Chii chave kuwanikwa telomerase activator-cycloastraganol?

Muna 1985, Greider et al. yakatanga kuwanikwa telomerase, uye iyi enzyme ichangobva kuwanikwa inogona kuwedzera kudzokorora kweDNA kumigumo yemachromosome kuchengetedza kureba kwetelomere. Telomerase ndeye ribonucleoprotein yakaoma ine catalytic musimboti unosanganisira TERT neTERC, iyo TERT ndiyo kiyi yekudzora chiitiko chetelomerase. Kureba kweTelomere kunoramba kuchipfupika sezvo masero anoparadzana. Kana yasvika pakukosha kwakakosha, inoita kuti DNA ikuvadze masaini, zvichitungamira kupfupika sero kutenderera uye nhevedzano yezvirwere zvekutadza kwematishu zvinoratidzwa nepfupi telomeres.

Muna 2010, kambani yekuAmerica yeGeron yakashanda pamwe neHong Kong University yeScience neTekinoroji pachirongwa chekutsvagisa chekutarisa telomerase activators. Zvakaonekwa kuticycloastraganolinogona kumisa telomerase chiitiko uye kukurudzira telomere kuwedzera. Kuwanikwa uku kwakasimudzira kuvandudzwa kwema telomerase activator. Kufambira mberi kwekutsvagisa uye zvine chekuita nekugadzirwa kwechigadzirwa che astragalus doro. Cycloastragenol (CAG) parizvino ndiyo yega yakashumwa telomerase activator pakati pezvigadzirwa zvechisikigo. Inogona kurwisa zvinobudirira telomere kupfupisa uye ine anti-kuchembera, anti-apoptosis, anti-fibrosis, immune regulation, kusimudzirwa kwesero kuwedzera uye kuporesa maronda, etc. Pharmacological mhedzisiro, nekudaro kuve nemhedzisiro yekurapa kune zvirwere zvine chekuita ne telomere dysfunction.

Cycloastragenol uye kukwegura

telomeres
Telomeres zvimiro zvakakosha kumagumo emakromosomes anodzivirira machromosome uye kupfupisa nekudzokorora kwechromosome uye kupatsanurwa kwesero. Masero anokwegurawo sezvo matelomere anopfupika.

telomerase
Telomerase inogona kugadzira matelomere kudzikamisa kureba uye chimiro chetelomeres, nekudaro ichidzivirira machromosome uye kunonoka kuchembera kwemasero.

Anti-kuchembera: A telomerase activator, iyo inoridza anti-kuchembera mhedzisiro nekuwedzera telomerase uye nekudaro kunonotsa kupfupikiswa kwetelomeres.

Telomeres zvivharo zviri kumagumo emakromosomes emasero anovadzivirira kubva pakukuvadzwa panguva yekuparadzaniswa kwesero. Sezvo masero ari kuramba achiparadzana, matelomere anoramba achipfupika, achisvika panzvimbo yakaoma apo masero achakwegura kana kufa. Telomerase inogona kuwedzera hurefu hwematelomere, uye hupenyu hwemaseru huchawedzera zvakafanira.

Kuchembera chikamu chisingadzivisiki chehupenyu; zvisinei, vatsvakurudzi vari kudzidza nzira dzakasiyana-siyana dzekurapa kuedza kudzivisa zvimwe zvinokonzerwa nekukwegura, kusanganisira kudzidza senolytics. Senolytics makomisheni anobvisa senescent (kuchembera) maseru uye akaratidzwa kuderedza mhedzisiro yekuchembera. Chidzidzo chitsva chinoratidza kuti cycloastraganol ine anti-kuchembera mhedzisiro.

Chidzidzo ichi, chakabva kuChina uye chakaburitswa muInternational Journal of Molecular Sciences, chakanangana nemasero emunhu ane hunhu nemakonzo ane radiation-induced senescence. Cycloastragenol inoderedza maseru maseru pasina kukanganisa masero asina-senescent. Cycloastragenol kurapwa zvakare kunoderedza mapuroteni mumasero ane senescent anodiwa mukukura kwesero uye kurarama. Uyezve, inodzivirira kufamba kwesero kwakabatana nezera-ane hukama hwekuzvimba maseru uye maitiro. Mbeva dzakura dzakabatwa ne cycloastraganol dzakawanikwa dziine mashoma maseru maseru uye yakagadziridzwa ine hukama nezera.

Cycloastragenol inoderedza maseru maseru

Senescence chiratidzo chinozivikanwa chekuchembera, asi vaongorori vakaona kuti kubvisa maseru emasero uye mamorekuru avo e-pro-inflammatory signing anogona kubatsira kudzivirira zvirwere zvine chekuita nezera uye kutombozvidzosera mune dzimwe nguva. Pano, vaongorori vakabata maseru emunhu ne cycloastraganol uye vakaona kuti yakanyatso bvisa maseru maseru pasina kukanganisa masero asina-senescent. Uye zvakare, ma cellular mamaki emasero e senescent akaderedzwa zvakanyanya mushure mekurapa cycloastraganol.

Ongororo yapfuura yakaratidza kuti PI3K/AKT/mTOR nzira-nzira yechiratidzo inobatanidzwa mukukura kwesero uye kurarama-inobatanidzwa mukugadzirisa zvirwere zvinotangwa nemasero emagetsi, zvichibatsira kukurudzira kugadzikana mumasero akapoteredza. Vatsvakurudzi vakaona kuti cycloastragenol yakabatsira kuderedza mapuroteni mumugwagwa uyu, zvichiratidza kuti musanganiswa unogona kushanda nekuvhara PI3K/AKT/mTOR nzira yekubatsira kudzivirira kuchembera. Uyezve, cycloastragenol yakaratidzwa kuderedza kukwanisa kwemasero emasero ekusimudzira senescence kuburikidza nekubudiswa kwemamorekuru ekuputika, kukura kwezvinhu, uye immunomodulators, zvinoenderana nemazano anoderedza PI3K, AKT, uye mTOR kusaina kunogona kuderedza mhedzisiro yekusimudzira senescence pakati pemasero akatenderedza. .

Cycloastragenol ndeye triterpene saponins uye inonyanya kuwanikwa kubva kuhydrolysis yeastragaloside IV. Iine huremu hudiki hwemamorekuru uye yakasimba lipophilicity, iyo inobatsira kupinza biofilm uye kunyura kwegastrointestinal kuwana zvirinani bioavailability. Kushanda kwe cycloastragalinol
1. Kurapa kwekukuvara kweuropi
2. Kuvandudza chiropa fibrosis
3. Kurapa kwe osteoporosis
4. Anti-aging effect
5. Kunonotsa kuchembera kwesero

Nei zvichidikanwa kugadzira cycloastraganol?

① Cycloastraganol ine dzakasiyana siyana dzemishonga senge inhibiting brain cell apoptosis uye neuroinflammation panguva yecerebral ischemia uye kuchengetedza ropa-brain barriers.
② Cycloastragenol ndiyo chete mamorekuru diki terpenoid musanganiswa ane telomerase chiitiko chakawanikwa kusvika parizvino uye inogona kurapa neurodegenerative zvirwere.
③ Iine mhedzisiro yekuvharisa myocardial fibrosis uye kuwedzera anti-tumor immune. Imorekuru rakakurumbira mukutsvagisa nekuvandudzwa kwemishonga inorwisa kuchembera.

Matambudziko aripo

Zviri mukati cycloastraganol muAstragalus membranaceus zvakaderera uye zvakaoma kuzviwana zvakananga. Iyo iripo cycloastraganol yekugadzira zano inotsamira pane yechinyakare Chinese mushonga kutorwa, iyo inonyanya kuwanikwa nekushandura astragaloside IV muAstragalus membranaceus. Kureva kuti, astragaloside IV inowanikwa kuburikidza nekudyara kweastragalus uye tekinoroji yetsika, uyezve astragaloside IV inoshandurwa kuita cycloastragaloside ichishandisa acidolysis, Smith degradation, enzyme uye microbial hydrolysis. Zvisinei, idzi nzira dzekugadzirira dzinodhura, dziri nyore kukonzera kusvibiswa kwezvakatipoteredza, zvakaoma kuparadzanisa uye kuchenesa, uye hazvibatsiri kushandiswa nekusimudzira. Naizvozvo, vanhu vakatendeudzira pfungwa dzavo kune artificial synthesis ye cycloastraganol.

Maitiro ekushandisa synthetic biology kugadzira? ---Synthetic Biology

Synthetic Biology inoreva dhizaini yakanangwa, shanduko, uye kunyangwe kusikwa kwe "hupenyu hwekugadzira" nemabasa asiri echisikigo pasi pekutungamirwa kwemazano einjiniya, ndiko kuti, engineering yebiology. Kazhinji kutaura, inogadzirwa uchishandisa biological nzira.