Mishonga mina yepamusoro yekudzivirira kukwegura yekuvandudza hutano hwemitochondrial: Ndeipi yakasimba kupfuura iyi?

Masayendisiti akaona kuti sezvatinokura, mitochondria yedu inodzikira zvishoma nezvishoma uye inoita simba shoma. Izvi zvinogona kukonzera zvirwere zvine chekuita nekukwegura zvakaita sezvirwere zvetsinga, chirwere chemwoyo, nezvimwewo.

Urolithin A

Urolithin A imhando yechisikigo ine antioxidant uye antiproliferative effects. Nyanzvi dzezvekudya kubva kuNova Southeastern University muUnited States dzakaona kuti kushandisa urolithin A senzira yekudya kunogona kunonotsa kukwegura uye kudzivirira kukura kwezvirwere zvine chekuita nekukwegura.
Urolithin A (UA) inogadzirwa nemabhakitiriya edu emudumbu mushure mekudya polyphenols inowanikwa muzvikafu zvakaita semapomegranate, mastrawberry, uye walnuts. Kuwedzera UA kune mbeva dzezera repakati kunoita kuti sirtuins ishande uye kunowedzera simba reNAD+ nemasero. Zvakakosha, UA yakaratidzwa kuti inobvisa mitochondria yakakuvara kubva mutsandanyama dzevanhu, nokudaro ichivandudza simba, kuramba kuneta, uye kushanda zvakanaka kwemitambo. Nokudaro, kuwedzera UA kunogona kuwedzera hupenyu nekudzivirira kukwegura kwetsandanyama.
Urolithin A haibvi zvakananga kubva mukudya, asi zvinhu zvakaita se ellagic acid uye ellagitannins zviri munzungu, mapomegraneti, mazambiringa nemamwe michero zvinogadzira urolithin A mushure mekugadziriswa netumbuyu.

Spermidine

Spermidine imhando yechisikigo yepolyamine yave ichinyanya kutariswa mumakore achangopfuura nekuda kwekugona kwayo kuwedzera hupenyu uye kuwedzera hupenyu. Kufanana neNAD+ neCoQ10, spermidine imorekuru inowanikwa zvakasikwa inoderera nekukura. Kufanana neUA, spermidine inogadzirwa nemabhakitiriya edu emudumbu uye inokonzera mitophagy - kubviswa kwe mitochondria isina hutano, yakakuvara. Zvidzidzo zvembeva zvinoratidza kuti kuwedzerwa kwespermidine kunogona kudzivirira kubva kuzvirwere zvemwoyo nekukwegura kwekubereka kwevakadzi. Pamusoro pezvo, spermidine yekudya (inowanikwa muzvikafu zvakasiyana-siyana zvinosanganisira soya nezviyo) yakavandudza ndangariro mumakonzo. Tsvagiridzo yakawanda inodiwa kuti uone kana zvakawanikwa izvi zvichigona kudzokororwa muvanhu.
Kuchembera kwakajairika kunoderedza kuwanda kwemhando dzechisikigo dzespermidine mumuviri, zvichienderana nekutsvagurudza kwakaburitswa muScientific Reports nevaongorori veKyoto Prefectural University of Medicine muJapan. Zvisinei, chiitiko ichi hachina kuonekwa kune vane makore zana;
Spermidine inogona kukurudzira autophagy.
Zvikafu zvine huwandu hwakawanda hwespermidine zvinosanganisira: chikafu chegorosi rose, kelp, howa hweshiitake, nzungu, bracken, purslane, nezvimwewo.

curcumin
Curcumin chinhu chinoshanda chiri mu turmeric chine simba rekudzivirira kuzvimba uye antioxidant.
Nyanzvi dzezvesainzi dzezvesainzi kubva kuPolish Academy of Sciences dzakaona kuti curcumin inogona kuderedza zviratidzo zvekukwegura uye kunonotsa kufambira mberi kwezvirwere zvine chekuita nekukwegura umo masero ezera anobatanidzwa zvakananga, nokudaro zvichiwedzera hupenyu hwemuviri.
Pamusoro peturmeric, zvekudya zvine curcumin yakawanda zvinosanganisira: ginger, gariki, hanyanisi, mhiripiri nhema, mustard uye curry.

zvinovaka muviri zveNAD+
Kune mitochondria, kune NAD+ (nicotinamide adenine dinucleotide), molecule inodiwa kuti simba riwedzere kugadzirwa. NAD+ inodzikira nekukura, izvo zvinoita sekunge zvinoenderana nekuderera kwebasa remitochondrial nekuda kwezera. Ichi ndicho chimwe chezvikonzero nei maNAD+ boosters akadai seNR (Nicotinamide Ribose) akagadzirwa kuti adzorere mazinga eNAD+.
Tsvagiridzo inoratidza kuti nekusimudzira NAD+, NR inogona kuwedzera kugadzirwa kwesimba remitochondrial uye kudzivirira kushushikana kunokonzerwa nekukwegura. Mishonga yekuwedzera yeNAD+ inogona kuvandudza mashandiro emhasuru, hutano hwehuropi, uye kugaya chikafu uku ichirwisa zvirwere zvinokanganisa tsinga. Pamusoro pezvo, inoderedza kuwedzera uremu, inovandudza insulin sensitivity, uye inogadzirisa mazinga emafuta mumuviri, senge kuderedza LDL cholesterol.