Sezvatinokura, miviri yedu inoshanduka-shanduka nenzira dzakasiyana-siyana dzinogona kukanganisa hutano hwedu hwese uye kugara zvakanaka. Chimwe chezviratidzo zvinoonekwa zvekukwegura kukura kwemakwinya, mitsetse mitete, uye ganda rinorembera. Kunyange pasina nzira yekumisa kukwegura, vaongorori vanga vachishanda nesimba kuti vawane makemikari anogona kunonotsa kana kutodzosera kumashure mamwe emhedzisiro yekukwegura. Urolithin A ndeimwe yemakemikari anoratidza tarisiro huru panyaya iyi. Ongororo ichangoburwa inoratidza kuti urolithin A inogona kuvandudza mashandiro emhasuru uye kutsungirira, kusimudzira mashandiro emitochondrial, uye kutokurudzira kubviswa kwezvikamu zvemasero zvakakuvara kuburikidza nemaitiro anonzi autophagy. Izvi zvinoita kuti urolithin A ive mukana wekuvandudza mishonga yekurwisa kukwegura. Kuwedzera kune mhedzisiro yayo yekurwisa kukwegura, urolithin A yakaongororwa nekuda kwebasa rayo rinogona kuita mukusimudzira hupenyu hurefu.
Tisati tanyatsoongorora zvinogona kukonzera kukwegura kwe urolithin A, ngatitangei tanzwisisa kuti kukwegura chii. Kukwegura inzira yakaoma inosanganisira kudzikira zvishoma nezvishoma kwebasa remasero uye kuunganidzwa kwekukuvara kwemasero nekufamba kwenguva. Maitiro aya anokanganiswa nezvinhu zvakasiyana-siyana zvinosanganisira majini, mararamiro, uye kusangana nemamiriro ezvinhu. Kutsvaga nzira dzekudzikisa kana kudzosera shure maitiro aya kwave kuri chinangwa chenguva refu mukutsvaga kukwegura.
Urolithin A yakaratidzwa kuti inomutsa nzira yemasero inonzi mitophagy, iyo inokonzera kubvisa nekudzokorodza mitochondria yakakuvara (simba resero). Mitochondria inoita basa rakakosha mukugadzirwa kwesimba uye inzvimbo huru ye reactive oxygen species (ROS), iyo inogona kukuvadza zvikamu zvemasero nekukurumidzisa kukwegura. Nekusimudzira mitophagy, urolithin A inobatsira kuchengetedza hutano hwemitochondrial uye kuderedza oxidative stress, iyo inofungidzirwa kuti inobatsira mukukwegura.
Zvidzidzo zvakawanda zvakapa mhedzisiro inovimbisa maererano nemhedzisiro ye urolithin A pakukwegura. Imwe ongororo yakaitwa pa nematodes yakawana kuti urolithin A yakawedzera hupenyu hwe nematodes kusvika ku45%. Zvakafanana zvakaonekwa muzvidzidzo pambeva, uko kuwedzerwa urolithin A kwakawedzera hupenyu hwavo hwepakati uye kwakavandudza hutano hwavo hwese. Izvi zvakawanikwa zvinoratidza kuti urolithin A ine mukana wekunonotsa kukwegura uye kuwedzera hupenyu.
Pamusoro pemigumisiro yayo pahupenyu hwese, urolithin A inewo mhedzisiro inoshamisa pahutano hwetsandanyama. Kukwegura kunowanzobatanidzwa nekurasikirwa netsandanyama uye kuderera kwesimba, chirwere chinozivikanwa sesarcopenia. Vaongorori vakaona kuti urolithin A inogona kukurudzira kukura kwetsandanyama uye kuwedzera simba retsandanyama. Muongororo yekiriniki yakaitwa nevakuru vakuru, urolithin A supplementation yakawedzera zvakanyanya tsandanyama uye yakawedzera mashandiro emuviri. Izvi zvakawanikwa zvinoratidza kuti urolithin A haina kungodzivirira kukwegura chete asiwo ine mabhenefiti anogona kubatsira hutano hwetsandanyama, kunyanya kune vakwegura.
Pamusoro pezvo, zvakakosha kutaura kuti urolithin A inobva mumapomegranate, asi huwandu hweurolithin A muzvigadzirwa zvemapomegranate hunogona kusiyana zvakanyanya. Nokudaro, mishonga yekugadzira inova sarudzo yakanaka uye yakachena uye iri nyore kuwana.
Urolithin A inotorwa kubva ku ellagitannins, iyo inowanzo kuwanikwa mune mimwe michero nenzungu. Aya ma ellagitannins anogadziriswa nemabhakitiriya emudumbu kuti agadzire urolithin A nedzimwe metabolites. Kana yangotorwa, urolithin A inokanganisa muviri padanho remasero.
Chimwe chezvakanakira zvikuru zve urolithin A kugona kwayo kukurudzira mitophagy, chinhu chakakosha pahutano hwemasero. Mitochondria inowanzonzi simba remasero uye inoita basa guru mukugadzirwa kwesimba. Zvisinei, sezvatinokura, kushanda zvakanaka kwemitochondrial kunoderera, zvichikonzera kusashanda zvakanaka kwemasero uye pamwe kukura kwezvirwere zvakasiyana-siyana zvine chekuita nekukwegura.
Mitophagy inzira yakakosha yekubvisa mitochondria yakakuvara uye isina kushanda zvakanaka, zvichibvumira mitochondria itsva, ine hutano kuti idzitsive. Urolithin A yakaratidzwa kuti inobatsira maitiro aya, ichikurudzira kuchinjana kwemitochondria uye inovandudza hutano hwemasero. Nekubvisa mitochondria isina kushanda zvakanaka, urolithin A inononoka kukwegura uye inoderedza njodzi yezvirwere zvine chekuita nekukwegura.
Pamusoro pemigumisiro yayo pamitophagy, urolithin A inewo simba rekudzivirira kuzvimba. Kuzvimba kwenguva refu ndiko kunokonzera zvirwere zvakasiyana-siyana, zvinosanganisira chirwere chemwoyo, kufuta, uye zvirwere zvinoderedza mashandiro etsinga. Tsvagiridzo yakawana kuti urolithin A inodzvinyirira zviratidzo zvekuzvimba uye inodzivisa kugadzirwa kwemakemikari anokonzera kuzvimba, nokudaro ichideredza njodzi yekuzvimba kwenguva refu nezvimwe zvirwere zvine chekuita nazvo.
Uyezve, urolithin A yakaratidza kugona kwayo seantioxidant ine simba. Kushushikana kwe oxidative kunokonzerwa nekusawirirana pakati pekugadzirwa kwema free radicals nekukwanisa kwemuviri kudzibvisa, uye kunoita basa rakakosha mukukwegura uye kukura kwezvirwere zvakasiyana-siyana. Urolithin A inogona kubvisa ma free radicals anokuvadza, kuwedzera kugona kwemuviri kudzivirira ma antioxidant, kudzivirira masero kubva mukukuvadzwa kwe oxidative, uye inogona kunonotsa kukwegura.
Tsvagiridzo inoratidzawo mabhenefiti angangovepo e urolithin A pahutano hwetsandanyama uye kushanda zvakanaka kwemitambo. Kukwegura kunowanzoenderana nekudzikira kwehuremu hwetsandanyama nesimba, zvichikonzera njodzi yakawedzerwa yekudonha, kutyoka, uye kurasikirwa nerusununguko. Urolithin A yakaratidzwa kuti inowedzera kugadzirwa kwemhasuru uye inovandudza mashandiro emhasuru, zvichigona kuderedza kurasikirwa kwetsandanyama kunokonzerwa nekukwegura.
Pamusoro pezvo, urolithin A yakawanikwa ichivandudza mashandiro ekurovedza muviri nekukurudzira kugadzirwa kwemapuroteni anobatanidzwa mukukura kwetsandanyama nekugadzirisa. Nekutsigira hutano hwetsandanyama uye kushanda zvakanaka kwemitambo, urolithin A inogona kubatsira kuchengetedza mararamiro anoshanda uye akazvimiririra sezvatinokura.
● Kurudzira hutano hwemudumbu
Kuti tiwedzere kugadzirwa kweUrolithin A mumuviri wedu, kugadzirisa hutano hwedumbu redu kwakakosha. Kudya microbiome yakasiyana-siyana uye inokura mudumbu kunoita kuti masero e ellagitannins ashande zvakanaka kuita urolithin A. Kudya chikafu chine fiber yakawanda chinosanganisira michero, miriwo, zviyo zvese, nenyemba kunosimbisa mabhakitiriya anobatsira mudumbu uye kunoita kuti pave nenzvimbo inobatsira kugadzirwa kweurolithin A.
● Urolithin A iri muchikafu
Pomegranate ndeimwe yenzvimbo dzakapfuma dzechisikigo dzinopa urolithin A. Muchero wacho pachawo une ellagitannins, dzinoshandurwa kuita urolithin A nebhakitiriya remudumbu panguva yekugaya. Muto wepomegranate zvakanyanya wakawanikwa uine huwandu hwakawanda hwe urolithin A uye unoonekwa sesarudzo yakanaka yekuwana mushonga uyu zvakasikwa. Kunwa girazi remuto wepomegranate zuva nezuva kana kuwedzera mapomegranate matsva pakudya kwako kunogona kubatsira kuwedzera kudya kwako urolithin A.
Mumwe muchero une urolithin A mastrawberry, ane ellagic acid yakawanda. Kufanana nemapomegranate, mastrawberry ane ellagitannins, ayo anoshandurwa kuita urolithin A nebhakitiriya remudumbu. Kuwedzera mastrawberry pakudya kwako, kuapa sechikafu chekudya, kana kuawedzera mumasmoothies ako inzira dzinonaka dzekuwedzera huwandu hwe urolithin A yako.
Pamusoro pemichero, dzimwe nzungu dzinewo ellagitannins, iyo inogona kunge iri sosi yechisikigo ye urolithin A. MaWalnuts, kunyanya, akawanikwa aine huwandu hwakawanda hwe ellagitannins, iyo inogona kushandurwa kuita urolithin A muura. Kuwedzera nzungu shoma pakudyiwa kwako kwezuva nezuva hakungobatsiri chete pahutano hwako hwese, asiwo pakuwana urolithin A zvakasikwa.
● Mishonga inovaka muviri uye urolithin A extract
Kune avo vari kutsvaga mushonga we urolithin A wakasimba uye wakavimbika, mishonga yekuwedzera inovaka muviri uye inotorwa inogona kuva sarudzo yakanaka. Kufambira mberi mukutsvaga kwakatungamira mukugadzirwa kwemishonga yekuwedzera yepamusoro inobva mu pomegranate extract yakagadzirwa zvakananga kuti ipe huwandu hwakakwana hwe urolithin A. Zvisinei, zvakakosha kusarudza mhando inozivikanwa uye inozivikanwa kuti ive nechokwadi chekuti chigadzirwa chacho chakanaka uye chakachengeteka.
● Nguva nezvinhu zvemunhu pachake
Zvakakosha kuziva kuti kushandurwa kwe ellagitannins kuita urolithin A kunosiyana pakati pevanhu, zvichienderana nekuumbwa kwe microbiota yavo mudumbu uye majini avo. Nokudaro, nguva inodiwa kuti uone kubatsirwa kukuru kubva mukushandiswa kwe urolithin A inogona kusiyana. Mwoyo murefu uye kugara kwenguva refu kwakakosha kana uchiisa chikafu kana zvekudya zvinovaka muviri zvakapfuma mu urolithin A mumabasa ako ezuva nezuva. Kupa muviri wako nguva yekuchinja uye kuwana kuenzana kuchakubatsira kuwana mibairo yechinhu ichi chinoshamisa.
Myland ikambani itsva yesainzi yehupenyu, yekugadzira zvinhu zvakasiyana-siyana uye kugadzira zvinhu inogadzira nekutsvaga mhando dzakasiyana dzezvinowedzera hutano zvine mhando inogara iripo uye kukura kwakasimba kwehutano hwevanhu. Urolithin A supplements inogadzirwa neMyland:
(1) Kuchena kwakanyanya: Urolithin A inogona kuva chigadzirwa chakachena zvikuru kuburikidza nekubviswa kwechisikigo uye kugadzirisa maitiro ekugadzira. Kuchena kwakanyanya kunoreva kuwanikwa kuri nani kwehupenyu uye kushomeka kwemigumisiro yakaipa.
(2) Kuchengetedzwa: Urolithin A chigadzirwa chechisikigo chakaratidzwa kuti chakachengeteka mumuviri wemunhu. Mukati mehuwandu hwemushonga, hapana migumisiro ine chepfu.
(3) Kugadzikana: Urolithin A ine kugadzikana kwakanaka uye inogona kuchengetedza kushanda kwayo uye kushanda kwayo pasi pemamiriro akasiyana-siyana uye mamiriro ekuchengetedza.
(4) Zviri nyore kunyudza: Urolithin A inogona kunyudzwa nekukurumidza nemuviri wemunhu, inopinda muropa kuburikidza nedumbu, uye inopararira kune nhengo dzakasiyana dzemuviri.
1. Kuvandudza hutano hwetsandanyama
Urolithin A ine mukana mukuru muhutano hwetsandanyama. Tsvagiridzo inoratidza kuti inosimudzira simba remitophagy, maitiro echisikigo anobvisa mitochondria isina kushanda zvakanaka kubva mumasero. Nekukurudzira mitophagy, urolithin A inobatsira mukuvandudzwa nekuvandudzwa kwetsandanyama, nokudaro ichivandudza mashandiro etsandanyama uye kuderedza kupera kwetsandanyama kunokonzerwa nekukwegura. Kugona uku kunoshamisa kweurolithin A kunovhura nzira yekurapa kuderedza chirwere chetsandanyama nekuvandudza simba remuviri.
2. Hunhu hwekudzivirira kuzvimba
Kuzvimba kunoita basa guru mukukura kwezvirwere zvakasiyana-siyana zvisingaperi, zvakaita sezvirwere zvemwoyo, zvirwere zvinokanganisa tsinga, uye kunyange mamwe marudzi ekenza. Urolithin A yakawanikwa ine simba rekudzivirira kuzvimba rinobatsira kurwisa kuzvimba padanho remasero. Nekuderedza huwandu hwemamorekuru anokonzera kuzvimba, urolithin A inobatsira kuchengetedza mhinduro yakaringana yekuzvimba, iyo yakakosha pakudzivirira nekutarisira zvirwere zvisingaperi.
3. Basa rakasimba rekudzivirira muviri
Kushushikana kwe oxidative, kunokonzerwa nekusawirirana pakati pe free radicals uye antioxidants mumiviri yedu, kunogona kukonzera kukuvara kwemasero uye kubatsira mukukura kwezvirwere zvakasiyana-siyana, kusanganisira izvo zvine chekuita nekukwegura. Urolithin A iantioxidant ine simba yechisikigo inobvisa free radicals inokuvadza uye inodzivirira masero edu kubva mukukuvadzwa kwe oxidative. Nekuisa urolithin A mukudya kwedu kana mukudya kwedu, tinogona kusimudzira dziviriro yemuviri wedu ye antioxidant uye kukurudzira kukwegura kwakanaka.
4. Chinosimudzira Hutano hweMatumbu
Mumakore achangopfuura, hutachiona hwemudumbu hwave kutariswa zvakanyanya nekuda kwemhedzisiro yahwo pahutano hwedu hwese uye kugara zvakanaka. Urolithin A inoita basa rakasiyana muhutano hwemudumbu nekusarudza mhando dzebhakitiriya dziri mudumbu. Inoshandurwa kuita chimiro chinoshanda nemabhakitiriya aya, nokudaro ichisimudzira kusimba kwemudumbu uye hutano hwemudumbu hwese. Pamusoro pezvo, tsvakiridzo yazvino inoratidza kuti urolithin A inogona kuwedzera kugadzirwa kwemafuta madiki, ayo anopa simba rinokosha kumasero ari mukati medumbu uye anotsigira nharaunda ine hutano mudumbu.
5. Migumisiro ye urolithin A inodzivirira kukwegura
(1) Kuvandudza hutano hwemitochondria: Mitochondria ndiyo sosi yesimba remasero edu uye ine basa rekugadzira simba. Sezvatinokura, kushanda zvakanaka kwemitochondria kunoderera. Urolithin A yakaratidzwa kuti inomutsa nzira chaiyo yemitochondria inonzi mitophagy, iyo inobvisa mitochondria yakakuvara uye inokurudzira kugadzirwa kwemitochondria itsva, ine hutano. Kudzorerwa kwehutano hwemitochondria kunogona kuvandudza kugadzirwa kwesimba uye simba rose.
(2) Kuvandudza autophagy: Autophagy inzira yekuzvichenesa yega masero umo zvikamu zvakakuvara kana zvisina kushanda zvakanaka zvinodzokororwa uye zvinobviswa. Mumasero ekukwegura, maitiro aya anononoka, zvichikonzera kuunganidzwa kwemarara emasero anokuvadza. Tsvagiridzo yakawana kuti urolithin A inogona kuwedzera autophagy, nokudaro ichichenesa masero zvinobudirira uye ichisimudzira hupenyu hwemasero.
Mubvunzo: Mishonga yekudzivirira kukwegura yakachengeteka here?
A: Kazhinji, mishonga yekudzivirira kukwegura inoonekwa seyakachengeteka kana ikatorwa maererano nemirairo inokurudzirwa yemuyero. Zvisinei, zvakakosha kubvunza nyanzvi yehutano usati watanga mishonga mitsva yekuwedzera muitiro wako, kunyanya kana uine zvimwe zvirwere kana kuti uri kutora mishonga yakanyorerwa nachiremba.
Mubvunzo: Zvinotora nguva yakareba sei kuti mishonga yekudzivirira kukwegura iratidze mhedzisiro?
A: Nguva yemhedzisiro inoonekwa inogona kusiyana zvichienderana nemunhu uye chinwiwa chiri kushandiswa. Kunyange hazvo vamwe vanhu vangatanga kuona kuvandudzwa mukati memavhiki mashoma, vamwe vangada nguva yakareba yekushandiswa nguva dzose vasati vaona shanduko huru muhutano hwavo nechitarisiko.
Chiziviso: Chinyorwa ichi ndecheruzivo rwese chete uye hachifanirwe kutorwa semazano ekurapa. Mamwe emashoko eblog anobva paInternet uye haasi ehunyanzvi. Iyi webhusaiti ine basa rekugadzirisa, kuronga nekugadzirisa zvinyorwa chete. Chinangwa chekutumira rumwe ruzivo hazvirevi kuti unobvumirana nemaonero ayo kana kusimbisa chokwadi chezviri mukati mayo. Gara uchibvunza nyanzvi yehutano usati washandisa chero mishonga yekuwedzera kana kuita shanduko kuhurongwa hwako hwehutano.
Nguva yekutumira: Zvita-04-2023
