Sezvatinokura, miviri yedu inowanzopfuura kuburikidza nekuchinja kwakasiyana-siyana kunogona kukanganisa hutano hwedu hwose uye kugara zvakanaka. Chimwe chezviratidzo zvinonyanya kuoneka zvekuchembera ndiko kukura kwemakwinya, mitsetse yakanaka, uye ganda rinonyura. Kunyange zvazvo pasina nzira yokumisa nayo kuchembera, vatsvakurudzi vave vachishanda nesimba kuti vawane mishonga inogona kunonoka kana kutoita kuti zvimwe zvinokonzerwa nokukwegura. Urolithin A ndeimwe yemakomboni anoratidza vimbiso huru panyaya iyi. Tsvagiridzo ichangoburwa inoratidza kuti urolithin A inogona kuvandudza mhasuru kushanda uye kutsungirira, kuwedzera mitochondrial basa, uye kunyange kukurudzira kubviswa kweakakuvadzwa masero emasero kuburikidza nemaitiro anonzi autophagy. Izvi zvinoita kuti urolithin A ive mumiriri anovimbisa wekuvandudzwa kwemishonga inorwisa kuchembera. Pamusoro pemhedzisiro yayo yekurwisa kuchembera, urolithin A yakadzidzwa nekuda kwebasa rayo rekusimudzira hupenyu hurefu.
Tisati tanyura mune zvinogona kurwisa kuchembera mhedzisiro yeurolithin A, ngatitangei kunzwisisa kuti kuchembera chii. Kuchembera inzira yakaoma inosanganisira kuderera zvishoma nezvishoma kwesero basa uye kuunganidzwa kwekukuvara kwemasero nekufamba kwenguva. Kuita uku kunokonzerwa nezvakasiyana zvinosanganisira genetics, mararamiro, uye kuratidzwa kwezvakatipoteredza. Kutsvaga nzira dzekudzikisa kana kudzosera maitiro aya chave chiri chinangwa chenguva refu mukutsvaga kwekuchembera.
Urolithin A yakaratidza kumisa nzira yemaserura inonzi mitophagy, iyo ine basa rekutsvaira nekudzokorodza yakakuvara mitochondria (simba resero). Mitochondria inoita basa rakakosha mukugadzirwa kwesimba uye ndiyo hombe sosi yeanoshanda okisijeni marudzi (ROS), ayo anogona kukuvadza zvikamu zvemasero uye kukurumidze kuchembera. Nekusimudzira mitophagy, urolithin A inobatsira kuchengetedza hutano hwemitochondrial uye kuderedza oxidative kusagadzikana, iyo inofungidzirwa kuti inobatsira pakukwegura.
Zvidzidzo zvakawanda zvakapa mhedzisiro inovimbisa maererano nemhedzisiro yeurolithin A pakukwegura. Imwe ongororo yenematodes yakaratidza kuti urolithin A yakawedzera hupenyu hwema nematodes kusvika 45%. Migumisiro yakafanana yakaonekwa mune zvidzidzo pamakonzo, uko kuwedzera neurolithin A kwakawedzera mararamiro avo akaenzana uye kwakavandudza hutano hwavo hwose. Izvi zvakawanikwa zvinoratidza kuti urolithin A ine mukana wekudzikisa kuchembera uye kuwedzera hupenyu.
Pamusoro pemhedzisiro yayo pahupenyu, urolithin A inewo zvinokatyamadza mhedzisiro pahutano hwemhasuru. Kukwegura kunowanzobatanidzwa nekurasikirwa kwemasuru uye kuderera kwesimba, chirwere chinonzi sarcopenia. Vatsvakurudzi vakaona kuti urolithin A inogona kukurudzira kukura kwemhasuru uye kuwedzera simba remhasuru. Muchiedzo chekiriniki chinosanganisira vanhu vakuru, urolithin A supplementation yakawedzera mhasuru uye kuvandudza kushanda kwemuviri. Izvi zvakawanikwa zvinoratidza kuti urolithin A haingove nemhedzisiro yekuchembera chete asiwo ine mabhenefiti ehutano hwetsandanyama, kunyanya kune vakwegura.
Pamusoro pezvo, zvakakosha kutaura kuti urolithin A inotorwa mumapomegraneti, asi huwandu hweurolithin A mumapomegranate zvigadzirwa hunogona kusiyana zvakanyanya. Naizvozvo, makomisheni ekugadzira anova sarudzo yakanaka uye akanyanya kuchena uye nyore kuwana.
Urolithin A inotorwa kubva ku ellagitannins, iyo inowanzowanikwa mune mimwe michero nenzungu. Aya ellagitannins anogadziriswa nemabhakitiriya emudumbu kuti abudise urolithin A uye mamwe metabolites. Kana yangobatwa, urolithin A inokanganisa muviri paserura.
Imwe yemabhenefiti akakosha eurolithin A kugona kwayo kukurudzira mitophagy, maitiro akakosha kune hutano hweserura. Mitochondria inowanzonzi inzvimbo dzesimba dzesero uye inoita basa rakakosha mukugadzira simba. Nekudaro, isu patinenge tichikura, kushanda kwemitochondrial kunodzikira, zvichikonzera kusashanda zvakanaka kwesero uye zvichigona kukura kwezvirwere zvakasiyana-siyana zvine chekuita nezera.
Mitophagy inzira yakakosha yekubvisa mitochondria yakakuvara uye isina kushanda, ichibvumira mitochondria mitsva, ine hutano kuvatsiva. Urolithin A yakaratidzwa kufambisa maitiro aya, kusimudzira mitochondrial kuchinja uye kuwedzera hutano hweserura. Nekubvisa mitochondria isingashande, urolithin A inononoka kuchembera uye inoderedza njodzi yezvirwere zvine chekuita nezera.
Pamusoro pemigumisiro yayo pamitophagy, urolithin A inewo anti-inflammatory properties. Kuzvimba kusingagumi mutyairi mukuru wemamiriro akati wandei ehutano, kusanganisira chirwere chemoyo, kufutisa, uye neurodegenerative zvirwere. Tsvagiridzo yakawana kuti urolithin A inodzvanya mamaki ekuzvimba uye inotadzisa kugadzirwa kweanokonzeresa macomputer, nekudaro ichidzikisa njodzi yekuzvimba kusingaperi uye zvirwere zvinoenderana.
Uyezve, urolithin A yakaratidza kugona kwayo se antioxidant ine simba. Oxidative stress inokonzerwa nekusaenzana pakati pekugadzirwa kwemahara radicals uye kugona kwemuviri kudzimisa, uye inoita basa rakakosha mukuchembera uye kukura kwezvirwere zvakasiyana. Urolithin A inogona kubvisa zvinokuvadza zvemahara radicals, kuwedzera simba rekudzivirira antioxidant remuviri, kudzivirira maseru kubva mukukuvadzwa kweoxidative, uye inogona kunonoka kuchembera.
Tsvagiridzo inoratidzawo mabhenefiti angangove eurolithin A kune hutano hwemhasuru uye kuita kwemitambo. Kuchembera kunowanzo kuperekedzwa nekuderera kwemhasuru uye simba, zvichikonzera kuwedzera kwengozi yekudonha, kuputsika, uye kurasikirwa kwekuzvimirira. Urolithin A yakaratidzwa kuwedzera tsandanyama faibha synthesis uye kuvandudza tsandanyama basa, zvinogona kuderedza zera-ane mhasuru kurasikirwa.
Pamusoro pezvo, urolithin A yakawanikwa ichiwedzera kurovedza muviri nekukurudzira kugadzirwa kwemapuroteni anobatanidzwa mukukura kwemhasuru uye kugadzirisa. Nekutsigira hutano hwemhasuru uye kuita kwemitambo, urolithin A inogona kubatsira kuchengetedza hupenyu hunoshanda uye hwakazvimirira patinenge tichikura.
● Kurudzira utano hwematumbo
Kuti tigone kusimudzira kugadzirwa kweUrolithin A mumiviri yedu, kugadzirisa hutano hwedu hwematumbo ndiko kwakakosha. Iyo yakasiyana-siyana uye inobudirira gut microbiome inogonesa kushandurwa kwakanaka kwe ellagitannins kuita urolithin A. Kudya chikafu chine fiber chinosanganisira michero, miriwo, zviyo zvakakwana, uye nyemba zvinovaka muviri unobatsira mabhakitiriya uye zvinogadzira nharaunda inokodzera kugadzirwa kweurolithin A.
● Urolithin A muzvokudya
Pomegranate ndeimwe yemhando dzakapfuma dze urolithin A. Muchero pachawo une precursor ellagitannins, iyo inoshandurwa kuita urolithin A nehutachiona hwemukati panguva yekugaya. Muto wepomegranate wakawanikwa uine huwandu hwakanyanya hweurolithin A uye inoonekwa seyakanakisa sarudzo yekuwana iyi komputa pachayo. Kunwa girazi repomegranate muto zuva nezuva kana kuwedzera mapomegraneti matsva pakudya kwako kunogona kubatsira kuwedzera yako urolithin A kutora.
Imwe muchero ine urolithin A is strawberries, iyo yakapfuma mu ellagic acid. Zvakafanana nematamba, sitiroberi ine ellagitannins, iyo inoshandurwa kuita urolithin A nemabhakitiriya emudumbu. Kuwedzera mastrawberries pakudya kwako, kuashandira sechikafu, kana kuwedzera kune ako masmoothies inzira dzinonaka dzekuwedzera urolithin A yako mazinga.
Mukuwedzera kune michero, mamwe nuts anewo ellagitannins, iyo inogona kunge yakave yakasikwa yeurolithin A. Walnuts, kunyanya, yakawanikwa ine yakawanda ye ellagitannins, iyo inogona kuchinjwa kuva urolithin A mumatumbo. Kuwedzera hushoma hwema walnuts pakudya kwako kwezuva nezuva hakuna kunaka kune hutano hwako hwese, asiwo nekutora urolithin A zvakasununguka.
● Zvokudya zvinovaka muviri uye urolithin A inotorwa
Kune avo vari kutsvaga yakawedzera yakanamirwa, yakavimbika dhizeti yeurolithin A, zvinovaka muviri zvinowedzera uye zvakatorwa zvingave sarudzo. Kufambira mberi mukutsvagisa kwaita kuti pave nekugadzirwa kwezvemhando yepamusoro-soro zvakatorwa kubva mupomegraneti yakanyatsogadzirwa kuti ipe huwandu hwakakwana hweurolithin A. Zvisineyi, zvakakosha kuti usarudze chiziviso chine mukurumbira uye chinozivikanwa kuti uve nechokwadi chemhando yechigadzirwa uye kuchengetedzwa.
● Nguva uye zvinhu zvomunhu oga
Checherechedzo, shanduko ye ellagitannins kuita urolithin A inosiyana pakati pevanhu, zvichienderana nekwavo gut microbiota kuumbwa uye genetic makeup. Naizvozvo, nguva inodiwa kuti uone kubatsirwa kwakakosha kubva kuurolithin A kushandiswa kunogona kusiyana. Kushivirira uye kusimba kwakakosha kana uchibatanidza urolithin A-yakapfuma chikafu kana ma supplements mumaitiro ako ezuva nezuva. Kupa muviri wako nguva yekuchinja uye kuwana mwero kuchakubatsira iwe kukohwa mibairo yeiyi komputa inoshamisa.
Myland inyanzvi yehupenyu hwesainzi yekuwedzera, tsika inosanganisa uye yekugadzira masevhisi kambani inogadzira uye inopa huwandu hwakasiyana hwezvekudya zvinovaka muviri zvine hunhu hunoenderana uye kukura kwakasimba kwehutano hwevanhu. Urolithin A yekuwedzera inogadzirwa ne myland:
(1) Kuchena kwepamusoro: Urolithin A inogona kuve yakakwira-kuchena chigadzirwa kuburikidza neakasikwa kudhirowa uye kunatsa maitiro ekugadzira. Kuchena kwepamusoro kunoreva zvirinani bioavailability uye kushoma kwakashata maitiro.
(2) Chengetedzo: Urolithin A chigadzirwa chechisikigo chakaonekwa kuti chakachengeteka kumuviri wemunhu. Mukati meyero renji, hapana chepfu mhedzisiro.
(3) Kugadzikana: Urolithin A ine kugadzikana kwakanaka uye inogona kuchengetedza basa rayo nekuita pasi pemamiriro akasiyana-siyana uye kuchengetedza mamiriro.
(4) Zviri nyore kutora: Urolithin A inogona kukurumidza kubatwa nemuviri wemunhu, inopinda muropa rekutenderera kuburikidza nematumbo, uye inogoverwa kune zvakasiyana-siyana uye nhengo.
1. Wedzera hutano hwetsandanyama
Urolithin A ine mukana mukuru mumunda wehutano hwemhasuru. Tsvagiridzo inoratidza kuti ine simba activator ye mitophagy, maitiro echisikigo anobvisa kusashanda mitochondria kubva kumaseru. Nekukurudzira mitophagy, urolithin A inobatsira mukuvandudzwa uye kuvandudzwa kwemhasuru tishu, nekudaro inovandudza kuita kwemhasuru uye kuderedza zera-ane mhasuru atrophy. Uku kugona kunonakidza kweurolithin A kunovhura nzira yekurapa kupindira kuderedza chirwere chetsandanyama nekuvandudza simba rose remuviri.
2. Anti-inflammatory properties
Kuzvimba kunoita basa rakakosha mukukura kwezvirwere zvakasiyana siyana zvisingaperi, senge chirwere chemoyo, neurodegenerative chirwere, uye kunyangwe mamwe marudzi egomarara. Urolithin A yakawanikwa iine simba rinopesana nekuzvimba zvinhu zvinobatsira kurwisa kuzvimba padanho remasero. Nekudzikisa mazinga epro-kuzvimba mamorekuru, urolithin A inobatsira kuchengetedza yakadzikama yekuzvimba mhinduro, iyo yakakosha pakudzivirira uye kubata chirwere chisingaperi.
3. Yakasimba antioxidant basa
Oxidative kusagadzikana, kunokonzerwa nekusaenzana pakati pemahara radicals uye antioxidants mumiviri yedu, inogona kukonzera kukuvara kwesero uye inobatsira mukukura kwezvirwere zvakasiyana siyana, kusanganisira izvo zvine chekuita nekuchembera. Urolithin A ine simba yechisikigo antioxidant iyo inobvisa inokuvadza mahara radicals uye inodzivirira masero edu kubva mukukuvadzwa kweiyo oxidative. Nekuisa urolithin A mukudya kwedu kana kuwedzera regimen, tinogona kuwedzera simba remuviri wedu rinodzivirira antioxidant uye kukurudzira kuchembera kune hutano.
4. Gut Health Booster
Mumakore achangopfuura, iyo gut microbiome yakawana kutariswa kwakanyanya nekuda kwekuita kwayo pahutano hwedu hwese uye kugara zvakanaka. Urolithin A inotora basa rakasiyana muhutano hwematumbo nekusarudza yakanangana nemhando dzebhakitiriya muura. Inoshandurwa kuita fomu inoshanda neaya mabhakitiriya, nekudaro ichisimudzira intestinal barriers kutendeseka uye hutano hwese hwematumbu. Pamusoro pezvo, tsvagiridzo yechangobva kuitika inoratidza kuti urolithin A inogona kusimudzira kugadzirwa kwepfupi-cheni fatty acids, iyo inopa simba rakakosha kumaseru akatenderedza colon uye kutsigira hutano hwematumbo nharaunda.
5. Anti-kuchembera mhedzisiro yeurolithin A
(1) Kuvandudza hutano hwemitochondrial: Mitochondria ndiyo inopa simba remasero edu uye ine basa rekugadzira simba. Sezvatinokura, kushanda kwemitochondrial kunoderera. Urolithin A yakaratidza kumisa imwe mitochondrial nzira inonzi mitophagy, iyo inobvisa mitochondria yakakuvadzwa uye inosimudzira kusikwa kwemitochondria itsva, ine utano. Kudzoreredzwa kwehutano hwemitochondrial kunogona kuvandudza kugadzirwa kwesimba uye hupenyu hwese.
(2) Enhance autophagy: Autophagy inzira yekuzvichenesa sero umo zvinhu zvakakuvara kana kusashanda zvinodzokororwa uye kubviswa. Mumasero ekuchembera, kuita uku kunowedzera kunonoka, zvichiita kuti kuunganidzwa kwemarara anokuvadza emasero. Tsvagiridzo yakawana kuti urolithin A inogona kuwedzera autophagy, nekudaro kuchenesa masero nekusimudzira hupenyu hurefu hwesero.
Mubvunzo: Zvinorwisa-kuchembera zvinowedzera zvakachengeteka here?
A: Kazhinji, anti-kuchembera zvinowedzera zvinoonekwa zvakachengeteka kana zvakatorwa mukati meinokurudzirwa dosage nhungamiro. Nekudaro, zvakakosha kubvunzana nenyanzvi yezvehutano usati waunza chero mitsva yekuwedzera muhurongwa hwako, kunyanya kana uine chero mamiriro ekurapa ari pasi pemamiriro ehutano kana uri kutora mishonga yekurapa.
Mubvunzo: Zvinotora nguva yakareba sei kuti anti-aging supplements kuratidza mhinduro?
A: Nguva yakatarwa yemhedzisiro inooneka inogona kusiyana zvichienderana nemunhu uye chaiyo yekuwedzera iri kushandiswa. Kunyange zvazvo vamwe vanhu vangatanga kuona kuvandudzwa mukati memavhiki mashomanana, vamwe vangada nguva yakareba yekushandiswa nguva dzose vasati vaona kuchinja kukuru muhutano hwavo hwose uye chitarisiko.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Zvita-04-2023
