Evodiamine chinhu chechisikigo chinowanikwa mumuchero wemuti weEvodiamine, unobva kuChina nedzimwe nyika dzeAsia. Yave ichishandiswa mumishonga yechivanhu yeChina kwemazana emakore nekuda kwekubatsira kwayo pahutano. Pakati pazvo, evodiamine ine mukana mukuru wekudzora kuzvimba uye kubatsira kuderedza uremu. Hunhu hwayo hwekudzivirira kuzvimba hunoita kuti ive yakakosha pakurapa zvirwere zvakasiyana-siyana zvekuzvimba, nepo kugona kwayo kuwedzera thermogenesis uye kukurudzira lipolysis kunogona kubatsira mukuderedza uremu.
Wakambosangana neshoko rekuti "evodiamine" ukazvibvunza kuti rinorevei chaizvo? Evodiamine, inobva mumuti weEvodiamine, chinhu chinowanikwa muChina nedzimwe nyika dzeAsia. Evodiamine iri muboka remaalkaloids anozivikanwa se "quinazole alkaloids," mishonga inotorwa kubva mumichero isina kuibva yemuti uye inozivikanwa nekurapa kwayo. Kwemazana emakore, mishonga yechivanhu yeChina yakashandisa simba reevodiamine kuderedza zvirwere zvakasiyana-siyana.
Evodiamine inozivikanwa nehunyanzvi hwayo hwekudzora muviri, nzira iyo muviri unogadzira kupisa, izvo zvinogona kuwedzera mwero wekugaya chikafu uye kukurudzira kupisa macalorie. Nekuwedzera kuwedzera kwekupisa muviri, evodiamine inogona kubatsira kupisa mafuta uye kudzora huremu.
Kuzvimba inzira yechisikigo yemuviri yekupindura kukuvara kana hutachiona. Zvisinei, kuzvimba kwenguva refu kunogona kutungamira kuzvirwere zvakasiyana-siyana. Nekuderedza kuzvimba, evodiamine inogona kubatsira kuvandudza hutano hwese uye kuderedza njodzi yezvirwere zvakasiyana.
Evodiamine inozivikanwa nehunyanzvi hwayo hwekupisa. Thermogenesis zvinoreva maitiro ekugadzira kupisa mumuviri. Saka evodiamine inogadzira sei kupisa?
Imwe yenzira iyo evodiamine inoshandisa simba rayo rekupisa ndeyekumutsa puroteni inonzi transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 ireceptor inowanikwa zvakanyanya mutsinga uye inobatanidzwa mukudzora tembiricha yemuviri uye metabolism. Kana evodiamine yakabatana neTRPV1, inokonzera mhinduro dzakasiyana dzemuviri, kusanganisira kuwedzera kwesimba rinoshandiswa uye thermogenesis.
Evodiamine yakawanikwa ichikurudzira ma adrenal glands kuti aburitse catecholamines dzakadai se epinephrine ne norepinephrine. Catecholamines inoita basa rakakosha mukuwedzera lipolysis, kuputswa kwemafuta akachengetwa kuita ma free fatty acids anogona kushandiswa senzvimbo yesimba. Maitiro aya anowedzera kukurudzira mhedzisiro ye evodiamine.
Pamusoro pezvo, evodiamine yakaratidzwa kuti inodzivisa mashandiro emamwe ma enzymes anobatanidzwa mukuumbwa nekuchengetedzwa kwemasero emafuta. Semuenzaniso, inodzivirira kuburitswa kwe peroxisome proliferator-activated receptor gamma (PPARγ), chinhu chinokurudzira kuunganidzwa kwemafuta mumafuta. Nekudzivisa mashandiro ePPARγ, evodiamine inogona kubatsira kudzivirira kuumbwa kwemasero matsva emafuta uye kuderedza kuchengetwa kwemafuta.
1. Kuderedza huremu
Chimwe chezvakanakira zvinozivikanwa zve evodiamine ndechekuti inogona kubatsira mukuderedza uremu. Tsvagiridzo inoratidza kuti evodiamine inogona kukurudzira ma "heat" receptors mumiviri yedu, anozivikanwa se transient receptor potential vanilloid 1 (TRPV1) receptors. Nekushandisa ma receptors aya, evodiamine inogona kubatsira kuwedzera thermogenesis uye oxidation yemafuta, nokudaro ichisimudzira metabolism uye mukana wekudzikira uremu. Pamusoro pezvo, inodzivirira kukura kwemasero matsva emafuta, ichitsigira zvakanyanya hunhu hwayo hwekuderedza uremu.
2. Hunhu hwekudzivirira kuzvimba
Kuzvimba kwenguva refu kunobatanidzwa nematambudziko akasiyana-siyana ehutano, anosanganisira chirwere chemwoyo, chirwere cheshuga, nezvimwewo. Evodiamine inoonekwa semushonga unodzivirira kuzvimba nekuda kwekukwanisa kwayo kudzivirira kugadzirwa kwemamorekuru anodzivirira kuzvimba. Zvidzidzo zvakati wandei zvakaratidza kuti evodiamine inogona kudzivirira kushanda kwenuclear factor-κB (NF-κB), chinhu chakakosha chinodzora kugadzirwa kwemajini anodzivirira kuzvimba. Nekudzivisa NF-κB, evodiamine inoderedza kuzvimba nekuderedza kugadzirwa kwema cytokines anokonzera kuzvimba akadai se interleukin-1β (IL-1β) uye tumor necrosis factor-α (TNF-α).
3. Hunhu hwekuderedza marwadzo uye marwadzo
Marwadzo, anowanzobatanidzwa nekuzvimba, chimwe chiratidzo chakakosha chinogona kukanganisa hupenyu zvakanyanya. Hunhu hwe evodiamine hunonyaradza marwadzo hwakadzidzwa zvakanyanya, nemigumisiro inokurudzira. Tsvagiridzo inoratidza kuti evodiamine inogona kumutsa transient receptor potential vanilloid 1 (TRPV1) channel, iyo inobatanidzwa mukutapurirana kwezviratidzo zvekurwadziwa. Nekumutsa nzira idzi, evodiamine inogona kudzivirira kunzwa kwekurwadziwa uye kupa zororo kune vanhu vane marudzi ese ekurwadziwa, kusanganisira marwadzo europi nekuzvimba.
4. Hutano hwemwoyo netsinga dzeropa
Kuchengetedza hurongwa hwakanaka hwemwoyo kwakakosha pahutano hwese. Evodiamine yakaratidzwa kuti ine mhedzisiro yakanaka pamwoyo, senge kuderedza BP uye kudzivirira kuungana kwemaplatelet. Nekuzorodza mitsipa yeropa uye kudzivirira kuumbwa kweropa rakagwamba, evodiamine inogona kubatsira kuvandudza kutenderera kweropa uye kuderedza njodzi yezvirwere zvemwoyo, kusanganisira kurwara nemoyo uye sitiroko.
5. Hutano hweMatumbu
Evodiamine inogona kuva nemigumisiro yakanaka pahutano hwematumbu nekusimudzira mashandiro ekugaya chikafu uye kuderedza matambudziko emudumbu. Tsvagiridzo inoratidza kuti evodiamine inogona kukurudzira kuburitswa kwema enzymes ekugaya chikafu uye kuvandudza kufamba kwemudumbu, zvichizobatsira kugaya chikafu uye kuderedza kusagadzikana kwekugaya chikafu. Pamusoro pezvo, simba re evodiamine rinogona kubatsira kurwisa mabhakitiriya ane njodzi uye kukurudzira microbiome yemudumbu ine hutano.
Evodiamine yakatumidzwa zita kubva kune imwe yenzvimbo dzayo huru dzemiti, Evodia rutaecarpa, inozivikanwa semuchero weEvodia kana kuti Evodia rutaecarpa. Chirimwa ichi chinobva kuEast Asia uye chave chichishandiswa mukurapa kwechivanhu kwemazana emakore. Michero isina kuibva yemuti weEvodia carota ndiyo inonyanya kuburitsa evodiamine. Chishamiso ichi chemiti chine maalkaloids akati wandei, kusanganisira evodiamine, ayo akaratidza mhedzisiro yakanaka pahutano.
Zvimwe zvinomera
Pamusoro peEvodiamine, evodiamine inowanikwa mune zvimwe zvirimwa zvakawanda. Izvi zvinosanganisira Alstonia macrophylla, Evodia lepta uye Euodia lepta, pakati pezvimwe. Zvirimwa izvi zvinobva kunzvimbo dzakasiyana dzeAsia, kusanganisira China, Japan, neThailand.
Zvinofadza kuti, manyuko aya emiti haasi echikamu chimwe nechimwe chemuti chete. Kunyange zvazvo michero isina kuibva iriyo inonyanya kushandiswa, evodiamine inogonawo kutorwa kubva mumashizha, madzinde, nemidzi yemiti iyi. Manyuko aya akasiyana-siyana anopa vaongorori nemasayendisiti mikana yakawanda yekutsvaga mabhenefiti akasiyana-siyana ehutano uye mashandisirwo eevodiamine.
●Muyero wakakodzera: Muyero wakakodzera we evodiamine unoenderana nezvinhu zvakati wandei zvakaita sezera remushandisi, hutano, nezvimwe zvirwere zvakawanda. Yeuka kuti zvigadzirwa zvechisikigo hazvisi nguva dzose zvakachengeteka, uye muyero unokosha. Zvakakosha kuverenga zvinyorwa zvezvigadzirwa nokungwarira uye kubvunza nyanzvi yehutano kuti uone muyero wakakodzera zvaunoda iwe pachako.
●Zvinhu Zvinofanira Kufungwa Nezvehutano Hwemunhu: Pakusarudza kushandisa chero mushonga wekuwedzera, kusanganisira evodiamine, zvakakosha kufunga nezvehutano hwemunhu, nhoroondo yezvekurapa, uye kushivirira kwake. Pamusoro pezvo, ziva nezvekushandisa mishonga pamwe chete uye funga nezvezvinhu zvine chekuita nehutano hwemunhu kuti uwedzere mabhenefiti eevodiamine uku uchideredza njodzi dzinobatanidzwa.
Mubvunzo: Evodiamine inoderedza sei kuzvimba?
A: Evodiamine yakawanikwa iine hunhu hwekudzivirira kuzvimba. Inodzivirira mashandiro emamorekuru ekuzvimba, akadai senuclear factor-kappa B (NF-kB) uye cyclooxygenase-2 (COX-2), ayo anoita basa guru mukuzvimba. Nekuderedza kugadzirwa kwemamorekuru aya, evodiamine inobatsira kuderedza kuzvimba mumuviri.
Mubvunzo: Evodiamine inogona kushandiswa here kuderedza uremu?
A: Evodiamine yakaongororwa kuti inogona kukanganisa sei kuderedza uremu. Zvinofungidzirwa kuti inomutsa maitiro anonzi thermogenesis, ayo anowedzera tembiricha yemuviri uye mwero wemetabolism. Izvi zvinogona kuwedzera kushandiswa kwemacalorie uye kubatsira mukuderedza uremu. Zvisinei, kutsvagurudza kwakawanda kunodiwa kuti pave nekushanda uye kuchengetedzeka kwe evodiamine pakuderedza uremu.
Chiziviso: Chinyorwa ichi ndecheruzivo rwese chete uye hachifanirwe kutorwa semazano ekurapa. Mamwe emashoko eblog anobva paInternet uye haasi ehunyanzvi. Iyi webhusaiti ine basa rekugadzirisa, kuronga nekugadzirisa zvinyorwa chete. Chinangwa chekutumira rumwe ruzivo hazvirevi kuti unobvumirana nemaonero ayo kana kusimbisa chokwadi chezviri mukati mayo. Gara uchibvunza nyanzvi yehutano usati washandisa chero mishonga yekuwedzera kana kuita shanduko kuhurongwa hwako hwehutano.
Nguva yekutumira: Gunyana-26-2023
