduka kwayo uye dzinova dzakaoma, dzakakora, uye dzakatetepa, zvichiita kuti "arteriosclerosis."

NAD + inogona kuwedzera basa re elastin mutsinga dzeropa, nekudaro kuchengetedza kusimba kwetsinga dzeropa uye kuchengetedza hutano hwetsinga yeropa.

Kurudzira metabolism

Metabolism ihuwandu hwemaitiro akasiyana emakemikari mumuviri. Muviri ucharamba uchichinjanisa zvinhu nesimba. Kana kuchinjana uku kwamira, hupenyu hwemuviri hunoperawo.

Muzvinafundo Anthony nechikwata chake chekutsvagisa paUniversity yeCalifornia, USA, vakawana kuti NAD+ inogona kunyatso kuvandudza kudzikira kwesero metabolism ine chekuita nekuchembera, nekudaro ichivandudza hutano hwevanhu nekuwedzera hupenyu.

Chengetedza hutano hwemwoyo

Mwoyo ndiyo nhengo inonyanya kukosha yevanhu, uye iyo NAD + nhanho mumuviri inoita basa rakakosha kuchengetedza kushanda kwakajairika kwemoyo.

Kudzikiswa kweNAD + kunogona kuve kwakabatana neiyo pathogenesis yezvirwere zvakawanda zvemoyo, uye nhamba huru yezvidzidzo zvekutanga zvakasimbisawo maitiro ekuwedzera NAD + pazvirwere zvemoyo.

Kudzivirira zvirwere zvemoyo uye cerebrovascular

Zvidzidzo zvakaratidza kuti anenge ese manomwe subtypes e sirtuins (SIRT1-SIRT7) ane hukama nekuitika kwechirwere chemoyo. Sirtuins anoonekwa seagistic tarisiro yekurapa kwezvirwere zvemoyo, kunyanya SIRT1.

NAD + ndiyo yega substrate yeSirtuins. Kuwedzerwa nenguva kweNAD + kumuviri wemunhu kunogona kumisa zvizere chiitiko chega rega reSirtuins, nekudaro kuchengetedza hutano hwemoyo nekudzivirira zvirwere zvemoyo.

Kurudzira kukura kwebvudzi

Chikonzero chikuru chekurasika kwebvudzi kurasikirwa kwebvudzi raamai sero simba, uye kurasikirwa kwebvudzi raamai sero simba imhaka yekuti iyo NAD + nhanho mumuviri wemunhu inodzikira. Masero aamai vebvudzi haana ATP yakakwana yekuita bvudzi mapuroteni synthesis, nekudaro achirasikirwa nehupenyu uye zvichikonzera kurasikirwa kwebvudzi.

Naizvozvo, kuwedzera NAD + kunogona kusimbisa kutenderera kweasidhi uye kugadzira ATP, kuitira kuti masero aamai vebvudzi ave nekukwanisa kuburitsa mapuroteni ebvudzi, nekudaro achivandudza kurasikirwa kwebvudzi.

Kwaunotenga Beta-NAD+ Supplement Yakachengeteka Pamhepo

Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena NAD + Supplement poda.

PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu NAD + Supplement poda inoedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu NAD + Supplement poda ndiyo sarudzo yakakwana.

Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.