Nei Alpha Ketoglutarate Magnesium Yakakosha Kuhutano Hwako

Calcium Alpha ketoglutarate (AKG) ndeyepakati metabolite ye tricarboxylic acid cycle uye inotora chikamu mukuumbwa kweamino acids, mavhitaminzi uye organic acids uye simba metabolism. Inogona kushandiswa sechikafu chekuwedzera uye ine tarisiro yakakura yekushandisa. Pamusoro pemabasa ayo ehupenyu mumuviri wemunhu, calcium alpha-ketoglutarate inoshandiswawo zvakanyanya mumunda wemishonga uye yave chinhu chakakosha chezvigadzirwa zvehutano zvakawanda uye mhinduro dzekurapa.

Chii chinonzi alpha-ketoglutarate?

AKG inowanzoitika endogenous intermediary metabolite iri chikamu cheKrebs cycle, zvichireva kuti miviri yedu inoigadzira. Indasitiri yekuwedzera inoburitsawo shanduro yekugadzira iyo yakafanana nemakemikari kune yakasikwa AKG.

Chii chinonzi AKG?

AKG imorekuru inobatanidzwa mune dzakawanda metabolic uye cellular nzira. Inoshanda semupi wesimba, precursor yekugadzirwa kweamino acid uye cell signing molecule, uye iri modulator ye epigenetic maitiro. Iyo imorekuru rakakosha mukutenderera kweKrebs, inoronga kumhanya kwese kwechipenyu che citric acid kutenderera. Inoshanda nenzira dzakasiyana-siyana mumuviri kubatsira kuvaka tsandanyama uye rubatsiro mukupora maronda, chinova chimwe chezvikonzero nei chakakurumbira munyika yekuvaka muviri.

AKG inoshandawo senge nitrogen scavenger, kudzivirira nitrogen kuwandisa uye kudzivirira kuvakwa kweammonia yakawandisa. Iyo zvakare yakakura sosi ye glutamate uye glutamine, iyo inomutsa mapuroteni synthesis mumamhasuru uye inodzivisa kuparara kweprotein.

Pamusoro pezvo, inodzora iyo 10-11 translocation (TET) enzyme inobatanidzwa muDNA demethylation uye Jumonji C domain-ine lysine demethylase, inova iyo huru histone demethylase. Nenzira iyi, mutambi akakosha mukugadzirisa gene uye kutaura.

AKG inogona kunonoka kuchembera here?

Pane humbowo hwekuti AKG inogona kukanganisa kuchembera, uye zvidzidzo zvakawanda zvinoratidza kuti ndizvo zvazviri. Chidzidzo che2014 chakaratidza kuti AKG yakawedzera hupenyu hwevanhu vakuru C. elegans neanenge 50% nekudzivisa ATP synthase uye chinangwa cherapamycin (TOR).

Muchidzidzo ichi, takaona kuti AKG haingowedzeri hupenyu chete asiwo inonokesa mamwe mapenotypes ane hukama nezera, sekurasikirwa kwekukurumidza kurongeka kwekufamba kwemuviri kunowanzoitika kune vakwegura C. elegans. Kuti tinzwisise kuti AKG inobata sei kukwegura, tichatsanangura nzira iyo AKG inodzivisa ATP synthase uye TOR kuti iwedzere hupenyu muC. elegans uye zvichida mamwe marudzi.

Mashandiro anoita calcium alpha-ketoglutarate

Kutanga, calcium alpha-ketoglutarate inoita basa rakakosha mune simba metabolism. Sechigadzirwa chepakati che tricarboxylic acid cycle (TCA cycle), calcium α-ketoglutarate inotora chikamu mu intracellular simba rekugadzira maitiro. Kuburikidza neTCA kutenderera, zvinovaka muviri zvakaita semakabhohaidhiretsi, mafuta, uye mapuroteni zvakasvibiswa uye zvakasvibiswa kuti zvibudise ATP (adenosine triphosphate) kupa simba kumasero. Seyakakosha yepakati muTCA cycle, calcium α-ketoglutarate inogona kukurudzira cell energy metabolism, kuwedzera simba remuviri, kubatsira kusimbisa simba remuviri uye kutsungirira, nekuvandudza kuneta kwemuviri.

Chechipiri, calcium α-ketoglutarate inoita basa rakakosha muamino acid metabolism. Amino acids ndiwo ekutanga mapuroteni, uye calcium α-ketoglutarate inobatanidzwa mukutendeuka uye metabolism yeamino acids. Muchiito chekushandura maamino acids kuita mamwe metabolites, calcium α-ketoglutarate inotenderera nemaamino acids kuti ibudise amino acids matsva kana α-keto acids, nokudaro kudzora kuenzana nekushandiswa kwemaamino acids. Pamusoro pezvo, calcium α-ketoglutarate inogonawo kushanda senge oxidation substrate yeamino acids, kutora chikamu mune oxidative metabolism yeamino acids, uye kuburitsa simba uye kabhoni dhaibhoni. Naizvozvo, calcium α-ketoglutarate yakakosha zvikuru mukuchengetedza iyo homeostasis yemamino acids uye protein metabolism mumuviri.

Pamusoro pezvo, calcium alpha-ketoglutarate inoshanda se antioxidant inobvisa mahara radicals uye inodzivirira masero kubva mukukuvadzwa kweiyo oxidative. Panguva imwecheteyo, calcium α-ketoglutarate inogonawo kugadzirisa basa rekudzivirira muviri, kukurudzira kushandiswa uye kupararira kwemasero ekudzivirira muviri, uye kuwedzera kudzivirira kwemuviri kuzvirwere uye utachiona. Naizvozvo, calcium α-ketoglutarate yakakosha zvikuru mukuchengetedza immune system yemuviri uye kurwisa zvirwere.

Tsvakurudzo pamusoro pemigumisiro ye calcium α-ketoglutarate pakukwegura

Kuchembera kunobata isu tese uye ingozi yezvirwere zvakawanda, uye maererano neMedicare indasitiri yedemographics, mukana wekurwara unowedzera nezera.

Calcium alpha-ketoglutarate yakakosha metabolite mumuviri wedu, inozivikanwa nebasa resero muKrebs cycle, kutenderera kwakakosha kune oxidation yemafuta acids uye amino acids, ichibvumira mitochondria kuburitsa ATP (ATP isimba remasero).

Izvo zvinosanganisira kurodha kwecalcium alpha-ketoglutarate process, saka calcium alpha-ketoglutarate inogona zvakare kushandurwa kuita glutamate uye yozoita glutamine, inogona kubatsira kukurudzira kuumbwa kweprotein uye collagen (collagen iA fibrous protein inoita 1/3). yemapuroteni ese ari mumuviri uye anobatsira kutsigira hutano hwemapfupa, ganda uye tsandanyama).

Calcium α-ketoglutarate, seyakawanda inobata chikafu chekuwedzera, ine yakafara tarisiro yekushandisa muzvigadzirwa zvehutano. Mabasa ayo akasiyana-siyana ehupenyu akadai se antioxidant, anti-aging, immune regulation uye amino acid metabolism inoita kuti ive chishandiso chine simba chekuvandudza hutano hwevanhu. Nekuwedzera kwekuziva kwehutano hwehutano uye kudzika kwekutsvakurudza kwesayenzi, zvinotendwa kuti kushandiswa kwe-α-ketoglutarate calcium mumunda wezvigadzirwa zvehutano huchawana kutariswa kwakawanda nekuvandudzwa.