Calcium Alpha ketoglutarate (AKG) inhengo yepakati pe tricarboxylic acid cycle uye inobata mukugadzirwa kwemaamino acids, mavhitamini uye organic acids uye simba metabolism. Inogona kushandiswa sekuwedzera kwekudya uye ine mikana yakawanda yekushandiswa. Kuwedzera kumabasa ayo ehupenyu mumuviri wemunhu, calcium alpha-ketoglutarate inoshandiswawo zvakanyanya mumunda wemishonga uye yave chikamu chakakosha chezvigadzirwa zvakawanda zvehutano uye mhinduro dzekurapa.
Chii chinonzi alpha-ketoglutarate?
AKG imusanganiswa wemakemikari unowanikwa mumasero emuviri uri chikamu cheKrebs cycle, zvichireva kuti miviri yedu inoigadzira. Indasitiri yekuwedzera mishonga inogadzirawo mhando yekugadzira yakafanana neAKG inogadzirwa mumasero.
Chii chinoitwa neAKG?
AKG imorekuru inobatanidzwa munzira dzakawanda dze metabolic uye cellular. Inoshanda semupi wesimba, inotungamira kugadzirwa kweamino acid uye cellular signaling molecule, uye inodzora maitiro e epigenetic. Imorekuru inokosha muKrebs cycle, ichidzora kumhanya kwese kwe citric acid cycle yemuviri. Inoshanda munzira dzakasiyana-siyana mumuviri kubatsira kuvaka tsandanyama uye kubatsira mukupora kwemaronda, inova imwe yezvikonzero nei ichifarirwa munyika yekuvaka muviri.
AKG inoshandawo semushonga wekubvisa nitrogen, ichidzivirira kuwanda kwenitrogen uye ichidzivirira kuunganidzwa kweammonia yakawandisa. Ndiyo zvakare sosi yakanaka yeglutamate neglutamine, izvo zvinokurudzira kugadzirwa kwemapuroteni mutsandanyama uye zvinodzivisa kuparara kwemapuroteni.
Pamusoro pezvo, inotonga enzyme ye10-11 translocation (TET) inobatanidzwa mukubvisa methylation yeDNA uye Jumonji C domain-containing lysine demethylase, inova ndiyo histone demethylase huru. Nenzira iyi, inyanzvi huru mukutonga uye kuratidzwa kwemajini.
AKG inogona kunonoka kukwegura here?
Pane humbowo hwekuti AKG inogona kukanganisa kukwegura, uye zvidzidzo zvakawanda zvinoratidza kuti ndizvo zvazviri. Ongororo yakaitwa muna 2014 yakaratidza kuti AKG yakawedzera hupenyu hweC. elegans yevakuru ne50% nekudzivisa ATP synthase uye chinangwa cherapamycin (TOR).
Muchidzidzo ichi, takaona kuti AKG haingowedzere hupenyu hwemuviri chete asiwo inononotsa mamwe maitiro ane chekuita nezera, akadai sekurasikirwa nekufamba kwemuviri nekukurumidza kunowanzoitwa neC. elegans yakwegura. Kuti tinzwisise kuti AKG inokanganisa sei kukwegura, tichatsanangura nzira idzo AKG inodzivisa ATP synthase neTOR kuti iwedzere hupenyu hwemuviri muC. elegans pamwe nedzimwe mhando.
Mashandiro anoita calcium alpha-ketoglutarate
Chekutanga, calcium alpha-ketoglutarate inoita basa rakakosha mukushandiswa kwesimba. Sechigadzirwa chepakati che tricarboxylic acid cycle (TCA cycle), calcium α-ketoglutarate inobata basa rekugadzira simba mukati memasero. Kuburikidza neTCA cycle, zvinovaka muviri zvakaita semakabhohaidhiretsi, mafuta, uye mapuroteni zvinosanganiswa uye zvinoora kuti zvigadzire ATP (adenosine triphosphate) kuti ipe simba kumasero. Sechikamu chakakosha cheTCA cycle, calcium α-ketoglutarate inogona kukurudzira kushandiswa kwesimba remasero, kuwedzera simba remuviri, kubatsira kuwedzera simba remuviri uye kutsungirira, uye kuvandudza kuneta kwemuviri.
Chechipiri, calcium α-ketoglutarate inoita basa rakakosha mukushandiswa kwemaamino acid. MaAmino acid ndiwo mayuniti ekutanga emapuroteni, uye calcium α-ketoglutarate inobatanidzwa mukushandurwa uye kushandiswa kwemaamino acid. Mukushandura maamino acid kuita mamwe ma metabolites, calcium α-ketoglutarate inochinjana nemaamino acids kugadzira maamino acid matsva kana α-keto acids, nokudaro ichidzora kuenzana uye kushandiswa kwemaamino acids. Pamusoro pezvo, calcium α-ketoglutarate inogona zvakare kushanda senzvimbo yekuoxidation yemaamino acids, kutora chikamu mukushandiswa kwemaamino acids, uye kugadzira simba necarbon dioxide. Naizvozvo, calcium α-ketoglutarate inokosha zvikuru mukuchengetedza homeostasis yemaamino acids uye kushandiswa kwemapuroteni mumuviri.
Pamusoro pezvo, calcium alpha-ketoglutarate inoshanda seantioxidant inobvisa ma free radicals uye inodzivirira masero kubva mukukuvadzwa kwe oxidative. Panguva imwe chete, calcium α-ketoglutarate inogonawo kudzora mashandiro e immune system, kukurudzira kushanda uye kuwanda kwemasero e immune system, uye kuwedzera kudzivirira kwemuviri kuzvirwere nehutachiona. Nokudaro, calcium α-ketoglutarate inokosha zvikuru mukuchengetedza kuenzana kwe immune system yemuviri uye kudzivirira zvirwere.
Tsvagiridzo pamusoro pemigumisiro yecalcium α-ketoglutarate pakukwegura
Kukwegura kunokanganisa tose uye chinhu chinokonzera zvirwere zvakawanda, uye zvichienderana nehuwandu hwevanhu vari muindasitiri yeMedicare, mukana wekurwara unowedzera nekukura.
Calcium alpha-ketoglutarate chinhu chakakosha mumuviri wedu, chinozivikanwa nebasa resero muKrebs cycle, cycle inokosha pakuoxidation yemafuta acids nemaamino acids, zvichibvumira mitochondria kugadzira ATP (ATP ndiyo sosi yesimba remasero).
Izvi zvinosanganisira kuzara kwe calcium alpha-ketoglutarate process, saka calcium alpha-ketoglutarate inogonawo kushandurwa kuita glutamate uye yozoitwa glutamine, iyo inogona kubatsira kukurudzira kugadzirwa kweprotein ne collagen (collagen iprotein yeA fibrous inoumba 1/3 yeprotein yese mumuviri uye inobatsira kutsigira hutano hwemapfupa, ganda uye tsandanyama).
Calcium α-ketoglutarate, sechikafu chinowedzera mabasa akawanda, ine mikana yakawanda yekushandiswa muzvigadzirwa zvehutano. Mabasa ayo akasiyana-siyana ehupenyu akadai seantioxidant, anti-aging, immune regulation uye amino acid metabolism anoita kuti ive chishandiso chine simba chekuvandudza hutano hwevanhu. Nekuwedzera kweruzivo rwehutano uye kuwedzera kwekutsvaga kwesainzi, zvinotendwa kuti kushandiswa kweα-ketoglutarate calcium mumunda wezvigadzirwa zvehutano kuchawana kutariswa kwakawanda uye kukura.
Chiziviso: Chinyorwa ichi ndecheruzivo rwese chete uye hachifanirwe kutorwa semazano ekurapa. Mamwe emashoko eblog anobva paInternet uye haasi ehunyanzvi. Iyi webhusaiti ine basa rekugadzirisa, kuronga nekugadzirisa zvinyorwa chete. Chinangwa chekutumira rumwe ruzivo hazvirevi kuti unobvumirana nemaonero ayo kana kusimbisa chokwadi chezviri mukati mayo. Gara uchibvunza nyanzvi yehutano usati washandisa chero mishonga yekuwedzera kana kuita shanduko kuhurongwa hwako hwehutano.
Nguva yekutumira: Gumiguru-15-2024
