Chii chaunoda kuziva nezve nicotinamide adenine dinucleotide (NAD+)?

NAD+ inonziwo coenzyme, uye zita rayo rakazara ndicotinamide adenine dinucleotide. Iyo yakakosha coenzyme mu tricarboxylic acid kutenderera. Inosimudzira metabolism yeshuga, mafuta, uye amino acids, inotora chikamu mukuumbwa kwesimba, uye inotora chikamu muzviuru zvekuitika musero rega rega. Huwandu hukuru hwe data rekuyedza hunoratidza kuti NAD + inosanganisirwa zvakanyanya mumhando dzakasiyana dzezviitwa zvemuviri mumutumbi, nekudaro kupindira mumabasa akakosha emasero senge simba metabolism, kugadzirisa kweDNA, genetic modification, kuzvimba, biological rhythms, uye kusagadzikana kuramba.

Zvinoenderana netsvakiridzo yakakodzera, iyo NAD + nhanho mumuviri wemunhu ichadzikira nezera. Kudzikira kweNAD + mazinga anogona kukonzera kudzikira kwetsinga, kurasikirwa kwekuona, kufutisa, basa remoyo kuderera uye kumwe kuderera kwekushanda. Naizvozvo, maitiro ekuwedzera iyo NAD + nhanho mumuviri wemunhu wagara uri mubvunzo. Musoro wekutsvaga unopisa munharaunda yebiomedical.

Nei NAD + ichiderera?

Nekuti, sezvatinokura, kukuvara kweDNA kunowedzera. Munguva yekugadziriswa kweDNA, kudiwa kwePARP1 kunowedzera, kuita kweSIRT kushoma, NAD + kushandiswa kunowedzera, uye huwandu hweNAD + hunodzikira.

Kana tikawedzera zvakakwanaNAD+, tichaona kuti mabasa akawanda omuviri anotanga kudzorera uduku.

Masero ane NAD+. Tichiri kuda kuiwedzera here?

Muviri wedu wakaumbwa nemasero anosvika 37 trillion. Masero anofanirwa kupedzisa "basa" rakawanda kana ma cellular reactions kuti azvichengetedze. Imwe neimwe ye37 trillion maseru ako inoenderana neNAD+ kuita basa rayo ririkuenderera mberi.

Sezvo huwandu hwehuwandu hwenyika huri kuchembera, zvirwere zvine chekuita nekuchembera zvakaita sechirwere cheAlzheimer, chirwere chemoyo, matambudziko emajoini, kurara uye matambudziko emwoyo zvave zvirwere zvakakosha zvinokanganisa hutano hwevanhu.

Naizvozvo, kubvira NAD yakawanikwa nemasayendisiti eAmerica, NAD yakapinda muhupenyu hwevanhu, uye NAD+ nekuwedzera kwayo zvakaratidza tarisiro huru yekushandisa mukudzivirira zvirwere zvine chekuita nekuchembera.

① NAD + inoita se coenzyme mu mitochondria kukurudzira metabolic balance. NAD + inobata basa rinonyanya kushanda muma metabolic maitiro senge glycolysis, TCA cycle (aka Krebs cycle kana citric acid cycle) uye elektroni yekufambisa cheni. Ndiwo mawaniro anoita masero simba. Kuchembera uye kudya kwakakwirira-calorie kunoderedza NAD + mazinga mumuviri.

Zvidzidzo zvakaratidza kuti mumakonzo echikuru, kutora NAD + yekuwedzera yakaderedzwa kudya- kana zera-ane uremu kuwana uye nekuvandudza kugona kwekurovedza muviri. Pamusoro pezvo, zvidzidzo zvakatodzora mhedzisiro yechirwere cheshuga mumakonzo echikadzi, zvichiratidza nzira nyowani dzekurwisa zvirwere zvemetabolism senge kufutisa.

NAD + inosungira kuma enzymes uye inotamisa maerekitironi pakati pemamorekuru. Maelectrons ndiwo hwaro hwesimba remagetsi. NAD + inoshanda pamaseru sekuchaja bhatiri. Kana maerekitironi akapera, bhatiri rinofa. Mumasero, NAD + inogona kusimudzira kufambisa kweelectronic uye kupa simba kumasero. Nenzira iyi, NAD + inogona kuderedza kana kuwedzera basa re enzyme, kukurudzira kutaura kwemajini uye kusaina kwesero.

② NAD + inobatsira kudzora kukuvara kweDNA

Sezvo zvipenyu zvichikura, zvakaipa zvezvakatipoteredza zvakaita semwaranzi, kusvibiswa, uye kudzokorora kweDNA kunokanganisa zvinogona kukanganisa DNA. Iyi ndiyo imwe yedzidziso dzekuchembera. Anenge ese maseru ane "molecular machine" kugadzirisa kukuvara uku.

Kugadzirisa uku kunoda NAD + nesimba, saka kukuvara kwakanyanya kweDNA kunodya zvakakosha maserura zviwanikwa. Basa rePARP, yakakosha DNA kugadzirisa mapuroteni, zvakare zvinoenderana neNAD +. Kuchembera kwakajairwa kunokonzeresa kukuvadzwa kweDNA kuungana mumuviri, RARP inowedzera, uye nekudaro kuwanda kweNAD + kunoderera. Mitochondrial DNA kukuvadzwa chero nhanho ichawedzera kupera uku.

③ NAD+inokanganisa basa rehupenyu hurefu gene Sirtuins uye inhibits kukwegura

Iyo ichangobva kuwanikwa yehupenyu hurefu hwemajini sirtuins, anozivikanwawo se "vachengeti vemajini," anoita basa rakakosha mukuchengetedza hutano hwesero. Sirtuins imhuri yema enzymes anobatanidzwa muserura kusagadzikana mhinduro uye kugadzirisa kukuvara. Ivo vanobatanidzwawo mukuvharirwa kwe insulin, kuchembera, uye mamiriro ehutano ane hukama senge neurodegenerative chirwere uye chirwere cheshuga.

NAD + ndiyo mafuta anobatsira sirtuin kuchengetedza genome kutendeseka uye kukurudzira kugadzirisa kweDNA. Senge mota haigone kurarama isina mafuta, Sirtuins inoda NAD + kuti ishande. Mhedzisiro kubva kuzvidzidzo zvemhuka inoratidza kuti kuwedzera NAD + mazinga ari mumuviri anomutsa sirtuin mapuroteni uye anowedzera hupenyu mumbiriso nemakonzo.

④ Mwoyo basa

Kusimudza NAD + mazinga anochengetedza moyo uye anovandudza kushanda kwemoyo. Kukwira kweropa kunogona kukonzera kukura kwemoyo uye tsinga dzakavharika, izvo zvinogona kukonzera sitiroko. Mushure mekuzadza iyo NAD + nhanho mumoyo kuburikidza neNAD + yekuwedzera, kukuvadzwa kumoyo kunokonzerwa nekudzoreredza kunorambidzwa. Zvimwe zvidzidzo zvakaratidza kuti NAD + yekuwedzera inodzivirirawo mbeva kubva mukusagadzikana kwemoyo.

⑤ Neurodegeneration

Mune mbeva dzine chirwere cheAlzheimer, kuwedzera NAD + mazinga anovandudza cognitive basa nekudzikisa kuunganidzwa kwemapuroteni anokanganisa kutaurirana kwehuropi. Kusimudza mazinga eNAD+ zvakare kunodzivirira masero ehuropi kubva pakufa kana pasina ropa rakakwana rinoyerera richienda kuuropi. NAD + inoita kunge iine vimbiso nyowani mukudzivirira kubva kune neurodegeneration nekuvandudza ndangariro.

⑥ Immune system

Sezvo isu tichikura, masoja emuviri wedu anodzikira uye tinobatwa zvakanyanya nehurwere. Tsvagiridzo ichangoburwa inoratidza kuti mazinga eNAD + anoita basa rakakosha mukudzora mhinduro dzemuviri uye kuzvimba uye kupona kwesero panguva yekukwegura. Chidzidzo ichi chinosimbisa kugona kwekurapa kweNAD + kwekusashanda kwemuviri.

Hukama pakati pebasa reNAD ​​+ nekuchembera

Coenzymes inotora chikamu mumetabolism yezvinhu zvakakosha zvakaita seshuga, mafuta, uye mapuroteni mumuviri wemunhu, uye anoita basa rakakosha mukudzora zvinhu zvemuviri uye simba metabolism uye kuchengetedza zvakajairwa physiological mabasa. NAD ndiyo inonyanya kukosha coenzyme mumuviri wemunhu, inonziwo coenzyme I. Inotora chikamu muzviuru zve redox enzymatic reactions mumuviri wemunhu. Icho chinhu chakakosha kune metabolism yesero yese. Iine mabasa akawanda, mabasa makuru ndeaya:

1. Kurudzira kugadzirwa kwebioenergy

NAD + inogadzira ATP kuburikidza nekufema kweserura, ichiwedzera zvakananga sero simba uye inosimudzira sero basa;

2. Gadzirisa majini

NAD+ ndiyo yega substrate yeDNA kugadzirisa enzyme PARP. Iyi mhando ye enzyme inobatanidzwa mukugadzirisa DNA, inobatsira kugadzirisa DNA yakakanganisika nemasero, inoderedza mukana wekuchinja kwesero, uye inodzivirira kuitika kwekenza;

3. Shandisa mapuroteni ehupenyu hurefu

NAD + inogona kumisa ese mapuroteni manomwe ehupenyu hurefu, saka NAD + ine kukosha kwakanyanya pakurwisa kuchembera uye kuwedzera hupenyu;

4. Simbisa immune system

NAD + inosimbisa immune system uye inovandudza masero edziviriro nekusarudza kukanganisa kupona uye kushanda kwemasero eT anodzora.

5. Kurudzira kukura kwebvudzi

Chikonzero chikuru chekurasika kwebvudzi kurasikirwa kwebvudzi raamai sero simba, uye kurasikirwa kwebvudzi raamai sero simba imhaka yekuti iyo NAD + nhanho mumuviri wemunhu inodzikira. Masero aamai vebvudzi haana ATP yakakwana yekuita bvudzi mapuroteni synthesis, nekudaro achirasikirwa nehupenyu uye zvichikonzera kurasikirwa kwebvudzi.

6. Kutarisira uremu, kukurudzira metabolism

Muna 2017, Muzvinafundo David Sinclair weHarvard Medical School nechikwata kubva kuAustralia Medical College vakaita ongororo yekuenzanisa pamakonzo echikadzi akafutisa ari kudzidzira patreadmill kwemavhiki e9 uye achitora NMN zuva nezuva kwemazuva gumi nemasere. Chidzidzo chacho chakawana kuti NMN inobata chiropa mafuta metabolism. Uye mhedzisiro ye synthesis sezviri pachena yakakura kupfuura iyo yekurovedza muviri.

Zvikuru, kuchembera kunoperekedzwa nekudzikira kunofambira mberi kwematishu uye maseru NAD + mazinga mune akasiyana siyana emhando zvipenyu, kusanganisira makonzo nevanhu. Kuderera kweNAD + mazinga anokonzeresa akabatana nezvirwere zvakawanda zvine chekuita nekuchembera, kusanganisira kuderera kwekuziva, gomarara, chirwere chemetabolism, sarcopenia, uye kushaya simba.

Ndingawedzera sei NAD + zuva nezuva?

Iko hakuna kusingaperi kupihwa kweNAD + mumuviri wedu. Zviri mukati uye chiitiko cheNAD + mumuviri wemunhu chinodzikira nezera, uye chinodzikira nekukurumidza mushure memakore makumi matatu, zvichikonzera kuchembera kwesero, apoptosis uye kurasikirwa kwekugona kuberekwa patsva. .

Zvakare, kudzikiswa kweNAD + kuchakonzerawo akateedzana matambudziko ehutano, saka kana NAD + isingagone kuzadzikiswa nenguva, mhedzisiro inogona kufungidzira.

1.Kuwedzera kubva pakudya

Zvikafu zvakaita semakabheji, broccoli, avocado, steak, howa, uye edamame zvine NAD + precursors, inogona kushandurwa kuita NAD* inoshanda mumuviri mushure mekunyudzwa.

2.Restrict kudya uye macalorie

Pakati nepakati caloric restriction inogona kumisa simba-inonzwa nzira mukati memasero uye zvisina kunanga kuwedzera NAD * mazinga. Asi iva nechokwadi chokuti unodya zvokudya zvine mwero kuti usangane nezvinodiwa nomuviri wako zvinovaka muviri

3. Ramba uchishingaira uye kurovedza muviri

Pakati nepakati aerobic kurovedza muviri sekumhanya uye kushambira kunogona kuwedzera intracellular NAD + mazinga, kubatsira kuwedzera oxygen kupihwa mumuviri uye kunatsiridza simba metabolism.

4. Tevera miitiro yokurara ine utano

Panguva yekurara, muviri wemunhu unoita akawanda akakosha metabolic uye kugadzirisa maitiro, kusanganisira iyo synthesis yeNAD*. Kurara zvakakwana kunobatsira kuchengetedza akajairwa mazinga eNAD

5. Supplement NAD+ precursor zvinhu

Nicotinic acid (NA) uye nicotinamide (NAM) ese ari maviri ekutanga eNAD +. Ivo vanogona kugadzirwa uye kushandurwa kuita NAD mumuviri wemunhu, nekudaro vachiwedzera zvirimo. Nekudaro, nekuda kwekugumira kweiyo synthesis nzira uye chiyero-inodzikamisa enzymes, iyo bioavailability yakaderera. .

6 Yakananga kuwedzera NAD+

Exogenous yekuwedzera yeNAD + inogona kukurumidza kudzoreredza NAD + mazinga mumuviri, zvichibvumira nhengo dzakakosha senge moyo nehuropi kuwana inoshanda zvakanyanya NAD + yekuwedzera.

Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena NAD + yekuwedzera hupfu.

PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu NAD + yekuwedzera poda yakaedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera iwe yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, yedu NAD + yekuwedzera hupfu ndiyo sarudzo yakakwana.

Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika yekugadzira uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.