Mumakore achangopfuura, kwave kuri kukura kufarira mune zvakasikwa komisheni izvo zvinogona kuwedzera hutano hwese uye kugara zvakanaka.Urolithin A uye urolithin B zvinhu zviviri zvechisikigo zvakatorwa kubva ku ellagitannins inowanikwa mune mimwe michero nenzungu.Yavo inorwisa-kuzvimba, antioxidant, uye mhasuru-kuvaka zvivakwa zvinovaita zvinonakidza makomisheni ekusimudzira hutano hwese.Kunyangwe urolithin A uye urolithin B zvine hukama zvivakwa, ivo vanewo mimwe misiyano yakakosha.
Urolithin A uye B mametabolites anogadzirwa mukati memuviri wemunhu semugumisiro wekugayiwa kwezvimwe zvikamu zvekudya, kunyanya ellagitannins.Ellagitannins iripo mumichero yakasiyana-siyana uye nzungu, kusanganisira matamba, sitirobheri, raspberries, blackberries, uye walnuts.Nekudaro, chikamu chidiki chete chevanhu chine mabhakitiriya emudumbu anokwanisa kushandura ellagitannins kuita urolithins, zvichiita kuti mazinga eurolithin muvanhu asiyana zvakanyanya.
Kune avo vane dambudziko rekuzadzisa zvido zvavo zve magnesium kuburikidza nekudya chete, magnesium supplements inogona kubatsira hutano munzira dzinoverengeka uye kuuya mumhando dzakadai semagnesium oxide, magnesium threonate, magnesium taurate, uye magnesium glycinate.Nekudaro, zvinokurudzirwa kubvunza nyanzvi yezvehutano usati watanga chero chirongwa chekuwedzera kudzivirira kusanganisa kunogona kuitika kana matambudziko.
Urolithin A ndiyo molecule yakawanda kwazvo mumhuri yeurolithin, uye iyo antioxidant uye anti-inflammatory properties yakanyatsodzidza.Zvidzidzo zvakaratidza kuti urolithin A inogona kuvandudza mitochondrial basa uye kudzivirira kukuvara kwemhasuru.Pamusoro pezvo, zvidzidzo zvakaratidza kuti urolithin A inogona kutadzisa kuwanda kwesero uye kukonzeresa kufa kwesero mumhando dzakasiyana dzekenza maseru.
Urolithin B yakakwezva kutarisisa kwevaongorori nekugona kwayo kuvandudza hutano hwematumbo uye kuderedza kuzvimba.Tsvagiridzo inoratidza kuti urolithin B inogona kuwedzera gut microbial siyana uye kuderedza pro-inflammatory cytokines senge interleukin-6 uye tumor necrosis factor alpha.Pamusoro pezvo, urolithin B yakawanikwa iine zvingangoita neuroprotective properties, nezvidzidzo zvinotaridza kuti inogona kubatsira kudzivirira zvirwere zveurourodegenerative zvakaita seParkinson neAlzheimer's.
Kunyangwe urolithin A uye urolithin B zvine hukama, vane mimwe misiyano yakakosha.Semuenzaniso, urolithin A yakaratidza kuti inoshanda zvakanyanya se-anti-inflammatory uye antioxidant kupfuura urolithin B. Urolithin B, kune rumwe rutivi, yakawanikwa ichibudirira mukudzivirira matambudziko ane chokuita nekufutisa, zvakadai se insulin resistance uye adipocyte. kusiyana.
Maitiro ekuita kweurolithin A uye urolithin B akasiyana zvakare.Urolithin A inomutsa peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) nzira, iyo inobata basa mumitochondrial biogenesis, nepo urolithin B inowedzera AMP-activated protein kinase (AMPK) nzira, iyo inobatanidzwa musimba reimbaostasis.Idzi nzira dzinobatsira kune hutano hunobatsira hwemakomponi aya.
●Anti-inflammatory Properties
Chirwere chisingaperi chinozivikanwa kuti chinokonzera zvirwere zvakawanda.Urolithin A yakaratidzwa kuve ine simba rekurwisa-kuzvimba zvivakwa, ichidzikisa kugadzirwa kwemamorekuru ekuputika.Nekudzvinyirira kuzvimba, zvinogona kubatsira kubata akasiyana asingaperi mamiriro akadai searthritis, chirwere chemoyo, uye mamwe marudzi egomarara.
●Utano Hwetsandanyama uye Simba
Sezvo isu tichikura, skeletal tsandanyama kurasikirwa kunova kunetseka kukuru.Urolithin A yakawanikwa inokurudzira masero emhasuru uye kuwedzera kushanda kwemhasuru, kusimudzira hutano hwemhasuru nesimba.Izvi zvine vimbiso kune vanhu vari kutsvaga kuchengetedza tsandanyama uye kurwisa kuderera kwemhasuru dzine chekuita nezera.
●Mitochondrial Hutano uye Hurefu Hwehupenyu
Urolithin A inoratidza akasimba mhedzisiro pamitochondria, inowanzonzi idzimba dzemagetsi emasero edu.Inotanga nzira inonzi mitophagy, iyo inosanganisira kubviswa kwakasarudzwa kwemitochondria yakakuvadzwa.Nekusimudzira hutano hwemitochondrial basa, urolithin A inogona kubatsira mukurarama kwenguva refu uye kudzivirira kubva kumamiriro ane hukama nezera senge neurodegenerative zvirwere.
●Antioxidant Chiito
Urolithin B ine simba antioxidant iyo inobatsira kuderedza inokuvadza mahara radicals mumuviri.Mahara radicals anonyanya kuita mamorekuru anogona kubatsira mukukuvadzwa kwesero uye oxidative kusagadzikana, kunokonzerwa nezvirwere zvakasiyana.Urolithin B's antioxidant chiitiko inobatsira kuchengetedza maseru edu kubva mukukuvadzwa kwakadaro uye inogona kuderedza njodzi yezvirwere zvisingaperi.
●Gut Hutano uye Microbiome Modulation
Ura hwedu hunoita basa rakakosha muhutano hwedu hwese, uye urolithin B yakabuda semutambi akakosha mukuchengetedza hutano hwegut microbiome.Inokurudzira kukura kwebeneficial mabhakitiriya uye inhibits kukura kwebhakitiriya inokuvadza, nekudaro ichisimudzira yakaenzana microbial nharaunda.Iyo yakakwana gut microbiome inosanganiswa nekuvandudza kugaya, immune immune, uye hutano hwepfungwa.
●Kurudzira hutano hwemhasuru
Urolithin B yakaratidza kukurudzira mitochondrial autophagy, cellular process inobatsira kubvisa yakakuvadzwa mitochondria kubva kumasero.Iyi nzira inobatsira kuvandudza hutano hwemhasuru uye basa, zvichiita kuti ive yekuwedzera kune avo vari kutsvaga kuvandudza kuita kwemuviri.Imwe ongororo yakawana kuti urolithin B inovandudza tsandanyama basa uye simba mumakonzo nevanhu.
Urolithins inogadzirwa mumiviri yedu mushure mekudya zvimwe zvekudya zvine ellagitannins.
a)Matamba
Mapomegranati ndeimwe yeakapfuma ekudya masosi ellagitannins, ayo anoshandurwa kuita urolithin A uye urolithin B nemabhakitiriya emudumbu.Kushandisa muchero wepomegranate, muto, kana zvimedu zvinogona kuwedzera kudya kwako kweaya makomisheni ane simba, kuwedzera hutano hweserura uye kuita anti-kuzvimba mhedzisiro.
b) Zvibereko
Zvibereko zvakasiyana-siyana zvakadai semastrawberries, raspberries, uye mablackberries ane huwandu hwakawanda hwe ellagitannins.Zvidzidzo zvakaratidza kuti kudya michero ine simba iyi inosimudzira kugadzirwa kweurolithin A uye urolithin B mumatumbu.Kuwedzera mabheri pakudya kwako hakungokwidziri kunaka chete asiwo kunopa hutano hwenguva refu hunobatsira.
c) Nzungu
Nzungu, kunyanya walnuts uye pecans, dzakapfuma sosi ellagitannins.Pamusoro pezvo, ivo vakazara nemafuta ane hutano, fiber, uye zvimwe zvakakosha zvinovaka muviri.Kusanganisira nzungu mukudya kwako kwezuva nezuva hakungope urolithin A uye B chete asiwo kunopa hutano hwakasiyana-siyana hwemoyo, uropi, uye kugara zvakanaka.
d) Mazambiringa ane makore Oak
Kunyangwe zvingauya sechikatyamadzo, kunwa zvine mwero kwewaini tsvuku ine muoki kunogonawo kubatsira mukugadzirwa kweurolithin.Mishonga iripo mumabhodhoro emuouki anoshandiswa kuchembera waini inogona kutorwa panguva yekuchembera, ichipinza waini ne ellagitannins.Zvisinei, zvakakosha kuyeuka kuti kunwa doro zvakanyanya kune hutano husina kunaka, saka kuenzanisa kunokosha.
e) Ellagitannin-yakapfuma zvinomera
Padivi pemapomegranati, zvimwe zvinomera zvakaita semuouki bark, sitiroberi, uye mashizha emuoki zvakangowanikwa zvakawanda mu ellagitannins.Kubatanidza zvidyarwa izvi mukudya kwako kunogona kubatsira kuwedzera mazinga eurolithin A uye urolithin B mumuviri wako, kutsigira hutano hweserura uye kugadzirisa hutano hwese.
Kubatanidzaurolithin A uye B mumararamiro ako, imwe nzira iri nyore ndeyekudya chikafu chakapfuma mu ellagitannins.Matamba, mastrawberries, raspberries, uye walnuts ndiwo akanakisa sosi.
Zvisinei, zvakakosha kuziva kuti ellagitannin content inosiyana mukati memichero imwe neimwe, uye havasi vose vane gut microbiota imwechete inokwanisa kushandura ellagitannins kuita urolithins.Naizvozvo, vamwe vanhu vanogona kusanyatso gadzira urolithin kubva kune aya ekudya masosi.ma supplements ndiyo imwe sarudzo yekuve nechokwadi chekudya kwakakwana kweurolithin A uye B.
Mubvunzo: Urolithin A uye Urolithin B inosimudzira sei hutano hwemitochondrial?
A: Urolithin A uye Urolithin B inomisa cellular nzira inonzi mitophagy, iyo ine basa rekubvisa yakakuvadzwa mitochondria kubva kumaseru.Nekusimudzira mitophagy, makomisheni aya anobatsira kuchengetedza hutano hwemitochondrial huwandu, hwakakosha pakugadzira simba uye kuita kwesero cellular.
Mubvunzo: Urolithin A uye Urolithin B inogona kuwanikwa kuburikidza nekuwedzera?
A: Ehe, Urolithin A uye Urolithin B yekuwedzera inowanikwa mumusika.Nekudaro, zvakakosha kuti uzive kuti kushanda uye kuchengetedzeka kweizvi zvinowedzera zvinogona kusiyana.Zvinokurudzirwa kuonana nenyanzvi yezvehutano usati watanga chero chikafu chitsva chekuwedzera.
Disclaimer: Ichi chinyorwa ndechezvinangwa zveruzivo chete uye hachifanirwe kutorwa sezano rekurapa.Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kushandura hutano hwehutano hwako.
Nguva yekutumira: Sep-13-2023
