Mishonga yechisikigo iri kudiwa zvakanyanya mumabasa ekutsvaga kwesainzi uye emishonga emazuva ano. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), sechinhu chakakosha chinobva mumiti, chakwezva kutariswa kukuru nekuda kwebasa rayo guru rezvehupenyu. Kune vaongorori vesainzi nemabhizinesi, zvakakosha kuwana vatengesi vakavimbika ve7,8-Dihydroxyflavone Powder. Iyo 7,8-Dihydroxyflavone Powder inopihwa naSuzhou Myland inenhamba yeCAS ye38183-03-8 uye kuchena kwayo kusvika ku98%, zvichikupa sarudzo yakavimbika.
7,8-Dihydroxyflavone(inozivikanwawo se7,8-DHF kana kuti proflavonoid) imorekuru inowanikwa zvakasikwa iri muboka remakomputa eflavonoid. Inowanikwa mumashizha eGodmania aesculifolia, Tridax procumbens uye primula.
7,8-DHF chinhu chinobva muorganic chine molecular formula C15H10O4. Chinonyungudika muorganic solvents uye chine ruvara rwakafanana, hwema, uye kuravira kunoenderana ne flavonoid compounds.
7,8-DHF yave chinhu chinobatsira pakurapa kenza. Yakaratidza migumisiro yakasiyana-siyana yemishonga yemuuropi muzvidzidzo zvepamberi pekiriniki, kusanganisira kuvandudza ndangariro, kukurudzira kufambira mberi kwetsinga dzeropa uye kudzivirira kuora kwetsinga dzeropa.
Semushonga une simba uye unosarudza mamorekuru madiki anokonzera tropomyosin receptor kinase B (TrkB), proflavin yakaratidza kushanda zvakanaka mumhuka kurwisa zvirwere zvakasiyana-siyana, kusanganisira chirwere cheAlzheimer.
Maflavonoids imhando yemakomichi epolyphenolic anowanikwa mumichero yakasiyana-siyana, miriwo, nezvimwe zvinomera. Mumakore achangopfuura, akanyanya kutariswa nekuda kwesimba rawo rekudzivirira muviri kubva pakukuvadza, kudzivirira kuzvimba, uye kudzivirira tsinga.
Mishonga iyi yakaratidzwa kuti ine mhedzisiro inobatsira pauropi, kusanganisira kusimudzira mashandiro epfungwa uye kudzivirira zvirwere zvinokanganisa tsinga. 7,8-DHF ndeimwe yemishonga inonyanya kuzivikanwa yepolyphenolic inogamuchira kutariswa kuri kuwedzera semushonga we nootropic. Yakadzidzwa nezvemhedzisiro yayo pamanzwiro, ndangariro, kudzidza, kuzvidya mwoyo, uye mamwe mabasa epfungwa.
Zvinofungidzirwa kuti mhedzisiro yetsinga dzeropa dze7,8-DHF inokonzerwa nekushanda kwayo nemareceptor chaiwo. Yakawanikwa kuti iTrkA, receptor inobatsira mukukura kwetsinga uye yakakosha pakurarama kwetsinga uye kuvandudza mashandiro etsinga.
7,8-DHF inoshanda nekudzora kutaurwa kwemareceptor akasiyana-siyana, kusanganisira glutamate receptor subunits uye BDNF. Inokanganisawo kuumbwa kwesynapse, kushandiswa kwesimba, uye kuburitswa kweacetylcholine mune dzimwe nzvimbo dzeuropi.
Tsvagiridzo pamusoro pe7,8-dihydroxyflavone yakawedzera mumhedzisiro yayo pahutano hwevanhu, kunyanya kutarisa kuti inotevedzera sei mashandiro eneurotrophic factor (BDNF) inobva muuropi, puroteni inokosha pakurarama kwetsinga uye kushanda kweprotein.
Panyaya yemashandisirwo ayo, 7,8-DHF yakaongororwa kuti ishandiswe pakurapa zvirwere zvetsinga nekuda kwekugona kwayo kupinda muropa neuropi.
7,8-Dihydroxyflavone inoitika zvakasikwa mune zvakasiyana-siyana zvekudya zvezvirimwa, zvinosanganisira:
●Michero: maapuro, michero, mazambiringa nemichero yecitrus
●Muriwo: hanyanisi, kale, broccoli nesipinachi
●Miti: Parsley, thyme ne oregano
Pamusoro pezviwanikwa izvi zvechisikigo, 7,8-DHF inowanikwawo muchimiro chekuwedzera kuti ive nyore uye yakarongwa kushandiswa.
Dzidza nezve flavonoids
Maflavonoids imakemikari epolyphenolic anoita basa rakakosha mukugadzira ruvara rwemiti, kusefa UV, uye kudzivirira zvirwere. Akakamurwa kuita mapoka madiki akati wandei, anosanganisira maflavonols, maflavones, maisoflavones, maflavanones, uye maanthocyanins. Chikamu chimwe nechimwe chine maumbirwo akasiyana emakemikari uye mabasa ehupenyu, zvichikonzera mabhenefiti akasiyana ehutano.
Chii chinonzi 7,8-dihydroxyflavone?
7,8-Dihydroxyflavone imhando yakakosha yeflavonoid iri muboka re flavonoid. Maumbirwo ayo emakemikari ane mapoka maviri e hydroxyl panzvimbo ye7 ne8 ye flavonoid backbone, iyo ine basa rehunhu hwayo hwakasiyana. Iyi kemikari inowanikwa zvakanyanya mumiti yakaita se dioscorea (yam) uye yakaongororwa nekuda kwehunhu hwayo hwekudzivirira tsinga, hunhu hwekudzivirira kuzvimba, uye kuvandudza kugona.
Kusiyana Kukuru Pakati pe7,8-DHF Nemamwe MaFlavonoid
1. Maumbirwo emakemikari
Musiyano uri pachena pakati pe7,8-DHF nedzimwe flavonoids inyaya yemakemikoro ayo. Kunyangwe maflavonoid mazhinji aine musana wakafanana, kuvapo kwemapoka ehydroxyl panzvimbo dzakatarwa kunogona kukanganisa zvakanyanya mashandiro avo ehupenyu. Semuenzaniso, quercetin, flavonol inozivikanwa, ine kurongeka kwakasiyana kwemapoka ehydroxyl, izvo zvinokanganisa kunyungudika kwayo uye kudyidzana kwayo nezvinangwa zvehupenyu.
2. Mabasa ehupenyu
7,8-DHF yakaratidzwa kuti ine mabasa akasiyana ehupenyu kana ichienzaniswa nemamwe ma flavonoid. Tsvagiridzo inoratidza kuti inomutsa nzira yekutumira zviratidzo zveuropi (BDNF) inotorwa kubva muuropi, iyo inokosha pakurarama, kukura uye kusiyanisa kwetsinga. Maitiro aya anonyanya kukosha kana tichitarisa zvirwere zvetsinga uye kudzikira kwekuziva.
Kusiyana neizvi, mamwe ma flavonoid akadai se catechins (anowanikwa mu green tea) uye anthocyanins (anowanikwa muma berries) anoshanda zvakanyanya kuburikidza ne antioxidant activity, kubvisa free radicals uye kuderedza oxidative stress. Kunyangwe izvi zvichibatsira, zvinogona kusakanganisa zvakananga neurotrophic factors nenzira imwecheteyo inoita 7,8-DHF.
3. Kuwanikwa kwehupenyu hwemuviri
Kuwanikwa kwemuviri kunoreva huwandu uye mwero unotorwa chinhu chinoshanda kana chikamu chinoshanda uye chinowanikwa panzvimbo yekushanda. 7,8-DHF yakaratidza kuwanikwa kwakanaka kwemuviri muzvidzidzo zvemhuka, zvichiratidza kuti inogona kuyambuka zvinobudirira chipingamupinyi cheropa-uropi, icho chakakosha pakudzivirira kwayo tsinga.
Kusiyana neizvi, kuwanikwa kwemamwe ma flavonoids mumuviri kunogona kusiyana zvakanyanya. Semuenzaniso, kunyangwe quercetin ichidyiwa zvakanyanya, kunwa kwayo kunowanzo kushoma nekuda kwekushandiswa kwayo nekukurumidza. Musiyano uyu mukuwanikwa kwemuviri mumuviri unokanganisa kushanda kwemakemikari aya mukuwana mhedzisiro yehutano inodiwa.
7,8-DHF maitiro ekuita: Mutemo weBDNF uye kushanda kweTrkb receptor
Panyaya yekushanda, 7,8-DHF inozivikanwa nekusimudzira kugadzirwa kweBDNF (neurotrophic factor inobva muuropi) nekusunga uye kuvhura receptor yayo TrkB. Pasina kunyanya kushandisa tekinoroji, izvi zvinotungamira mukuita mabasa akawanda emasero anobatsira kuchengetedza mashandiro akanaka etsinga dzeropa uye kukurudzira kugadzirwa kwetsinga dzeropa.
Maitiro makuru e7,8-DHF:
(1) Brain-derived neurotrophic factor (BDNF) nebasa rayo mukuita kuti neuroplasticity ishande zvakanaka
Nekuwanikwa kwekuti kutaura kweuropi kunobva kuuropi (BDNF) kunoderera muzvirwere zvinoderedza mashandiro etsinga, kunyanya chirwere cheAlzheimer's (AD), kukosha kwacho mukuchengetedza nekusimudzira hutano hwehuropi kuri kuramba kuchionekwa.
BDNF inokosha pamabasa akasiyana-siyana etsinga dzetsinga sezvo ichisimudzira kutapurirana kwesynaptic, synaptogenesis, uye synaptic plasticity kuburikidza nekutumira masaini nemaTrkB receptors. Izvi zvinoita kuti nzira yekutumira masaini yeBDNF-TrkB ive chinangwa chakanaka chekuvandudza nzira dzekurapa dzakanangana nekurwisa zvirwere zvinokanganisa tsinga dzetsinga.
(2) Nzira yekutumira chiratidzo cheTropomyosin receptor kinase B (Trkb)
Iyo tropomyosin receptor kinase B (TrkB) receptor ine basa rakakosha mukugadzirisa mhedzisiro yeBDNF pama neuron. Semugamuchiri we transmembrane tyrosine kinase, TrkB ndiyo receptor huru yeBDNF uye inotanga kuwanda kwezviitiko zve intracellular signaling events kana zvabatana ne neurotrophic factors.
BDNF inoita kuti TrkB itange nzira dzakasiyana dzemukati memasero, dzinosanganisira phosphatidylinositol 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK)-extracellular signal-regulated kinase (ERK), uye phospholipase Cγ (PLCγ)-protein kinase C (PKC). Imwe neimwe yenzira idzi inobatsira kune chimwe chinhu chakasiyana chekushanda kwetsinga uye kugara zvakanaka.
Nzira yePI3K-Akt yakakosha pakusimudzira kupona kwetsinga dzeropa uye kudzivirira apoptosis. BDNF-TrkB signaling inomutsa nzira iyi kuti iwedzere kupona kwemasero nekudzivisa zvinhu zvinosimudzira apoptosis uye kukurudzira zvinhu zvinorwisa apoptosis, nokudaro ichivimbisa kuchengetedzwa kwema neuron ane hutano.
Kune rumwe rutivi, nzira yeMAPK-ERK inoita basa rakakosha mukusiyana kwetsinga dzeropa uye kuwanda kwadzo. BDNF-TrkB signaling inokurudzira kushanda kwenzira yeMAPK-ERK, iyo inotsigira kukura kwetsinga dzeropa uye kusiyanisa kwadzo uye kubatanidzwa kwadzo mu network dzetsinga dzeropa dziripo.
Nzira yePLCγ-PKC yakakosha pakugadzirisa synaptic plasticity, iyo nzira huru yekudzidza nekuyeuka. BDNF-TrkB signaling inogadzirisa mashandiro enzira iyi, zvichizopedzisira zvaita kuti pave nekuchinja kwesimba resynaptic nekubatana.
Kuchinja uku kunokurudzira kugadziriswa uye kurongeka patsva kwemasero etsinga dzetsinga zvichienderana nezviitiko zvitsva uye zvinokurudzira zvakatipoteredza.
Nekushanda semushonga weTrkB agonist, 7,8-DHF inoshandisa mhedzisiro yayo ye nootropic kunyanya nekudzora nzira dzekutumira masaini dzine chekuita neBDNF, nokudaro ichisimudzira kuumbwa kwetsinga dzeropa uye kuwedzera plasticity yesynaptic.
Nekutevedzera migumisiro yeBDNF, 7,8-DHF inobatsira kudzivirira ma neuron kubva mukukuvadzwa, inosimudzira kurarama kwawo, uye inokurudzira kukura nekuchengetedzwa kwekubatana kutsva kwe neuron. Kugona uku kukurudzira neuroplasticity, kuvandudza mashandiro ekuziva, uye kuderedza zviratidzo zvezvirwere zve neuron kunoita kuti 7,8-DHF ive mukana wekuvandudza mishonga uye kutsvagurudza kwakawedzerwa.
7,8-DHF Mabhenefiti eNootropic: Kuvandudza Kuziva uye Kudzivirira Neurological
Nezvemabhenefiti ayo e nootropic, 7,8-DHF inoshanda nenzira ina huru:
Kubatanidza nekudzorera ndangariro: basa rinoenderana ne hippocampus
7,8-DHF yakawanikwa ichivandudza kuunganidzwa kwendangariro nekudzoka mumabasa akasiyana-siyana ekudzidza nekuyeuka anoenderana nehippocampus mumakonzo. Izvi zvakawanikwa zvinoratidza kuti 7,8-DHF inogona kunge iri nootropic inovimbisa, Inogona kushandiswa kuvandudza mashandiro endangariro muvanhu vane hutano uye avo vane dambudziko rekuyeuka.
Synaptic plasticity: kugona kwenguva refu uye kuora mwoyo
7,8-DHF yakaratidzwa kuti inodzora synaptic plasticity nekusimudzira LTP uye kuderedza LTD mu hippocampus. Mhedzisiro iyi inofungidzirwa kuti inokonzerwa nekukwanisa kwayo kumutsa TrkB receptors uye mushure mezvo kuwedzera nzira yeBDNF signaling. Kuchinja uku kwesynaptic plasticity kunobatsira mukuvandudzwa kwebasa rekuziva rinoonekwa mushure mekupiwa kwe7,8-DHF.
Hunhu hweAntioxidant: Kubvisa ROS uye lipid peroxidation
7,8-DHF ine simba rekudzivirira muviri sezvinoratidzwa nekukwanisa kwayo kubvisa reactive oxygen species (ROS) uye kuderedza lipid peroxidation. Izvi zvinobatsira mukudzivirira tsinga dzetsinga nekuderedza kukuvara kwetsinga dzetsinga uye kusashanda zvakanaka kwetsinga dzetsinga.
Mhedzisiro yekudzivirira kuzvimba: inodzora activation ye microglial uye kugadzirwa kwe cytokine
Pamusoro pesimba rayo rekudzivirira muviri, 7,8-DHF yakawanikwa iine simba rekudzivirira kuzvimba nekuchinja mashandiro e microglial uye kuderedza kugadzirwa kwema cytokines anodzivirira kuzvimba akadai seTNF-α neIL-1β. Izvi zvinowedzera kubatsira mukudzivirira tsinga dzeuropi nekudzivirira kukuvara kwetsinga dzeuropi kunokonzerwa nekuzvimba.
Kana uchitsvaga mutengesi we7,8-DihydroxyflavoneUpfu, unogona kufunga nezvezvinhu zvinotevera:
1. Mukurumbira wemutengesi
Kusarudza mutengesi ane mukurumbira wakanaka kwakakosha. Unogona kuwana ruzivo rwemukurumbira wemutengesi nekutarisa ongororo dzevatengi, mishumo yeindasitiri, uye maforamu ehunyanzvi. Suzhou Myland ine mukurumbira wakanaka muindasitiri, ine mhinduro dzakanaka dzevatengi uye mhando yechigadzirwa inozivikanwa zvakanyanya.
2. Hunhu hwechigadzirwa
Iva nechokwadi chekuti zvigadzirwa zvinopihwa nevatengesi zvinoenderana nezvinodiwa zvepasi rose uye zvinodiwa pakudzora mhando. Suzhou Myland 7,8-Dihydroxyflavone Powder yakaedzwa zvakanyanya uye ine kuchena kusvika ku98%, zvichiita kuti chigadzirwa chishande zvakanaka uye chive chakachengeteka.
3. Chitupa uye Kutevedzera Mutemo
Kusarudza mutengesi ane GMP (Good Manufacturing Practice) uye ISO certification kunoita kuti maitiro ekugadzira asvike padanho repasi rose. Suzhou Myland inotevedzera mitemo iyi zvakasimba kuti ive nechokwadi chekugadzikana uye kugara kwenguva refu kwezvigadzirwa zvese.
4. Rutsigiro rwehunyanzvi uye masevhisi
Mutengesi akavimbika anofanira kupa rutsigiro rwehunyanzvi uye sevhisi yevatengi. Suzhou Myland ine timu yehunyanzvi inogona kupa vatengi mazano ekushandisa chigadzirwa uye nhungamiro yehunyanzvi kubatsira vatengi kuwana mhedzisiro iri nani mukutsvagisa nekushandisa.
5. Mutengo nenguva yekutumira
Mutengo nenguva yekutumira zvinhu zvakakoshawo pakusarudza mutengesi. Unogona kukumbira mitengo kubva kune vatengesi vakawanda woenzanisa mitengo yavo nenguva yekutumira kuti uwane sarudzo yakakodzera. Suzhou Myland
inopa mitengo inokwikwidzana uye nguva dzekutumira dzinochinjika uku ichivimbisa mhando yechigadzirwa.
Maitiro Ekuwana Powder ye7,8-Dihydroxyflavone
Kana uchitsvaga 7,8-Dihydroxyflavone Powder yemhando yepamusoro, Suzhou Myland ndiyo sarudzo yako yakanakira. Unogona kutibata ne:
Webhusaiti yepamutemo: Shanyirawebhusaiti yepamutemo yeSuzhou Mylandkuti udzidze zvakawanda nezveruzivo rwechigadzirwa uye rutsigiro rwehunyanzvi.
Kubvunzana paIndaneti: Kutaurirana zvakananga nechikwata chedu chebasa revatengi kuburikidza nebasa rekubvunzana paIndaneti rinopihwa newebhusaiti kuti uwane ruzivo rwechigadzirwa uye makotesheni aunoda.
Runhare: Fonera nhamba yedu yekutaurirana kuti utaure nevashandi vekutengesa vane hunyanzvi uye uwane ruzivo rwakadzama nezvechigadzirwa uye mazano ekutenga.
Kubvunza nezve email: Munogonawo kutibvunza nezveruzivo rwechigadzirwa kuburikidza neemail, uye tichakupindurai nekukurumidza sezvinobvira.
Kuwana vatengesi ve7,8-Dihydroxyflavone Powder vakavimbika hakusi nyore, asi nekutarisa mukurumbira wemutengesi, mhando yechigadzirwa, chitupa uye kutevedzera mitemo, rutsigiro rwehunyanzvi nebasa, pamwe nemutengo nenguva yekutumira, unogona kuita sarudzo yakangwara. Sarudza. Suzhou Myland ndiyo shamwari yako yakakodzera ne7,8-Dihydroxyflavone Powder yayo yakachena uye sevhisi yakanaka yevatengi. Tinotarisira kushanda nemi kuti tiongorore zvimwe zvinogoneka zve7,8-Dihydroxyflavone.
Mubvunzo: Proflavin inogona kuvandudza kugona kudzidza here?
A: Ehe, proflavin yakaratidzwa kuti inowedzera mukana wekudzidza muzvidzidzo zvemhuka nekusimudzira kufambira mberi kwetsinga dzeropa uye kubatana kwesynaptic. Inodzora masisitimu e neurotransmitter akakosha pakudzidza, kunyanya mu hippocampus, nzvimbo yakakosha yeuropi yekudzidza.
Mubvunzo: Ko 7,8-DHF inobatsira here kupora kwepfungwa mushure mekukuvara?
A: Ehe, zvidzidzo zvepamberi pekiriniki zvinoratidza kuti 7,8-DHF inogona kubatsira kupora kwepfungwa mushure mekukuvara kweuropi nekukurudzira kuchengetedzwa kwetsinga uye kuvandudzwa kwetsinga. Inoderedza kufa kwetsinga uye inotsigira kukura kwetsinga itsva, zvichigona kuvandudza mashandiro epfungwa akakanganiswa nekukuvara kana kukuvara kweischemic.
Mubvunzo: Ndeipi basa rinoitwa ne7,8-dihydroxyflavone mukudzikira kwepfungwa kunokonzerwa nekukwegura?
A: Ongororo iri kubuda inoratidza kuti 7,8-DHF inogona kuderedza kudzikira kwepfungwa kunokonzerwa nekukwegura nekudzivirira kubva mukushushikana kwe oxidative uye kuzvimba, zvinhu zvakajairika muzvirwere zvepfungwa zvine chekuita nekukwegura.
Nekuwedzera mazinga eBDNF uye kushanda kweTrkB receptor, zvinobatsira kuchengetedza kugona kwekufunga, kunyangwe zvidzidzo zvakawanda zvevanhu zvichidikanwa kuti vaongorore zvizere mhedzisiro iyi.
Mubvunzo: Ko 7,8-DHF inogona kuvandudza kutarisisa uye mashandiro ekushanda kwemuviri here?
A: Ongororo dzekutanga dzemhuka dzinoratidza kuti 7,8-DHF inogona kuvandudza kutarisisa uye mashandiro emuviri nekuvandudza kurongeka kwema neurotransmitter uye kubatana kwetsinga munzvimbo dzeuropi dzinobatanidzwa mukuita uku.
Chiziviso: Chinyorwa ichi ndecheruzivo rwese chete uye hachifanirwe kutorwa semazano ekurapa. Mamwe emashoko eblog anobva paInternet uye haasi ehunyanzvi. Iyi webhusaiti ine basa rekugadzirisa, kuronga nekugadzirisa zvinyorwa chete. Chinangwa chekutumira rumwe ruzivo hazvirevi kuti unobvumirana nemaonero ayo kana kusimbisa chokwadi chezviri mukati mayo. Gara uchibvunza nyanzvi yehutano usati washandisa chero mishonga yekuwedzera kana kuita shanduko kuhurongwa hwako hwehutano.
Nguva yekutumira: Gumiguru-16-2024
