Mitochondria yakakosha sesimba remasero emuviri wedu, ichipa simba rakakura kuchengetedza moyo wedu uchirova, mapapu edu achifema uye muviri wedu uchishanda kuburikidza nekuvandudzwa kwemazuva ese. Nekudaro, nekufamba kwenguva, uye nezera, zvimiro zvedu zvinogadzira simba, mitochondria, inotapukirwa nekukuvara uye kurasikirwa nekugona kwavo kushanda nemazvo. Kushanda zvizere mitochondria kwakakosha kuhupenyu hwemunhu. Nekudaro, mitochondria zvakare inokonzeresa zvakanyanya kukuvara kubva kwakasiyana masosi, kusanganisira oxidative kusagadzikana, kuzvimba, uye chepfu yezvakatipoteredza. Zvinhu izvi zvinogona kukonzera kukuvadza kune mitochondrial DNA, kukanganisa kugona kwavo kugadzira ATP uye mamwe makomisheni akakosha.
Neraki, muviri wedu unosarudza kubvisa yakakuvara uye isingashande mitochondria kubva mumasero edu kuburikidza ne mitochondrial autophagy kuitira kuchengetedza hutano huri nani uye kudzivirira zvimwe zvakashata zveiyi yakakuvadzwa mitochondria, maererano nezvidzidzo zvinoratidza kuti maitiro e mitochondrial autophagy ane basa mukurwisa- kuchembera. Ngatinzwisise chinongedzo pakati pemitochondria uye anti-kuchembera!
Ndeapi mabasa emitochondria?
Mitochondria yakakosha organelles inoburitsa simba mumasero edu. Basa ravo guru nderekugadzira adenosine triphosphate (ATP), inova mari yesimba remasero edu. Iyo yakawanda mitochondria yatinayo, iyo yakawanda ATP yatinogona kugadzira, izvo zvinotungamira kuwedzera simba uye kuderera kuneta. Pakati pemabasa makuru ainoita ndeaya:
(1)kupa simba uye metabolic intermediates kumuviri
(2)Mitochondrial autophagy inoziva mitochondria yakakuvadzwa uye inovabvisa nenzira kwayo, uye kubviswa kweiyo mitochondria yakakuvadzwa inosimudzira biosynthesis ye mitochondria itsva.
(3)Inogona kuita basa mukudzivisa kufa kwesero nekubvisa mitochondria
(4)Yakave yakabatana nekuvandudzwa kwehuwandu hwezvinetso zvehutano, kusanganisira chirwere chemoyo, neurodegenerative zvirwere uye kunyange mamwe marudzi egomarara.
Chii chinobatana pakati pemitochondria uye anti-kuchembera?
Zvidzidzo zvakaratidza kuti sezvatinokura, kubvumidzwa kuburikidza ne mitochondrial autophagy kunokanganisa, zvinoreva kuti masero emitochondrial haakwanise kujekesa mabasa avo. Pasina yakagadziridzwa yemhando yekudzora maitiro senge mitochondrial autophagy, kukuvara kweserura kunogona kukurumidza.
Muzvidzidzo zvemhuka, hupenyu hwakareba hwakaonekwa apo majini anodzora mitochondrial autophagy anoratidzwa, zvichiratidza kuti mitochondrial autophagy uye hupenyu hurefu hwakabatana. Pamusoro pezvo, kukanganisa mitochondrial autophagy inowanzoonekwa mune dzakawanda zvirwere zvine chekuita nezera, kusanganisira chirwere cheParkinson neAlzheimer, chirwere chemoyo, uye kenza, zvichiratidza kuti kupindira kunonangana nemitochondrial autophagy kunogona kuita basa mukudzivirira uye kurapwa kwechirwere. Pakupedzisira, kiyi yekuchembera zvine nyasha iri mukunzwisisa uye kutsigira maitiro akaomarara anoita kuti muviri urambe uchishanda. Nekushanda kusimudzira hutano hwemitochondrial autophagy uye kuita sarudzo dzemararamiro dzinoisa pamberi kugara kwedu zvakanaka, tinogona kuvhura zvakavanzika zvehupenyu hurefu uye hune hutano!
Maitiro ekuwedzera mitochondrial autophagy
(1)Funga nezve kutsanya kwechikamu uye calorie restriction
Zvidzidzo zvakaratidza kuti mitochondrial autophagy inogona kukurudzirwa neakasiyana emararamiro ekupindira. Semuenzaniso, kurovedza muviri kwakaratidzwa kuwedzera mitochondrial autophagy, nokudaro kuvandudza mitochondrial basa. Uye zvakare, kupindira kwechikafu senge kutsanya kwepakati kana kurambidzwa kwekoriori kunogonawo kukurudzira mitochondrial autophagy, zvichikonzera kuwedzera hutano mitochondria.
(2)Kusarovedza muviri nguva dzose
Kuekisesaiza ndiko kuri nyore uye kuri nyore kutevedzera. Inogona kukurudzira hutano uye hupenyu hurefu pamwe nekuvandudza mitochondrial basa pamwe nekuita mitochondrial autophagy, saka kurovedza muviri kunogona kurongeka zvine musoro neimwe simba, aerobic uye kutsungirira kudzidzira kuwedzera mitochondrial autophagy.
(3)Urolithin A imorekuru inokonzeresa mitochondrial autophagy
Urolithin A inhengo yemetabolite inogadzirwa nekushandurwa kwe ellagic tannins nehutachiona hwemukati. Zvikonzero zvayo ndeye ellagic acid uye ellagitannin, iyo inogona kuwanikwa mumiti yakawanda inodyiwa, yakadai sepomegranate, sitirobheri, raspberries, walnuts, nezvimwewo, asi kwete kuti iripo muzvokudya, nokuti mamwe mabhakitiriya anogona kushandura ellagitannin kune urolithin. Uye urolithin A, organic compound yakaumbwa kubva mukudya kwekutanga, ndicho chinhu chakaratidzwa kukonzera mitochondrial autophagy.
Kukosha kwe mitochondrial autophagy
Mitochondrial autophagy inzira yechisikigo uye yakakosha iyo inobatsira kuchengetedza hutano mitochondria mukati memasero edu. Kuita uku kunosanganisira kuona mitochondria yakakuvara kana kusashanda uye nekusarudza kuibvisa kubva musero kugadzira nzira mitochondria itsva, inogoneka kuvatsiva. Panguva imwecheteyo, maitiro emitochondrial autophagy anobatsira kuve nechokwadi chekuti simba remuviri wedu rinoramba rakagadzikana uye kuti masero edu nematishu zvinoramba zvine hutano uye zvinoshanda.
Mukupedzisa, kuchengetedza mitochondria ine hutano kwakakosha kuhutano hwedu hwese uye kugara zvakanaka, uye masero edu akachinja maitiro anonzi mitochondrial autophagy kuti tive nechokwadi chekuti tine kuenderera mberi kwehutano mitochondria. Zvisinei, mararamiro emararamiro (akadai sekurovedza muviri) uye kupindira kwezvokudya (zvakadai sekudya ketogenic) uye kushandiswa kwezvinowedzera zvinogona kutsigira mitochondrial basa uye kubatsira kudzivirira zvirwere zvine chokuita nezera. Nekuchengeta mitochondria yedu, tinogona kuve nechokwadi chekuti tine simba uye simba ratinoda kuti tirarame hupenyu hwakazara.
Mukuwedzera, isu tinogona kunyatsoziva kubatana pakati pemitochondria uye anti-kuchembera, sezvatinokura, iyo mitochondrial autophagy process inokanganisa, ndiko kuti, inotungamira mukuunganidzwa kwemitochondria mumasero, ayo kutsanya, calorie restriction, urolithin A. , nezvimwewo zvinogona kukonzera mitochondrial autophagy uye inogona kuvandudza hutano uye anti-kuchembera, uko zvese NAD + uye urolithin A zvinobatsira mukugadzirwa kwemitochondria itsva kuburikidza nemaitiro anonzi biogenesis process inonzi biogenesis; zvisinei, urolithin A ine rimwe basa rinokosha. Inokwidziridza maitiro anonzi mitochondrial autophagy, umo mitochondria yakakuvadzwa inobviswa uye inodzokororwa kuita mitochondria itsva, inoshanda zvakanyanya. Vanhu vazhinji muhupenyu hwedu vangasakwanisa kusimudzira maekisesaizi kwenguva yakareba, asi chigadzirwa chatinopa, Urolithin A, chinogona kupa hutano hwakakwana.
Mubvunzo: Pane here chikafu muhupenyu hwako chinogona kubatsira kudzivirira kuchembera nguva isati yakwana?
A: Hongu, zvimwe zvikafu zvakapfuma mune antioxidants, mavitamini nemaminerari zvinogona kubatsira kukurudzira ganda rine hutano uye kunonoka kuchembera. Mienzaniso inosanganisira michero, miriwo, mapuroteni asina kusimba uye mafuta ane utano.
Nguva yekutumira: Jun-01-2023
