Sei Uchifanira Kutenga Spermidine Powder? Tsananguro Yezvakanakira Zvikuru

Spermidine,inozivikanwawo sespermidine, chinhu chinonzi triamine polyamine chinowanikwa zvakanyanya mumiti yakaita segorosi, soya, nembatatisi, tupukanana tudiki twakaita selactobacilli nebifidobacteria, uye matishu akasiyana-siyana emhuka. Spermidine ihydrocarbon ine skeleton yekabhoni yakaita sezigzag inoumbwa nemaatomu manomwe ekabhoni nemaamino groups kumativi ese uye pakati.

Ongororo dzemazuva ano dzakaratidza kuti spermidine inobatanidzwa mumabasa akakosha ehupenyu akadai sekudzokororwa kweDNA mumasero, kunyorwa kwemRNA, uye kushandurwa kwemapuroteni, pamwe nemaitiro akawanda ezvirwere zvakaita sekudzivirira kushushikana kwemuviri uye metabolism. Inodzivirira mwoyo nemidziyo yeropa, inodzivirira bundu, uye inodzora kuzvimba, nezvimwewo. Basa rakakosha rehupenyu.

Spermidine inoonekwa semushonga une simba we autophagy, nzira yekudzokorodza masero mukati memasero iyo masero ekare anozvivandudza uye anodzoreredza kushanda. Spermidine inoita basa rakakosha mukushanda kwemasero uye kurarama. Mumuviri, spermidine inogadzirwa kubva ku putrescine yayo yekutanga, iyo inovawo mhedzisiro yeimwe polyamine inonzi spermine, iyo inokoshawo pakushanda kwemasero.

Spermidine neputrescine zvinokurudzira autophagy, sisitimu inoputsa tsvina iri mukati memasero uye inodzokorodza zvikamu zvemasero uye inzira yekudzora mhando ye mitochondria, simba resero. Autophagy inoputsa uye inorasa mitochondria yakakuvara kana isina kunaka, uye kurasa mitochondria inzira inodzorwa zvakanyanya. Polyamines inokwanisa kubatana kumarudzi akasiyana-siyana emamorekuru, zvichiita kuti ashande zvakasiyana-siyana. Anotsigira maitiro akadai sekukura kwemasero, kugadzikana kweDNA, kuwanda kwemasero, uye apoptosis. Polyamines inoita seyakashanda zvakafanana nezvinhu zvinokura panguva yekupatsanurwa kwemasero, ndosaka putrescine nespermidine zvakakosha pakukura uye kushanda kwenyama ine hutano.

Vaongorori vakadzidza kuti spermidine inodzivirira sei masero kubva mukushushikana kwe oxidative, izvo zvinogona kukuvadza masero uye kutungamira kuzvirwere zvakasiyana-siyana. Vakaona kuti spermidine inomutsa autophagy. Chidzidzo ichi chakaona majini akati wandei akakosha anokanganiswa nespermidine anoderedza kushushikana kwe oxidative uye anokurudzira autophagy mumasero aya. Pamusoro pezvo, vakaona kuti kuvharira nzira ye mTOR, iyo inowanzobatanidzwa mukudzivisa autophagy, kwakawedzera mhedzisiro yekudzivirira yespermidine.

Ndezvipi zvekudya zvine spermidine yakawanda?

Spermidine ipolyamine inokosha. Pamusoro pekugadzirwa kwayo nemuviri wemunhu pachawo, manyuko ayo akawanda ezvekudya uye tupukanana twemudumbu ndiwo nzira huru dzekuuwana. Huwandu hwespermidine muzvikafu zvakasiyana-siyana hunosiyana zvakanyanya, negorosi riri soya rinozivikanwa nemiti. Zvimwe zvekudya zvinosanganisira grapefruit, soy products, beans, corn, whole grains, pizi, pizi, green peppers, broccoli, oranges, green tea, rice bran uye green peppers itsva. Pamusoro pezvo, zvekudya zvakaita se shiitake mushrooms, amaranth seeds, cauliflower, mature cheese uye durian zvinewo spermidine.

Zvakakosha kuziva kuti kudya kweMediterranean kune chikafu chakawanda chine spermidine yakawanda, izvo zvinogona kubatsira kutsanangura chiitiko che "blue zone" apo vanhu vanorarama kwenguva yakareba munzvimbo dzakati. Zvisinei, kune vanhu vasingakwanise kudya spermidine yakakwana kuburikidza nekudya, spermidine supplements inzira inoshanda. spermidine iri mu supplements idzi imorekuru imwe chete inowanikwa zvakasikwa, zvichiita kuti ive imwe nzira inoshanda.

Chii chinonzi putrescine?

Kugadzirwa kweputrescine kunosanganisira nzira mbiri, dzose dzinotanga neamino acid arginine. Munzira yekutanga, arginine inotanga yashandurwa kuita agmatine inokonzereswa nearginine decarboxylase. Zvadaro, agmatine inozoshandurwazve kuita N-carbamoylputrescine kuburikidza nekushanda kweagmatine iminohydroxylase. Pakupedzisira, N-carbamoylputrescine inoshandurwa kuita putrescine, zvichipedzisa maitiro ekushandura. Nzira yechipiri iri nyore, inoshandura zvakananga arginine kuita ornithine, uye yozoshandura ornithine kuita putrescine kuburikidza nekushanda kweornithine decarboxylase. Kunyangwe nzira mbiri idzi dziine matanho akasiyana, dzese dzinopedzisira dzachinja kubva kuarginine kuenda kuputrescine.

Putrescine idiamine inowanikwa munhengo dzakasiyana-siyana dzakadai sepancreas, thymus, ganda, uropi, chibereko nemazai. Putrescine inowanikwawo muzvikafu zvakaita segorosi, mhiripiri, soya, pistachios, uye maranjisi. Ongororo dzichangobva kuitwa dzakaratidza kuti putrescine chinhu chakakosha chinodzora metabolic chinogona kusangana nema macromolecules ebhayoloji akadai seDNA, RNA, ligands dzakasiyana-siyana (dzakadai seβ1 neβ2 adrenergic receptors), uye mapuroteni emembrane, zvichikonzera shanduko dzakawanda dzemuviri kana dzepathological mumuviri.

Mhedzisiro yeSpermidine

Kushanda kweAntioxidant: Spermidine ine simba guru rekuchengetedza maantioxidant uye inogona kuita zvinopesana nemafree radicals kuderedza kukuvara kwemasero kunokonzerwa nemafree radicals. Mumuviri, spermidine inogonawo kukurudzira kuratidzwa kwemaantioxidant enzymes uye kuwedzera kugona kweantioxidant.

Kudzora kushandiswa kwesimba: Spermidine inobatsira mukugadzirisa kushandiswa kwesimba rezvinhu zvipenyu, inogona kukurudzira kutorwa kweglucose nekushandiswa kwayo mushure mekudya, uye inokanganisa huwandu hwekushandiswa kwesimba re aerobic uye kushandiswa kwesimba re anaerobic nekutonga kushanda kwekugadzirwa kwesimba re mitochondrial.

mugumisiro wekudzivirira kuzvimba

Spermidine ine simba rekudzivirira kuzvimba uye inogona kudzora kuratidzwa kwezvinhu zvinozvimba uye kuderedza kuitika kwekuzvimba kwenguva refu. Inonyanya kuenderana nenzira ye nuclear factor-κB (NF-κB).

Kukura, kukura uye kudzora masoja emuviri: Spermidine inoitawo basa rakakosha mukukura, kukura uye kudzora masoja emuviri. Inogona kukurudzira kuburitswa kwehomoni yekukura mumuviri wemunhu uye kubatsira kusimudzira kukura kwematishu akasiyana-siyana nenhengo dzemuviri. Panguva imwe chete, mukudzora masoja emuviri, spermidine inowedzera kudzivirira kwemuviri kuhutachiona nezvirwere nekudzora kugadzirwa kwemasero machena eropa uye kukurudzira kubviswa kwemarudzi eoxygen anobatsira.

Kunonoka kukwegura: Spermidine inogona kukurudzira autophagy, nzira yekuchenesa mukati memasero inobatsira kubvisa organelles nemapuroteni akakuvara, nokudaro ichinonotsa kukwegura.

Kudzora masero eGlial: Spermidine inoita basa rakakosha mukutonga masero eglial. Inogona kutora chikamu muhurongwa hwekutumira masaini emasero uye kubatana kwebasa pakati pemasero etsinga, uye inoita basa rakakosha mukuvandudza tsinga, kutapurirana kwesynaptic, uye kuramba tsinga dzeropa.

Kudzivirira Mwoyo: Muchikamu chemwoyo, spermidine inogona kuderedza kuunganidzwa kwemafuta mumasero ane atherosclerotic plaques, kuderedza hypertrophy yemwoyo, uye kunatsiridza mashandiro e diastolic, nokudaro zvichiita kuti mwoyo udzivirirwe. Pamusoro pezvo, kudya spermidine muzvokudya kunovandudza BP uye kunoderedza zvirwere zvemwoyo nerufu.

Muna 2016, tsvakiridzo yakaburitswa muAtherosclerosis yakasimbisa kuti spermidine inogona kuderedza kuunganidzwa kwemafuta mumasero ane atherosclerotic plaques. Mugore rimwe chetero, tsvakiridzo yakaburitswa muNature Medicine yakasimbisa kuti spermidine inogona kuderedza hypertrophy yemwoyo uye kuvandudza mashandiro e diastolic, nokudaro ichidzivirira moyo uye kuwedzera hupenyu hwembeva.

Kuvandudza chirwere cheAlzheimer

Kudya spermidine kunobatsira pakushanda kwendangariro dzevanhu. Chikwata chaPurofesa Reinhart wekuAustralia chakaona kuti kurapwa kwespermidine kunogona kuvandudza kushanda kwenjere dzevakwegura. Chidzidzo ichi chakatora dhizaini ye multi-center double-blind uye chakanyoresa vakwegura 85 mudzimba nhanhatu dzevakwegura, avo vakakamurwa zvisina tsarukano mumapoka maviri uye vakashandisa madosi akasiyana espermidine. Basa ravo rekuziva rakaongororwa kuburikidza nekuyedzwa kwendangariro uye rakakamurwa mumapoka mana: pasina dementia, dementia isina kusimba, dementia iri pakati nepakati uye dementia yakanyanya. Sampuli dzeropa dzakaunganidzwa kuti dziongorore huwandu hwespermidine muropa ravo. Mhedzisiro yacho yakaratidza kuti huwandu hwespermidine hwaive hwakabatana zvakanyanya nebasa rekuziva muboka risiri redementia, uye huwandu hwekuziva hwevanhu vakwegura vane dementia isina kusimba hwakavandudzika zvakanyanya mushure mekudya madosi akawanda espermidine.

Autophagy

Spermidine inogona kukurudzira autophagy, senge nzira yekudzivirira mTOR (target of rapamycin). Nekukurudzira autophagy, inobatsira kubvisa organelles nemapuroteni akakuvara mumasero uye kuchengetedza hutano hwemasero.

Spermidine hydrochloride inoshandiswa mumhando dzakasiyana dzemishonga.

Muchikamu chemishonga, spermidine hydrochloride inoshandiswa semushonga unodzivirira chiropa unogona kuvandudza mashandiro echiropa nekuderedza kukuvara kwechiropa. Pamusoro pezvo, spermidine hydrochloride inogona kushandiswa kurapa zvirwere zvakaita secholesterol yakakwira, hypertriglyceridemia, uye chirwere chemwoyo.

Spermidine hydrochloride inoshanda nekuderedza huwandu hwehomocysteine ​​​​(Hcy) muropa, nokudaro ichideredza njodzi yezvirwere zvemwoyo. Zvidzidzo zvakaratidza kuti spermidine hydrochloride inogona kukurudzira metabolism yeHcy uye kuderedza njodzi yezvirwere zvemwoyo nekuderedza huwandu hweHcy muropa.

Chidzidzo pamusoro pemigumisiro ye spermidine hydrochloride panjodzi yezvirwere zvemwoyo chakaratidza kuti spermidine hydrochloride inogona kuderedza huwandu hweHcy muropa, nokudaro ichideredza njodzi yezvirwere zvemwoyo. Muchidzidzo ichi, vaongorori vakakamura vatori vechikamu mumapoka maviri, rimwe richipiwa spermidine hydrochloride supplementation uye rimwe richipiwa placebo.

Zvakabuda muongororo zvakaratidza kuti vatori vechikamu vakagamuchira spermidine hydrochloride supplementation vaive nemazinga eHcy muropa akaderera zvakanyanya uye njodzi yezvirwere zvemwoyo yakadzikira zvakanyanya. Pamusoro pezvo, kune zvimwe zvidzidzo zvinotsigira basa respermidine hydrochloride mukuderedza njodzi yezvirwere zvemwoyo.

Mumunda wezvekudya, spermidine hydrochloride inoshandiswa semushonga wekuwedzera kunaka uye humectant kuwedzera kunaka kwechikafu uye kuchengetedza hunyoro hwechikafu. Pamusoro pezvo, spermidine hydrochloride inogonawo kushandiswa semushonga wekuwedzera kukura kwemhuka uye mhando yetsandanyama.

Muzvizoro, spermidine hydrochloride inoshandiswa semushonga unobvisa hunyoro uye antioxidant kuchengetedza hunyoro hweganda uye kuderedza kukuvara kwe free radicals. Pamusoro pezvo, spermidine hydrochloride inogona kushandiswawo muzvizoro zvezuva kuderedza kukuvara kwemwaranzi ye ultraviolet paganda.

Mumunda wekurima, spermidine hydrochloride inoshandiswa senzira yekudzora kukura kwezvirimwa kukurudzira kukura kwezvirimwa uye kuwedzera goho.