Chii chinonzi 7,8-Dihydroxyflavone uye Nei Uchifanira Kuitira Hanya?

7,8-Dihydroxyflavone (7,8-DHF)flavonoid inongoitika, musanganiswa wepolyphenolic unowanikwa mumhando dzakasiyana dzezvirimwa. Flavonoids inozivikanwa nekuda kweiyo antioxidant zvimiro uye inoita basa rakakosha mumiti yekudzivirira nzira. 7,8-Dihydroxyflavone inonyanya kuwanikwa mumiti yakadai seGodmania aesculifolia uye Tridax procumbens.

7,8-Dihydroxyflavone yakasiyana nedzimwe flavonoid mukukwanisa kwayo kutevedzera basa reuropi-derived neurotrophic factor (BDNF). BDNF ipuroteni inotsigira kurarama, kukura, uye kushanda kwemaneuron muuropi. Inobata basa rakakosha muuroplasticity, kugona kwehuropi kuzvironga patsva nekugadzira mitsva yekubatanidza neural. Ichi chivakwa che7,8-DHF chinovhura nzira dzakawanda dzekutsvagisa, kunyanya mumunda weurouroscience.

Nzira yekuita

Iyo yekutanga nzira iyo 7,8-Dihydroxyflavone inoshandisa mhedzisiro yayo ndeye activation yeTrkB (tropomyosin receptor kinase B) receptor. TrkB ndeye yakakwirira-yakabatana receptor yeBDNF. Kana 7,8-Dihydroxyflavone inosunga kuTrkB, inokonzera mutsara we intracellular signaling nzira dzinokurudzira kupona neuronal, kukura, uye kusiyanisa.

Zvidzidzo zvepamberi zvakaratidza kuti 7,8-dihydroxyflavone inogona kutevedzera BDNF (brain-derived neurotrophic factor) uye kuwedzera kutaura kwayo uye mazinga muhippocampus. Mumhando dzemhuka, ine mukana wekurapa kune akati wandei zvirwere zvetsinga kana kusagadzikana, zvinoti sitiroko, kuora mwoyo, uye chirwere cheParkinson. Muzvidzidzo zviviri zvakasiyana, 7,8-dihydroxyflavone yakaratidza kukosha kwemuromo bioavailability uye yakawanikwa ichiyambuka brain-blood barrier (BBB). Nekuti inoshanda pane nitric oxide yekusaina nzira uye yakagadziriswa TrkB receptor (tropomyosin receptor kinase B)

Iyo neurotrophic factor BDNF inonyanya kutumira masaini nekusunga kune chaiwo mareceptor, nekudaro ichikanganisa maitiro ehupenyu hwemaneuroni. Nepo 7,8-DHF inogona kutevedzera mashandiro eiyo neurotrophic factor BDNF, kiyi iri munzira yayo yekudyidzana neBDNF receptor. Zvidzidzo zvakaratidza kuti 7,8-DHF inogona kusunga kune BDNF receptor TrkB uye kumisa nzira dzezasi dzechiratidzo.

Kunyanya, kana 7,8-DHF ichisungirira kuTrkB, inokonzeresa nhevedzano yezviitiko zvemukati zvechiratidzo chekuchinja. Izvi zvinosanganisira activation yeprotein kinases yakadai sePI3K/Akt uye MAPK/ERK nzira. Kuita kweidzi nzira kwakakosha mukusimudzira kupona neuronal, kukura, uye synaptic plasticity. Nekutevedzera kuvhurwa kwenzira idzi neBDNF, 7,8-DHF inobatsira kusimudzira neuronal kuchinjika uye kuramba kushushikana kwekunze.

7,8-DHF inorongawo kutaura kwemajini mukati meeuroni. Inogona kukanganisa kunyorwa kwemajini ane chekuita neurodevelopment, neuroprotection uye synapse formation, nekudaro kutevedzera mhedzisiro yeBDNF padanho rema molecular. Iyi modulation yejini kutaura kunoenderera mberi kutsigira basa re7,8-DHF mukusimudzira hutano hwetsinga.

7,8-Dihydroxyflavone (7,8-DHF) inonzi monophenolic flavonoid ine maitiro akawanda. Inoita senge agonist kune neurotrophic tyrosine kinase receptor TrkB (Kd = 320nM) uye inodzivirira TrkB-inoratidza neurons kubva kuapoptosis. Brain-derived neurotrophic factor (BDNF) ipuroteni ine neurotrophic mhedzisiro yakakosha pakuumbwa kwehuropi, kudzidza uye ndangariro.

• Neuroprotection: 7,8-DHF inonzi neuroprotective mumhando dzemhuka dzehosha yeParkinson, inotsigira manzwiro ekudzidza mumakonzo uye inodzosera kumashure kukanganiswa kwendangariro mumakonzo echirwere cheAlzheimer, uye inogonawo kuvandudza kushanda kwemota uye kurebesa kuvhima kwenguva yekupona kwemhando dzemhuka dzine chirwere. BDNF inogona kuvandudza neuroplasticity uye neuron kupona, kubatsira huropi kuburitsa hutsva hwekubatanidza neural, kugadzirisa masero ehuropi anotadza, uye kudzivirira masero ehuropi ane hutano. Izvo zvakakosha pakuumbwa kwehuropi, kudzidza uye ndangariro, uye zvinogona kudzivirira huropi kubva kune zera-ane chekuita nekukanganisika kwekuziva. Kudzikira mukugona kwekuziva uye kudzivirira kubva kune neurodegenerative zvirwere senge chirwere cheAlzheimer uye chirwere cheParkinson.

• Inogadzirisa kupona kweuronal: 7,8-DHF inogona kusunga kuTrkB uye kumisa nzira dzekudzikisa pasi, dzakadai sePI3K/Akt uye MAPK/ERK nzira. Iko kushandiswa kweidzi nzira kwakakosha pakusimudzira kupona neuronal, kukura uye synaptic plasticity. zvakakosha. BDNF iriwo neurotrophic factor inogona kumisa intracellular signing pathways nekusunga kune TrkB receptors uye kukurudzira kupona uye kukura kweneuroni.

• Kurudzira synaptic plasticity: 7,8-DHF inogona kukurudzira kuumbwa nekusimbiswa kwe synapses nekuita TrkB receptors, nokudaro kuvandudza kushanda kwesynaptic transmission. BDNF inofungidzirwawo kukurudzira kuumbwa nekusimbaradzwa kwemasynapses, nekudaro ichiwedzera kushanda kwesynaptic kutapurirana uye nekudaro kusimudzira kugona kwekudzidza nekuyeuka.

• Migumisiro pakudzidza nekuyeuka: 7,8-DHF inogona kuvandudza unyanzvi hwekudzidza nekuyeuka mumakonzo, izvo zvingave zvine chokuita nemigumisiro yaro pane neuronal kupona uye synaptic plasticity. BDNF inoitawo basa rakakosha mukudzidza nekurangarira maitiro nekusimudzira kupona kwemaneuron uye kuumbwa kwemasynapses, nekudaro kunatsiridza kugona kwekudzidza nekuyeuka.

• Inogadzirisa mafungiro: 7,8-DHF ine mafungiro-modulating migumisiro, iyo inogona kunge yakabatana nemigumisiro yayo pane neuronal kupona uye synaptic plasticity. BDNF inofungidzirwawo kuti inobata basa mukugadzirisa manzwiro kuburikidza nekugadzirisa kupona kwema-neuron uye kuumbwa kwema-synapses, nokudaro kukanganisa kutaura kwemanzwiro.

Muchidimbu, 7,8-DHF uye BDNF vane nzira dzakafanana dzekuita neuroprotection, kugadzirisa neuronal kupona, kukurudzira synaptic plasticity, kukanganisa kudzidza nekuyeuka, nekugadzirisa manzwiro.

Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena 7,8-Dihydroxyflavone.

PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu 7,8-Dihydroxyflavone inoedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu 7,8-Dihydroxyflavone ndiyo sarudzo yakakwana.

Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.