Salidroside: Kufumura chakavanzika chehunhu hweRhodiola rosea hwekudzivirira mabhakitiriya

Salidroside iantioxidant yechisikigo inodzivirira masero etsinga nekubvisa ROS uye kudzivirira apoptosis yemasero.

Kuwanda kwecalcium mumuviri ndicho chimwe chezvinhu zvikuru zvinokonzera apoptosis yemasero etsinga. Rhodiola rosea extract uye salidroside zvinogona kuderedza kuwedzera kwemazinga ecalcium akasununguka mukati memasero anokonzerwa nekushushikana kwe oxidative uye kudzivirira masero e cortical evanhu kubva ku glutamate. Salidroside inogona kudzivirira lipopolysaccharide-induced microglial activation, kudzivirira kugadzirwa kweNO, kudzivirira inducible nitric oxide synthase (iNOS) activity, uye kuderedza mazinga eTNF-α neIL-1β, IL-6.

Salidroside inodzivirira NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) uye response regulator of development uye DNA damage 1 (REDD1)/mammalian target ye rapamycin (mTOR)/p70 ribosome. Nzira yeprotein S6 kinase signaling pathway inomutsa AMP-dependent protein kinase/silent information regulator 1, RAS homologous gene family member A/MAPK uye PI3K/Akt signaling pathways.

1. Salidroside inodzivirira kukuvara kwemafree radicals uye inodzivirira muviri

Muviri unogona kugadzira huwandu hwakati hwema free radicals endogenous panguva yemaitiro emuviri, uye huwandu hwakati hwema free radicals hunodiwa kuti muviri urambe uchiita mabasa emuviri. Kunewo nzira yekubvisa ma free radicals mumuviri kuti ibvise ma free radicals anopfuura ma physiological doses kuitira kuti isakuvadze hutano hwemuviri.

Zvisinei, pasi pesimba rezvimwe zvinhu zvakakosha zvakatipoteredza, ma free radicals emuviri anozove akawandisa uye anodarika mwero we free radicals, zvichikonzera kusaenzana mukugadzirwa kwe oxygen free radicals mumuviri, zvichikonzera kuunganidzwa kwe oxygen free radicals mumuviri, zvichikonzera kukuvara kwe membrane yesero.

Tsvagiridzo inoratidza kuti nharaunda ine oxygen yakawanda pasi pemamiriro ezvinhu epasi pevhu inogona kukonzera kusawirirana mukugadzirwa kwema radicals asina oxygen, zvichiunganidza ma free radicals mukati memasero uye kuwedzera zvigadzirwa zve lipid peroxidation. Zvidzidzo zvakaratidza kuti salidroside inogona kudzivirira masero enyama nekubvisa ma free radicals mumuviri.

2. Salidroside inodzivirira hypoxia kuchengetedza kugadzikana kwekushanda kwemitochondrial

Inenge 80-90% yeokisijeni iri mukati memasero inoshandiswa mukugadzira ATP uye kugadzira ROS yemhando dzeokisijeni dzinoita kuti masero arambe achishanda zvakanaka. 10-20% chete yeokisijeni ndiyo isina chinhu kunze kwe mitochondria yekugadzirwa kwezvinhu, kucheneswa, kuchinjika kwemasero (detoxification), nezvimwewo. Basa rekufema reMitochondrial rinowedzerwa kana paine hypoxia shoma kana kuti pakutanga kwe hypoxia, iyo inoratidzwa semhinduro yemuviri yekufema.

Kushaya okisijeni kwakanyanya kunotanga kukanganisa kufambiswa kweoxygen mumitochondria uye kusashanda zvakanaka kwemuviri, kuderedza kugadzirwa kwema neurotransmitters, uye kuderedza kugona kwe biotransformation, nokudaro zvichikanganisa mashandiro enyama nenhengo. Zvidzidzo zvakaratidza kuti salidroside inogona kuchengetedza mashandiro emitochondria nekuderedza huwandu hweROS mumitochondria yesero, kuwedzera mashandiro eSOD, uye kuwedzera huwandu hwemitochondria.

3. Kudzivirira kwesalidroside mumoyo

Zvidzidzo zvakaratidza kuti hurongwa hwemwoyo ndiyo nzira huru inoshandura nzvimbo ine oxygen shoma. Nzvimbo ine oxygen shoma inokonzera kuti metabolism yemuviri ishaye simba uye isawane simba rakawanda, zvichikonzera zviratidzo zvakaita se oxygen shoma, ischemia, uye apoptosis yemasero emwoyo. Zvidzidzo zvakaratidza kuti salidroside inogona kusimudzira mashandiro emwoyo uye kuvandudza microcirculation nekukudza tsinga dzeropa dzeropa nedzeropa, kuvandudza kufamba kweropa kwemoyo, kushandura hemodynamics yemoyo, kuderedza mutoro wemwoyo, uye kuderedza kukuvara kwemoyo.
Muchidimbu, salidroside inogona kushanda pamwoyo kuburikidza nenzira dzakasiyana-siyana, nzira, uye zvinangwa, kuchengetedza apoptosis yemasero emwoyo inokonzerwa nezvikonzero zvakasiyana-siyana, uye kugadzirisa mamiriro emuviri ekushaya simba uye kushaya simba kweropa. Munzvimbo isina oxygen, kupindira kwaRhodiola rosea kwakakosha zvikuru mukudzivirira nyama dzemuviri nenhengo uye kuchengetedza kugadzikana kwemabasa emasero. Inoita basa rakakosha mukudzivirira nekuderedza kurwara kwekukwirira.
Mamiriro aripo pari zvino ekugadzirwa kwesalidroside

1) Kunyanya kuvimba nekubviswa kwezvirimwa

Rhodiola rosea imhando yechinhu chitsvasalidroside.Semhando yechirimwa chinomera kwenguva refu, Rhodiola rosea inonyanya kukura munzvimbo dzine kutonhora kwakanyanya, anoxia, kuoma, uye musiyano mukuru wekupisa pakati pemasikati nehusiku pakukwirira kwemamita 1600-4000. Ndiyo imwe yemiti yemusango. China ndeimwe yenzvimbo huru dzinogadzira Rhodiola rosea pasi rose, asi mararamiro eRhodiola rosea akasiyana zvikuru. Hazvisi zvakaoma kurima nekugadzira chete, asi goho remhando dzesango rakaderera zvikuru. Musiyano wegore negore weRhodiola rosea wakakwira kusvika matani 2,200.

2) Kugadzirwa kwemakemikari uye kuviriswa kwezvipenyu

Nekuda kwehuwandu hwakaderera uye mutengo wakakwira wekugadzira muzvirimwa, kuwedzera kune nzira dzekugadzira dzechisikigo, nzira dzekugadzira salidroside dzinosanganisirawo nzira dzekugadzira makemikari, nzira dzekuvirisa zvipenyu, nezvimwewo. Pakati padzo, sezvo tekinoroji iri kuramba ichikura, kuvirisa zvipenyu kwave nzira huru yehunyanzvi yekuvandudza kutsvagisa nekugadzira salidroside. Parizvino, Suzhou Mailun yawana mhedzisiro yekutsvagisa nekusimudzira uye yakawana kufambira mberi kwemaindasitiri.