Chii chinonzi 7,8-Dihydroxyflavone uye Nei Uchifanira Kufarira?

7,8-Dihydroxyflavone (7,8-DHF)iflavonoid inowanikwa zvakasikwa, chinhu chinonzi polyphenolic compound chinowanikwa mumiti yakasiyana-siyana. Flavonoids dzinozivikanwa nekuda kwesimba radzo rekudzivirira muviri uye dzinoita basa rakakosha mukudzivirira zvirimwa. 7,8-Dihydroxyflavone inonyanya kuwanikwa mumiti yakaita seGodmania aesculifolia neTridax procumbens.

7,8-Dihydroxyflavone yakasiyana nedzimwe flavonoids mukukwanisa kwayo kutevedzera mashandiro eneurotrophic factor (BDNF) muuropi. BDNF ipuroteni inotsigira kupona, kukura, uye kushanda kwema neuron muuropi. Inoita basa guru mu neuroplasticity, kugona kweuropi kuzvigadzirisa nekugadzira neural connections itsva. Iyi hunhu hwe7,8-DHF hunovhura nzira dzakawanda dzekutsvagisa, kunyanya mumunda we neuroscience.

Maitiro ekuita

Nzira huru iyo 7,8-Dihydroxyflavone inoshandisa simba rayo ndeyekushanda kweTrkB (tropomyosin receptor kinase B) receptor. TrkB ireceptor ine hukama hwakakura neBDNF. Kana 7,8-Dihydroxyflavone yakabatana neTrkB, inotanga nzira dzakasiyana-siyana dzekutumira mameseji mukati memasero dzinokurudzira kupona, kukura, uye kusiyana kwemasero.

Zvidzidzo zvepamberi pekiriniki zvakaratidza kuti 7,8-dihydroxyflavone inogona kutevedzera BDNF (neurotrophic factor inobva muuropi) uye inowedzera kuratidzwa kwayo uye huwandu hwayo mu hippocampus. Mumhando dzemhuka, ine mukana wekurapa zvirwere zvakasiyana-siyana zvetsinga kana matambudziko, kusanganisira sitiroko, kushungurudzika, uye chirwere cheParkinson. Muzvidzidzo zviviri zvakasiyana, 7,8-dihydroxyflavone yakaratidza kuwanikwa kwakakosha kwemuromo uye yakawanikwa ichiyambuka brain-blood barrier (BBB). Nekuti inoshanda panzira ye nitric oxide signaling uye inoshanda TrkB receptor (tropomyosin receptor kinase B)

Chinhu chinonzi neurotrophic factor BDNF chinonyanya kutumira masaini nekusunga kune mareceptor chaiwo, nokudaro zvichikanganisa mashandiro emuviri ema neuron. Kunyange zvazvo 7,8-DHF ichigona kutevedzera mhedzisiro ye neurotrophic factor BDNF, chinhu chikuru chiri mukushanda kwayo ne BDNF receptor. Zvidzidzo zvakaratidza kuti 7,8-DHF inogona kusunga kune BDNF receptor TrkB uye kuvhura nzira dzekuisa masaini dzinotevera.

Zvikuru sei, kana 7,8-DHF yakabatana neTrkB, inokonzera zviitiko zvakasiyana-siyana zve transduction signal mukati memasero. Izvi zvinosanganisira activation yeprotein kinases dzakadai sePI3K/Akt uye MAPK/ERK pathways. Activation yenzira idzi inokosha pakusimudzira kupona kwetsinga dzeropa, kukura, uye synaptic plasticity. Nekutevedzera activation yenzira idzi neBDNF, 7,8-DHF inobatsira kusimudzira kuchinjika kwetsinga dzeropa uye kuramba kushushikana kwekunze.

7,8-DHF inodzorawo kuratidzwa kwemajini mukati memauroni. Inogona kukanganisa kunyorwa kwemajini ane chekuita nekukura kwetsinga, kudzivirira kwetsinga uye kuumbwa kwesynapse, nokudaro ichitevedzera mhedzisiro yeBDNF padanho remamorekuru. Kugadziriswa uku kwekutaura kwemajini kunotsigirawo basa re7,8-DHF mukusimudzira hutano hwetsinga.

7,8-Dihydroxyflavone (7,8-DHF) iflavonoid ine mhedzisiro yakawanda. Inoshanda semushonga we neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) uye inodzivirira ma neuron anoburitsa TrkB kubva kuapoptosis. Brain-derived neurotrophic factor (BDNF) ipuroteni ine mhedzisiro ye neurotrophic inokosha pakuumbwa kweuropi, kudzidza uye kurangarira.

• Kudzivirira tsinga dzeuropi: 7,8-DHF inodzivirira tsinga dzeuropi mumhuka dzine chirwere cheParkinson, inotsigira kudzidza kwemanzwiro mumbeva uye inodzosera kumashure ndangariro dzisina kunaka mumhuka dzine chirwere cheAlzheimer, uye inogona zvakare kuvandudza mashandiro emuviri uye kuwedzera nguva yekurarama kwemhuka dzine chirwere. BDNF inogona kuvandudza neuroplasticity uye kupona kwetsinga dzeuropi, kubatsira uropi kugadzira tsinga itsva dzeuropi, kugadzirisa masero europi asina kushanda zvakanaka, uye kudzivirira masero europi ane hutano. Zvakakosha pakuumbwa kweuropi, kudzidza uye kurangarira, uye inogona kudzivirira uropi kubva mukukanganisika kwepfungwa kunokonzerwa nekukwegura. Kuderera kwehunyanzvi hwepfungwa uye kudzivirira kubva kuzvirwere zvetsinga dzakadai sechirwere cheAlzheimer nechirwere cheParkinson.

• Inodzora kupona kwetsinga dzeropa: 7,8-DHF inogona kusunganidza kuTrkB uye kuita kuti nzira dzekutumira masaini dzishande, dzakadai sePI3K/Akt uye MAPK/ERK pathways. Kusumudza nzira idzi kwakakosha pakusimudzira kupona kwetsinga dzeropa, kukura uye synaptic plasticity. Zvakakosha. BDNF zvakare chinhu chinokanganisa tsinga dzeropa chinogona kusumudza nzira dzekutumira masaini dzeropa dzemukati memasero nekusumudza kumareceptor eTrkB uye kukurudzira kupona nekukura kwemaneuron.

• Kusimudzira plasticity yesynaptic: 7,8-DHF inogona kukurudzira kuumbwa nekusimbiswa kwesynapses nekushandisa TrkB receptors, nokudaro ichivandudza kushanda kwesynapses. BDNF inofungidzirwawo kuti inokurudzira kuumbwa nekusimbiswa kwesynapses, nokudaro ichiwedzera kushanda kwesynapses uye nokudaro ichivandudza kugona kwekudzidza nekurangarira.

• Mhedzisiro pakudzidza nekurangarira: 7,8-DHF inogona kuvandudza kugona kwekudzidza nekurangarira mumakonzo, izvo zvingave zvine chekuita nemhedzisiro yayo pakurarama kwetsinga dzeuropi uye synaptic plasticity. BDNF inoitawo basa rakakosha mukudzidza nekurangarira nekukurudzira kupona kwetsinga dzeuropi uye kuumbwa kwesynapses, nokudaro ichivandudza kugona kwekudzidza nekurangarira.

• Inochinja mafungiro: 7,8-DHF ine mhedzisiro yekuchinja mafungiro, iyo inogona kunge yakabatana nemigumisiro yayo pakurarama kwetsinga dzeuropi uye synaptic plasticity. BDNF inofungidzirwawo kuti ine basa mukudzora manzwiro nekudzora kurarama kwetsinga dzeuropi uye kuumbwa kwesynapses, nokudaro ichikanganisa kutaura kwemanzwiro.

Muchidimbu, 7,8-DHF neBDNF dzine nzira dzakafanana dzekushanda mukudzivirira tsinga, dzinodzora kupona kwetsinga, dzinosimudzira kubatanidzwa kwetsinga dzeropa, dzinokanganisa kudzidza nekurangarira, uye dzinodzora manzwiro.

Suzhou Myland Pharm & Nutrition Inc. ikambani yakanyoreswa neFDA inopa 7,8-Dihydroxyflavone yemhando yepamusoro uye yakachena.

KuSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yepamusoro. 7,8-Dihydroxyflavone yedu yakaedzwa zvakasimba kuti ionekwe kuti yakachena uye ine simba, zvichiita kuti uwane chinowedzera chemhando yepamusoro chaunogona kuvimba nacho. Kunyangwe uchida kutsigira hutano hwemasero, kusimbisa masoja emuviri wako kana kusimudzira hutano hwese, 7,8-Dihydroxyflavone yedu ndiyo sarudzo yakakwana.

Nemakore makumi matatu eruzivo uye zvichitungamirirwa netekinoroji yepamusoro uye nzira dzeR&D dzakanyatsogadzirwa, Suzhou Myland Pharm yakagadzira zvigadzirwa zvakasiyana-siyana zvinokwikwidzana uye yakava kambani itsva yekuwedzera sainzi yehupenyu, kugadzira zvinhu zvakagadzirwa uye kugadzira zvinhu.

Pamusoro pezvo, Suzhou Myland Pharm ikambani yakanyoreswa neFDA. Zvishandiso zveR&D zvekambani, nzvimbo dzekugadzira, uye zvishandiso zvekuongorora ndezvemazuva ano uye zvinoshanda zvakawanda, uye zvinogona kugadzira makemikari kubva pamamirigiramu kusvika kumatani muhukuru, uye zvinoenderana neISO 9001 standards uye specifications dzekugadzira GMP.