Mishonga yemasikirwo iri kuwedzera kudiwa muongororo yemazuva ano yesainzi uye maindasitiri emishonga. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), semushonga wakakosha wechirimwa, wakwezva kutarisisa kwakapararira nekuda kwekuita kwayo kwakakosha. Kune vaongorori vesainzi nemabhizinesi, zvakakosha kuti uwane vatengesi vanovimbika ve7,8-Dihydroxyflavone Powder. Iyo 7,8-Dihydroxyflavone Powder yakapihwa naSuzhou Myland inenhamba yeCAS ye38183-03-8 uye kuchena kunosvika 98%, zvichikupa sarudzo yakavimbika.
7,8-Dihydroxyflavone(inozivikanwawo se7,8-DHF kana proflavonoid) imorekuru rinongoitika riri reboka reflavonoid remakomboni. Inowanikwa mumashizha eGodmania aesculifolia, Tridax procumbens uye primula.
7,8-DHF isanganiswa yeorganic ine molecular formula C15H10O4. Inonyungudika muorganic solvents uye ine hunhu hweruvara, hwema uye kuravira kwakabatana nemafuta eflavonoid.
7,8-DHF yakabuda sechinhu chinovimbisa nootropic compound. Yakaratidza huwandu hwehuropharmacological mhedzisiro mune preclinical zvidzidzo, kusanganisira kuvandudza ndangariro, kukurudzira neurogenesis nekudzivirira neurodegeneration.
Senge ine simba uye inosarudza diki molecule agonist yetropomyosin receptor kinase B (TrkB), proflavin yakaratidza kushanda mumhando dzemhuka kurwisa zvirwere zvakasiyana, kusanganisira chirwere cheAlzheimer.
Flavonoids ikirasi yemapolyphenolic makomisheni anowanikwa mumhando dzakasiyana dzemichero, miriwo, uye zvimwe zvinorimwa. Mumakore achangopfuura, vakawana kutariswa kwakanyanya nekuda kweiyo antioxidant, anti-inflammatory, uye neuroprotective properties.
Aya makomisheni akaratidzwa kuve ane mhedzisiro inobatsira pahuropi, kusanganisira kuwedzera kugona kwekuziva uye kudzivirira neurodegenerative zvirwere. 7,8-DHF ndeimwe yemakomisheni ane mukurumbira epolyphenolic anogamuchira kuwedzera kutariswa seanotropic. Yakave ichidzidzwa nekuda kwezvinogona kuitika pamanzwiro, ndangariro, kudzidza, kunetseka, uye mamwe mabasa ekuziva.
Izvo zvinokonzerwa neurological ye7,8-DHF inofungidzirwa kuti inopindirana nekubatana kwayo nemamwe ma receptors. Yakawanikwa iri TrkA, receptor inobatanidzwa muhutano hwekukura kwechiratidzo uye yakakosha kune neuronal kupona uye plastiki.
7,8-DHF inoshanda nekugadzirisa kutaura kwezvakasiyana-siyana zvinogamuchirwa, kusanganisira glutamate receptor subunits uye BDNF. Inobatawo kuumbwa kwe synapse, simba metabolism, uye kusunungurwa kweacetylcholine mune dzimwe nzvimbo dzehuropi.
Tsvagiridzo pa7,8-dihydroxyflavone yakawedzera kuita mhedzisiro yayo pahutano hwevanhu, kunyanya kutarisa kuti inotevedzera sei basa reuropi-derived neurotrophic factor (BDNF), protein yakakosha kune neuronal kupona uye kushanda. yeprotein.
Maererano nekushandiswa kwayo, 7,8-DHF yakaongororwa kuti inogona kushandiswa mukurapa zvirwere zvetsinga nekuda kwekukwanisa kwayo kupinda muropa-brain barrier.
7,8-Dihydroxyflavone inowanzoitika mumhando dzakasiyana dzekudya kwezvirimwa, kusanganisira:
● Zvibereko: maapuro, mabheri, mazambiringa nemichero yecitrus
● Miriwo: hanyanisi, kare, broccoli uye sipinachi
● Herbs: Parsley, thyme uye oregano
Kuwedzera kune aya masosi masosi, 7,8-DHF inowanikwawo mune yekuwedzera fomu kuitira nyore uye kurongwa kushandiswa.
Dzidza nezve flavonoids
Flavonoids mapolyphenolic makomisheni anoita basa rakakosha muchirimwa pigmentation, UV kusefa, uye kuramba zvirwere. Iwo akakamurwa muzvikamu zvidiki, kusanganisira flavonols, flavones, isoflavones, flavanones, uye anthocyanins. Imwe neimwe subclass ine akasiyana emakemikari zvimiro uye biological zviitiko, zvichikonzera akasiyana hutano mabhenefiti.
Chii chinonzi 7,8-dihydroxyflavone?
7,8-Dihydroxyflavone imhando yakakosha yeflavonoid inova yeflavonoid subclass. Chimiro chayo chemakemikari chine maviri hydroxyl mapoka panzvimbo 7 uye 8 yeflavonoid musana, iyo inotarisira kune yayo yakasarudzika. Mushonga uyu unowanikwa zvakanyanya muzvirimwa zvakaita sedioscorea (yam) uye wakadzidzwa nekuda kwezvinogona kuita neuroprotective mhedzisiro, anti-inflammatory properties, uye cognitive kuwedzera.
Misiyano Yakakosha Pakati pe7,8-DHF uye Mamwe Flavonoids
1. Chimiro chemakemikari
Musiyano unonyanya kuoneka pakati pe7,8-DHF nemamwe maflavonoid chimiro chayo chemakemikari. Kunyangwe maflavonoid mazhinji achigovana musana wakafanana, kuvepo kwemapoka ehydroxyl panzvimbo dzakatarwa kunogona kukanganisa zvakanyanya basa ravo rehupenyu. Semuenzaniso, quercetin, flavonol inozivikanwa, ine hurongwa hwakasiyana hwemapoka e-hydroxyl, iyo inokanganisa kunyungudika kwayo uye kushamwaridzana nezvinangwa zvehupenyu.
2. Biological chiitiko
7,8-DHF yakaratidzwa kuva neakasarudzika biological zviitiko zvichienzaniswa nemamwe maflavonoids. Tsvagiridzo inoratidza kuti inomutsa uropi-yakatorwa neurotrophic factor (BDNF) siginecha nzira, iyo yakakosha kune neuron kupona, kukura uye kusiyanisa. Iyi nzira inonyanya kukosha mumamiriro ezvirwere zveurourodegenerative uye kuderera kwekuziva.
Kusiyana neizvi, mamwe maflavonoid akadai sekatechini (anowanikwa mugirini tii) uye anthocyanins (anowanikwa mumabheri) anoshanda zvakanyanya kuburikidza nekuita antioxidant, scavenging free radicals uye kuderedza oxidative kusagadzikana. Kunyange zvazvo zvinhu izvi zvinobatsira, zvingasakanganisa zvakananga neurotrophic zvinhu nenzira imwechete iyo 7,8-DHF inoita.
3. Bioavailability
Bioavailability inoreva chiyero uye mwero wekuti chinhu chinoshanda kana chikamu chinoshanda chinotorwa uye chinowanikwa panzvimbo yechiito. 7,8-DHF yakaratidza bioavailability yakanaka muzvidzidzo zvemhuka, zvichiratidza kuti inogona kunyatsoyambuka ropa-brain barrier, iyo yakakosha kune yayo neuroprotective mhedzisiro.
Kusiyana neizvi, bioavailability yeimwe flavonoids inogona kusiyana zvakanyanya. Semuenzaniso, kunyange zvazvo quercetin inopedzwa zvakanyanya, kubatwa kwayo kunowanzo kugumira nekuda kwekukurumidza kwemetabolism. Uyu mutsauko mubioavailability unokanganisa kushanda kwemakomponi aya mukuwana mhedzisiro yehutano hunodiwa.
7,8-DHF nzira yekuita: BDNF mutemo uye Trkb receptor activation
Mukutaura kwemaitiro ekuita, 7,8-DHF inozivikanwa kukurudzira kugadzirwa kweBDNF (brain-derived neurotrophic factor) nekusunga nekuita kuti receptor yayo TrkB. Pasina kuwana tekinoroji yakawandisa, izvi zvinotungamira kune kuwanda kwezviitiko zvemaserura zvinobatsira mukuchengetedza kwakaringana neuronal basa uye kusimudzira neurogenesis.
7,8-DHF's main mode yekuita:
(1) Brain-derived neurotrophic factor (BDNF) uye basa rayo mune neuroplasticity
Nekuwanikwa kwekuti brain-derived neurotrophic factor (BDNF) kutaura kwakaderedzwa muzvirwere zveurourodegenerative, kunyanya chirwere cheAlzheimer (AD), kukosha kwayo mukuchengetedza nekusimudzira hutano hwehuropi huri kuramba huchibuda pachena.
BDNF yakakosha kune akasiyana-siyana neuronal mabasa sezvo ichikurudzira synaptic transmission, synaptogenesis, uye synaptic plasticity kuburikidza nekuisa chiratidzo neTrkB receptors. Izvi zvinoita kuti BDNF-TrkB isaina nzira ive inovimbisa chinangwa chekuvandudza kwekurapa kupindira kune chinangwa chekurwisa neurodegenerative zvirwere.
(2) Tropomyosin receptor kinase B (Trkb) receptor chiratidzo nzira
Iyo tropomyosin receptor kinase B (TrkB) receptor inoita basa rakakosha mukuyananisa mhedzisiro yeBDNF pane neuroni. Se transmembrane tyrosine kinase receptor, TrkB ndiyo yekutanga receptor yeBDNF uye inotanga kubuda kwezviitiko zvekusaina intracellular pakusunga kune neurotrophic factor.
BDNF inomutsa TrkB kuti itange nzira dzinoverengeka dzakakosha dzemukati, kusanganisira phosphatidylinositol 3-kinase (PI3K) -Akt, mitogen-activated protein kinase (MAPK) -extracellular signal-regulated kinase (ERK), uye phospholipase Cγ (PLCγ) -protein kinase ( PKC) nzira. Imwe neimwe yenzira idzi inobatsira kune imwe nzira yeurouronal basa uye kugara zvakanaka.
Iyo PI3K-Akt nzira yakakosha mukusimudzira kupona neuronal uye kuvharidzira apoptosis. BDNF-TrkB siginecha inomutsa nzira iyi kuti iwedzere kupona kwesero nekudzivisa pro-apoptotic zvinhu uye kukurudzira anti-apoptotic zvinhu, nokudaro kuve nechokwadi kuchengetedzwa kwehutano neuroni.
Kune rimwe divi, iyo MAPK-ERK nzira inoita basa rakakosha mukusiyanisa neuronal uye kuwanda. BDNF-TrkB siginecha inosimudzira activation yeMAPK-ERK nzira, iyo inotsigira neuronal maturation uye kusiyanisa uye kubatanidzwa kwavo mune iripo neuronal network.
Iyo PLCγ-PKC nzira yakakosha pakugadzirisa synaptic plasticity, yakakosha maitiro ekudzidza nekuyeuka. BDNF-TrkB siginecha inogadzirisa chiitiko cheiyi nzira, inozotungamira kune shanduko musimba re synaptic uye kubatana.
Iyi modulation inosimudzira kuchinjika uye kurongekazve kweneural maseketi mukupindura kune zvitsva zviitiko uye kwezvakatipoteredza zvinokurudzira.
Nokuita seTrkB agonist, 7,8-DHF inoshandisa migumisiro yayo ye nootropic kunyanya nekugadzirisa BDNF-yakabatana nzira dzechiratidzo, nokudaro kukurudzira neurogenesis uye kusimbisa synaptic plasticity.
Nekutevedzera mhedzisiro yeBDNF, 7,8-DHF inobatsira kuchengetedza neuroni kubva mukukuvadzwa, inosimudzira kurarama kwavo, uye inosimudzira kukura nekuchengetedza kweiyo neuronal kubatana kutsva. Uku kugona kusimudzira neuroplasticity, kunatsiridza mashandiro enjere, uye kubvisa zviratidzo zvezvirwere zvetsinga kunoita 7,8-DHF mumiriri anovimbisa wekuvandudza zvinodhaka uye kuenderera mberi nekutsvaga.
7,8-DHF Nootropic Benefits: Cognitive Enhancement uye Neuroprotection
Nezve mabhenefiti ayo e-nootropic, 7,8-DHF inoshanda kuburikidza ne4 nzira huru:
Memory kubatanidzwa uye kudzoreredza: basa rinotsamira pane hippocampus
7,8-DHF yakawanikwa kuti iwedzere kubatanidzwa kwendangariro uye kudzoreredza mune dzakasiyana siyana dzehippocampus-inotsamira kudzidza uye ndangariro mabasa mumakonzo modhi. Izvi zvakawanikwa zvinoratidza kuti 7,8-DHF inogona kunge iri nootropic inovimbisa, Inogona kushandiswa kuvandudza ndangariro basa muvanhu vane hutano uye avo vane ndangariro kukanganisa.
Synaptic plastiki: kugona kwenguva refu uye kuora mwoyo
7,8-DHF yakaratidzwa kudzora synaptic plasticity nekusimudzira LTP uye kuderedza LTD muhippocampus. Izvi zvinokonzeresa zvinofungidzirwa kuti zvinoyananiswa nekugona kwayo kumisa TrkB receptors uyezve kuwedzera iyo BDNF kusaina nzira. Iyi modulation ye synaptic plasticity inobatsira mukuvandudzika kwekuita kwekuziva kunocherechedzwa kunotevera 7,8-DHF kutonga.
Antioxidant zvivakwa: ROS scavenging uye lipid peroxidation
7,8-DHF ine antioxidant properties sezvinoratidzwa nekukwanisa kwayo kutsvaira reactive oxygen marudzi (ROS) uye kuderedza lipid peroxidation. Izvi zvinokonzeresa mhedzisiro yayo neuroprotective nekudzikisa oxidative kusagadzikana-induced neuronal kukuvara uye kusashanda.
Anti-inflammatory effect: inogadzirisa microglial activation uye cytokine kugadzirwa
Mukuwedzera kune iyo antioxidant properties, 7,8-DHF yakawanikwa iine anti-inflammatory effects kuburikidza nekugadzirisa microglial activation uye kuderedza kugadzirwa kwepro-inflammatory cytokines yakadai seTNF-α uye IL-1β. Izvi zvinowedzera kuwedzera kune yayo neuroprotective uye nootropic mhedzisiro nekudzivirira kuzvimba-mediated neuronal kukuvara.
Pakutsvaga mutengesi we7,8-DihydroxyflavonePowder, unogona kufunga zvinotevera zvinhu:
1. Mukurumbira wemupi
Kusarudza mutengesi ane mukurumbira wakanaka kwakakosha. Iwe unogona kuwana manzwiro emukurumbira wemutengesi nekutarisa kuongororwa kwevatengi, mishumo yeindasitiri, uye maforamu ehunyanzvi. Suzhou Myland inonakidzwa nemukurumbira wakanaka muindastiri, ine mhinduro yakanaka yevatengi uye inozivikanwa zvakanyanya mhando yechigadzirwa.
2. Chigadzirwa chemhando
Ita shuwa kuti zvigadzirwa zvinopihwa nevatengesi zvinoteedzera zviyero zvepasirese uye zvemhando yepamusoro zvinodiwa. Suzhou Myland 7,8-Dihydroxyflavone Powder yakamboyedzwa zvemhando yepamusoro uye ine kuchena kunosvika 98%, kuve nechokwadi kuti chigadzirwa chinoshanda uye kuchengetedzeka.
3. Certification uye Kutevedzera
Kusarudza mutengesi ane GMP (Yakanaka Kugadzira Kudzidzira) uye ISO certification inova nechokwadi chekuti maitiro ayo ekugadzira anosangana nezviyero zvepasirese. Suzhou Myland inoteedzera aya mazinga kuti ive nechokwadi chekugadzikana uye kuenderana kwebatch yega yega yezvigadzirwa.
4. Tsigiro yehunyanzvi uye masevhisi
Mutengesi akavimbika anofanira kupa nyanzvi yehunyanzvi rutsigiro uye basa revatengi. Suzhou Myland ine timu yehunyanzvi yehunyanzvi iyo inogona kupa vatengi mazano ekushandiswa kwechigadzirwa uye kutungamira kwehunyanzvi kubatsira vatengi kuwana mhedzisiro iri nani mukutsvaga nekushandisa.
5. Mutengo uye nguva yekuendesa
Mutengo uye nguva yekuendesa zvakare zvakakosha kufunga pakusarudza mutengesi. Iwe unogona kukumbira makotesheni kubva kune akawanda vatengesi uye enzanisa mitengo yavo uye nguva dzekutumira kuti uwane yakanyanya kukodzera sarudzo. Suzhou Myland
inopa mitengo yemakwikwi uye nguva dzinochinjika dzekutumira uchive nechokwadi chemhando yechigadzirwa.
Nzira yekuwana 7,8-Dihydroxyflavone Powder
Kana iwe uchitsvaga yemhando yepamusoro 7,8-Dihydroxyflavone Powder, Suzhou Myland ndiyo sarudzo yako yakanaka. Unogona kutibata ne:
Webhusaiti yepamutemo: Shanyira iyowebhusaiti yepamutemo yeSuzhou Mylandkuti udzidze zvakawanda nezve ruzivo rwechigadzirwa uye rutsigiro rwehunyanzvi.
Kubvunzurudza pamhepo: Taurirana zvakananga neboka redu revashandi vevatengi kuburikidza nebasa rekubvunza pamhepo rinopihwa newebhusaiti kuti uwane ruzivo rwechigadzirwa uye makotesheni aunoda.
Kubata parunhare: Fonera nhamba yedu yekuonana kuti utaure nevashandi vekutengesa uye uwane ruzivo rwakadzama rwechigadzirwa uye mazano ekutenga.
Email kubvunza: Unogona zvakare kutikumbira ruzivo rwechigadzirwa kuburikidza neemail, uye isu tichakupindura iwe nekukurumidza sezvinobvira.
Kutsvaga vatengesi ve7,8-Dihydroxyflavone Powder vanovimbika hazvisi nyore, asi nekuteerera kune mukurumbira wemutengesi, mhando yechigadzirwa, chitupa uye kuteedzera, rutsigiro rwehunyanzvi uye sevhisi, pamwe nemutengo uye nguva yekuendesa, unogona kuita sarudzo ine hungwaru. sarudza. Suzhou Myland ndiyo yako yakanakira shamwari ine yayo yakakwirira-kuchena 7,8-Dihydroxyflavone Powder uye yakanakisa sevhisi yevatengi. Isu tinotarisira kushanda newe kuti tiongorore zvimwe zvekushandisa zve7,8-Dihydroxyflavone.
Mubvunzo: Ko proflavin inogona kuvandudza kugona kudzidza?
A: Hongu, proflavin yakaratidzwa kuwedzera kugona kudzidza muzvidzidzo zvemhuka nekusimudzira neurogenesis uye synaptic connections. Inogadzirisa masisitimu eurotransmitter akakosha pakuita kudzidza, kunyanya muhippocampus, nzvimbo yakakosha yehuropi pakudzidza.
Mubvunzo: Ko 7,8-DHF inobatsira kupora kwekuziva mushure mekukuvara here?
A: Hongu, zvidzidzo zvepreclinical zvinoratidza kuti 7,8-DHF inogona kubatsira kupora kwekuziva mushure mekukuvara kwehuropi nekusimudzira neuroprotection uye neurogeneration. Iyo inoderedza kufa neuronal uye inotsigira kukura kweiyo neuroni nyowani, inogona kuvandudza cognitive basa rakakanganiswa nekukuvara kana ischemic kukuvara.
Q:Ibasa rei rinoitwa ne7,8-dihydroxyflavone mukuchembera-nechekuita nekuziva kudzikira?
A: Tsvagiridzo iri kubuda inoratidza kuti 7,8-DHF inogona kunonoka kuderera kwekuziva kwakabatana nekuchembera nekudzivirira kubva kune oxidative kusagadzikana uye kuzvimba, zvinowanzoitika muzvirwere zvine chekuita nezera.
Nekusimudzira mazinga eBDNF uye TrkB receptor activation, inobatsira kuchengetedza kugona kwekuziva, kunyangwe zvimwe zvidzidzo zvevanhu zvichidikanwa kuti unyatsoongorora mhedzisiro iyi.
Q:Ko 7,8-DHF inogona kuvandudza kutarisisa uye basa rekutonga?
A: Zvidzidzo zvepakutanga zvemhuka zvinoratidza kuti 7,8-DHF inogona kuvandudza kutarisa uye basa rekutonga nekusimudzira mutemo weurotransmitter uye neural connections munzvimbo dzeuropi dzinobatanidzwa mune izvi.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Oct-16-2024
