Chii chinonzi spermidine? Gwaro riri nyore rekushandisa spermidine

Spermidinerudzi rwepolyamine. Polyamines imhando diki, ine mafuta, ine polycationic (-NH3+) biomolecules. Kune polyamines huru ina mumhuka dzinoyamwisa: spermine, spermidine, putrescine uye cadaverine. Spermine ndeye tetramines, spermidine ndeye triamines, putrescine uye cadaverine ndeye diamines. Huwandu hwakasiyana hwemapoka emaamino hunovapa hunhu hwakasiyana hwemuviri.

Spermidine muvanhu

Spermidine haisi mumbeu chete, asi inowanikwawo mune dzimwe nhengo dzemuviri wemunhu. Kuwanda kwespermidine mukati memasero kunonyanya kuenderana nezvinhu zvina:

①Kugadzirwa kwemasero:

Arginine → putrescine → spermidine ← spermine. Arginine ndiyo chinhu chikuru chekugadzira spermidine mumasero. Inokonzereswa ne arginase kugadzira ornithine ne urea. Ornithine inoshandiswa kugadzira putrescine pasi pe ornithine decarboxylase (ODC1). Iri ndiro danho rinoganhurira mwero, putrescine inogadzira spermidine pasi pe spermidine synthase (SPDS). Spermidine inogonawo kugadzirwa nekuora kwespermine.

②Kutorwa kwemasero:

Zvakakamurwa muzvikamu zvekudya zvinodyiwa uye kugadzirwa kwehutachiona mudumbu. Zvikafu zvakapfuma mu spermidine zvinosanganisira wheat germ, natto, soya, howa, nezvimwewo. Urume ne spermidine zvinodyiwa kubva muchikafu zvinokurumidza kunyudzwa kubva mudumbu uye zvinoparadzirwa pasina kuora, saka huwandu hwe spermidine muropa hunosiyana-siyana. Mabhakitiriya eprobiotic mudumbu microbiota akadai seBifidobacterium anogonawo kugadzira spermidine.

③Kukatabolisma:

Urume huri mumuviri hunozorora zvishoma nezvishoma kuita spermidine neputrescine neN1-acetyltransferase (SSAT), polyamine oxidase (PAO) nedzimwe amine oxidases, nepo putrescine ichizoshandurwa kuita aminobutyric acid neoxidases. Pakupedzisira, maamine ions necarbon dioxide zvinogadzirwa uye zvinoburitswa mumuviri.

Zera:

Kuwanda kwespermidine kunochinja nekukura. Vaongorori vakayera kuwanda kwepolyamines mumatishu akasiyana-siyana uye nhengo dzembeva dzine mavhiki matatu, gumi nemavhiki makumi maviri nematanhatu uye vakaona kuti yaingoramba iripo mupancreas, uropi nechibereko. Kuchinja muura kunodzikira zvishoma nekukura, uye kunodzikira zvakanyanya muthymus, spleen, ovary, chiropa, dumbu, mapapu, itsvo, moyo netsandanyama. Hazvina kuoma kuti tifungidzire kuti zvikonzero zvekuchinja uku zvinosanganisira kuchinja kwekudya, kuchinja kwechimiro chemaruva emudumbu, kudzikira kwebasa repolyamine synthase, nezvimwewo.

Chinangwa chechisikigo chespermidine

Sei molekyuru diki iri nyore kudaro iri chinhu chakakosha mumuviri wemunhu? Chakavanzika chiri mumagadzirirwo ayo: Spermidine imolekyuru diki ine mafuta akawanda (-NH3+) inowanikwa muchimiro chine mapuroteni akawanda pasi pemamiriro epH emuviri, ine maion akanaka akapararira mukati meketani yekabhoni. Kuchaja kwemagetsi, kune basa rakasimba remuviri.

Saka, ingave nucleic acids, phospholipids, mapuroteni ane acidic ane acidic residues, pectic polysaccharides ane carboxyl groups uye sulfates, kana neurotransmitters nemahormone (dopamine, epinephrine, serotonin, thyroid hormone, nezvimwewo) ane maumbirwo akafanana, Inogona kunge iri chinangwa chekusunga spermidine. Akanyanya kukosha ndeaya:

① Nucleic acid:

Ongororo dzakawana kuti ma polyamine mazhinji aripo muchimiro che polyamine-RNA complexes mukati memasero, ane 1-4 equivalents ye polyamine bound pa 100 equivalents ye phosphate compounds. Nokudaro, basa guru re spermidine rine chekuita nekuchinja kwemaumbirwo uye kushandurwa kweRNA, zvakaita sekuchinja matanho akasiyana-siyana ekugadzirwa kweprotein nekuchinja chimiro chechipiri che mRNA, tRNA ne rRNA. Spermidine inogonawo kugadzira "mabhiriji" akasimba pakati pe double-helical DNA strands, kuderedza kuwanikwa kwe free radicals kana zvimwe zvinokuvadza DNA, uye kudzivirira DNA kubva pakupisa uye X-ray.

②Mapuroteni:

Spermidine inogona kusunga mapuroteni ane simba guru uye kuchinja chimiro cheprotein, nokudaro ichikanganisa mashandiro ayo emuviri. Mienzaniso inosanganisira protein kinases/phosphatases (chinobatanidza chakakosha munzira dzakawanda dzekutumira masaini), maenzymes anobatanidzwa mu histone methylation uye acetylation (inokanganisa kutaura kwemajini nekuchinja epigenetics), acetylcholinesterase (chikamu chakakosha chezvirwere zvinokanganisa tsinga dzeropa). mumwe wemishonga yekurapa), ion channel receptors (senge AMPA, AMDA receptors), nezvimwewo.

Suzhou Myland ikambani yakanyoreswa neFDA inopa hupfu hweSpermidine hwemhando yepamusoro uye hwakachena.

KuSuzhou Myland, takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yepamusoro. Upfu hwedu hweSpermidine hwakaedzwa zvakasimba kuti huve hwakachena uye hune simba, zvichiita kuti uwane chinowedzera chemhando yepamusoro chaunogona kuvimba nacho. Kunyangwe uchida kutsigira hutano hwemasero, kusimbisa masoja emuviri wako kana kusimudzira hutano hwese, upfu hwedu hweSpermidine ndiyo sarudzo yakakwana.

Nemakore makumi matatu eruzivo uye zvichitungamirirwa netekinoroji yepamusoro uye nzira yeR&D yakagadziriswa zvakanyanya, Spermidine yakagadzira zvigadzirwa zvakasiyana-siyana zvinokwikwidza kuti ive kambani yekuwedzera sainzi yehupenyu, kugadzira zvinhu zvakagadzirwa uye kugadzira zvinhu.

Pamusoro pezvo, Suzhou Myland ikambani inogadzirwa neFDA. Zvishandiso zveR&D zvekambani, nzvimbo dzekugadzira, uye zvishandiso zvekuongorora ndezvemazuva ano uye zvinoshanda zvakawanda, uye zvinokwanisa kugadzira makemikari kubva pamamirigiramu kusvika kumatani muhukuru, uye zvinoenderana neISO 9001 standards uye specifications dzekugadzira GMP.