Nhasi, sezvo avhareji yekurarama kwevanhu pasi rese iri kuwedzera zvishoma nezvishoma, kurwisa kuchembera kwave musoro unokosha. Munguva ichangopfuura, Urolithin A, izwi raizivikanwa zvishoma munguva yakapfuura, zvishoma nezvishoma rave richionekwa nevanhu. Icho chinhu chakakosha metabolized kubva mu intestinal microorganisms uye yakabatana zvakanyanya nehutano. Ichi chinyorwa chichazarura chakavanzika cheichi chishamiso chechisikigo chinhu - urolithin A.
Nhoroondo yeurolithin A (UA)inogona kuteverwa kumashure kwe 2005. Inonzi metabolite ye intestinal microorganisms uye haigoni kuwedzerwa zvakananga kuburikidza nemagetsi ekudya. Nekudaro, precursor yayo ellagitannins yakapfuma mumichero yakasiyana senge mapomegranati nemastrawberries.
Basa reurolithin A
Musi waKurume 25, 2016, chidzidzo chikuru mumagazini "Nature Medicine" yakakwevera pfungwa dzevateereri nezvekubatana kwayo nekunonoka kuchembera kwevanhu. Kubva zvakaonekwa muna 2016 kuti UA inokwanisa kuwedzera hupenyu hweC. elegans, UA yakashandiswa pamatanho ese (hematopoietic stem cell, ganda, uropi (nhengo), immune system, hupenyu hwemunhu) uye mumhando dzakasiyana siyana. (C. elegans, melanogaster Mhedzisiro yekurwisa kuchembera yakanyatsoratidzwa munhunzi dzemichero, mbeva, uye vanhu.
(1) Anti-kuchembera uye kuwedzera tsandanyama basa
Muedzo wekiriniki wakasarudzika wakabudiswa muJAMA Network Open, bhuku rinotsigira re Journal of the American Medical Association, rakaratidza kuti kune vakwegura kana vanhu vane dambudziko rekufamba nekuda kwehurwere, UA supplements inogona kubatsira kuvandudza hutano hwetsandanyama uye kuita maekisesaizi anodiwa.
(2) Batsira mukusimudzira anti-tumor kugona kwe immunotherapy
Muna 2022, boka rekutsvagisa raFlorian R. Greten kubva kuGeorg-Speyer-Haus Institute of Tumor Biology uye Experimental Therapeutics muGermany vakawana kuti UA inogona kukonzera mitophagy muT masero, kukurudzira kuburitswa kwePGAM5, kumisa iyo Wnt kusaina nzira, uye. kukurudzira T memory stem masero. kuumbwa, nokudaro kukurudzira anti-tumor immunity.
(3) Dzosera kuchembera kwehematopoietic stem masero uye immune system
Muchidzidzo che2023, Yunivhesiti yeLausanne muSwitzerland yakadzidza maitiro ayo pahematopoietic system nekubvumira mbeva dzine mwedzi gumi nemisere kuti dzidye urolithin A-yakapfuma zvokudya kwemwedzi 4 uye kuongorora kuchinja kwemasero eropa mwedzi wega wega. Kufurira.
Mhedzisiro yakaratidza kuti kudya kweUA kwakawedzera huwandu hwehematopoietic stem masero uye lymphoid progenitor masero, uye kudzikisa huwandu hwe erythroid progenitor masero. Kuwana uku kunoratidza kuti kudya uku kunogona kudzoreredza dzimwe shanduko mune hematopoietic system inoenderana nekukwegura.
(4) Anti-inflammatory effect
Basa rinopesana nekuputika kweUA rine simba rakawanda uye rinogona kudzivirira zvakanyanya zvakasiyana-siyana zvezvinokonzera zvirwere zvakadai seTNF-α. Ndizvo chaizvo nekuda kweichi chikonzero kuti UA inobata basa mukurapa kwakasiyana-siyana kwekuzvimba kusanganisira huropi, mafuta, moyo, matumbo uye chiropa tishu. Inogona kubvisa kuzvimba mumhando dzakasiyana-siyana.
(5) Neuroprotection
Dzimwe nyanzvi dzakasimbisa kuti UA inogona kuvharidzira mitochondria-inoenderana neapoptosis nzira uye kugadzirisa p-38 MAPK nzira yekusaina, nekudaro ichivharisa oxidative kusagadzikana-induced apoptosis. Semuenzaniso, UA inogona kuvandudza mwero wekupona kwemaneuroni anokurudzirwa neoxidative kusagadzikana uye ine yakanaka neuroprotective basa.
(6) Mhedzisiro yemafuta
UA inogona kukanganisa cellular lipid metabolism uye lipogenesis. Zvidzidzo zvakaratidza kuti UA inogona kukonzeresa activation yebrown mafuta uye browning yemafuta machena, uku ichidzivirira kuunganidzwa kwemafuta kunokonzerwa nekudya.
(7) Kuvandudza kufutisa
UA inogona zvakare kuderedza kuunganidzwa kwemafuta muadipocytes uye maseru echiropa akagadzirwa mu vitro uye kuwedzera mafuta oxidation. Inogona kushandura iyo isingashande T4 mu thyroxine kuita yakanyanya kushanda T3, inosimudzira metabolic mwero uye kupisa kugadzirwa kuburikidza ne thyroxine kusaina. , nokudaro kuita basa rokudzora kufutisa.
(8) Chengetedza maziso
Iyo mitophagy inducer UA inogona kuderedza oxidative kusagadzikana mune yakwegura retina; inoderedza chiyero che cytosolic cGAS uye inoderedza glial cell activation mune yakwegura retina.
(9) Kuchengeta ganda
Pakati pezvose zvakawanikwa mammalian intestinal metabolites, UA ine yakasimba antioxidant basa, yechipiri chete kune proanthocyanidin oligomers, makatechini, epicatechin uye 3,4-dihydroxyphenylacetic acid. wait.
Urolithin A application scenarios
Muna 2018, UA yakasarudzwa neUS Food and Drug Administration sechinhu chinodyika "chinowanzo zivikanwa seyakachengeteka" uye chinogona kuwedzerwa kumaprotein shakes, zvinwiwa zvinotsiva zvekudya, oatmeal ipapo, zvinovaka muviri maprotein uye zvinwiwa zvemukaka (kusvika 500 mg). / kushumira) ), Greek yogati, high-protein yoghurt uye mukaka mapuroteni anozununguka (kusvika ku1000 mg / kushumira).
UA inogonawo kuwedzerwa kune zvigadzirwa zvekuchengetedza ganda, zvinosanganisira masikati makrimu, usiku creams uye serum musanganiswa, yakagadzirirwa kuwedzera hydration yeganda uye zvakanyanya kuderedza wrinkles, kunatsiridza ganda kubva mukati kunze, uye zvinobudirira kurwisa zvinooneka zviratidzo zvekukwegura. , kubatsira ganda kugara vechidiki.
Urolithin A kugadzira maitiro
(1) Kuvirisa
Kugadzirwa kwekutengesa kweUA kunotanga kuwanikwa kuburikidza nehunyanzvi hwekuvirisa, iyo inonyanya kuviriswa kubva kumakanda epomegranate uye ine urolithin A inodarika 10%.
(2) Chemical synthesis process
Nekuenderera mberi kwekuvandudza uye kuvandudza kwekutsvaga, kemikari synthesis inzira yakakosha yekugadzirwa kwemaindasitiri yeurolithin A. Suzhou Myland Pharm ihwo hutsva hwesainzi yekuwedzera, tsika synthesis uye yekugadzira masevhisi kambani inogona kupa Yepamusoro-kuchena, yakakura-vhoriyamu urolithin A. upfu mbishi zvinhu.
Disclaimer: Ichi chinyorwa ndecheruzivo rwese chete uye hachifanirwe kutorwa sechero zano rekurapa. Imwe yeruzivo rweblog post runobva kuInternet uye haina hunyanzvi. Iyi webhusaiti inongova nebasa rekugadzirisa, kufomatidza uye kugadzirisa zvinyorwa. Chinangwa chekuendesa rumwe ruzivo hachirevi kuti unobvumirana nemaonero ayo kana kusimbisa uchokwadi hwezvirimo. Nguva dzose bvunza nyanzvi yezvehutano usati washandisa chero chekuwedzera kana kuita shanduko kuhutano hwako hwehutano.
Nguva yekutumira: Aug-23-2024
