Gwaro reMutangi weUrolithin A: Chii uye Kuti Rinoshanda Sei

Kunzwisisa Urolithin A

Usati wanyatsoongorora basa rayo mukuderedza uremu, zvakakosha kunzwisisa mashandiro uye hunhu hwe urolithin A. Iyi makemikari echisikigo anozivikanwa nekukwanisa kwayo kumutsa mitophagy, maitiro anobvisa mitochondria yakakuvara kubva mumasero. Mitochondria inowanzonzi simba resero, ichiita basa rakakosha mukugadzira simba. Nekusimudzira mitophagy, urolithin A inobatsira kuchengetedza hutano hwemitochondrial uye mashandiro ayo, izvo zvakakosha pakugadzirwa kwemasero ese.

Urolithin A uye Kuderedza Huremu

Ongororo dzinoverengeka dzakaratidza kuti urolithin A inogona kuva nemigumisiro yakanaka pakuderedza uremu. Imwe ongororo, yakaburitswa mumagazini inonzi Nature Medicine, yakawana kuti urolithin A inogona kuvandudza mashandiro emhasuru uye kutsungirira kwemakonzo. Izvi zvakakosha nekuti kuwedzera mashandiro emhasuru uye kutsungirira kunogona kubatsira pakuwedzera metabolic rate, zvichigona kubatsira mukuderedza uremu uye kutungamira.

Uyezve, urolithin A yakaratidzwa kuti inowedzera kushandiswa kwemafuta mumuviri uye inoderedza kuunganidzwa kwemafuta mumafuta. Chidzidzo chakaburitswa mumagazini inonzi Nature Metabolism chakaratidza kuti kuwedzerwa kweurolithin A kwakaita kuti mafuta mumuviri aderedzwe uye kuvandudza mashandiro emuviri mumbeva dzakafuta. Izvi zvakawanikwa zvinoratidza kuti urolithin A inogona kuita basa rekudzora kushandiswa kwemafuta mumuviri uye kukurudzira kuumbwa kwemuviri kwakanaka.

Zvidzidzo zvevanhu uye tsvakurudzo yeramangwana

Kunyange hazvo humbowo hwakawanikwa muzvidzidzo zvemhuka huchivimbisa, ongororo yevanhu pamusoro pemigumisiro yeurolithin A pakuderedza uremu ichiri mishoma. Zvisinei, bvunzo yekiriniki yakaitwa nevaongorori veÉcole Polytechnique Fédérale de Lausanne (EPFL) muSwitzerland yakapa rumwe ruzivo nezvemabhenefiti ayo. Muedzo uyu waisanganisira vanhu vakafuta uye vakafuta vakapihwa urolithin A supplements kwemwedzi mina. Mhedzisiro yacho yakaratidza kuti urolithin A supplementation yakabatana nekudzikira kwehuremu hwemuviri nedenderedzwa rechiuno, pamwe nekuvandudzwa kwehutano hwemuviri.

Pasinei nezvakawanikwa zvinokurudzira izvi, kutsvagurudza kwakawanda kunodiwa kuti tinzwisise zvizere kukanganisa kweurolithin A pakuderedza uremu muvanhu. Zvidzidzo zveramangwana zvinofanira kuongorora nzira dzayo dzekushanda, chiyero chakakodzera, uye mhedzisiro yenguva refu pakuumbwa kwemuviri uye kugadzirwa kwemuviri.

Chii chinobatsira urolithin A?

Chimwe chezvakanakira zvikuru zve urolithin A ibasa rayo mukusimudzira hutano hwe mitochondria. Mitochondria ndiyo simba remasero edu, ine basa rekugadzira simba uye kuchengetedza mashandiro emasero. Sezvatinokura, kushanda zvakanaka kwe mitochondria yedu kunoderera, zvichikonzera matambudziko akasiyana-siyana ehutano ane chekuita nekukwegura. Urolithin A yakawanikwa ichivandudza mitochondria biogenesis, maitiro ekugadzira mitochondria itsva, uye kuvandudza mashandiro ayo. Nekutsigira hutano hwe mitochondria, urolithin A inogona kubatsira muhuwandu hwesimba, kushanda kwemuviri, uye kurarama kwenguva refu.

Uyezve, urolithin A ine simba rekudzivirira kuzvimba. Kuzvimba kwenguva refu kwakabatana nematambudziko akawanda ehutano, anosanganisira chirwere chemwoyo, chirwere cheshuga, uye zvirwere zvetsinga. Zvidzidzo zvakaratidza kuti urolithin A inogona kubatsira kugadzirisa nzira dzekuzvimba, kuderedza kugadzirwa kwemamorekuru anokonzera kuzvimba uye kukurudzira mhinduro yakaringana yekudzivirira muviri. Nekuderedza kuzvimba kwenguva refu, urolithin A inogona kubatsira mukudzivirira nekutarisira zvirwere zvine chekuita nekuzvimba.

Pamusoro pemigumisiro yayo pahutano hwemitochondrial uye kuzvimba, urolithin A yakaratidza tarisiro mukutsigira mashandiro emhasuru uye kupora. Tsvagiridzo inoratidza kuti urolithin A inogona kuwedzera kuwanda kwemasero emhasuru uye kugadzirwa kwemapuroteni, izvo zvakakosha pakukura kwemhasuru nekugadzirisa. Izvi zvine zvazvinoreva kune vatambi nevanhu vari kutsvaga kuchengetedza tsandanyama nesimba, kunyanya sezvavanokura. Uyezve, urolithin A inogona kubatsira mukupora mushure mekurovedza muviri kwakaoma, zvichigona kuderedza kukuvara kwemhasuru uye kukurumidzisa kupora kwemhasuru.

Chimwe chinhu chinonakidza chinobatsira che urolithin A ndechekuti inogona kubatsira mukusimudzira hutano hwematumbu. Urolithin A inoita basa rakakosha mukuchengetedza hutano hwese, ichipesvedzera kugaya, mashandiro ekudzivirira muviri, uye kunyange hutano hwepfungwa. Urolithin A yakaratidzwa kuti ine mhedzisiro yakafanana ne prebiotic, zvichireva kuti inogona kukurudzira kukura kwemabhakitiriya anobatsira mudumbu. Nekutsigira urolithin A ine hutano, urolithin A inogona kubatsira mukuvandudza kugaya, mashandiro ekudzivirira muviri, uye kuenzana kwese kwenzvimbo yedumbu.

Uyezve, tsvakiridzo itsva inoratidza kuti urolithin A inogona kuva neproperties dzinodzivirira tsinga dzeuropi, zvichipa mabhenefiti anogona kubatsira pahutano hwehuropi. Zvidzidzo zvakaratidza kuti urolithin A inogona kubatsira kubvisa mitochondria yakakuvara kana kuti isina kushanda zvakanaka mumasero europi, nzira inozivikanwa semitophagy. Izvi zvinogona kuva nemigumisiro kuzvirwere zvetsinga dzakadai seAlzheimer's neParkinson's diseases, uko kusashanda zvakanaka kwemitochondrial kunoita basa guru.

Inguva ipi yezuva yandinofanira kutora urolithin A?

Mubvunzo mumwe unowanzo bvunzwa nevanhu vanoda kushandisa urolithin A muhupenyu hwavo hwezuva nezuva ndewekuti, "Ndinofanira kutora urolithin A nguvai pazuva?"

Kunyange zvazvo pasina mhinduro imwe chete inopindirana nemubvunzo uyu, pane zvimwe zvinhu zvekufunga nezvazvo pakusarudza nguva yakanakisa yekunwa urolithin A kuti uwane mabhenefiti akanyanya. Chimwe chinhu chakakosha chekufunga nezvacho ndechekuwanikwa kweurolithin A mumuviri, zvinoreva kugona kwemuviri kupinza nekushandisa mushonga uyu zvinobudirira. Tsvagiridzo inoratidza kuti urolithin A inonyanya kunwisa kana ikatorwa pamwe chete nechikafu chine mafuta, sezvo izvi zvichigona kuwedzera kuwanikwa kwayo mumuviri.

Panyaya yekutora nguva, dzimwe nyanzvi dzinokurudzira kutora urolithin A mangwanani nekudya kwekuseni. Izvi zvinogona kubatsira kuona kuti mushonga wacho unonyungudutswa zvakanaka uye zvinogona kupa simba remasero kuti zuva ritange kushanda. Pamusoro pezvo, kutora urolithin A mangwanani kunogona kubatsira kutsigira kupora kwetsandanyama uye kushanda zvakanaka kwemuviri, zvichiita kuti ive sarudzo yakanaka kune vanhu vanoita maekisesaizi kana kuti vanoita maekisesaizi nguva dzose.

Kune rumwe rutivi, vamwe vanhu vangasarudza kutora urolithin A manheru, sechikamu chemaitiro avo ehusiku. Izvi zvinogona kubatsira pakusimudzira kugadziriswa kwemasero uye kudzoreredzwa kwesimba panguva yekuzorora kwemuviri uye nguva yekupora. Kutora urolithin A manheru, kunogona kutsigira maitiro emuviri ekuchenesa nekuvandudza masero, zvichigona kubatsira pahutano hwese hwemasero uye kurarama kwenguva refu.

Pakupedzisira, nguva yakanakisa yekutora urolithin A inogona kusiyana zvichienderana nezvinodiwa nemunhu uye mararamiro ake. Zvakakosha kufunga nezvemaitiro ake ega, maitiro ekudya, uye chero zvinangwa zvehutano zvakananga paunosarudza nguva yakakodzera yekuisa urolithin A muchirongwa chezuva nezuva. Kubvunza nyanzvi yehutano kana mupi wehutano ane ruzivo kunogonawo kupa nhungamiro yakasarudzika panguva yakakodzera yekutora urolithin A kuti uwane mabhenefiti ayo anogona kuwedzerwa.

Ndiani asingafaniri kutora urolithin A?

Vakadzi vane pamuviri uye vanoyamwisa vanofanira kudzivisa kushandisa urolithin A supplements, sezvo pasina tsvakurudzo yakawanda pamusoro pemigumisiro yayo panguva yekuzvitakura uye yekuyamwisa. Zvakanaka nguva dzose kungwarira uye kubvunza nyanzvi yehutano usati watora chero supplements itsva munguva idzi dzinonetsa.

Vanhu vane allergies dzinozivikanwa kana kuti vane allergies kune urolithin A kana zvimwe zvinhu zvine chekuita nayo vanofanirawo kurega kutora mishonga yekuwedzera ye urolithin A. Kurwara kunogona kubva pakushoma kusvika pakukomba, saka zvakakosha kuziva nezve chero zvinhu zvinogona kukonzera allergies mumushonga wekuwedzera.

Vanhu vane zvirwere zvidiki, kunyanya zvine chekuita nekushanda kweitsvo kana chiropa, vanofanira kubvunza chiremba wavo vasati vatora urolithin A. Sezvo urolithin A ichigadziriswa muchiropa uye ichiburitswa kuburikidza neitsvo, vanhu vane dambudziko rekushanda kwechiropa kana itsvo vangada kudzivirira kana kutarisa zvakanyanya kudya urolithin A kudzivirira chero matambudziko angangoitika.

Pamusoro pezvo, vanhu vari kutora mishonga kana zvimwe zvinovaka muviri vanofanira kutsvaga rubatsiro kubva kuna chiremba vasati vawedzera urolithin A muchirongwa chavo. Pane mukana wekuti urolithin A ishande pamwe chete nemimwe mishonga kana zvinovaka muviri, saka zvakakosha kuve nechokwadi chekuti hapana migumisiro yakaipa kana kudzikira kwekushanda kwemamwe marapirwo.