Mitochondria inokosha zvikuru sesimba remasero emuviri wedu, ichipa simba guru rekuchengetedza moyo wedu uchirova, mapapu edu achifema uye miviri yedu ichishanda kuburikidza nekuvandudzwa kwezuva nezuva. Zvisinei, nekufamba kwenguva, uye nekukura, zvimiro zvedu zvinogadzira simba, mitochondria, zvinova nyore kukuvadzwa uye zvinorasikirwa nekugona kwazvo kushanda zvinobudirira. Mitochondria inoshanda zvizere inokosha kuhupenyu hwemunhu. Zvisinei, mitochondria inogonawo kukuvadzwa zvakanyanya kubva kune zvakasiyana-siyana, kusanganisira oxidative stress, kuzvimba, uye chepfu dzezvakatipoteredza. Zvinhu izvi zvinogona kukonzera kukuvara kweDNA yemitochondrial, zvichikanganisa kugona kwayo kugadzira ATP nezvimwe zvinhu zvakakosha.
Nerombo rakanaka, muviri wedu unobvisa mitochondria yakakuvara uye isina kushanda zvakanaka kubva mumasero edu kuburikidza ne mitochondrial autophagy kuitira kuchengetedza hutano hwakanaka uye kudzivirira mimwe migumisiro yakaipa yemitochondria iyi yakakuvara, zvichienderana neongororo dzinoratidza kuti maitiro e mitochondrial autophagy ane basa mukudzivirira kukwegura. Ngatinzwisisei hukama huripo pakati pemitochondria nekudzivirira kukwegura!
Ndeapi mabasa e mitochondria?
Mitochondria inhengo dzinokosha dzinogadzira simba mumasero edu. Basa radzo guru nderekugadzira adenosine triphosphate (ATP), inova ndiyo simba remasero edu. Kana tiine mitochondria yakawanda, tinogona kugadzira ATP yakawanda, izvo zvinotungamira mukuwedzera simba uye kudzikira kwekuneta. Mamwe emabasa ayo makuru ndeaya:
(1)kupa simba uye zvinhu zvinovaka muviri mumuviri
(2)Mitochondrial autophagy inoziva mitochondria yakakuvara uye inoibvisa nekusarudza, uye kubviswa kwemitochondria iyi yakakuvara kunokurudzira biosynthesis yemitochondria itsva.
(3)Inogona kuita basa rekudzivirira kufa kwemasero nekubvisa mitochondria
(4)Zvakabatana nekukura kwematambudziko akasiyana-siyana ehutano, anosanganisira chirwere chemwoyo, zvirwere zvinokanganisa mashandiro etsinga uye kunyange mamwe marudzi ekenza.
Chii chiri kubatana pakati pemitochondria nekudzivirira kukwegura?
Ongororo dzakaratidza kuti sezvatinokura, kubviswa kwemasero emumitochondrial autophagy kunokanganiswa, zvinoreva kuti masero emumitochondrial haakwanise kushanda zvakanaka. Pasina nzira dzakagadziriswa dzekudzora mhando dzakadai semitochondrial autophagy, kukuvara kwemasero kunogona kukurumidziswa.
Muzvidzidzo zvemhuka, hupenyu hurefu hwakaonekwa kana majini anodzora autophagy yemitochondrial akaonekwa, zvichiratidza kuti autophagy yemitochondrial nehupenyu hurefu zvakabatana. Pamusoro pezvo, autophagy yemitochondrial isina kunaka inowanzoonekwa muzvirwere zvakasiyana-siyana zvine chekuita nekukwegura, zvinosanganisira chirwere cheParkinson neAlzheimer, chirwere chemwoyo, nekenza, zvichiratidza kuti kupindira kunonangana ne autophagy yemitochondrial kunogona kuva nebasa mukudzivirira nekurapa zvirwere. Pakupedzisira, kiyi yekukwegura iri mukunzwisisa nekutsigira maitiro akaomarara anoita kuti muviri urambe uchishanda. Nekushanda kukurudzira autophagy ine hutano yemitochondrial uye kuita sarudzo dzemararamiro dzinoisa pamberi hutano hwedu, tinogona kuvhura zvakavanzika zvehupenyu hurefu uye hune hutano!
Nzira yekuwedzera autophagy yemitochondrial
(1)Funga nezvekuderedza kutsanya zvishoma nezvishoma uye kuderedza macalorie
Zvidzidzo zvakaratidza kuti mitochondrial autophagy inogona kukurudzirwa nemaitiro akasiyana-siyana ehupenyu. Semuenzaniso, kurovedza muviri kwakaratidzwa kuti kunowedzera mitochondrial autophagy, nokudaro zvichivandudza mashandiro emitochondrial. Pamusoro pezvo, nzira dzekudya dzakadai sekutsanya nguva nenguva kana kuderedza macalorie zvinogonawo kukurudzira mitochondrial autophagy, zvichikonzera kuwedzera kweutano hwakanaka hwemitochondria.
(2)Kurovedza muviri zvisina kurongeka
Kurovedza muviri ndiko kuri nyore uye kuri nyore kutevedzera. Kunogona kukurudzira hutano nekugara kwenguva refu pamwe nekuvandudza mashandiro emuviri pamwe nekukurudzira autophagy yemuviri, saka kurovedza muviri kunogona kurongwa zvine musoro nekudzidziswa kwesimba, aerobic uye kutsungirira kuti uwedzere autophagy yemuviri.
(3)Urolithin A imorekuru inokonzera autophagy yemitochondrial
Urolithin A imusanganiswa wemetabolite unobva pakushandurwa kwe ellagic tannins nemabhakitiriya emudumbu. Zvinotangira i ellagic acid ne ellagitannin, zvinowanikwa mumiti yakawanda inodyiwa, senge pomegranate, strawberry, raspberries, walnuts, nezvimwewo, asi kwete kuti inowanikwa muchikafu, nekuti mamwe mabhakitiriya chete ndiwo anogona kushandura ellagitannin kuita urolithin. Uye urolithin A, musanganiswa weorganic unoumbwa kubva muzvinokonzera kudya, ndicho chinhu chakaratidzwa kuti chinokonzera autophagy ye mitochondrial.
Kukosha kwe autophagy ye mitochondrial
Mitochondrial autophagy inzira yechisikigo uye inokosha inobatsira kuchengetedza mitochondria ine hutano mukati memasero edu. Maitiro aya anosanganisira kuona mitochondria yakakuvara kana kuti isina kushanda zvakanaka uye kuibvisa musero nenzira yekusarudza kuti mitochondria itsva, inoshanda, itsive. Panguva imwe chete, maitiro e mitochondrial autophagy anobatsira kuona kuti simba remuviri wedu rinoramba rakagadzikana uye kuti masero edu nenyama zvinoramba zvine hutano uye zvichishanda.
Mukupedzisa, kuchengetedza mitochondria ine hutano kwakakosha kuhutano hwedu hwese uye kugara zvakanaka, uye masero edu akagadzira nzira inonzi mitochondrial autophagy kuti tive nechokwadi chekuti tine mitochondria ine hutano nguva dzose. Zvisinei, nzira dzekurarama nadzo (dzakadai sekurovedza muviri) uye nzira dzekudya (dzakadai sekudya ketogenic) uye kushandiswa kwezvinowedzera zvinogona kutsigira mashandiro emitochondrial uye kubatsira kudzivirira zvirwere zvine chekuita nekukwegura. Nekutarisira mitochondria yedu, tinogona kuva nechokwadi chekuti tine simba nesimba ratinoda kuti tirarame hupenyu hwakazara.
Pamusoro pezvo, tinogona kuziva zvakajeka hukama huripo pakati pemitochondria nekudzivirira kukwegura, sezvatinokura, maitiro e autophagy yemitochondrial anokanganiswa, kureva kuti, anotungamira mukuunganidzwa kwemitochondria mumasero, ayo kutsanya, kudziviswa kwemacalorie, urolithin A, nezvimwewo zvinogona kukonzera autophagy yemitochondrial uye zvinogona kuvandudza hutano nekudzivirira kukwegura, uko NAD+ ne urolithin A zvinobatsira mukugadzirwa kwemitochondria itsva kuburikidza nemaitiro anonzi biogenesis process anonzi biogenesis; zvisinei, urolithin A ine rimwe basa rakakosha. Inogadzirisa maitiro anonzi mitochondrial autophagy, umo mitochondria yakakuvara inobviswa uye inodzokororwa kuita mitochondria itsva, inoshanda zviri nani. Vanhu vazhinji muhupenyu hwedu vangasakwanisa kuramba vachiita maekisesaizi kwenguva yakareba, asi chigadzirwa chatinopa, Urolithin A, chinogona kupa hutano hwakanaka.
Mubvunzo: Pane zvekudya zvakananga muhupenyu hwako zvinogona kubatsira kudzivirira kukwegura nguva isati yakwana here?
A: Ehe, zvimwe zvekudya zvakapfuma mu antioxidants, mavhitamini nemaminerari zvinogona kubatsira kukurudzira ganda rine hutano uye kunonoka kukwegura. Mienzaniso inosanganisira michero, miriwo, mapuroteni asina mafuta akawanda uye mafuta ane hutano.
Nguva yekutumira: Chikumi-01-2023
