Sei Uchifanira Kutenga Spermidine Powder? Kubatsira Kwakakosha Kunotsanangurwa

Spermidine,inozivikanwawo se spermidine, ndeye triamine polyamine chinhu chinowanikwa zvakanyanya muzvirimwa zvakaita segorosi, soya bhinzi, uye mbatatisi, tupukanana twakadai selactobacilli uye bifidobacteria, uye akasiyana mhuka tishu. Spermidine ihydrocarbon ine zigzag-shaped carbon skeleton inoumbwa ne7 carbon atomu uye amino mapoka kumativi ose uye pakati.

Tsvagiridzo yemazuva ano yakaratidza kuti spermidine inobatanidzwa mumararamiro akakosha senge cellular DNA replication, mRNA transcription, uye mapuroteni kududzira, pamwe nemaitiro akawanda epathophysiological akadai sekudzivirira kushushikana kwemuviri uye metabolism. Iine cardiovascular protection uye neuroprotection, anti-tumor, uye mutemo wekuzvimba, etc. Basa rinokosha rehupenyu.

Spermidine inoonekwa seine simba activator ye autophagy, intracellular recycling process kuburikidza neiyo masero ekare anozvivandudza iwo uye kuitazve basa. Spermidine inoita basa rakakosha mukushanda kwesero uye kurarama. Mumuviri, spermidine inogadzirwa kubva kune yayo precursor putrescine, iyo inozoita inotangira kune imwe polyamine inonzi spermine, iyo yakakoshawo kusero basa.

Spermidine uye putrescine inosimudzira autophagy, sisitimu inopwanya intracellular tsvina uye inodzokorodza zvikamu zvemasero uye imhando yekudzora nzira ye mitochondria, dzimba dzesimba dzesero. Autophagy inoputsika uye inorasa yakakuvara kana yakaremara mitochondria, uye kuraswa kwemitochondrial inzira inodzorwa zvakasimba. Polyamines inokwanisa kusunga kune marudzi akasiyana-siyana emamorekuru, achiita kuti ive yakasiyana-siyana. Ivo vanotsigira maitiro akadai sekukura kwesero, kugadzikana kweDNA, kuwanda kwesero, uye apoptosis. Polyamines inoratidzika kushanda zvakafanana nekukura kwezvinhu panguva yekuparadzaniswa kwesero, ndosaka putrescine uye spermidine zvakakosha pakukura uye kushanda kwenyama ine hutano.

Vatsvakurudzi vakadzidza kuti spermidine inodzivirira sei masero kubva kune oxidative stress, iyo inogona kukuvadza masero uye kutungamirira kuzvirwere zvakasiyana-siyana. Vakaona kuti spermidine inomutsa autophagy. Chidzidzo ichi chakaratidza akati wandei akakosha majini akabatwa nespermidine anoderedza oxidative kusagadzikana uye kukurudzira autophagy mumasero aya. Mukuwedzera, vakawana kuti kuvhara mTOR nzira, iyo inowanzobatanidzwa mukudzivisa autophagy, inowedzera kuwedzera spermidine's protective effects.

Ndezvipi zvokudya zvine spermidine?

Spermidine inokosha polyamine. Pamusoro pekugadzirwa nemuviri wemunhu pachawo, huwandu hwayo hwechikafu uye hutachiona hwematumbu zvakare akakosha ekupa nzira. Huwandu hwespermidine mukudya kwakasiyana-siyana hunosiyana zvakanyanya, nembeu yegorosi ndiyo inonyanyozivikanwa chirimwa. Zvimwe zvekudya zvinosanganisira magrapefruit, zvigadzirwa zvesoya, bhinzi, chibage, zviyo, pizi, pizi, mhiripiri, broccoli, maranjisi, green tea, rice bran uye mhiripiri nyoro. Pamusoro pezvo, zvekudya zvakaita sehowa hweshiitake, mhodzi dzeamaranth, cauliflower, chizi yakakura uye durian zvakare zvine spermidine.

Zvakakosha kuziva kuti kudya kweMediterranean kune zvakawanda zvezvokudya zvine spermidine, izvo zvinogona kubatsira kutsanangura "blue zone" chiitiko apo vanhu vanogara kwenguva refu mune dzimwe nzvimbo. Zvisinei, kune vanhu vasingakwanisi kudya zvakakwana spermidine kuburikidza nekudya, spermidine supplements ndiyo imwe nzira inoshanda. Iyo spermidine mune izvi zvinowedzera zvakafanana zvinongoitika molecule, zvichiita kuti ive imwe inoshanda imwe nzira.

Chii chinonzi putrescine?

Kugadzirwa kwe putrescine kunosanganisira nzira mbiri, dzose dzinotanga neamino acid arginine. Munzira yekutanga, arginine inotanga kushandurwa kuita agmatine yakagadziriswa nearginine decarboxylase. Zvadaro, agmatine inoshandurwazve kuita N-carbamoylputrescine kuburikidza nekuita kweagmatine iminohydroxylase. Pakupedzisira, N-carbamoylputrescine inoshandurwa kuita putrescine, ichipedzisa maitiro ekushandura. Yechipiri nzira iri nyore, inoshandura zvakananga arginine kuita ornithine, uyezve inoshandura ornithine kuita putrescine kuburikidza nekuita kweornithine decarboxylase. Kunyangwe idzi nzira mbiri dziine nhanho dzakasiyana, ivo vese vanozowana shanduko kubva kuarginine kuenda ku putrescine.

Putrescine idhiamine inowanikwa munhengo dzakasiyana dzakadai serwatata, thymus, ganda, huropi, chibereko uye mazai. Putrescine inowanikwawo mune zvekudya zvakaita segorosi germ, green pepper, soya beans, pistachios, uye maranjisi. Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti putrescine chinhu chakakosha chemetabolism inodzora iyo inogona kudyidzana neiyo biological macromolecules senge yakaipa chaja DNA, RNA, akasiyana ligands (senge β1 uye β2 adrenergic receptors), uye membrane mapuroteni. , zvichitungamira kune zvakatevedzana zve physiological kana pathological shanduko mumuviri.

Spermidine effect

Antioxidant chiitiko: Spermidine ine yakasimba antioxidant basa uye inogona kuita nemahara radicals kuderedza oxidative kukuvara kumasero anokonzerwa nemahara radicals. Mumuviri, spermidine inogonawo kukurudzira kutaura kwe antioxidant enzymes uye kuwedzera antioxidant simba.

Kugadziriswa kwesimba metabolism: Spermidine inobatanidzwa mukugadzirisa simba rekugadzirisa simba rezvipenyu, rinogona kukurudzira kutora uye kushandiswa kweglucose mushure mekudya kwekudya, uye inokanganisa chiyero che aerobic metabolism uye anaerobic metabolism nekugadzirisa kushanda kwemitochondrial simba rekugadzira.

anti-inflammatory effect

Spermidine ine anti-inflammatory effects uye inogona kugadzirisa kutaura kwezvinhu zvinoputika uye kuderedza kuitika kwechirwere chisingaperi. Inonyanya kuenderana nenyukireya factor-κB (NF-κB) nzira.

Kukura, kukura uye kudzivirira kwekudzivirira: Spermidine inoitawo basa rinokosha mukukura, kukura uye kudzivirira kwekudzivirira. Inogona kukurudzira secretion yekukura kwehomoni mumuviri wemunhu uye kubatsira kusimudzira kukura kweakasiyana matishu uye nhengo dzemuviri. Panguva imwecheteyo, mumutemo wekudzivirira zvirwere, spermidine inowedzera kudzivirira kwemuviri kune mavhairasi nezvirwere nekugadzirisa kugadzirwa kwemasero machena eropa uye kukurudzira kubviswa kwemhando yeokisijeni inoshanda.

Kunonoka kuchembera: Spermidine inogona kukurudzira autophagy, nzira yekuchenesa mukati memasero inobatsira kubvisa akakuvadzwa organelles uye mapuroteni, nekudaro kunonoka kuchembera.

Glial cell regulation: Spermidine inoita basa rakakosha rekutonga mumasero eglial. Inogona kutora chikamu mumasero ekusaina masisitimu uye inoshanda yekubatanidza pakati pemasero etsinga, uye inoita yakakosha kudzora basa mukuvandudza neuron, synaptic kutapurirana, uye kuramba neuropathy.

Kudzivirirwa kwemoyo: Mumunda wemoyo, spermidine inogona kuderedza lipid kuunganidza mu atherosclerotic plaques, kuderedza cardiac hypertrophy, uye kunatsiridza diastolic basa, nekudaro kuwana kuchengetedzwa kwemoyo. Mukuwedzera, kudya kwe spermidine kunovandudza BP uye kunoderedza kushaya mwoyo uye kufa.

Muna 2016, tsvagiridzo yakaburitswa muAtherosclerosis yakasimbisa kuti spermidine inogona kuderedza lipid kuunganidza mu atherosclerotic plaque. Mugore rimwe chetero, chidzidzo chakabudiswa muNature Medicine chakasimbisa kuti spermidine inogona kuderedza cardiac hypertrophy uye kuvandudza diastolic basa, nokudaro kudzivirira mwoyo uye kuwedzera hupenyu hwemakonzo.

Kuvandudza chirwere cheAlzheimer

Kudya kweSpermidine kunobatsira pakurangarira kwevanhu basa. Chikwata chaProfessor Reinhart vekuAustralia chakawana kuti kurapwa kwespermidine kunogona kuvandudza basa rekuziva kwevakwegura. Chidzidzo ichi chakatora dhizaini yakapetwa kaviri-mapofu uye yakanyoresa vanhu vakura makumi masere nevashanu mudzimba dzevakwegura 6, avo vakapatsanurwa zvisina tsarukano kuita mapoka maviri uye vakashandisa madosi akasiyana espermidine. Basa ravo rekuziva rakaongororwa kuburikidza nekuyedzwa kwendangariro uye rakakamurwa kuita mapoka mana: hapana dementia, nyoro, dementia ine mwero uye yakakomba dementia. Sampuli dzeropa dzakaunganidzwa kuti dziongorore kuwanda kwespermidine muropa ravo. Zvigumisiro zvakaratidza kuti spermidine concentration yakabatana zvikuru nekushanda kwekuziva muboka risina dementia, uye ruzivo rwekuziva kwevanhu vakwegura vane hunyoro kusvika pakati pekuderera kwakavandudzika zvikuru mushure mekudya mazamu akawanda espermidine.

Autophagy

Spermidine inogona kukurudzira autophagy, yakadai semTOR (chinangwa cherapamycin) inhibitory nzira. Nekusimudzira autophagy, inobatsira kubvisa akakuvadzwa organelles uye mapuroteni mumasero uye inochengetedza hutano hwesero.

Spermidine hydrochloride inoshandiswa munzvimbo dzakasiyana-siyana

Mumunda wemishonga, spermidine hydrochloride inoshandiswa sehepatoprotective drug inogona kuvandudza kushanda kwechiropa uye kuderedza kukuvara kwechiropa. Pamusoro pezvo, spermidine hydrochloride inogona kushandiswa kurapa mamiriro akadai seyakakwira cholesterol, hypertriglyceridemia, uye chirwere chemoyo.

Spermidine hydrochloride inoshanda nekudzikisa plasma homocysteine ​​​​(Hcy) mazinga, nekudaro kuderedza njodzi yechirwere chemoyo. Zvidzidzo zvakaratidza kuti spermidine hydrochloride inogona kukurudzira metabolism yeHcy uye kuderedza njodzi yehutano hwemwoyo nekuderedza mazinga eplasma Hcy.

Chidzidzo pamusoro pemigumisiro ye spermidine hydrochloride panjodzi yehutano hwemwoyo yakaratidza kuti spermidine hydrochloride inogona kuderedza plasma Hcy mazinga, nokudaro kuderedza ngozi yehutano hwemwoyo. Muchidzidzo ichi, vaongorori vakapatsanura vatori vechikamu kuita mapoka maviri, mumwe achiwana spermidine hydrochloride supplementation uye mumwe achigamuchira placebo.

Mhedzisiro yekudzidza yakaratidza kuti vatori vechikamu vakagamuchira spermidine hydrochloride supplementation vaive vakaderera zvakanyanya plasma Hcy mazinga uye kuderera kunowirirana munjodzi yechirwere chemoyo. Pamusoro pezvo, kune zvimwe zvidzidzo zvinotsigira basa respermidine hydrochloride mukudzikisa njodzi yechirwere chemoyo.

Mumunda wezvekudya, spermidine hydrochloride inoshandiswa sechinhu chinonakisa uye chinonyorovesa kusimudzira kuravira kwechikafu uye kuchengetedza hunyoro hwechikafu. Pamusoro pezvo, spermidine hydrochloride inogona zvakare kushandiswa seyekuwedzera chikafu chekuvandudza mwero wekukura uye mhando yemhasuru yemhuka.

Muzvizoro, spermidine hydrochloride inoshandiswa sehumectant uye antioxidant kuchengetedza hunyoro hweganda uye kuderedza mahara radical kukuvara. Mukuwedzera, spermidine hydrochloride inogonawo kushandiswa mune sunscreens kuderedza kukuvadzwa kwemirairo ye ultraviolet paganda.

Mumunda wekurima, spermidine hydrochloride inoshandiswa semugadziri wekukura kwechirimwa kusimudzira kukura kwezvirimwa uye kuwedzera goho.