Sezvatinokura, kuchengetedza hutano hwedu hwese kunowedzera kukosha.Tsvagiridzo inoenderana inoratidza kuti nicotinamide riboside, chimiro chevhitamini B3, inogona kurwisa kuchembera kweserura uye kukurudzira kuchembera kune hutano.Nicotinamide Riboside Pamusoro pekugadzirisa masero ekuchembera, nicotinamide riboside inoratidzawo chivimbiso mukuvandudza hutano hwese uye hupenyu hurefu.Zvidzidzo zvemhuka zvinoratidza kuti NR yekuwedzera inogona kuwedzera hupenyu uye kugadzirisa hutano mumamiriro akasiyana-siyana ane hukama nezera, kusanganisira kufutisa, chirwere chemoyo, uye neurodegenerative chirwere.
Kuchembera inzira yechisikigo iyo zvipenyu zvose zvinosangana nazvo.Sevanhu, miviri yedu nepfungwa zvinochinja zvakawanda sezvatinokura.
Shanduko yakanyatsojeka ndeyeganda, rine makwinya, mavara ezera, nezvimwe zvichionekwa.Pamusoro pazvo, tsandanyama dzinopera simba, mapfupa anotadza kusimba, majoini anooma, uye kufamba kwemunhu kunogumira.
Chimwe chinhu chakakosha pakuchembera ndiko kuwedzera kwengozi yezvirwere zvisingaperi sechirwere chemoyo, chirwere cheshuga, uye mamwe marudzi egomarara.Uyezve, kuderera kwekuziva nderimwe dambudziko rinowanzoitika.Kurasikirwa nendangariro, kuomerwa nekuisa pfungwa pachinhu chimwe, uye kuderera kwesimba repfungwa kunogona kukanganisa hupenyu hwedu hwezuva nezuva.
Vanhu vakura vakawanda vanonzwawo kusurukirwa, kuora mwoyo, kana kuti kuzvidya mwoyo, kunyanya kana vachirwara kana kuti vakafirwa.Mumamiriro ezvinhu aya, zvakakosha kutsvaga rubatsiro rwepfungwa kubva kumhuri, shamwari, uye kunyange nyanzvi.
Kunyange zvazvo tisingakwanisi kumisa kuchembera, pane nzira dzatinogona kudzinonotsa nadzo toramba tichitaridzika souduku kwenguva refu.Anti-aging supplements ndiyo imwe sarudzo yakanaka.
NAD + yakakosha coenzyme inowanikwa mumasero mapenyu ese.Basa rayo guru nderekusimudzira masero emetabolism nekubatsira kufambiswa kweelectron mune dzakawanda biological process sekugadzira simba.Nekudaro, isu patinenge tichikura, NAD + mazinga mumiviri yedu anodzikira.Zvimwe zvidzidzo zvinoratidza kuti kuderera kweNAD + mazinga kunogona kunge kuri kukonzera kuchembera.
Imwe yezvakanyanya kukosha mukutsvaga kweNAD + kuwanikwa kweNAD + precursor molecule inonzi nicotinamide riboside (NR).NR imhando yevhitamini B3 inoshandurwa kuita NAD + mukati memasero edu.Zvidzidzo zvakawanda zvemhuka zvakaratidza mhedzisiro inovimbisa, zvichiratidza kuti NR yekuwedzera inogona kuwedzera NAD + mazinga uye inogona kudzoreredza kuderera kwezera.
Zvirwere zvakawanda zvine hukama nezera, senge neurodegenerative chirwere uye metabolic dysfunction, zvine chekuita nekukanganisa mitochondrial basa.Mitochondria ndiwo masimba emasero edu, ane basa rekugadzira simba.NAD+ inoita basa rakakosha mukuchengetedza yakakwana mitochondrial basa.Nekuchengetedza hutano hwemitochondrial, NAD + ine mukana wekudzikisa njodzi yezvirwere zvine chekuita nezera uye kuwedzera hupenyu.
Uye zvakare, NAD + inobatanidzwa mukuita kwe sirtuins, mhuri yemapuroteni ane hukama nehupenyu hurefu.Sirtuins inogadzirisa zvakasiyana-siyana zvehupenyu, kusanganisira DNA kugadzirisa, cellular stress mhinduro, uye kuzvimba.NAD + yakakosha kuSirtuin basa, ichishanda se coenzyme inomutsa basa rayo enzymatic.Nekuwedzera NAD + uye kuwedzera Sirtuin basa, tinogona kunonoka kuchembera nekusimudzira hutano uye hupenyu hurefu.
Zvidzidzo zvakawanda zvakaratidza kuti NAD + yekuwedzera ine mhedzisiro mumhando dzemhuka.Semuenzaniso, kumwe kuongorora mumakonzo kwakaratidza kuti kuwedzera neNR kwakavandudza mhasuru basa uye kutsungirira.Zvimwe zvidzidzo zvakaratidza kuti NR yekuwedzera inogona kusimudzira metabolic basa mumakonzo akura, zvichiita kuti ive yakafanana neyemakonzo madiki.Izvi zvakawanikwa zvinoratidza kuti NAD + yekuwedzera inogona kuve nemhedzisiro yakafanana muvanhu, kunyangwe kumwe kutsvagisa kuchidikanwa.
Nicotinamide riboside(inozivikanwawo se niagen) imwezve fomu ye niacin (inozivikanwawo sevhitamini B3) uye inowanikwa zvakasikwa muhuwandu hudiki mumukaka nezvimwe zvekudya.Inogona kushandurwa kuitaNAD+ mukati memasero.Sechinotangira, NR inotorwa nyore nyore uye kutakurwa mumaseru, kwainoshandurwa kuita NAD+ kuburikidza nenhevedzano yemaitiro enzymatic.
NR yekuwedzera zvidzidzo mune zvese mhuka uye zvidzidzo zvevanhu zvakaratidza mhedzisiro inovimbisa.Mumakonzo, NR yekuwedzera yakawanikwa ichiwedzera NAD + mazinga mumatishu akasiyana uye inovandudza metabolic uye mitochondrial basa.
NAD + inobatanidzwa mumhando dzakasiyana dzemaserura dzinodzikira nezera, kusanganisira kugadzirisa kweDNA, kugadzirwa kwesimba, uye kudzora kwemajini.Zvinofungidzirwa kuti kuzadzazve NAD + mazinga neNR kunogona kudzoreredza basa remaserura, nekudaro kuvandudza hutano nekuwedzera hupenyu.
Pamusoro pezvo, mukudzidza kwevarume vakafuta uye vakafuta, NR yekuwedzera yakawedzera NAD + mazinga, nekudaro ichivandudza insulin senitivity uye mitochondrial basa.Izvi zvakawanikwa zvinoratidza kuti NR yekuwedzera inogona kunge iine zvingangoita mukugadzirisa zvirwere zvemetabolism senge Type 2 chirwere cheshuga uye kufutisa.
1. Zvokudya zvechisikigo zve nicotinamide riboside
Imwe inogona kuve sosi yeNR zvigadzirwa zvemukaka.Zvimwe zvidzidzo zvakaratidza kuti zvigadzirwa zvemukaka zvine huwandu hweNR, kunyanya mukaka wakasimbiswa neNR.Nekudaro, iyo NR yemukati mune izvi zvigadzirwa yakadzikira uye kuwana huwandu hwakakwana kuburikidza nekudya kwega kunogona kuve kwakaoma.
Kuwedzera kune zvekudya masosi, NR yekuwedzera inowanikwa mune capsule kana hupfu fomu.Izvi zvinowedzera zvinowanzobva kune zvakasikwa zvakadai sembiriso kana bhakitiriya kuvirisa.Yeast-yakatorwa NR inowanzoonekwa seyakavimbika uye inoenderera sosi nekuti inogona kugadzirwa muhuwandu pasina kuvimba nemhuka.Bhakitiriya inogadzirwa NR ndiyo imwe sarudzo, inowanzo wanikwa kubva kune chaiwo mabhakitiriya anowanzo gadzira NR.
2. Wedzera nicotinamide riboside
Iyo inonyanya kuzivikanwa uye yakavimbika sosi ye nicotinamide riboside iri kuburikidza nekudya zvekuwedzera.NR supplements inopa nzira iri nyore uye inoshanda yekuve nechokwadi chekudya kwakakwana kweiyi komputa yakakosha.Pakusarudza yakanakisa NR yekuwedzera, zvakakosha kufunga zvinotevera zvinhu:
a) Hunhu Husimbiso: Tsvaga zvekuwedzera izvo zvinogadzirwa nemakambani ane mukurumbira uye unoomerera kune yakasimba yemhando yekudzora zviyero.Izvi zvinovimbisa kuti iwe unowana chemhando yepamusoro chigadzirwa chisina tsvina kana zvinosvibisa.
b) Bioavailability: NR supplements inoshandisa advanced delivery systems senge encapsulation kana liposome tekinoroji kusimudzira bioavailability yeNR kuitira kuti inyatso kutorwa uye kushandiswa nemuviri.Sarudza rudzi urwu rwekuwedzera kuti uwedzere mabhenefiti aunowana kubva kuNR.
c) Kuchena: Ita shuwa kuti NR yekuwedzera yaunosarudza yakachena uye haina zvisingakoshi zvekuwedzera, mafirita kana kuchengetedza.Kuverenga mavara uye kunzwisisa zvinosanganiswa zvinogona kukubatsira kuita sarudzo ine ruzivo.
1. Kuvandudza kugadzirwa kwesimba remagetsi
NR inoita basa rakakosha mukugadzirwa kwemorekuru wakakosha nicotinamide adenine dinucleotide (NAD+).NAD + inobatanidzwa mumhando dzakasiyana dzemaserura, kusanganisira simba metabolism.Sezvo isu tichikura, mazinga eNAD + mumiviri yedu anodzikira, zvichikonzera kudzikiswa kwesimba rekugadzira.Nekusimudzira synthesis yeNAD +, NR inobatsira kumutsiridza maseru uye kugonesa kugadzirwa kwesimba kwakasimba.Iri simba remaserura rinowedzerwa rinowedzera simba, rinovandudza kushanda kwemuviri, uye rinoderedza kuneta.
2. Anti-kuchembera uye DNA kugadzirisa
Kuderera kweNAD + mazinga ane chekuita nekuchembera uye zvirwere zvine chekuita nezera.NR inogona kuwedzera NAD + mazinga emuviri, zvichiita kuti ive inorwisa-kuchembera mumiririri.NAD + inobatanidzwa mumagadzirirwo eDNA, kuve nechokwadi chekuvimbika kwemajini edu.Nekusimudzira kugadzirisa kweDNA, NR inogona kubatsira kudzivirira kukuvara kweDNA kwakabatana nezera uye kutsigira kuchembera kune hutano.Pamusoro pezvo, basa reNR mukumisikidza sirtuins, kirasi yemapuroteni anozivikanwa kudzora hutano hweserura uye hupenyu hurefu, inowedzera kuwedzera kugona kwayo kwekudzivirira kuchembera.
3. Utano hwemwoyo
Kuchengetedza hutano hwemoyo system kwakakosha kune hutano hwese.Nicotinamide riboside yakaratidza zvinovimbisa mhedzisiro pahutano hwemoyo.Inotsigira kushanda kwevascular endothelial cells, inosimudzira kubuda kweropa uye inoderedza kuzvimba.NR zvakare inovandudza mitochondrial basa mumasero emwoyo, kudzivirira oxidative kusagadzikana uye optimize kugadzirwa kwesimba.Izvi zvinogona kubatsira kuderedza njodzi yezvirwere zvemoyo senge atherosclerosis uye kutadza kwemoyo.
4. Neuroprotection uye cognitive basa
NR yakaratidzwa kuva neuroprotective properties, zvichiita kuti ive shamwari inogona kuchengetedza hutano hwehuropi.Inogona kuva nemigumisiro yakanaka pane neuronal basa uye kudzivirira kubva kune zera-ane hukama hwekuziva kuderera.Nekuwedzera NAD + mazinga, NR inotsigira mitochondrial basa mumasero ehuropi, inosimudzira kugadzirwa kwesimba uye inosimudzira kugadziridzwa kwemasero.Kuvandudza mitochondrial basa kunogona kuwedzera kugona kwekuziva senge ndangariro, kutarisisa, uye kujeka kwepfungwa.
5. Weight Management uye Metabolic Health
Kuchengeta huremu hune hutano uye metabolic balance kwakakosha kuhutano hwedu hwese.NR yakabatanidzwa kune zvinobatsira pametabolism, zvichiita kuti ive rubatsiro runogona mukugadzirisa uremu.NR inomisa puroteni inonzi Sirtuin 1 (SIRT1), iyo inodzora metabolic maitiro akadai seglucose metabolism uye kuchengetedza mafuta.Nekuita SIRT1, NR inogona kubatsira kuonda uye kuvandudza hutano hwemetabolism, nekudaro ichidzikisa njodzi yezvirwere zvakaita sekufutisa uye Type 2 chirwere cheshuga.
Mubvunzo: Chii chinonzi Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) inotangira Nicotinamide Adenine Dinucleotide (NAD +), coenzyme inoita basa rakakosha mumhando dzakasiyana dzehupenyu, kusanganisira kugadzirwa kwesimba uye kudzora metabolic uye cellular mabasa.
Mubvunzo: Ko Nicotinamide Riboside (NR) inogona kubatsira metabolism here?
A: Ehe, Nicotinamide Riboside (NR) yakawanikwa ichibatsira metabolism.Nekuwedzera NAD + mazinga, NR inogona kumisa mamwe ma enzymes anobatanidzwa mumetabolism, senge sirtuins.Iyi activation inogona kuwedzera kugona kwemetabolism, kuvandudza insulin senitivity, uye kutsigira hutano huremu manejimendi.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa.Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi.Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa.Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo.Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Nov-13-2023
