Kuchembera inzira iyo chipenyu chose chinofamba nacho. Vanhu havagoni kudzivirira kukwegura, asi vanogona kutora matanho ekuderedza kukwegura uye kuitika kwezvirwere zvinokonzerwa nezera. Imwe komboni yakagamuchira kutariswa kwakawanda-nicotinamide riboside, inozivikanwawo seNR. SeNAD + precursor, nicotinamide riboside inofungidzirwa kuti ine zvinoshamisa anti-kuchembera maitiro.Nekuwedzera NAD + mazinga, nicotinamide riboside inosimudzira sirtuin chiitiko, inovandudza mitochondrial basa, uye inomisa nzira dzakasiyana siyana dzemaserura dzinobatanidzwa mukurwisa kukwegura.
Nicotinamide riboside (NR) imhando yevhitamini B3, inozivikanwawo se nicotinic acid kana nicotinic acid. Mushonga unowanzoitika unowanikwa mune zvidiki mune zvimwe zvekudya, semukaka, mbiriso, uye mimwe miriwo.
NR ndiyo inotangira nicotinamide adenine dinucleotide (NAD+), coenzyme iripo mumasero mapenyu ese. NAD + inoita basa rakakosha mumhando dzakasiyana dzezvipenyu, kusanganisira kugadzirwa kwesimba, kugadzirisa kweDNA, uye kudzora kwesero metabolism. Sezvo isu tichikura, yedu NAD + mazinga anowanzo kuderera, izvo zvinogona kukanganisa aya akakosha mabasa. NR yekuwedzera yakatsanangurwa senzira yekuwedzera NAD + mazinga uye pamwe kudzikamisa kuchembera.
Imwe yemabhenefiti makuru eNR yekuwedzera kugona kwayo kusimudzira mitochondrial basa. Mitochondria ndiwo masimba emusero, ane basa rekugadzira mazhinji esimba resero nenzira yeadenosine triphosphate (ATP). NR yakaratidzwa kusimudzira kugadzirwa kweATP nekuwedzera NAD + mazinga, nekudaro ichikurudzira kugadzirwa kwesimba rakakwana uye cellular metabolism. Uku kuwedzera kwekugadzirwa kwesimba kunogona kubatsira akasiyana matishu uye nhengo, kusanganisira huropi, moyo, uye tsandanyama.
●Wedzera simba remagetsi
Nicotinamide riboside inoita basa rakakosha mukupa simba kusimba resero, iyo mitochondria. Komitani iyi inotangira nicotinamide adenine dinucleotide (NAD+), yakakosha coenzyme inobatanidzwa mune akawanda cellular maitiro, kunyanya simba metabolism. Tsvagiridzo inoratidza kuti kuwedzera neNR kunogona kuwedzera NAD + mazinga uye kukurudzira kufema kwakanaka kweseru uye kugadzira simba.
NAD + mazinga anowanzo kuderera sezvatinokura, zvichitungamira kune kushaya simba mitochondrial uye kuderera kwese simba mazinga. Nekudaro, nekuwedzera nicotinamide riboside, zvinokwanisika kudzosera kudzikira uku uye kudzoreredza mazinga esimba revechidiki. NR yakawanikwa zvakare kuwedzera kutsungirira kwemuviri uye kuvandudza kuita kwemitambo, zvichiita kuti ive komboni inokwezva kune vatambi uye vanhu vari kutsvaga hutano hwakakwana.
●Wedzera kugadzirisa masero uye anti-kuchembera
Chimwe chinhu chinonakidza chenicotinamide riboside kugona kwayo kusimudzira kugadzirisa kweDNA uye kurwisa kukuvara kunoenderana nezera. NAD + chinhu chakakosha mukugadzirisa kweDNA. Nekuwedzera NR kuwedzera NAD + mazinga, tinogona kuwedzera kugona kwesero kugadzirisa DNA, nekudaro zvakanyanya kudzivirira kubva mukuchembera.
Pamusoro pezvo, NR yakave yakabatanidzwa mukutonga kwenzira dzakakosha dzehupenyu hurefu, senge sirtuins, iyo inoita basa rakakosha mukuchengetedza hutano hweserura. Aya majene ehupenyu hurefu anobatsira kukwidziridza masero ekudzivirira kurwisa kushushikana uye kukurudzira hupenyu hurefu. Nekumisikidza sirtuins, nicotinamide riboside inogona kubatsira kunonoka zvirwere zvine chekuita nezera uye zvinogona kuwedzera hutano hwedu.
●Kudzivirira neurodegenerative zvirwere
Zvirwere zveNeurodegenerative senge Alzheimer's neParkinson zviri kuwedzera kuwanda munharaunda yedu. Tsvagiridzo inoratidza kuti nicotinamide riboside inogona kunge iine chivimbiso mukudzivirira izvi zvirwere zvinopedza simba. Zvidzidzo zvakawana kuti NR manejimendi inosimudzira mitochondrial basa, inoderedza oxidative kusagadzikana, uye inovandudza neuroplasticity, izvo zvese zvinobatsira kune hutano huropi.
Pamusoro pezvo, NR yekuwedzera yakabatanidzwa kune yakawedzera yekuziva basa, kuchengetedza ndangariro, uye nekuvandudza kutarisa uye kutarisisa nguva. Nepo kumwe kutsvagisa kuchidikanwa, izvi zvekutanga zvakawanikwa zvinoratidza kuti nicotinamide riboside inogona kuratidza kuve inogona kudzivirira nhanho kana tsigiro kune vanhu vari panjodzi yekuora mwoyo.
●Wedzera insulin senitivity
Zvidzidzo zvakawanda zvakaratidza kuti NR ine mukana wekuvandudza hutano hwese metabolic. Yakaratidzwa kuwedzera insulin senitivity, chinhu chinokosha pakuchengetedza hutano hwehutano hwehuga uye kudzivirira kukura kwechirwere cheshuga 2. Zvidzidzo zvakawanawo kuti NR yekuwedzera inogona kuvandudza lipid metabolism, nekudaro ichidzikisa kutenderera cholesterol uye triglyceride mazinga. Izvi zvinokonzeresa zvakanyanya kukosha kune vanhu vane metabolic kusagadzikana kana avo vakafuta kana kufutisa.
●Iine antioxidant simba
Pamusoro pezvo, NR yakaratidzwa kuwedzera masero edziviriro kubva kune oxidative kusagadzikana. Oxidative stress inoitika kana paine kusaenzana pakati pekugadzirwa kweiyo reactive okisijeni mhando (ROS) uye kugona kwemuviri kudzimisa nema antioxidants. Yakakwira huwandu hweoxidative kusagadzikana inogona kukuvadza maseru uye kubatsira mukufambira mberi kwezvirwere zvakasiyana, kusanganisira gomarara, chirwere chemoyo, uye neurodegenerative chirwere. Zvidzidzo zvakawana kuti kuwedzera NR kunogona kuvandudza iyo antioxidant kugona kwemasero uye kuderedza kukanganiswa kweiyo oxidative kusagadzikana pamuviri.
Tsvagiridzo inoratidza kuti nicotinamide riboside ine mukana wekunonoka kuchembera nekuwedzera mazinga e nicotinamide adenine dinucleotide (NAD+) molecule. NAD + imorekuru rakakosha iro rinoita basa rakakosha muserura metabolism.
NAD + mazinga anodzikira sezvatinokura. Kuderera uku kunoonekwa sechikonzero chikuru chekukwegura. Nekuwedzera NAD + mazinga, nicotinamide riboside inogona kubatsira kudzikamisa kudzikira uku uye kunonotsa mhedzisiro yekuchembera.
NAD + inobatanidzwa mune akawanda akakosha maserura maitiro, anosanganisira kugadzirwa kwesimba, kugadzirisa kweDNA, uye gene expression. Nekuwedzera NAD + mazinga, nicotinamide riboside inogona kuwedzera maitiro aya nekuvandudza mashandiro eserura.
Ongororo dzinoverengeka dzakaratidza mhedzisiro inovimbisa mumhuka nemasero evanhu. Mune imwe ongororo, vaongorori vakawana kuti nicotinamide riboside yekuwedzera yakawedzera NAD + mazinga munyama mhasuru, nekudaro ichivandudza mitochondrial basa uye kuita maekisesaizi mumakonzo.
Imwe ongororo yakawana kuti nicotinamide riboside yekuwedzera yakavandudza insulin senitivity uye kushivirira kweglucose mukufutisa, prediabetic mbeva. Izvi zvinoratidza kuti nicotinamide riboside inogona zvakare kuve nemabhenefiti ehutano hwemetabolism.
Muchidzidzo chidiki chidiki chevakuru vepakati uye vakuru, nicotinamide riboside yekuwedzera yakawedzera NAD + mazinga uye yakavandudza BP uye kuomarara kwemoyo, maviri akakosha mamaki ehutano hwemoyo.
Mune imwe ongororo, vaongorori vakawana kuti nicotinamide riboside yekuwedzera yakavandudza mhasuru kushanda uye kudzivirira kurasikirwa kwemhasuru muvakuru vakuru. Izvi zvinoratidza kuti nicotinamide riboside inogona kuve nemabhenefiti ekupokana nezera-ane mhasuru kudzikira.
Zvakakosha kuziva kuti kuchembera inzira yakaoma inokonzerwa nezvakawanda, kusanganisira genetics, mararamiro uye zvakatipoteredza. Nicotinamide riboside inofanirwa kutariswa seyekuwedzera inogona kubatsira kunonoka kuchembera uye kutsigira kuchembera kune hutano kwete bara remashiripiti.
ZvakawandaNAD+ precursors akaonekwa, kusanganisira nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), uye nicotinic acid (NA). Aya maprecursors anoshandurwa kuita NAD + kamwe mukati mesero.
Pakati peaya maprecursors, nicotinamide riboside yakawana kutariswa kwakapararira nekuda kwekugadzikana kwayo, bioavailability, uye kugona kuwedzera zvinobudirira mazinga eNAD +. NR ndiyo inongoitika fomu yevhitamini B3 uye inowanikwa muhuwandu hwekutevera mumukaka nezvimwe zvekudya. Yakaratidzwa kuwedzera NAD + synthesis uye inomutsa chiitiko che sirtuins, boka remapuroteni ane hukama nehupenyu hurefu.
Imwe yemabhenefiti e nicotinamide riboside kugona kwayo kunzvenga matanho epakati anodiwa kuNAD + synthesis. Inogona kushandurwa yakananga kuNAD + pasina kudiwa kwemamwe ma enzymes. Kusiyana neizvi, zvimwe zvinotangira senicotinamide mononucleotide zvinoda mamwe nhanho enzymatic inosanganisira nicotinamide phosphoribosyltransferase (NAMPT) kuti ishandurwe kuita NAD +.
Zvidzidzo zvakawanda zvakafananidza kushanda kwe nicotinamide riboside kune mamwe ma NAD + precursors, uye NR inogara ichibuda pamusoro. Muchidzidzo chepamberi mumakonzo ekuchembera, nicotinamide riboside yekuwedzera yakawanikwa ichiwedzera NAD + mazinga, kuvandudza mitochondrial basa, uye kuwedzera mhasuru mashandiro.
A randomized, double-blind, placebo-controlled controlled study muvakuru vane hutano hwakaratidzawo migumisiro inovimbisa. NAD + mazinga akawedzera zvakanyanya muvatori vechikamu vanotora nicotinamide riboside zvichienzaniswa neboka re placebo. Pamusoro pezvo, ivo vakashuma yakagadziridzwa yekuziva basa uye kuderedzwa kuzvibata kuneta.
Nepo mamwe ma NAD+ precursors, akadai se nicotinamide mononucleotide uye niacin, vakaratidza mhedzisiro paNAD+ mazinga mune zvimwe zvidzidzo, havasati varatidza mwero wakafanana wekubudirira se nicotinamide riboside.
Izvo zvakakosha kuti uzive kuti kunyangwe nicotinamide riboside ichiita kunge inoshanda zvakanyanya pakuwedzera NAD + mazinga, mhinduro dzega dzingasiyana. Vamwe vanhu vanogona kuona kuti mamwe maprecursor, akadai senicotinamide mononucleotide kana niacin, akakodzera kune zvavanoda chaizvo.
Nicotinamide riboside yekuwedzera inowanikwa muhwendefa, capsule, uye mafomu ehupfu. Kuwana iyo chaiyo NR dosage kunoenderana zvakanyanya neakasiyana zvinhu, kusanganisira zera, hutano, uye mhedzisiro yaunoda. Naizvozvo, zvine hungwaru nguva dzose kubvunza nyanzvi yezvehutano usati watanga chero nyowani yekuwedzera regimen, sezvo ivo vachigona kupa zano remunhu zvichienderana nezvako chaizvo zvaunoda.
Uyezve, nemukurumbira weNR uchikwira uye zvisingaverengeki mhando dzichifashukira mumusika, zvakakosha kusarudza yakavimbika uye ine mukurumbira sosi. Heano zvimwe zvinhu zvakakosha zvekufunga kana uchisarudza NR yekuwedzera:
1. Kuchena uye Hunhu: Tarisa zvigadzirwa zvakaedzwa uye zvakasimbiswa kuti zvive nechokwadi kuti zvinosangana nemhando dzakasimba. Tarisa zvekuwedzera izvo zvisina mafirita, zvinokuvadza zvinowedzera, uye zvinogona kusvibisa.
2. Maitiro Ekugadzira: Sarudza zvigadzirwa zvinogadzirwa muFDA-yakanyoreswa zvivakwa uye tevera Yakanaka Manufacturing Practice (GMP) nhungamiro. Izvi zvinovimbisa kuenderana kwechigadzirwa, kuchengeteka uye kushanda.
4. Mukurumbira uye Ongororo yeVatengi: Tarisa kuongororwa kwevatengi uye zviyero kuti uwane nzwisiso mukubudirira kwekuwedzera uye kugutsikana kwevatengi.
Mubvunzo: Nicotinamide Riboside (NR) inoshanda sei?
A: Nicotinamide Riboside (NR) inoshanda nekuwedzera mazinga eNAD + mumuviri. NAD + inobatanidzwa mukugadzirwa kwesimba remagetsi, kugadzirisa DNA, uye kuchengetedza hutano uye kushanda kwe mitochondria.
Mubvunzo: Ndeapi anogona kurwisa-kukwegura mhedzisiro yeNicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) yakaratidza kuvimbisa anti-kuchembera mhedzisiro kuburikidza nebasa rayo mukusimudzira NAD + mazinga. Kuwedzera NAD + mazinga anogona kusimudzira mitochondrial basa, kunatsiridza kugadzirwa kwesimba remagetsi, uye kukurudzira kugadzirisa kweDNA, izvo zvese zvinogona kubatsira mukurwisa kuderera kwezera nekuvandudza hutano hwese.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Nov-10-2023
