Zvinhu zvemitophagy zvakachengeteka & zvinhu zvitsva zvinodzivirira kukwegura - Urolithin A

Nhoroondo yeurolithin A (UA)inogona kuteverwa kusvika mugore ra2005. Inhengo yemuviri wezvipembenene zvemudumbu uye haigone kuwedzerwa zvakananga kuburikidza nenzira dzekudya. Zvisinei, ma ellagitannins ayo ekutanga ane michero yakasiyana-siyana yakaita semapomegranate nemastrawberry.

Basa re urolithin A

Musi wa25 Kurume 2016, chidzidzo chikuru chakaitwa mumagazini inonzi "Nature Medicine" chakakwezva vateereri kutariso yekubatana kwayo nekunonoka kukwegura kwevanhu. Kubva zvakawanikwa muna 2016 kuti UA inogona kuwedzera hupenyu hweC. elegans zvinobudirira, UA yave ichishandiswa pamatanho ese (masero eropa, nyama yeganda, uropi (nhengo), masoja ekudzivirira muviri, hupenyu hwemunhu mumwe nemumwe) uye mumarudzi akasiyana-siyana (C. elegans, melanogaster). Mhedzisiro yekudzivirira kukwegura yakaratidzwa zvakanyanya munhunzi dzemichero, mbeva, nevanhu.

(1) Kudzivirira kukwegura uye kusimudzira mashandiro emhasuru
Kuedzwa kwekiriniki kwakaitwa nemaitiro asina kurongeka kwakabudiswa muJAMA Network Open, imwe magazini yeJournal of the American Medical Association, kwakaratidza kuti kune vakwegura kana vanhu vanonetseka nekufamba nekuda kwekurwara, mishonga yeUA inogona kubatsira kuvandudza hutano hwetsandanyama nekuita maekisesaizi anodiwa.

(2) Kubatsira mukuvandudza kugona kwekurapa nekudzivirira gomarara
Muna 2022, chikwata chekutsvagisa chaFlorian R. Greten kubva kuGeorg-Speyer-Haus Institute of Tumor Biology and Experimental Therapeutics muGermany chakaona kuti UA inogona kukonzera mitophagy mumasero eT, kukurudzira kuburitswa kwePGAM5, kumutsa nzira yeWnt signaling, uye kukurudzira kuumbwa kwemasero eT memory stem., nokudaro ichisimudzira kudzivirirwa kwechirwere chegomarara.

(3) Kudzorera kukwegura kwemasero eropa uye masoja ekudzivirira muviri
Muchidzidzo chakaitwa muna 2023, Yunivhesiti yeLausanne muSwitzerland yakadzidza nezvekushanda kwayo pahurongwa hweropa nekubvumira mbeva dzine mwedzi gumi nemisere kudya chikafu chine urolithin A kwemwedzi mina uye kutarisa shanduko mumasero avo eropa mwedzi wega wega.
Zvakawanikwa zvakaratidza kuti kudya kweUA kwakawedzera huwandu hwemasero eropa uye masero elymphoid progenitor, uye kwakaderedza huwandu hwemasero eerythroid progenitor. Izvi zvinoratidza kuti kudya uku kunogona kuchinja zvimwe zvekuchinja kuri kuitika muropa nekuda kwekukwegura.

(4) Mugumisiro wekudzivirira kuzvimba
Basa reUA rekudzivirira kuzvimba rine simba guru uye rinogona kudzivirira zvakanyanya zvinhu zvakasiyana-siyana zvinokonzeresa kuzvimba zvakaita seTNF-α. Ndicho chikonzero nei UA ichitamba basa mukurapa kwakasiyana-siyana kunosanganisira uropi, mafuta, moyo, ura uye chiropa. Inogona kuderedza kuzvimba munyama dzakasiyana-siyana.

(5) Kudzivirirwa kwetsinga dzeuropi
Vamwe vaongorori vakasimbisa kuti UA inogona kudzivirira nzira ye apoptosis ine chekuita ne mitochondria uye kudzora nzira ye p-38 MAPK signaling, nokudaro ichidzivisa oxidative stress-induced apoptosis. Semuenzaniso, UA inogona kuvandudza mwero wekurarama kwema neuron anokurudzirwa ne oxidative stress uye ine basa rakanaka rekudzivirira tsinga.

(6) Mhedzisiro yemafuta
UA inogona kukanganisa metabolism yemafuta mumasero uye lipogenesis. Zvidzidzo zvakaratidza kuti UA inogona kukonzera kushanda kwemafuta machena uye kusviba kwemafuta machena, uku ichidzivirira kuunganidzwa kwemafuta kunokonzerwa nekudya.

(7) Kuvandudza kufuta
UA inogonawo kuderedza kuunganidzwa kwemafuta mumasero emafuta nemasero echiropa anorimwa mu vitro uye kuwedzera oxidation yemafuta. Inogona kushandura T4 isingashande zvakanyanya mu thyroxine kuita T3 inoshanda zvakanyanya, zvichiwedzera mwero wemetabolism uye kugadzirwa kwekupisa kuburikidza ne thyroxine signaling. , nokudaro ichitamba basa rekudzora kufuta.

(8) Dzivirira maziso
Iyo mitophagy inducer UA inogona kuderedza oxidative stress mu retina yakwegura; inoderedza huwandu hwe cytosolic cGAS uye inoderedza kushanda kwemasero eglial mu retina yakwegura.

(9) Kutarisira ganda
Pakati pezvinhu zvose zvinowanikwa mudumbu remhuka dzinoyamwisa, UA ine simba guru rekudzivirira muviri, yechipiri kune proanthocyanidin oligomers, catechins, epicatechin uye 3,4-dihydroxyphenylacetic acid.

Maitiro ekushandisa Urolithin A

Muna 2018, UA yakasarudzwa neUS Food and Drug Administration sechinhu chinodyiwa "chinowanzo zivikanwa sechisina njodzi" uye chinogona kuwedzerwa kumaprotein shakes, zvinwiwa zvinotsiva meal, instant oatmeal, nutritional protein bars nezvinwiwa zvemukaka (kusvika 500 mg/chikamu)), Greek yogurt, high-protein yogurt uye milk protein shakes (kusvika 1000 mg/chikamu).

UA inogonawo kuwedzerwa kune zvigadzirwa zvekuchengetedza ganda, zvinosanganisira makirimu emasikati, makirimu ehusiku uye musanganiswa we serum, zvakagadzirirwa kuwedzera kunyorova kweganda uye kuderedza makwinya zvakanyanya, kunatsiridza magadzirirwo eganda kubva mukati zvichienda kunze, uye kurwisa zvinobudirira zviratidzo zvinoonekwa zvekukwegura. , zvichibatsira ganda kuramba riri diki.

Maitiro ekugadzira Urolithin A

(1) Maitiro ekuvirisa
Kugadzirwa kweUA mumabhizimisi kunotanga kuwanikwa kuburikidza netekinoroji yekuvirisa, iyo inonyanya kuviriswa kubva pamakanda emapomegranate uye ine urolithin A yakawanda inopfuura 10%.
(2) Maitiro ekugadzira makemikari
Nekuenderera mberi kwekuvandudzwa kwetsvagurudzo, kugadzira makemikari inzira yakakosha yekugadzira urolithin A mumaindasitiri. Suzhou Myland Pharm ikambani itsva yekuwedzera sainzi yehupenyu, kugadzira makemikari akagadzirwa uye kugadzira inogona kupa zvinhu zvakagadzirwa nehupfu hweurolithin A hwakachena uye hwakawanda.