Chii chinonzi Choline Alfoscerate uye Chingabatsira Sei Uropi Hwako?

Sechinhu chinobva mumuviri wemunhu, L-α-glycerophospholine inogona kupinda muropa-uropi uye ine bioavailability yakakura kwazvo. Ichi chikafu chemhando yepamusoro chakakosha mumuviri wemunhu. "Chidziviriro cheropa-uropi chimiro chakasimba, chakaita semadziro pakati pe capillary plexuses yeuropi. L-α-glycerophosphocholine inogona kupinda nyore nyore muropa-uropi uye inoita basa mukusimudzira ndangariro, kuvandudza kufunga, uye ine mabhenefiti anogona mukuderedza kuzvidya mwoyo, kugadzikana kwemanzwiro, uye kuwedzera simba retsandanyama nekutsungirira. "Mhedzisiro yekudya yeL-α-glycerophosphocholine inonyanya kuratidzwa muzvikamu zvishanu.

Chimwe chacho ndechekuvandudza mashandiro ehuropi. Kuwanda kwemasero etsinga muuropi, simba rawo rinowedzera, anokurumidza kutumira zviratidzo zvetsinga, uye simba rehuropi rekugadzirisa rinowedzerawo simba. L-α-glycerophosphocholine inogona kuvandudza mashandiro ehuropi zvakanyanya nekuwedzera simba remasero etsinga uye kugona kutumira zviratidzo zvetsinga. Panyaya yekuwedzera cholinergic neurotransmission, kutumira zviratidzo pakati pemasero etsinga kunoenderana nekutumira kwe neurotransmitters, uye acetylcholine chinhu chakakosha chemakemikari chinotuma uye chinopa neurotransmitter inoita kuti pfungwa dzishande zvakanaka uye inochengetedza kubatana pakati pehuropi nemuviri wese.

L-α-glycerophosphocholine inogona kusanganiswa kuita 3-glycerol phosphate necholine muuropi uye ndiyo inonyanya kuwanika acetylcholine. Inogona kusimudzira ndangariro nekuvandudza kufunga nekukurudzira kugadzirwa nekuburitswa kweacetylcholine muuropi. Panyaya yekuwedzera kugadzikana uye kuyerera kwemasero, L-α-glycerophosphocholine inogona kukurudzira kugadzirwa kwephosphoinositide, nokudaro ichisimudzira kugadzikana uye kuyerera kwemasero. Maneuron ane maumbirwo asina kukanganiswa anogona kuendesa ruzivo zviri nani. Kuvandudza kugona kwekufunga kwemuviri.

Chechipiri kudya kunovaka muviri uye kudzivirira tsinga. Zvinhu zvinokonzera tsinga, zvinhu zvinokonzera kukura kwetsinga, zvinogona kudzora kusiyana kwemasero ekutanga uye kukurudzira kuumbwa kwekubatana kutsva kwetsinga. L-α-glycerophosphocholine inogona kukurudzira kuburitswa kwezvinhu zvakasiyana-siyana zvinokonzera tsinga uye kumutsa nzira dzekutumira zviratidzo zvine chekuita nekurarama kwemasero, nokudaro inoita kuti tsinga dzidzivirire uye inovandudza huwandu hwepfungwa dzemuviri. Panguva imwe chete, L-α-glycerophosphocholine inogonawo kukurudzira kuburitswa kwehomoni yekukura uye kuchengetedza hutano hwemuviri nekuwedzera huwandu hwehomoni yekukura yemuviri.

Chechitatu iantioxidant. Kuoxidation nekuzvimba ndizvo zvinonyanya kukonzera kukwegura nekufa kwemasero europi. L-α-glycerophosphocholine inogona kubvisa ma free radicals mumuviri, kurwisa oxidative stress, uye inogonawo kuderedza nuclear factor NF-κB, tumor necrosis factor TNF-α, uye interleukins. Kuburitswa kwezvinhu zvinozvimba zvakaita seIL-6 kunodzivirira kuzvimba kweuropi, nokudaro zvichidzosera shure zvakanyanya kudzikira kwebasa repfungwa uye kudzivirira kuitika nekukura kwezvirwere zvinokanganisa tsinga.

Mhedzisiro yakakosha iyi yakatsigirwa nemigumisiro yekiriniki. Muchidzidzo che "Mhedzisiro yeL-α-glycerophosphocholine pakukuvara kwendangariro kunokonzerwa nezera", vanhu vana vakapihwa placebo, uye vamwe vanhu vashanu vakapihwa. Mushure mekunwa L-α-glycerophosphocholine (1200 mg/zuva) nemuromo kwemwedzi mitatu, maelectrode gumi nematanhatu akashandiswa kunyora mafungu europi kwemaminitsi mashanu vanhu vacho pavakanga vakamuka uye vachizorora. Mhedzisiro yacho yakaratidza kuti zvichienzaniswa neplacebo, L-alpha-glycerophosphocholine yakawedzera zvakanyanya huwandu hwemafungu europi anokurumidza kupfuura mamwe uku iine tsika yekuderedza mafrequency anononoka. Kureva kuti, inogona kuwedzera simba reuropi revanhu vezera repakati uye kunonotsa kukwegura kwemuviri.

Chechina ndechekudzora manzwiro. Dopamine inogona kuita kuti vanhu vafare, uye serotonin ne gamma-aminobutyric acid zvinogona kudzora mafungiro emuviri. L-α-glycerophosphocholine inogona kukurudzira kuburitswa kwedopamine, kuwedzera kutaura kwe dopamine transporters, kuvandudza dopamine neurotransmission muuropi, uye kuwedzera huwandu hwe serotonin mu striatum ne prefrontal cortex; inogonawo kukurudzira zvakanyanya endogenous. Kuburitswa kwe γ-aminobutyric acid mu sexual cortical tissue kunoderedza kushaya hope, nokudaro ichishandisa mhedzisiro yayo yekurwisa kuora mwoyo, kuderedza kuzvidya mwoyo uye kugadzirisa mafungiro.

Chechishanu ndechekuvandudza mashandiro emitambo. Panguva yekurovedza muviri, L-alpha-glycerophosphocholine inovandudzawo kuumbwa kwemuviri nekuwedzera tsandanyama uye kuvandudza mashandiro ese emuviri nekuwedzera kugadzirwa kwehomoni yekukura nekukurumidza uye simba rinobuda. Pamusoro pezvo, L-α-glycerophosphocholine inogonawo kukurumidzisa kutapurirana kwema neurotransmitter, kuvandudza kushanda kwekubatana kwetsinga dzeropa, kuwedzera kugona kwekugumburwa uye kutsungirira kwetsandanyama dzemapfupa, nokudaro ichivandudza simba rekurovedza muviri kwemuviri, kudzivirira kuneta, uye kuita pesvedzero yakanaka pakukura kwetsandanyama.

Saka vanhu vanogona kuwana kupi chikafu ichi chine mabhenefiti akawanda kudaro? Kutaura zvazviri, L-α-glycerophosphocholine inowanikwa muzvikafu zvakawanda zvakaita semazai, huku, uye rainbow trout, asi huwandu hwacho hunowanzova hushoma. Sekureva kwe "Second Edition of the US General Food Choline Content Database" yakaburitswa neUnited States Department of Agriculture, huwandu hweL-α-glycerophosphocholine muhuwandu hwezvikafu zvinosvika mazana matanhatu nemakumi matatu muzvikamu makumi maviri nemaviri zvakaratidza kuti L-α-glycerophosphocholine pa 100 gramu yechikafu. Hunhu hweglycerophosphocholine hunobva pa0 kusvika 190 mg. Nokudaro, kuti zvizadzise zvinodiwa nekukura kwemuviri wemunhu, kukura uye metabolism, zvimwe zvinowedzerwa zvinogona kugadzirwa nemazvo.

Kugadzira mishonga yemakemikari ndeimwe yenzira huru dzekugadzira L-α-glycerophosphocholine. Uchishandisa polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide nemvura sezvinhu zvakabikwa, mushure mekusanganiswa kwemvura uye esterification reaction, inobviswa ruvara, tsvina inobviswa, inonatswa, inonatswa uye inoomeswa. L-α-glycerophosphocholine inogadzirwa nedzimwe nzira inogona kuwedzerwa kune zvinwiwa zvisina kupfava, zvinwiwa zvemitambo, kofi, gummies, oatmeal energy bars, nezvimwewo, uye inogona kushandisa mhedzisiro yayo yekudya nenzira yakatarwa kuti isangane nehutano hwakasiyana hwevanoda.

MuUnited States, Japan, Canada nedzimwe nyika, L-α-glycerophosphocholine yave ichishandiswa zvakanyanya mukudya. Zvigadzirwa zvine chekuita nazvo zvinosanganisa zvekudya zvinovaka muviri, zvinwiwa, gummies nezvimwe zvikamu, uye chigadzirwa chimwe nechimwe chine Mabasa akajeka, chiyero chinokurudzirwa uye mapoka anokurudzirwa.

Suzhou Myland Pharm & Nutrition Inc. ikambani yakanyoreswa neFDA inopa Alpha GPC powder yemhando yepamusoro uye yakachena.

KuSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yepamusoro. Upfu hwedu hweAlpha GPC hwakaedzwa zvakasimba kuti huve hwakachena uye hune simba, zvichiita kuti uwane chinowedzera chemhando yepamusoro chaunogona kuvimba nacho. Kunyangwe uchida kutsigira hutano hwemasero, kusimbisa masoja emuviri wako kana kusimudzira hutano hwese, upfu hwedu hweAlpha GPC ndiyo sarudzo yakakwana.

Nemakore makumi matatu eruzivo uye zvichitungamirirwa netekinoroji yepamusoro uye nzira dzeR&D dzakanyatsogadzirwa, Suzhou Myland Pharm yakagadzira zvigadzirwa zvakasiyana-siyana zvinokwikwidzana uye yakava kambani itsva yekuwedzera sainzi yehupenyu, kugadzira zvinhu zvakagadzirwa uye kugadzira zvinhu.

Pamusoro pezvo, Suzhou Myland Pharm ikambani yakanyoreswa neFDA. Zvishandiso zveR&D zvekambani, nzvimbo dzekugadzira, uye zvishandiso zvekuongorora ndezvemazuva ano uye zvinoshanda zvakawanda, uye zvinogona kugadzira makemikari kubva pamamirigiramu kusvika kumatani muhukuru, uye zvinoenderana neISO 9001 standards uye specifications dzekugadzira GMP.