Salidroside: Kufumura chakavanzika cheRhodiola rosea's antioxidant properties

Salidroside ndeye yakasikwa antioxidant inodzivirira masero etsinga nekutsvaira ROS uye inhibiting cell apoptosis.

Intracellular calcium overload ndechimwe chezvikonzero zvikuru zve neuronal apoptosis. Rhodiola rosea inobvisa uye salidroside inogona kuderedza kuwedzera kwe intracellular yemahara calcium mazinga anokonzerwa neoxidative kusagadzikana uye kudzivirira masero ecortical evanhu kubva ku glutamate. Salidroside inogona kudzivisa lipopolysaccharide-induced microglial activation, inhibit NO kugadzirwa, inhibit inducible nitric oxide synthase (iNOS) basa, uye kuderedza TNF-α uye IL-1β, IL-6 mazinga.

Salidroside inhibits NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) uye mhinduro regulator yekuvandudza uye DNA kukuvara 1 (REDD1)/mammalian target ye rapamycin (mTOR)/p70 ribosome Iprotein S6 kinase inoratidzira nzira inoshandisa AMP-inotsamira. protein kinase / silent information regulator 1, RAS homologous gene nhengo yemhuri A/MAPK uye PI3K/Akt kusaina nzira.

1. Salidroside inopikisa kukuvara kwemahara uye inodzivirira muviri

Muviri unogona kuburitsa imwe huwandu hweendogenous emahara radicals panguva yakajairika physiological process, uye imwe physiological dose yemahara radicals inodiwa kuchengetedza zvakajairwa zvemuviri zviitiko. Kune zvakare yemahara radical scavenging system mumuviri yekubvisa mahara radicals anopfuura physiological doses kuitira kuti isakuvadza hutano hwemuviri.

Nekudaro, pasi pesimba rezvimwe zvakakosha zvezvakatipoteredza zvinhu, endogenous endogenous radicals yemuviri inove yakawandisa uye ichipfuura iyo system yemahara radical scavenging rate, zvichikonzera kusaenzana kweiyo okisijeni yemuviri yemahara radical yekugadzira-scavenging system, zvichitungamira mukuunganidzwa kweokisijeni yemahara radicals. mumuviri, nokudaro zvichikonzera kukuvara kwesero membrane. kukuvara.

Tsvagiridzo inoratidza kuti nharaunda yehypoxic pasi pemamiriro emubani inogona kukonzera kusaenzana kweokisijeni-isina radical metabolism, kuunganidza intracellular free radicals uye kuwedzera lipid peroxidation zvigadzirwa. Zvidzidzo zvakaratidza kuti salidroside inogona kudzivirira masero ematishu nekubvisa mahara radicals mumuviri.

2. Salidroside inopikisa hypoxia kuchengetedza kugadzikana kwebasa remitochondrial

Inenge 80-90% ye intracellular oxygen inoshandiswa kubiological oxidation mumitochondria kugadzira ATP uye kuumba reactive oxygen marudzi ROS kuchengetedza zvakajairwa hupenyu zviitiko zvemasero. Chete 10-20% yeokisijeni yakasununguka kunze kwemitochondria ye biosynthesis, kuora, biotransformation (detoxification), etc. Mitochondrial kufema basa rinowedzerwa mu hypoxia munyoro kana mukutanga kwe hypoxia, iyo inoratidzwa semhinduro yekudzorera hurongwa hwekufema hwemuviri.

Yakanyanya hypoxia inozotanga kukanganisa iyo yekunze oxygenation ye mitochondria uye inoshanda metabolic kusagadzikana kwemuviri, kuderedza kugadzirwa kwemaurotransmitters, uye kunetesa biotransformation kugona, nekudaro kukanganisa mashandiro ematishu uye nhengo. Zvidzidzo zvakaratidza kuti salidroside inogona kuchengetedza kuchengetedza kwekuita mitochondrial nekudzikisa ROS zvirimo musero mitochondria, kuwedzera SOD chiitiko, uye kuwedzera huwandu hwemitochondria.

3. Myocardial protective effect ye salidroside

Zvidzidzo zvakaratidza kuti iyo yemoyo system ndiyo huru system inoshandura hypoxic nharaunda. A hypoxic nharaunda ichaita kuti muviri aerobic metabolism iite simba uye kusakwana kwesimba rekupa, zvichitungamira kune zviratidzo zvakaita se hypoxia, ischemia, uye apoptosis yemyocardial masero. Zvidzidzo zvakaratidza kuti salidroside inogona kuwedzera kushanda kwemoyo uye kuvandudza microcirculation nekuwedzera arterial uye venous tsinga dzeropa, kuvandudza myocardial kuyerera kweropa, kushandura hemodynamics yemoyo, kuderedza mutoro wemoyo, uye attenuating myocardial ischemic kukuvara.
Muchidimbu, salidroside inogona kuita pane yemoyo system kuburikidza nemaitiro akawanda, nzira, uye zvinangwa, kuchengetedza myocardial cell apoptosis inokonzerwa nezvikonzero zvakawanda, uye kugadzirisa ischemia yemuviri uye hypoxia mamiriro. Munharaunda ye hypoxic, kupindira kweRhodiola rosea kwakakosha zvikuru mukuchengetedza matishu emuviri uye nhengo uye kuchengetedza kugadzikana kwesero mabasa. Inoita basa rakakosha mukudzivirira nekuderedza hurwere hwepamusoro.
Ikozvino mamiriro ekugadzirwa kwesalidroside

1) Kunyanya kuvimba nekuchera chirimwa

Rhodiola rosea ndiyo mbishi yezvinhusalidroside.Serudzi rweperennial herbaceous chirimwa, Rhodiola rosea inokura zvakanyanya munzvimbo dzine kutonhora kwakanyanya, anoxia, kuoma, uye mutsauko mukuru wekupisa pakati pemasikati nehusiku pahupamhi hwemamita 1600-4000. Ndechimwe chemiti yemusango. China ndiyo imwe yenzvimbo huru dzekugadzira Rhodiola rosea munyika, asi mararamiro eRhodiola rosea akanyanya kukosha. Hazvina kuoma chete kurima zvekugadzira, asi goho remhando dzesango rakaderera zvakanyanya. Iyo yegore yekuda gap yeRhodiola rosea yakakwira se2,200 matani.

2) Chemical synthesis uye biological fermentation

Nekuda kwekushomeka kwemukati uye mutengo wakakwira wekugadzira muzvirimwa, kunze kwenzira dzechisikigo dzekuchera, nzira dzekugadzira salidroside dzinosanganisira nzira dzemakemikari synthesis, biological fermentation nzira, nezvimwe. Pakati pazvo, sezvo tekinoroji ichiramba ichikura, biological fermentation yave inonyanya kufarirwa. tekinoroji nzira yekuvandudza kwekutsvagisa uye kugadzirwa kwesalidroside. Parizvino, Suzhou Mailun yakawana tsvakiridzo nebudiriro mhedzisiro uye yakawana maindasitiri.