Kuzarura Maitiro Azvino muAlpha GPC Zvekuwedzera zve2024

Choline Alfoscerate,inozivikanwawo seAlpha-GPC, chinhu chakatorwa kubva muchirimwa lecithin, asi haisi phospholipid, asi phospholipid inotorwa kubva kuLipophilic fatty acid zvinhu. Alpha-GPC chikafu chinoshanda chinowanikwa mumasero ese emammalian. Nekuti yakanyanya hydrophilic, inokurumidza kubatwa mushure mekutonga nemuromo. GPC inotangira acetylcholine (ACh) uye inobata chivimbiso chikuru mukusashanda kwecholine.

GPC inoyambuka chivharo cheropa-uropi uye inopa sosi yecholine ye biosynthesis ye ACh uye phosphatidylcholine. Phospholipids uye acetylcholine, kana yawanikwa pamazinga akanyanya, inosimudzira hutano hwekuziva, hwepfungwa uye hwehuropi. Mukuwedzera, kuenzana kwakaenzana kweAlpha-GPC neAch kunogona kukurudzira maitiro ehupenyu nekuvandudza kushanda kwemuviri. ACh inotora chikamu mukugadzirisa tsandanyama uye ndiyo huru yeurotransmitter inodzora mhinduro dzemuviri pakuita maekisesaizi.

Sezvo kufamba kwemhasuru kwese kwakabatana nekumisikidza, uye chibvumirano chine hukama neiyo inowanikwa cellular ACh concentration, kuwedzera ACh mazinga anogadzirisa kuita kwemhasuru. Kuenzaniswa nezvimwe zvakajairika choline precursors, Alpha-GPC zvakachengeteka uye zvinobudirira inowedzera choline mazinga muropa neuropi. Ongororo dzakawanda dzakasimbisa mabhenefiti akasiyana-siyana eAlpha-GPC uye akataura kuti kuwedzera kwemuromo kunogona kuita basa rakakosha mukusimudzira basa retsinga, kuita kwemuviri, nekuvandudza ndangariro.

Alpha-GPC kushanda zvakanaka

Wedzera simba rehuropi

Kuwanda kwenhamba yemasero etsinga muuropi, kusimba kwesimba radzo, kukurumidza kwaanoita kutumira masaini etsinga, uye kusimba kwesimba rekugadzirisa uropi. Alpha-GPC inogona kunyatsonatsiridza huropi hunoshanda nekusimudzira simba remasero etsinga uye kugona kutapurirana kwezviratidzo zvetsinga. Panyaya yekusimudzira cholinergic neurotransmission, kutapurirana kwechiratidzo pakati pemasero etsinga kunovimba nekufambiswa kwemaurotransmitters, uye acetylcholine chinhu chakakosha chemakemikari messenger uye neurotransmitter inovimbisa kushingaira kufunga uye kuchengetedza kubatana pakati pehuropi nemuviri wese. Alpha-GPC inogona kuderedzwa kuita 3-glycerol phosphate uye choline muuropi uye ndiyo inonyanya kugovera acetylcholine. Inogona kuwedzera ndangariro nekuvandudza kufunga nekusimudzira synthesis uye kuburitswa kweacetylcholine muuropi. Panyaya yekusimudzira kugadzikana uye kunyunguduka kwemasero membranes, Alpha-GPC inogona kukurudzira kuumbwa kwephosphoinositide, nekudaro ichiwedzera kugadzikana uye fluidity yemasero membranes. MaNeuroni ane chimiro chakazara anogona kufambisa zvirinani ruzivo nekuvandudza kugona kwemuviri kufunga. Shandisa.

Chengetedza tsinga

Izvo zvinokura zvinhu zvetsinga yetsinga, zvinoti neurotrophic factor, inogona kudzora stem cell kusiyanisa uye kukurudzira kuumbwa kwetsva neural connections. Alpha-GPC inogona kukurudzira kuvanzika kwezvinhu zvakasiyana-siyana zveurourotrophic uye kushandura nzira dzechiratidzo dzine chokuita nekupona kwesero, nokudaro zvichiita neuroprotective effect. Kuvandudza danho rekuziva kwemuviri. Panguva imwecheteyo, Alpha-GPC inogonawo kukurudzira kugadzirwa kwehomoni yekukura uye kuchengetedza hutano hwemuviri nekuwedzera kukura kwehomoni yemuviri.

Antioxidant

Oxidation uye kuzvimba ndizvo zvinokonzeresa kuchembera kwemasero europi uye kufa. Alpha-GPC inogona kutsvaira mahara radicals mumuviri, kurwisa oxidative kusagadzikana, uye inogona zvakare kuderedza kuzvimba senge nuclear factor NF-κB, tumor necrosis factor TNF-α, uye interleukin IL-6. Kuburitswa kwezvinhu kunopesana nekuzvimba kwehuropi, nekudaro zvakanyanya kudzoreredza kuderera kwekuziva basa uye kudzivirira kuitika uye kukura kwezvirwere zveurourodegenerative. Migumisiro yakakodzera yakatsigirwa nemigumisiro yekliniki.

Muchidzidzo "The Effect of Alpha-GPC on Age-Related Memory Impairment", 4 zvidzidzo zvakapiwa placebo, uye zvimwe zvidzidzo zve 5 zvakapiwa Alpha-GPC (1200 mg / zuva), mushure mekuenderera mberi kwekutonga kwemuromo kwemwedzi ye3, 16. ma electrode akashandiswa kurekodha masaisai ehuropi kwemaminetsi e5 apo vanhu vaive vakamuka uye vachizorora. Mhedzisiro yacho yakaratidza kuti kana ichienzaniswa ne placebo, Alpha-GPC yakakwanisa kuwedzera zvakanyanya chikamu chemafungu ehuropi anokurumidza, uku iine tsika yekudzikisa inononoka ma frequency. Ndiko kuti, inogona kuwedzera simba rehuropi hwevanhu vepakati uye kunonoka kuchembera kwemuviri.

Dzora manzwiro

Dopamine inogona kuita kuti vanhu vanzwe kufara, uye serotonin uye gamma-aminobutyric acid inogona kugadzirisa mafungiro emuviri. Alpha-GPC inogona kukurudzira kusunungurwa kwe dopamine, up-regulate kutaura kwedopamine transporters, kunatsiridza dopamine neurotransmission muuropi, uye kuwedzera mazinga e serotonin mu striatum uye prefrontal cortex; inogonawo kukurudzira zvakanyanya γ- Kusunungurwa kweaminobutyric acid kunobvisa kushaya hope, nokudaro kunoshandisa anti-depressant, kuzvidya mwoyo uye kugadzirisa mafungiro.

Mukuwedzera, Alpha-GPC inoratidzika kunge inokwanisa kuwedzera kubatwa kwesimbi isiri-heme muzvokudya, zvakafanana nemigumisiro yevhitamini C pachiyero che 2: 1 nesimbi, saka Alpha-GPC inofungidzirwa kuva, kana pa. zvishoma zvinobatsira, kuvandudzwa kwezvigadzirwa zvenyama. Phenomenon yenonheme iron absorption. Pamusoro pezvo, kuwedzera neAlpha-GPC kunogona kubatsirawo kupisa mafuta uye kutsigira lipid metabolism. Izvi zvinokonzerwa nebasa recholine se lipophilic nutrient. Hutano mazinga echikafu ichi anovimbisa kuti mafuta acids anowanikwa kune cell mitochondria, iyo inogona kushandura mafuta aya kuita ATP kana simba.

Regulatory updates

Alpha GPC yanga ichishandiswa kweanopfuura makore gumi. Parizvino, Alpha GPC chinhu chitsva chekudya muJapan uye chinowanzoshandiswa mukugadzira chikafu chinoshanda. Pamusoro pezvo, United States, Canada, Switzerland nedzimwe nyika dzakatevedzana dzakabvumidza kana kubvumidza Alpha GPC kuti iwedzere kuchikafu mushure meJapan. MuUnited States, Alpha GPC inodzorwa seChinhu Chinozivikanwa SeYakachengeteka (GRAS). MuCanada, Alpha GPC inotenderwa sechisikigo chehutano chigadzirwa.

Misika yekushandisa uye maitiro echigadzirwa

Tichifunga nezve data isina kukwana pamusoro pekuchengetedzwa kweAlpha GPC mucheche, vakadzi vane pamuviri, uye vakadzi vanoyamwisa, zvichienderana nenheyo yekudzivirira njodzi, mapoka ari pamusoro apa haafaniri kuidya, uye chinyorwa nemirayiridzo inofanira kuratidza boka risina kukodzera. MuUnited States, Japan, Canada nedzimwe nyika, Alpha GPC yakashandiswa zvakanyanya mukudya. Zvigadzirwa zvinoenderana zvinovhara zvekudya zvinowedzera, zvinwiwa, gummies uye mamwe mapoka, uye chimwe nechimwe chigadzirwa chine basa rakajeka uye rinokurudzirwa kushandiswa.

Nhamba uye mapoka anokurudzirwa. Semuenzaniso, muUnited States, kune zvinopfuura 300 zvekudya zvinowedzera zveAlpha GPC chete, nemigumisiro inonzi inosanganisira kuvandudza chiyeuchidzo nekuziva basa, kuvandudza kushanda kwemotokari, nezvimwewo.
Ikozvino mamiriro ekugadzira tekinoroji

Tsvagiridzo inoratidza kuti makemikari synthesis ndeimwe yemhando huru dzekugadzira nzira dzeAlpha GPC. Kushandisa polyphosphoric acid, choline chloride, R-3-chloro-1,2-propanediol, sodium hydroxide uye mvura sezvinhu zvakasvibirira, mushure mekugadzirisa uye esterification reaction, yakasvibiswa, tsvina inobviswa, yakasimbiswa, yakanatswa uye yakaomeswa. inogona kuwanikwa nemamwe maitiro. Nekudaro, echinyakare kemikari synthesis, kemikari hydrolysis, makemikari alcoholysis uye dzimwe nzira dzese dzinosangana nematambudziko sekusvibiswa kwezvakatipoteredza, kudhura kwakanyanya, uye maitiro akaomarara ekugadzirira.

Mumakore achangopfuura, kugadzirira kweAlpha GPC nenzira dzebioenzymatic kwakagamuchira kutariswa kwakanyanya. Aqueous-phase enzymatic nzira, isiri-aqueous-phase enzymatic nzira, nezvimwewo zvakaonekwa imwe mushure meimwe. Kuenzaniswa nemaitiro emakemikari, kugadzirira kweAlpha GPC nenzira dzebioenzymatic kune mamiriro ekuita zvinyoro uye maitiro akareruka. , yakakwira catalytic kunyatsoshanda uye yakakodzera kugadzirwa kwakakura kwekutengesa.

Suzhou Myland Pharm & Nutrition Inc. ndeye FDA-yakanyoreswa mugadziri inopa yepamusoro-mhando uye yakakwirira-kuchena Alpha GPC Yekuwedzera hupfu.

PaSuzhou Myland Pharm takazvipira kupa zvigadzirwa zvemhando yepamusoro nemitengo yakanakisa. Yedu Alpha GPC Supplement powder inoedzwa zvakasimba kuchena uye potency, kuve nechokwadi kuti iwe unowana yemhando yepamusoro yekuwedzera yaunogona kuvimba nayo. Kunyangwe iwe uchida kutsigira hutano hweserura, kuwedzera immune system yako kana kuwedzera hutano hwese, ourAlpha GPC Supplement poda ndiyo sarudzo yakakwana.

Iine makore makumi matatu echiitiko uye ichisundwa nehunyanzvi hwepamusoro uye akakwenenzverwa zvakanyanya R&D mazano, Suzhou Myland Pharm yakagadzira mhando yezvigadzirwa zvemakwikwi uye ive yekuvandudza hupenyu hwesainzi yekuwedzera, tsika synthesis uye kugadzira masevhisi kambani.

Uye zvakare, Suzhou Myland Pharm zvakare iri FDA-yakanyoreswa mugadziri. Zviwanikwa zvekambani zveR&D, zvivakwa zvekugadzira, uye zviridzwa zvekuongorora ndezvemazuva ano uye zvinoshanda, uye zvinogona kugadzira makemikari kubva kumamirigiramu kusvika kumatani muchiyero, uye zvinoenderana neISO 9001 zviyero uye kugadzirwa kweGMP.

Alpha GPC inozivikanwa kuve hygroscopic, zvichireva kuti inotora hunyoro kubva kumhepo yakatenderedza. Nechikonzero ichi, ma supplements anofanirwa kuchengetwa mumidziyo isina mhepo uye haifanirwe kuratidzwa kumhepo kwenguva yakareba.

Pfungwa dzekupedzisira

Alpha GPC inoshandiswa kuendesa choline kuhuropi mukati meropa-brain barriers. Iyo inotangira kune acetylcholine, neurotransmitter inosimudzira hutano hwekuziva. Alpha GPC yekuwedzera inogona kushandiswa kubatsira hutano hwako hwekuziva nekuvandudza ndangariro, kudzidza, uye kuisa pfungwa. Tsvagiridzo inoratidzawo kuti Alpha GPC inobatsira kuwedzera simba remuviri uye simba remhasuru.