Chii chinonzi Choline Alfoscerate uye Inogona Sei Kubatsira Uropi Hwako?

Sechinhu chisingaperi chiri mumuviri wemunhu, L-α-glycerophosphocholine inogona kupinda muropa-brain barriers uye ine yakanyanya kukwira bioavailability. Icho chikafu chemhando yepamusoro icho chakakosha kumuviri wemunhu. "Ropa-brain chipingamupinyi chakakora, 'madziro'-sechimiro pakati pecapillary plexuses yeuropi. L-α-glycerophosphocholine inogona kupinda nyore muropa-brain chipingamupinyi uye kuita basa mukusimudzira ndangariro, kunatsiridza kufunga, uye Iyo. ine mabhenefiti angangoita mukubvisa kushushikana, kudzikamisa manzwiro, uye kuwedzera simba remhasuru uye kutsungirira "Zvinovaka muviri zvinokonzerwa neL-α-glycerophosphocholine zvinonyanya kuratidzwa mune 5 zvinhu.

Imwe ndeyekuvandudza kushanda kwehuropi. Kuwanda kwenhamba yemasero etsinga muuropi, kusimba kwesimba radzo, kukurumidza kwaanoita kutumira masaini etsinga, uye kusimba kwesimba rekugadzirisa uropi. L-α-glycerophosphocholine inogona kunyatsovandudza kushanda kwehuropi nekusimudzira simba remasero etsinga uye kugona kutapurirana kwezviratidzo zvetsinga. Panyaya yekusimudzira cholinergic neurotransmission, kutapurirana kwechiratidzo pakati pemasero etsinga kunovimba nekufambiswa kwemaurotransmitters, uye acetylcholine chinhu chakakosha chemakemikari messenger uye neurotransmitter inovimbisa kushingaira kufunga uye kuchengetedza kubatana pakati pehuropi nemuviri wese.

L-α-glycerophosphocholine inogona kuparara kuita 3-glycerol phosphate uye choline muuropi uye ndiyo inonyanya kushanda yeacetylcholine. Inogona kuwedzera ndangariro nekuvandudza kufunga nekusimudzira synthesis uye kuburitswa kweacetylcholine muuropi. Mukutaura kwekusimudzira kugadzikana uye fluidity yemasero emagetsi, L-α-glycerophosphocholine inogona kukurudzira kuumbwa kwephosphoinositide, nokudaro kunowedzera kugadzikana uye kunyunguduka kwemasero emagetsi. MaNeuroni ane zvimiro zvisina kusimba anogona kufambisa zvirinani ruzivo. Kuvandudza kugona kwemuviri kufunga.

Chechipiri kudya uye kudzivirira tsinga. Neurotrophic factor, kukura kwezvinyama zvetsinga, zvinogona kudzora stem cell kusiyanisa uye kukurudzira kuumbwa kwetsva neural connections. L-α-glycerophosphocholine inogona kukurudzira kuvharwa kwezvinhu zvakasiyana-siyana zveurourotrophic uye kushandura nzira dzechiratidzo dzine chokuita nekupona kwesero, nokudaro Inoshandisa neuroprotective effect uye inovandudza hutano hwekuziva kwemuviri. Panguva imwecheteyo, L-α-glycerophosphocholine inogonawo kukurudzira kugadzirwa kwehomoni yekukura uye kuchengetedza hutano hwemuviri nekuwedzera kukura kwehomoni yemuviri.

Yechitatu ndeye antioxidant. Oxidation uye kuzvimba ndizvo zvinokonzeresa kuchembera uye kufa kwemasero europi. L-α-glycerophosphocholine inogona kubvisa mahara radicals mumuviri, kurwisa oxidative kusagadzikana, uye inogonawo kuderedza nuclear yenyu NF-κB, tumor necrosis factor TNF-α, uye interleukins. Kuburitswa kwezvinhu zvinopisa senge IL-6 kunopesana nekuzvimba kwehuropi, nekudaro zvakanyanya kudzoreredza kuderera kwekuita kwekuziva uye kudzivirira kuitika uye kukura kwezvirwere zveurourodegenerative.

Migumisiro yakakodzera yakatsigirwa nemigumisiro yekliniki. Muchidzidzo "The Effect of L-α-glycerophosphocholine pazera-related memory impairment", 4 zvidzidzo zvakapiwa placebo, uye zvimwe zvidzidzo zve5 zvakapiwa Mushure mekutora L-α-glycerophosphocholine (1200 mg / zuva) nemuromo kwemwedzi ye3. , 16 electrodes yakashandiswa kunyora mafungu europi kwemaminitsi mashanu apo zvidzidzo zvakanga zvakamuka uye zvichizorora. Mhedzisiro yacho yakaratidza kuti kana ichienzaniswa ne placebo, L-alpha-glycerophosphocholine yakawedzera zvakanyanya chikamu chemafungu ehuropi anokurumidza asi aine tsika yekudzikisa zvishoma zvishoma. Ndiko kuti, inogona kuwedzera simba rehuropi hwevanhu vepakati uye kunonoka kuchembera kwemuviri.

Chechina ndechekudzora manzwiro. Dopamine inogona kuita kuti vanhu vanzwe kufara, uye serotonin uye gamma-aminobutyric acid inogona kugadzirisa mafungiro emuviri. L-α-glycerophosphocholine inogona kukurudzira kusunungurwa kwe dopamine, up-regulate kutaura kwevanotakura dopamine, kunatsiridza dopamine neurotransmission muuropi, uye kuwedzera mazinga e serotonin mu striatum uye prefrontal cortex; inogonawo kukurudzira zvakanyanya endogenous Kusunungurwa kwe γ-aminobutyric acid mune zvepabonde cortical tissue kunobvisa kushaya hope, nokudaro kushandisa maitiro ayo anopikisa, kuzvidya mwoyo uye kugadzirisa mafungiro.

Yechishanu ndeyekuvandudza kuita kwemitambo. Panguva yekurovedza muviri, L-alpha-glycerophosphocholine inovandudzawo kuumbwa kwemuviri nekuwedzera mhasuru uye kuvandudza huwandu hwese metabolic chiitiko nekuwedzera acute kukura kwehomoni kugadzirwa uye kubuda kwesimba. Uye zvakare, L-α-glycerophosphocholine inogonawo kukurumidza kutapurirana neurotransmitter, kuvandudza kushanda kweiyo neuromuscular connections, kuwedzera chibvumirano uye kutsungirira kwemaskeletal tsandanyama, nekudaro kunowedzera simba rekuita kwemuviri, kurwisa-kuneta, uye kuita pesvedzero yakanaka pakukura kwetsandanyama. . pesvedzero.

Saka vanhu vangawanepi chikafu ichi chine mabhenefiti akawanda kudaro? Muchokwadi, L-α-glycerophosphocholine iri mune zvakawanda zvekudya zvakaita semazai, huku, uye muraraungu trout, asi zvirimo zvinowanzo diki. Zvinoenderana ne "Second Edition yeUS General Chikafu Choline Yemukati Database" yakaburitswa neUnited States Dhipatimendi rezvekurima, zvirimo muL-α-glycerophosphocholine muhuwandu hwe630 chikafu muzvikamu makumi maviri nemaviri zvakaratidza kuti L-α-glycerophosphocholine pazana. magiramu ezvokudya Zvinyorwa zveglycerophosphocholine zvinobva ku0 kusvika ku190 mg. Nokudaro, kuitira kuti usangane nezvinodiwa zvekukura kwemuviri wemunhu, kukura uye metabolism, zvimwe zvinowedzera zvinogona kuitwa zvakakodzera.

Kemikari synthesis ndiyo imwe yenzira huru dzekugadzira L-α-glycerophosphocholine. Kushandisa polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide uye mvura sezvinhu zvakasvibirira, mushure mekugadzirisa uye esterification reaction, yakasvibiswa, tsvina inobviswa, yakasimbiswa, yakanatswa uye yakaomeswa. L-α-glycerophosphocholine yakagadzirwa nemamwe maitiro inogona kuwedzerwa kune zvinwiwa zvinwiwa, zvinwiwa zvemitambo, kofi, gummies, oatmeal energy bars, nezvimwewo, uye inogona kushandisa mhedzisiro yayo yehutano nenzira yakanangwa kusangana neakasiyana hutano hutano hwevatengi. need.

MuUnited States, Japan, Canada nedzimwe nyika, L-α-glycerophosphocholine yakashandiswa zvakanyanya mukudya. Zvigadzirwa zvinoenderana zvinovhara zvekudya zvinowedzera, zvinwiwa, gummies uye mamwe mapoka, uye chimwe nechimwe chigadzirwa chine akajeka Mabasa, inokurudzirwa dosi uye anokurudzirwa mapoka.

Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yemhando yepamusoro uye yakakwirira-kuchena Alpha GPC hupfu.

PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu Alpha GPC poda yakaedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu Alpha GPC hupfu ndiyo sarudzo yakakwana.

Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.