Chii chinonzi telomerase activator-cycloastraganol chiri kuwanikwa pari zvino?

Muna 1985, Greider nevamwe vake vakatanga kuwana telomerase, uye iyi enzyme ichangobva kuwanikwa inogona kuwedzera DNA repeats kumigumo yemachromosomes kuti irambe iine urefu hwe telomere. Telomerase i complex ye ribonucleoprotein ine catalytic core inosanganisira TERT neTERC, iyo TERT ndiyo kiyi yekudzora mashandiro e telomerase. Telomere urefu hunoramba huchipfupika sezvo masero achipatsanurana. Kana yasvika pakukosha kwakakosha, inokonzera zviratidzo zvekukuvadzwa kweDNA, zvichikonzera kupfupika kwemasero uye zvirwere zvakasiyana-siyana zvekutadza kwetishu zvinoratidzwa nema telomere mapfupi.

Muna 2010, kambani yekuAmerica Geron yakashanda pamwe neHong Kong University of Science and Technology pachirongwa chekutsvagisa chekuongorora ma telomerase activators. Zvakaonekwa kuticycloastraganolinogona kumutsa basa re telomerase uye kukonzera kuwedzera kwe telomere. Kuwanikwa uku kwakasimudzira zvikuru kukura kwe telomerase activators. Kufambira mberi kwekutsvaga uye kugadzirwa kwe astragalus alcohol ine chekuita nekugadzirwa kwechigadzirwa ichi. Cycloastragenol (CAG) parizvino ndiyo yega telomerase activator inonzi pakati pezvigadzirwa zvechisikigo. Inogona kurwisa zvinobudirira kupfupisa telomere uye ine anti-aging, anti-apoptosis, anti-fibrosis, immune regulation, kukurudzira kuwanda kwemasero uye kuporesa maronda, nezvimwewo. Mhedzisiro yemishonga, nokudaro iine mhedzisiro inogona kurapwa pazvirwere zvine chekuita ne telomere disadvantage.

Cycloastragenol uye kukwegura

matelomere
MaTelomere maumbirwo akakosha ari kumagumo emachromosome anodzivirira machromosome uye anopfupika nekudzokororwa kwemachromosome uye kupatsanurwa kwemasero. Masero anokurawo sezvo matelomere anopfupika.

telomerase
Telomerase inogona kugadzira matelomere kuti igare yakagadzikana nehurefu uye chimiro chematelomere, nokudaro ichidzivirira machromosome uye inonotsa kukwegura kwemasero.

Kurwisa kukwegura: Chinhu chinodzivirira kukwegura chinonzi telomerase activator, chinoita basa rekudzivirira kukwegura nekuwedzera telomerase uye nokudaro chinononotsa kupfupika kwema telomeres.

MaTelomeres zvivharo zviri kumagumo emachromosome emasero zvinoadzivirira kubva mukukuvadzwa panguva yekupatsanurwa kwemasero. Sezvo masero achiramba achipatsanurwa, matelomere anoramba achipfupika, zvichisvika padanho rakakosha apo masero anokwegura kana kufa. Telomerase inogona kuwedzera urefu hwematelomere, uye hupenyu hwemasero hunowedzera zvichienderana neizvi.

Kukwegura chikamu chisingadzivisiki chehupenyu; zvisinei, vaongorori vari kudzidza nzira dzakasiyana-siyana dzekurapa kuti vaedze kudzivirira zvimwe zvemigumisiro yekukwegura, kusanganisira kudzidza nezvesenolytics. Senolytics imishonga inobvisa masero ekukwegura uye yakaratidzwa kuti inoderedza migumisiro yekukwegura. Chidzidzo chitsva chinoratidza kuti cycloastraganol ine mhedzisiro yekurwisa kukwegura.

Chidzidzo ichi, chakabva kuChina uye chakaburitswa muInternational Journal of Molecular Sciences, chakanyanya kutarisa masero evanhu akachembera uye mbeva dzine kuchembera kunokonzerwa nemwaranzi. Cycloastragenol inoderedza masero akachembera pasina kukanganisa masero asiri akachembera. Kurapa kweCycloastragenol kunoderedzawo mapuroteni ari mumasero akachembera anodiwa kuti masero akure uye ararame. Pamusoro pezvo, kunodzivisa kufamba kwemasero kunobatanidzwa nemasero ekuzvimba ane chekuita nekukwegura uye maitiro. Mbeva dzakwegura dzakarapwa neCycloastraganol dzakawanikwa dziine masero mashoma akachembera uye dzakavandudza kusashanda zvakanaka kwemuviri kunoenderana nekukwegura.

Cycloastragenol inoderedza masero ekukura kwevana

Kukwegura chiratidzo chinozivikanwa chekukwegura, asi vaongorori vakaona kuti kubvisa masero akwegura uye mamorekuru awo anokonzera kuzvimba kunogona kubatsira kudzivirira zvirwere zvine chekuita nekukwegura uye kutozvidzosera kumashure mune dzimwe nguva. Pano, vaongorori vakarapa masero evanhu necycloastraganol uye vakaona kuti inobvisa masero akwegura pasina kukanganisa masero asiri akwegura. Pamusoro pezvo, zviratidzo zvemasero emasero akwegura zvakaderera zvakanyanya mushure mekurapwa necycloastraganol.

Ongororo yapfuura yakaratidza kuti nzira yePI3K/AKT/mTOR—nzira yekuratidza inobatanidzwa mukukura kwemasero uye kupona—inobatanidzwa mukuzvimba kunotangwa nemasero achangoberekwa, zvichibatsira kukurudzira kukura kwemasero mumasero akapoteredza. Vaongorori vakaona kuti cycloastragenol yakabatsira kuderedza mapuroteni munzira iyi, zvichiratidza kuti chinhu ichi chinogona kushanda nekuvhara nzira yePI3K/AKT/mTOR kubatsira kudzivirira kukwegura. Uyezve, cycloastragenol yakaratidzwa kuti inoderedza kugona kwemasero achangoberekwa kukurudzira kukura kwemasero kuburikidza nekuburitswa kwemamorekuru anokuvadza, zvinhu zvinokura, uye zvinogadzirisa immune, zvichienderana nemazano ekuti kuderedza PI3K, AKT, uye mTOR signaling kunogona kuderedza mhedzisiro inokurudzira kukura kwemasero pakati pemasero akapoteredza.

Cycloastragenol ndeye triterpene saponins uye inonyanya kuwanikwa kubva mukusanganiswa kwe astragaloside IV. Ine huremu hudiki uye lipophilicity yakasimba, iyo inobatsira kupinda kwe biofilm uye kunyudzwa kwemudumbu kuti iwane bioavailability iri nani. Kushanda kwe cycloastragalinol
1. Kurapa kukuvara kwehuropi
2. Kuvandudza fibrosis yechiropa
3. Kurapa osteoporosis
4. Kudzivirira kukwegura
5. Kunonoka kukwegura kwemasero

Sei zvichikosha kugadzira cycloastraganol?

① Cycloastraganol ine migumisiro yakasiyana-siyana yemishonga yakadai sekudzivirira apoptosis yemasero europi uye neuroinflammation panguva ye ischemia yeuropi uye kuchengetedza chipingamupinyi cheropa neuropi.
② Cycloastragenol ndiyo yega molecule diki yeterpenoid compound ine basa retelomerase rakawanikwa kusvika parizvino uye rinogona kurapa zvirwere zvinokanganisa tsinga.
③ Ine mhedzisiro yekudzivirira myocardial fibrosis uye kuwedzera dziviriro yemuviri inodzivirira bundu. Imorekuru inozivikanwa mukutsvaga nekugadzira mishonga inodzivirira kukwegura.

Matambudziko aripo

Huremu hwecycloastraganol muAstragalus membranaceus hwakaderera zvikuru uye zvakaoma kuhuwana zvakananga. Nzira iripo yekugadzira cycloastraganol inotsamira pakubvisa mishonga yechivanhu yeChinese, iyo inonyanya kuwanikwa nekushandura astragaloside IV muAstragalus membranaceus. Kureva kuti, astragaloside IV inowanikwa kuburikidza nekudyara astragalus uye tekinoroji yekurima tissue, uye ipapo astragaloside IV inoshandurwa kuita cycloastragaloside uchishandisa acidolysis, Smith degradation, enzyme uye microbial hydrolysis. Zvisinei, nzira idzi dzekugadzirira dzinodhura, dziri nyore kukonzera kusvibiswa kwezvakatipoteredza, dzakaoma kupatsanura nekuchenesa, uye hadzina kukodzera kushandiswa nekusimudzira. Nokudaro, vanhu vakatendeukira kukugadzirwa kwe cycloastraganol.

Mashandisiro angaita biology yekugadzira zvinhu kuti igadzire zvinhu? --- Biology yekugadzira zvinhu

Biology yekugadzira zvinhu (Synthetic Biology) zvinoreva dhizaini, kushandurwa, uye kunyange kugadzirwa kwe "hupenyu hwekugadzira" hune mabasa asiri echisikigo pasi pekutungamirirwa kwepfungwa dzeinjiniya, kureva, hunyanzvi hwebiology. Kazhinji, inogadzirwa uchishandisa nzira dzebhayoloji.