Chii chaunofanira kuziva nezve palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) imusanganiswa wemafuta acid amide unowanikwa zvakasikwa uyo wakakwezva kutariswa kwezvingangove zvakanakira hutano hwayo. Musanganiswa uyu unowanikwa munyama dzakasiyana-siyana mumuviri wese, uye tsvakiridzo inoratidza kuti palmitamideethanol (PEA) inogona kuderedza kuzvimba, kuderedza marwadzo, uye inogonawo kukurudzira hutano hwemudumbu nekunonoka kukwegura. Inogona kunge iine mabhenefiti akasiyana-siyana ehutano. Zviri mukati zvinotevera zvichaongorora mabhenefiti ehutano epalmitoylethanolamide (PEA), mashandiro ayo mumuviri wemunhu, uye mawanirwo epalmitoylethanolamide (PEA) yepamusoro.

Chii chinonzi palmitoylethanolamide (PEA)?

Palmitoylethanolamide (PEA) mushonga wakaita se endocannabinoid unowanikwa zvakasikwa unozivikanwa nekuva kwawo kwenguva refu unoderedza marwadzo uye unoderedza kuzvimba. Pamusoro pekugadzirwa nemuviri, PEA inowanikwa muzvikafu zvakasiyana-siyana zvinosanganisira: chizi, zai, nyama, mukaka, nzungu, soy lecithin.

Waizviziva here? Kana muviri ukasangana nezvinhu zvinokunetsa, zvakaita sekukuvara kana kuzvimba, mazinga ePEA anochinja kuti arambe akasimba mumasero.

Palmitoylethanolamide inokanganisa sei muviri wemunhu?

Masayendisiti haasati anyatsonzwisisa mashandiro anoita palmitoylethanolamide. Kunyange zvakadaro, tafambira mberi zvikuru, nekuda kwaPurofesa Rita Levi-Montalcini, avo muna 1992-1996 vakatsanangura mashandiro anoita palmitoylethanolamide. Kubva ipapo, vakaramba vachidzidza nezvemigumisiro ye palmitoylethanolamide pakurwadziwa kwetsinga dzeropa uye allergies.

Palmitoylethanolamide inogona kuunza mabhenefiti mana makuru pahutano kuvanhu:

●Kuderedza kuzvimba.

●Deredza kushanda kwemaseru emuviri (allergy).

●Simbisa mashandiro ehurongwa hwehemp hwe endogenous.

●Shandisa mareceptor chaiwo mumuviri.

PEA inoshandisa sei mhedzisiro yayo yekudzivirira kuzvimba uye marwadzo?

Mabhenefiti ePEA pahutano anosanganisira mhedzisiro pamasero ekudzivirira muviri anodzora kuzvimba, kunyanya muuropi. PEA inogona kubatsira kuderedza kugadzirwa kwezvinhu zvinozvimba. Zvisinei, PEA inonyanya kushanda pamareceptors ari pamasero, ayo anodzora mashandiro akasiyana-siyana emasero. Mareceptor aya anonzi maPPAR. PEA nemamwe macompounds anobatsira kumutsa PPAR anogona kuderedza marwadzo uye anogona zvakare kuwedzera metabolism nekupisa mafuta, kuderedza triglycerides muropa, kuwedzera cholesterol yeHDL muropa, kuvandudza kudzora shuga muropa, uye kubatsira kuderedza uremu.

Mabhenefiti ePalmitoylethanolamide

Nekuda kwemhedzisiro yayo yekunyaradza marwadzo uye yekudzivirira kuzvimba, tsvakiridzo inoratidza kuti PEA inogona kubatsira nezvirwere zvakasiyana-siyana zvine chekuita nemarwadzo, zvakaita sefibromyalgia, sciatica, uye osteoarthritis.

1. Kuderedza marwadzo uye kuzvimba

Marwadzo asingaperi idambudziko guru rinotambudza varwere pasi rese, uye sezvo huwandu hwevanhu huchikura, dambudziko iri richawedzera kukosha. Rimwe remabasa epalmitoylethanolamide nderekuti rinogona kubatsira kuderedza marwadzo nekuzvimba. Palmitoylethanolamide inosangana nemaCB1 neCB2 receptors, izvo zvikamu zvakakosha zve endogenous hemp system. Sisitimu iyi ine basa rekuchengetedza homeostasis kana kuenzana mumuviri.

Kana kukuvara kana kuzvimba kukaitika, muviri unoburitsa zvinhu zvehemp zve endogenous kuti zvibatsire kudzora maitiro ekudzivirira muviri. Palmitoylethanolamide inogona kubatsira kuwedzera huwandu hwehemp mumuviri, nokudaro ichideredza marwadzo nekuzvimba.

Pamusoro pezvo, palmitoylethanolamide inogona kuderedza kuburitswa kwemakemikari anokonzera kuzvimba uye kuderedza kuzvimba kwetsinga. Izvi zvinoita kuti palmitoylethanolamide ive chishandiso chinogona kubatsira kudzora marwadzo uye kuzvimba. Zvidzidzo zvinoratidza kuti palmitoylethanolamide inogonawo kushanda pakurwadziwa kwesciatica uye carpal tunnel syndrome.

2. Fibromyalgia

Zvidzidzo zvakawanda zvinoratidza kuti PEA inogona kubatsira kuderedza zviratidzo zvefibromyalgia, chirwere chisingaperi chetsinga chinokonzera marwadzo akapararira. Kana ikashandiswa sechibatsiro pakurapa kwechinyakare, kunwa PEA kunoderedza marwadzo uye kunovandudza hupenyu hwemunhu nekufamba kwenguva. Sekureva kweimwe ongororo, kutora PEA kwemwedzi mitatu kwakaderedza zvakanyanya marwadzo kuvanhu vane fibromyalgia.

3. Kurwadziwa kwemusana

Ongororo yekutanga inoratidza kushanda kwePEA pakurwadziwa kwemusana. Ongororo yakaitwa muna 2017 yakaratidza kuti PEA yakadzikisawo kurwadziwa kwakanyanya muvarwere vane chirwere chekuvhiyiwa kwemusana chisina kubudirira.

Vanhu vanotambura nesciatica, kurwadziwa kunobva pasi pemusana zvichidzika pasi pegumbo rimwe kana maviri, vanogonawo kuwana zororo mushure mekutora PEA. Kuedzwa kwakaitwa nemaitiro asina kurongeka, asina kupofumadzwa kaviri, kwakadzorwa ne placebo kwakadzidza mhedzisiro yePEA ine dose yakakwira neyakaderera uchienzanisa ne placebo. Marwadzo akaderedzwa neanopfuura 50% muboka remishonga ine dose yakakwira. Kunyangwe PEA ine dose yakaderera isina kuwana mwero wakafanana wekuderedza marwadzo semushonga wakakwira, madose ese ari maviri aishanda zvakanyanya kupfuura placebo.

4. Osteoarthritis

PEA inogona kubatsira vanhu vane osteoarthritis, chirwere chinoratidzwa nekuora kwemapfupa nemapfupa ejoini. Vatori vechikamu mune imwe ongororo vakawana PEA vakaona kuvandudzwa kukuru muWestern Ontario neMcMaster Universities Osteoarthritis Index (WOMAC) scores zvichienzaniswa neboka re placebo. WOMAC ibvunzo rakagadzirirwa kuongorora mamiriro nezviratidzo (semuenzaniso, kurwadziwa, kuomarara, mashandiro emuviri) muvarwere vane osteoarthritis yemabvi nechiuno.

Imwe ongororo yaisanganisira varwere vane marwadzo e temporomandibular arthritis (TMJ) ane chekuita ne osteoarthritis yakaratidza kuti kuwedzerwa kwePEA kwakavandudza zvakanyanya kusimba kwemarwadzo mushure memazuva gumi nemana zvichienzaniswa ne ibuprofen. Boka rakapihwa PEA kwemazuva gumi nemana rakaratidza kuvandudzika kukuru mukuvhura muromo zvakanyanya (chiyero chekurerutsira marwadzo) kupfuura boka re ibuprofen.

5. Kurwadziwa kwetsinga

Zvidzidzo zvekutanga uye kuongororwa kwemhuka zvinoratidza kuti PEA inogona kubatsira nekurwadziwa kwetsinga (kunokonzerwa nekukuvara kwetsinga dzinotakura mameseji pakati peuropi nemuzongoza), kunyanya kuvanhu vane carpal tunnel syndrome, chirwere cheshuga neuropathy, chemotherapy Vanhu vane peripheral neuropathy, kurwadziwa kwenguva refu kwechiuno, uye kurwadziwa kunokonzerwa nesitiroko uye multiple sclerosis. Mimwe miedzo yekiriniki inodiwa kuti ione kushanda kwePEA mukugadzirisa marwadzo etsinga.

6. Kukwegura Kwakanaka

Kunonotsa kukwegura chinangwa chakakosha chinotsvagwa nenyanzvi dzakawanda pasi rose. Palmitoylethanolamide inoonekwa semushonga unodzivirira kukwegura unogona kubatsira kudzivirira masero kubva mukukuvadzwa ne oxidative, inova ndiyo honzeri huru yekukwegura.

Kana masero akasangana ne free radicals yakawanda, oxidative reactions inogona kuitika, zvichikonzera kufa kwemasero nguva isati yakwana. Kudya chikafu chisina kunaka, kusvuta, nezvimwe zvinokonzerwa nezvakatipoteredza zvakaita sekusvibiswa kwemhepo zvinowedzerawo kukuvara kwe oxidative. Palmitoylethanolamide inogona kudzivirira kukuvara uku nekubvisa free radicals uye kuderedza kuzvimba mumuviri.

Pamusoro pezvo, palmitoylethanolamide ethanol yakaratidzwa kuti inogona kukurudzira kugadzirwa kwecollagen nemamwe mapuroteni eganda akakosha. Nokudaro, inogona kuderedza kutaridzika kwemakwinya uye mitsetse midiki, ichishanda sedziviriro kubva mukati memasero.

Suzhou Myland Pharm & Nutrition Inc. ikambani yakanyoreswa neFDA inopa hupfu hwePalmitoylethanolamide (PEA) hwemhando yepamusoro uye hwakachena.

KuSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yepamusoro. Upfu hwedu hwePalmitoylethanolamide (PEA) hunoongororwa zvakasimba kuti hune kuchena uye simba, zvichiita kuti uwane chinowedzera chemhando yepamusoro chaunogona kuvimba nacho. Kunyangwe uchida kutsigira hutano hwemasero, kusimbisa masoja emuviri wako, kana kusimudzira hutano hwese, upfu hwedu hwePalmitoylethanolamide (PEA) ndiyo sarudzo yakakwana.

Nemakore makumi matatu eruzivo uye zvichitungamirirwa netekinoroji yepamusoro uye nzira dzeR&D dzakanyatsogadzirwa, Suzhou Myland Pharm yakagadzira zvigadzirwa zvakasiyana-siyana zvinokwikwidzana uye yakava kambani itsva yekuwedzera sainzi yehupenyu, kugadzira zvinhu zvakagadzirwa uye kugadzira zvinhu.

Pamusoro pezvo, Suzhou Myland Pharm ikambani yakanyoreswa neFDA. Zvishandiso zveR&D zvekambani, nzvimbo dzekugadzira, uye zvishandiso zvekuongorora ndezvemazuva ano uye zvinoshanda zvakawanda, uye zvinogona kugadzira makemikari kubva pamamirigiramu kusvika kumatani muhukuru, uye zvinoenderana neISO 9001 standards uye specifications dzekugadzira GMP.