Chii chinonzi N-Boc-O-Benzyl-D-Serine uye Nei Zvine Basa?

Mumaindasitiri emakemikari nemishonga, N-Boc-O-benzyl-D-serine yakakosha amino acid inotorwa nekuda kwekushandiswa kwayo mukugadzirwa kwebioactive molecules nemishonga. Yakwezva kutarisisa kukuru kwekushandiswa kwayo kwakakura mukusimudzira."N-Boc" inoreva boka rinodzivirira re tert-butoxycarbonyl (Boc), iro rinowanzoshandiswa kudzivirira boka remamino acids mukugadzirwa kwepeptide. "O-Benzyl" zvinoreva kuti boka re benzyl rakasungirirwa kuboka re hydroxyl re serine, nokudaro richiwedzera kugadzikana uye kunyungudika.

N-Boc-O-benzyl-D-serine Nhanganyaya

N-Boc-O-benzyl-D-serine (CAS:47173-80-8), inoratidzika sehupfu hwakachena kusvika kune-chena, N- Boc-O-Benzyl-D-serine inobva kune amino acid D-serine. Nekuda kweiyo yakasarudzika zvimiro, inoita basa rakakosha mumakemikari synthesis uye peptide chemistry. Izvi zvinotevera tsananguro yakadzama yezvikamu zvayo: apo N-Boc inoreva tert-butoxycarbonyl (Boc) boka rinodzivirira.

Mapoka ekudzivirira anoshandiswa muorganic synthesis kuchengetedza kwenguva zvikwata zvinoshanda, zvichibvumira maitiro ekusarudza pasina kukanganiswa kubva kune dzimwe nzvimbo dzekuita. O-benzyl inoratidza kuti boka re benzyl rakasungirirwa kune okisijeni yeboka re hydroxyl re serine. Benzyl yakajairika inonhuhwirira inotsiva iyo inogona kukanganisa kunyungudika uye reactivity yemakomponi. D-serine ndeimwe yemaenantiomers maviri e serine uye ndeyemhuri methionine. Serine yakakosha amino acid ye biosynthesis, kugadzirwa kwesimba uye intracellular inoderedza agent kugadzirwa. Aya maitiro akakosha pakukura nekuwanda kwemasero egomarara.

N-Boc-O-benzyl-D-serine Basa rekutanga

1. D-serine inogona kuderedza zviratidzo zvekuderera kwekuziva.

Glutaminergic signing inozivikanwa kuti iwedzere kuumbwa kwendangariro nekuti activation yeNMDA receptors inokonzeresa calcium influx uye kuunganidzwa kwe calmodulin-inotsamira kinase (CaMK) uye CREB-inosunga mapuroteni, ayo anoita kuti ape mukana wenguva refu (LTP), iyo inoumba hwaro hwe nzira inozivikanwa seyendangariro, uye inoguma nekuwedzera kweNMDA kusaina (kunyanya kuburikidza neNR2B subunit) zvichikonzera kuwedzera kwendangariro uye LTP. Iyi zvakare ndiyo nzira yekusimudzira ndangariro inocherechedzwa ine magnesium L-threonate. Nekuti D-serine inogona kuwedzera kusaina kuburikidza neNMDA receptors, yakapetwa nebasa reD-serine mukuita uku uye kunzwisiswa kunozivikanwa kwemaseru ehippocampal kune D-serine kukurudzira, zvinotendwa kuti kuwedzera D-serine kunogona kukurudzira ndangariro nekudzidza.

2.Tsvagiridzo yakawana kuti kurasikirwa kweMenin protein mu hypothalamus chinhu chakakosha chinotungamira mukuchembera, uye kuwedzera D-serine kunogona kuvandudza kukanganisa kwenjere mumakonzo akura.

Zvidzidzo zvakawana kuti hypothalamus inoitawo basa rakakosha mukusaziva kwekuziva kunokonzerwa nekuchembera. Munguva yekuchembera, iyo Menin protein mu hypothalamus (inozonzi Menin) zvishoma nezvishoma inoderera nekuchembera, inokanganisa kuumbwa kweD-serine, ichiwedzera kukurumidza kuchembera uye kusagadzikana kwekuziva. Mukuwedzera, D-serine supplementation inogona kuvandudza zvakanyanya kuchembera phenotype uye kuderedza kukanganiswa kwekuziva mumakonzo akwegura.

Zvigumisiro zvechidzidzo zvakaratidza kuti mushure mekuwedzera D-serine, mazinga eD-serine mu hypothalamus uye hippocampus yemapoka matatu emakonzo akawedzera zvakanyanya kana achienzaniswa nemhando imwechete yemakonzo asina kuwedzerwa neD-serine (p. <0.01), uye chimiro chavo chekuziva chakavandudzwa. Kuvandudza kunokosha (p <0.05), zvichiratidza kuti D-serine supplementation inogona kunge iri nzira yekurapa yekuvandudza kukanganisa kwekuziva kukwegura.

N-Boc-O-Benzyl-D-Serine vs. Mamwe Amino Acids: Ndeupi Musiyano?

1. Kusiyana kwemaitiro

Musiyano wakanyanya kujeka pakati peN-Boc-O-benzyl-D-serine uye mamwe maamino acids chimiro chayo. Nepo standard amino acids ine musana wakareruka unosanganisira amino mapoka, carboxyl mapoka nemacheni eparutivi, N-Boc-O-benzyl-D-serine ine mamwe mapoka anoshanda anoshandura maitiro ayo.

Semuenzaniso, boka reBoc rinopa dziviriro panguva yepeptide synthesis, zvichibvumira maitiro akaomarara kuti aitwe pasina kudiwa kwedivi maitiro. Mapoka eBenzyl anowedzera kupindirana kwehydrophobic, nekudaro kukanganisa kupeta uye kugadzikana kwepeptides nemapuroteni.

2. Maitiro anoshanda

N-Boc-O-Benzyl-D-Serine inoratidza yakasarudzika inoshanda zvivakwa zvichienzaniswa nemamwe amino acids. Yayo D configuration inobvumira kuti iwirirane zvakasiyana nemasikirwo ehupenyu kana ichienzaniswa neyakajairwa L inogadziriswa inowanikwa mumapuroteni mazhinji. Izvi zvinogona kutungamira kune shanduko mukuita kwebiology, zvichiita kuti ive chishandiso chakakosha mukugadzira zvinodhaka nekusimudzira.

Kusiyana neizvi, zviri nyore, zvakajairika amino acids senge glycine kana alanine hazvina mwero wakafanana wekuomarara kana kuti chaiwo mukudyidzana kwavo. Izvi zvinoita kuti N-Boc-O-Benzyl-D-Serine inonyanya kubatsira muzvidzidzo zveuuropharmacology uye kupindirana kwekugamuchira.

3. Zvikumbiro mukutsvaga nemishonga

N-Boc-O-Benzyl-D-Serine yakakwezva kutarisa munzvimbo dzakasiyana-siyana, kunyanya muminda yemishonga chemistry uye neurobiology. Kugona kwayo kuenzanisa chiitiko cheNMDA chekugamuchira kunoita kuti ive mumiriri wemushonga wekudzidza kusagadzikana kwetsinga senge schizophrenia uye chirwere cheAlzheimer. Vatsvagiri vari kuongorora kugona kwayo semumiririri wekurapa kuti awedzere kugona kwekuziva kana kuderedza neurodegenerative maitiro.

Kusiyana neizvi, amino acids akawanda akadai seleucine kana valine anowanzo kudzidziswa nezvebasa ravo mumhasuru metabolism uye protein synthesis. Nepo ivo vachikosha kune hutano hwese uye kugara zvakanaka, kwavo kwakanangwa kunyorera mune neuropharmacology kwakasiyana neN-Boc-O-Benzyl-D-Serine.

4. Synthesis uye Kugadzikana

Iyo synthesis yeN-Boc-O-benzyl-D-serine inosanganisira yakanyanya kuoma kuita kemikari pane yakajairwa amino acids. Kuunzwa kwemapoka ekudzivirira uye kudiwa kwemamiriro ekuita chaiwo kunogona kuita kuti kuumbwa kwavo kuve kunetsa. Zvisinei, zvigadziriso izvi zvinowedzerawo kugadzikana kwayo, zvichiita kuti ive yakakodzera kune zvakasiyana-siyana zvekuedza.

Mukupesana, akajairwa amino acids anowanzo kuwanikwa uye ari nyore kugadzira, asi anogona kusapa iwo mwero wakafanana wekugadzikana kana kujeka kunodiwa kune epamusoro tsvakiridzo maapplication.

D-Real-Life Applications yeN-Boc-O-Benzyl-D-Serine

Serine inotamba yakakosha physiological mabasa mumuviri wemunhu, kunyanya kudzora uye kudzivirira kwetsinga system. N-Boc-O-benzyl-D-serine seyakagadzirwa serine ikirasi yakakosha yebioactive molecules iyo inowanzoshandiswa mu peptide synthesis uye mamwe organic chemistry application, kunyanya mukugadzirwa kwezvinodhaka uye bioactive komisheni. Boka rinodzivirira rinogona kubviswa pasi pemamiriro chaiwo kuti riwane emahara amino acids kana zvimwe zvinobva kune imwe tsvakiridzo kana kushandisa. Inoshandiswa zvakanyanya mune zvekurapa uye biological research.

1. Chemical synthesis uye peptide chemistry

N-Boc-O-benzyl-D-serine inoshandiswa sechivakwa chekuvaka mumakemikari synthesis yeakasiyana makomisheni uye zvakare iri chinhu chakakosha mupeptide chemistry. Kushandiswa kwaro mundima iyi kunokonzerwa nekukwanisa kwayo kuiswa muzvikamu zvakakura zvema molecular, zvichibatsira kugadzirwa kwemishonga mitsva uye bioactive molecules.

2. Indasitiri yemishonga

N-Boc-O-benzyl-D-serine yakashandiswa sefamberi yekugadzirira kweinotsiviwa naphthodiazolidinones. Aya makomisheni anoita seprotein tyrosine phosphatase degraders uye ane anogona kurapa maapplication mukurapa cancer uye metabolic zvirwere. Kushatisa kweiyi phosphatase kunobatsira kudzora nzira dzekuratidzira sero, nekudaro ichipa nzira yekurapa yekurwisa zvirwere izvi.

3. Tsvakurudzo nekusimudzira

Mukutsvaga nekusimudzira, N-Boc-O-benzyl-D-serine inoshandiswa kugadzira mamorekuru matsva ane zvingangoita biological chiitiko. Chimiro chayo chakasiyana chinobvumira masayendisiti kuti aongorore zvimiro zvayo uye mashandisirwo ekugadzira mishonga yehunyanzvi uye marapirwo emhando dzakasiyana dzehutano.

Ndekupi Kutenga N-Boc-O-benzyl-D-serine?

Semugadziri weN-Boc-O-benzyl-D-serine poda, Suzhou Myland yakakunda kuvimba kwevatengi vakawanda nezvigadzirwa zvayo zvepamusoro-soro uye kutonga kwakasimba kwehutano. Iyo kambani yakazvipira kupa vatengi zvinhu zvemhando yepamusoro uye kuvabatsira kubudirira mumaindasitiri avo.

1. Yakavimbika chigadzirwa chemhando

Suzhou Myland's N-Boc-O-benzyl-D-serine poda inoedzwa kakawanda kuti ive nechokwadi chekuchena kwayo uye mhando inosangana nezviyero zveindasitiri. Iyo kambani ine inyanzvi yekuongorora mhando yetimu iyo inoitisa ongororo yezvigadzirwa nguva nenguva kuti ive nechokwadi chekugadzikana kwebatch yega yega yezvigadzirwa.

2. Flexible kupa masimba

Kunyangwe iri batch diki kana hombe-odha, Suzhou Mailun Biotechnology inogona kupindura zviri nyore kuti ive nechokwadi chekuti zvinodiwa nevatengi zvinozadzikiswa. Iyo kambani yakagadzira yakakwana logistics system yekukurumidza kuendesa zvigadzirwa kune vatengi.

3. Professional technical support

Suzhou Myland's R&D timu inoumbwa nenhamba yenyanzvi dzeindasitiri uye inogona kupa vatengi kubvunzana kwehunyanzvi uye rutsigiro kubatsira vatengi kunzwisisa uye kushandisa N-Boc-O-benzyl-D-serine.

4. Mutengo wemakwikwi

Pachimiro chekuona kunaka kwechigadzirwa, Suzhou Myland inopa mitengo yemakwikwi kubatsira vatengi kudzikisa mutengo wekutenga nekuvandudza kukwikwidza kwemusika.

Kusarudza iyo chaiyo N-Boc-O-benzyl-D-serine supplier ndiyo kiyi yekuve nechokwadi chemhando yechigadzirwa uye kuchengetedzeka. Suzhou Myland yave sarudzo yakavimbika muindastiri neayo epamusoro-kuchena zvigadzirwa, yakasimba yemhando yekudzora uye masevhisi ehunyanzvi. Ungave uri kambani yemishonga kana sangano rekutsvaga kwesainzi, Suzhou Myland inogona kukupa yemhando yepamusoro N-Boc-O-benzyl-D-serine poda kuti ikubatsire tsvagiridzo yako nekusimudzira. Kuti uwane rumwe ruzivo, ndapota shanyira Suzhou Myland's yepamutemo webhusaiti.