Mugadziri weupfu hweAgomelatine Nhamba yeCAS: 138112-76-2 99% kuchena kwezvishandiso zvekuwedzera
Vhidhiyo yeChigadzirwa
Zvimiro zveChigadzirwa
| Zita rechigadzirwa | Agomelatine |
| Rimwe zita | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Nhamba yeCAS | 138112-76-2 |
| Fomura yemamorekuru | C15H17NO2 |
| Kurema kwemasero | 243.3082 |
| Kuchena | 99.0% |
| Chitarisiko | Upfu chena |
| Kurongedza | 1kg/bhegi 25kg/dhiramu |
| Kushandiswa | Zvinhu zvekugadzira zvechigadzirwa chehutano |
Sumo yechigadzirwa
Agomelatine yakatanga kuburitswa muEurope muna 2009 uye ikozvino yatenderwa kushandiswa munyika dzinopfuura makumi manomwe. Kusiyana nemishonga yechinyakare yekudzora kuora mwoyo, agomelatine inoshanda nekutarisa melatonin uye serotonin receptors muuropi. Nekushanda semushonga wekudzivirira kurara kwe melatonin receptors, agomelatine inobatsira kugadzirisa maitiro ekurara akakanganiswa anowanzobatanidzwa nekuora mwoyo. Iyi nzira haingobatsiri chete kuvandudza kunaka kwekurara asiwo inobatsira kudzoreredza mafambiro echisikigo e circadian. Pamusoro pezvo, agomelatine inoshanda semupikisi kune mamwe ma serotonin receptors (5-HT2C receptors). Ichi chiito chakasiyana cheviri chinowedzera kuwanikwa kweserotonin muuropi, neurotransmitter ine basa rekutonga mafungiro. Nekudzora mazinga e serotonin, agomelatine inogona kushanda semushonga unoshanda wekudzora kuora mwoyo, ichideredza zviratidzo zvakaita sekusuruvara, kurasikirwa nechido, kunzwa kwemhosva kana kusava nebasa. Pamusoro pezvo, agomelatine inogona kupa mamwe mabhenefiti. Tsvagiridzo inoratidza kuti inogona kubatsira kuvandudza mashandiro ekuziva Tsvagiridzo inoratidza kugona kwayo kusimudzira ndangariro, kutarisisa, uye mashandiro esimba, zvichiita kuti ive nzvimbo inonakidza yekutsvagisa mune ramangwana.
Chinhu
(1) Kuchena kwakanyanya: Agomelatine inogona kuwana zvigadzirwa zvakachena zvakanyanya kuburikidza nekugadzira kwakanatswa. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu uye kushomeka kwemigumisiro yakaipa.
(2) Kuchengetedzeka: Kuchengeteka kwakanyanya, kusawirirana kushoma.
(3) Kugadzikana: Agomelatine ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.
Mashandisirwo
Agomelatine mushonga wekurwisa kushushikana kwepfungwa uye melatonin antagonist. Inoderedza zviratidzo zvekushungurudzika nekudzora melatonin MT1 receptors (inoderedza zviratidzo zve cortical alarm) uye MT2 receptors (circadian sleep rhythm) uye serotonin levels. Inotorwa husiku, inotevedzera rhythm yechisikigo yekuburitswa kwemelatonin uye inogona kuvandudza zvakanyanya kunaka kwekurara. Maitiro ayo ekushanda anotyora kuburikidza nesystem ye monoamine transmitter. Inoshanda ma melatonin receptors MT1 na MT2 uye inopesana nema 5-HT2C receptors. Inovandudza kunaka kwekurara, inodzoreredza rhythm yezvemuviri, uye ine simba rekurwisa kushushikana kwepfungwa; pakati pazvo, nekurwisa ma 5-HT2C receptors pa postsynaptic membrane, inogona kuwedzera kuburitswa kweDA neNE mu prefrontal cortex, ichiita simba rekurwisa kushushikana kwepfungwa. Kana MT agonism uye 5-HT2C receptor antagonism zvikabatana, simba rakasiyana rinogona kugadzirwa, richikurudzira kuburitswa kweDA neNE dzakawanda munzvimbo yePFC brain, zvichiwedzera kusimbisa simba rekurwisa kushushikana kwepfungwa. Pamusoro pezvo, agomelatine inogona kukurudzira kuburitswa kwe neurotrophic factor inobva muuropi muPFC uye kudzivirira kuburitswa kwe glutamate inokonzerwa nekushushikana munzvimbo yeuropi yeamygdala.
