Chii chinonzi spermidine? Nhungamiro iri nyore kune spermidine

Spermidineimhando ye polyamine. Polyamines madiki, ane mafuta, polycationic (-NH3+) biomolecules. Kune mana makuru emapoliamine mumhuka dzinoyamwisa: spermine, spermidine, putrescine uye cadaverine. Spermine ndeye tetramines, spermidine ndeye triamines, putrescine uye cadaverine ndeye diamines. Nhamba dzakasiyana dzemapoka emamino dzinovapa dzakasiyana hunhu hwemuviri.

Spermidine muvanhu

Spermidine haingovepo chete muurume, asi zvakare inoparadzirwa zvakanyanya mune mamwe matushu uye masero emuviri wemunhu. Iyo intracellular spermidine concentration inonyanya kuenderana nezvinhu zvina:

①Intracellular synthesis:

Arginine → putrescine → spermidine ← urume. Arginine ndiyo huru mbishi zvinhu zve synthesis ye spermidine mumasero. Iyo inogadziriswa neArginase kugadzira ornithine uye urea. Ornithine inobva yashandiswa kugadzira putrescine pasi pechiito che ornithine decarboxylase (ODC1). Iyi ndiyo nhanho-yekumisa nhanho), putrescine inogadzira spermidine pasi pechiito che spermidine synthase (SPDS). Spermidine inogonawo kugadzirwa nekuderera kwespermine.

②Extracellular kutora:

Yakakamurwa mukudya kwekudya uye intestinal microbial synthesis. Zvokudya zvakapfuma muspermidine zvinosanganisira gorosi germ, natto, soya bhinzi, howa, etc. Spermine uye spermidine inopinzwa kubva mukudya inokurumidza kutorwa kubva muura uye inoparadzirwa pasina kuderedzwa, saka iyo concentration ye spermidine muropa ndeye Concentrations yakanyanya siyana. Probiotic mabhakitiriya mu intestinal microbiota yakadai seBifidobacterium inogonawo kugadzira spermidine.

③Catabolism:

Spermine mumuviri inoora zvishoma nezvishoma kuita spermidine uye putrescine neN1-acetyltransferase (SSAT), polyamine oxidase (PAO) uye mamwe amine oxidase, nepo putrescine inoshandurwazve kuita aminobutyric acid neoxidases. Pakupedzisira, amine ions uye carbon dioxide inogadzirwa uye inobudiswa kubva mumuviri.

④Zera:

Kuwanda kwe spermidine kunoshanduka nezera. Vatsvakurudzi vakayera kuwanda kwema polyamines mumhando dzakasiyana-siyana uye nhengo dzemasvondo matatu, 10-vhiki uye 26-vhiki yemakonzo uye vakawana kuti yakanyatsochengetedzwa mupancreas, uropi uye chibereko. Kuchinja muura kunoderera zvishoma nezera, uye kuderera zvakanyanya mu thymus, spleen, ovary, chiropa, dumbu, mapapu, itsvo, mwoyo uye tsandanyama. Hazvisi zvakaoma kwatiri kuti tifungidzire kuti zvikonzero zvekuchinja uku zvinosanganisira kuchinja kwezvokudya, kuchinja mumatumbo emaruva emudumbu, kuderedzwa kwebasa re polyamine synthase, nezvimwewo.

Zvinangwa zvechisikigo zve spermidine

Nei morekuru duku rakapfava kudaro riri chinhu chinokosha chinokosha kumuviri womunhu? Chakavanzika chiri muchimiro chayo: Spermidine is a polycationic (-NH3+) fatty amine amine molecule inowanikwa mune yakawanda-protonated fomu pasi pefiziological pH mamiriro, ane maion akanaka akagoverwa mukati meketani yekabhoni. Magetsi kuchaja, ane simba physiological chiitiko.

Naizvozvo, ingave iri nucleic acids, phospholipids, acidic proteins ine acidic residues, pectic polysaccharides ine carboxyl mapoka uye sulfates, kana neurotransmitters nemahomoni (dopamine, epinephrine, serotonin, thyroid hormone, etc.) ine zvimiro zvakafanana, Zvinogoneka chinangwa chespermidine. kusunga. Izvo zvakanyanya kukosha ndezvi:

① Nucleic acid:

Zvidzidzo zvakawana kuti mapoliamine mazhinji aripo ari muchimiro chepoliamine-RNA complexes mukati memasero, ane 1-4 akaenzana epolyamine akasungwa pa100 yakaenzana yephosphate compounds. Nokudaro, basa guru re spermidine rine chokuita nekuchinja kwemaitiro uye kushandura kweRNA, sekukanganisa zvikamu zvakasiyana-siyana zveprotein synthesis nekukanganisa chikamu chechipiri chemRNA, tRNA uye rRNA. Spermidine inogonawo kugadzira "mabhiriji" akagadzikana pakati pekaviri-helical DNA tambo, kuderedza kuwanika kwemahara radicals kana mamwe DNA-anokuvadza maajenti, uye kudzivirira DNA kubva pakupisa denaturation uye X-ray mwaranzi.

②Protein:

Spermidine inogona kusunga kune mapuroteni anotakura mhosva dzakakura dzisina kunaka uye kuchinja nzvimbo yeprotein, zvichiita kuti iite basa rehupenyu. Mienzaniso inosanganisira mapuroteni kinases/phosphatases (chinongedzo chakakosha munzira dzakawanda dzekuchinjisa chiratidzo), ma enzymes anosanganisirwa mu histone methylation uye acetylation (inokanganisa gene kutaura nekuchinja epigenetics), acetylcholinesterase (chikamu chakakosha chezvirwere zveurourodegenerative). imwe yemishonga yekurapa), ion chiteshi receptors (senge AMPA, AMDA receptors), nezvimwe.

Suzhou Myland ndeye FDA yakanyoreswa mugadziri inopa mhando yepamusoro uye yakakwirira kuchena Spermidine poda.

PaSuzhou Myland, takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu Spermidine poda yakaedzwa zvakasimba kuti iwane kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu Spermidine poda ndiyo sarudzo yakakwana.

Nemakore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye yakagadziridzwa zvakanyanya R&D zano, Spermidine yakagadzira mhando yezvigadzirwa zvemakwikwi kuti ive inovandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zveR&D zvekambani, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinokwanisa kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye magadzirirwo ekugadzira GMP.