Muminda ye biochemistry uye mishonga, Spermine (polyamine), se biomolecule inokosha, yave kutariswa zvakanyanya nekuda kwebasa rayo guru mukukura kwemasero, kuwanda uye maitiro akasiyana-siyana ehupenyu. Sezvo kutsvagurudza hutano, kukwegura uye mashandiro emasero kuri kuramba kuchienderera mberi, kudiwa kweSpermine kuri kuramba kuchikwira. Zvisinei, kune vagadziri vakawanda veSpermine vari pamusika, uye nzira yekuwana mugadziri weSpermine akavimbika yave basa rakakosha kune vaongorori nemabhizinesi. Paunenge uchitsvaga mugadziri weSpermine akavimbika, zvakakosha kusarudza mutengesi ane mukurumbira.Suzhou Mylandyava sarudzo yekutanga yevaongorori vesainzi nemabhizinesi mazhinji nezvigadzirwa zvayo zvakachena, rutsigiro rwehunyanzvi uye mitengo inokwikwidzana. Ungave uri kuita tsvakiridzo yekutanga kana kugadzira maapplication, Suzhou Mailun Biotechnology inogona kukupa Spermine yemhando yepamusoro kuti ikubatsire murwendo rwako rwekutsvaga nekugadzira zvinhu zvitsva. Paunosarudza Suzhou Myland, hauzongowani zvigadzirwa chete, asiwo mubatsiri akavimbika.
Urume inorongwa se polyamine, boka remakemikari e organic anozivikanwa nekuvapo kwemapoka akawanda eamine. Polyamines, kusanganisira putrescine, spermidine, uye spermine, zvakakosha pakukura nekushanda kwemasero. Anobatanidzwa mumhando dzakasiyana dzehupenyu dzakadai sekukura kwemasero, kusiyana, uye apoptosis. Kunyanya, spermine chigadzirwa chekushandurwa kwe spermidine, imwe polyamine.
Urume ipolyamine ine mapoka maviri eamino uye mapoka maviri eimino, iyo ine basa rakakosha rekusimudzira kuwanda kwemasero. Urume, semusanganiswa weorganic unoita basa rakakosha muzvinhu zvipenyu, tsananguro yahwo nehunhu hwayo inyaya inokosha muminda yebiology nekemesitiri.
Chinhu ichi hachina kungosiyana chete muchimiro, chine maamino akawanda nemapoka eimino, asiwo chinoita basa rinokosha mumuviri wezvinhu zvipenyu. Urume chinhu chakasimba chisina ruvara.
Inonyungudika nyore nyore mumvura patembiricha yekunze yakajairika, uye kana yabatanidzwa, inoumba mvura ine hunhu hwealkaline. Panyaya yemakemikari, spermine inoburitsa nitrogen oxides ine chepfu kana yapiswa, iyo inoda kutarisirwa kwakanyanya pakubata nekuchengetedza spermine.
Muhupenyu hwemunhu, nzira yekugadzira urume inosanganisira maitiro akaomarara ekushandura ma enzyme pakati pe putrescine (chinhu chiri nyore che diamine) ne S-adenosylmethionine. Maitiro aya anosanganisira maitiro akaomarara e biochemical, zvichiratidza kusiyana uye kukosha kwema enzymes muzvisikwa.
Urume nespermidine zvinowanikwa pamwe chete mumabhakitiriya nemasero mazhinji emhuka, uye zvese zvinhu zvakakosha mukukura kwemasero. Rimwe remabasa makuru ehurume nderekusimudzira kuwanda kwemasero. Urume hunoita basa guru mukupatsanurwa nekukura kwemasero, kunyanya mukugadzikana kweDNA uye kugadzirwa kweprotein.
Inogonawo kuratidza hunhu hwepolycationic pasi pemamiriro eacidic, izvo zvinobvumira spermine kubatana neDNA, RNA nemamwe mamorekuru, nokudaro zvichikanganisa mashandiro uye chimiro chemasero.
Kubva pamaonero echimiro, urume hunogona kuonekwa sechimwe chinhu chinobva muamino acid derivatives. Maumbirwo ahwo akaomarara ane chekuita netetraamine anohupa basa rakasiyana rehupenyu uye mabasa ekutonga muviri.
Muzvikamu zvemakemikari, urume, putrescine, spermidine, nezvimwewo zvinoumba mhuri yemapolyamines aripo zvakanyanya muzvinhu zvipenyu. Mamorekuru aya anoita basa rekudzora magene, kudzora kutenderera kwesero, uye kutora chikamu munzira dzakasiyana-siyana dzekutumira masaini emasero.
Saka, urume hausi chete chinhu chiri nyore cheorganic, asiwo chinhu chikuru muhurongwa hwakanaka hwekudzora hupenyu. Tsvagiridzo yayo inosanganisira minda yakawanda yakasiyana-siyana yakadai semolecular biology, genetics, uye pharmacology.
Chii chinonzi autophagy?
Autophagy inzira inokosha mukati memasero inochengetedza mashandiro emasero akajairwa nekukanganisa uye kudzokorodza mapuroteni ne organelles akakuvara. Autophagy inogona kubvisa zvinhu zvinokuvadza kubva mumasero, kubatsira masero kurarama nematambudziko, kukurudzira hutano hwemasero uye kuwedzera hupenyu hwemasero.
Basa re autophagy mukudzivirira kukwegura
Bvisa tsvina yemasero: Sezvatinokura, huwandu hwakawanda hwemapuroteni akakuvara uye maorganelles anoungana mumasero. Zvinhu izvi zvinokuvadza zvinogona kukanganisa mashandiro emasero uye kutungamira mukukwegura nezvirwere. Autophagy inogona kukanganisa marara aya, kuchengetedza hutano hwemasero, uye kunonotsa kukwegura.
Chengetedza hutano hwemitochondria: Mitochondria iindasitiri yesimba remasero, uye kudzikira kwebasa rawo ndechimwe chezvinhu zvikuru zvinokonzera kukwegura. Autophagy inononoka kukwegura kwemasero nekubvisa mitochondria yakakuvara, kuchengetedza basa remitochondria, uye kuderedza kugadzirwa kwemarudzi eoxygen anokuvadza (ROS).
Kukurudzira kupona kwemasero: Autophagy inogona kupa simba rekutsigira masero kuti ararame kana zvinovaka muviri zvisipo. Pamusoro pezvo, autophagy inokurudzirawo kuzvivandudza kwemasero ekutanga uye kugadzurwa kwenyama, zvichichengetedza chimiro chemuviri chehudiki.
Urume: chinhu chinokonzeresa autophagy
Urume imusanganiswa wepolyamine unowanikwa muzvisikwa zvese zvipenyu zvinokurudzira autophagy zvakanyanya. Ongororo dzakawana kuti kuwedzerwa kwespermine yekunze kunogona kuwedzera hupenyu muzvisikwa zvakasiyana-siyana, kusanganisira mbiriso, nematodes, fruit fruit, uye mbeva.
Kukurudzira autophagy: Urume hunokonzera autophagy nekudzivisa acetyltransferase (yakadai seEP300), nokudaro huchibvisa zvinhu zvinokuvadza mumasero uye huchidzivirira zvirwere zvine chekuita nekukwegura.
Inodzivirira kuzvimba uye inorwisa mabhakitiriya: Urume hune simba rekudzivirira kuzvimba uye inorwisa mabhakitiriya, hunosimudzira mashandiro emuviri e mitochondria, hunosimudzira protein homeostasis, uye hunodzivirira hutano hwemasero.
Kuvandudza mashandiro emuviri ekudzivirira chirwere: Urume hunogona kukurudzira kuumbwa kwemasero eT ekurangarira, kudzivirira kukwegura kwemasimba ekudzivirira chirwere, uye kuwedzera simba remuviri rekudzivirira zvirwere.
zvakawanikwa pakutsvagisa
Kureba kwenguva yehupenyu: Kuwedzera mbeu dzembeu dzekunze kunogona kuwedzera hupenyu hwezvisikwa zvakasiyana-siyana. Semuenzaniso, kupa mbeu dzembeu dzembeu zvekudya kwakawedzera hupenyu hwadzo uye kwakaratidza mhedzisiro yekudzivirira mwoyo netsinga.
Dziviriro yekurwisa kenza nemwoyo: Urume hunovandudza kutarisa kwekudzivirira kenza uye mhedzisiro yekudzivirira mwoyo nekuita kuti autophagy iite. Mumakonzo, mhedzisiro iyi inorasika kana autophagy ikadziviswa.
Inoderedza kuzvimba uye inovandudza dziviriro yemuviri: Tsvagiridzo inoratidza kuti urume hunogona kuderedza kupindura kwekuzvimba uye kuvandudza mashandiro edziviriro yemuviri nekukurudzira kuumbwa kwemasero eT-memory.
Senzira yakakosha yekudzivirira masero, autophagy inoita basa guru mukudzivirira kukwegura. Urume, senzira yechisikigo yekukonzera autophagy, ine mhedzisiro yakakura pakunonotsa kukwegura nekudzivirira zvirwere zvine chekuita nayo nekukurudzira autophagy, anti-inflammatory uye antioxidant nzira. Kuwedzera kudya urume kuburikidza nekudya kana kuwedzera kunogona kuva nzira inoshanda yekukurudzira kukwegura kwakanaka.
1. Hutano nekukura kwemasero
Chimwe chezvakanakira zvikuru zvespermine ibasa rayo mukusimudzira hutano nekukura kwemasero. Urume hunokosha pakukura kwemasero uye kusiyanisa uye hunokosha pakugadzirisa nekuvandudza tishu. Hunosimbisa chimiro cheDNA neRNA uye hunovimbisa kushanda zvakanaka kwemasero. Izvi zvakakosha zvikuru kana ronda richipora uye kukuvara kuchidzoka, uko kunofanira kupatsanurwa nekukurumidza kwemasero.
Pamusoro pezvo, spermine yakaratidzwa kuti inodzivirira masero kubva mukushushikana kwe oxidative, izvo zvinogona kukonzera kukuvara kwemasero uye kukwegura. Nekubvisa ma free radicals, spermine inobatsira kuchengetedza kushanda kwemasero, zvichibatsira pahutano hwese uye kurarama kwenguva refu.
2. Hunhu hwekudzivirira kukwegura
Sezvatinokura, miviri yedu inosangana nekuchinja kwakasiyana-siyana, kusanganisira kudzikira kwehuwandu hwema polyamines akadai se spermine. Tsvagiridzo inoratidza kuti spermine inogona kunge iine hunhu hwekudzivirira kukwegura, zvichiita kuti ive chinhu chinokosha mukuchengetedza ganda uye zvigadzirwa zvehutano. Kugona kwayo kukurudzira kukura nekugadzirisa masero kunogona kubatsira kurwisa zviratidzo zvinoonekwa zvekukwegura, zvakaita semakwinya uye ganda rinorembera.
Pamusoro pezvo, hunhu hwe spermine hunodzivirira ganda hunoita basa rakakosha mukuderedza kushushikana kwe oxidative, chinhu chakakosha pakukura kweganda. Nekuisa spermine mukuchengetedza ganda rako, haungogadzirise chitarisiko cheganda rako chete, asiwo unotsigira hutano hwaro pamasero.
3. Rutsigiro rwemasoja emuviri
Sistimu yakasimba yekudzivirira muviri inokosha pahutano hwese, uye urume hunogona kuita basa rekuwedzera mashandiro ekudzivirira muviri. Tsvagiridzo inoratidza kuti urume hunogona kugadzirisa mashandiro ekudzivirira muviri uye kubatsira muviri kudzivirira zviri nani kubva kuhutachiona nezvirwere. Zvakaratidzwa kuti zvinokurudzira kugadzirwa kwemasero ekudzivirira muviri, akadai se lymphocytes, ayo akakosha mukurwisa utachiona.
Pamusoro pezvo, hunhu hwespermine hunoderedza kuzvimba hunogona kubatsira kuderedza kuzvimba kwenguva refu, uko kunobatanidzwa nematambudziko akasiyana-siyana ehutano, kusanganisira zvirwere zve autoimmune uye hutachiona husingaperi. Nekutsigira hutano hwedziviriro yemuviri, spermine inogona kubatsira kusimbisa kugona kwemuviri kurwisa zvirwere.
4. Kudzivirira tsinga dzeuropi
Uropi ndeimwe yenhengo dzakaomarara mumuviri wemunhu, uye kuchengetedza hutano hwacho kwakakosha. Uropi hwacho hwave kucherechedzwa nekuda kwesimba rahwo rekudzivirira tsinga, izvo zvinogona kubatsira kudzivirira zvirwere zvinokanganisa tsinga. Tsvagiridzo inoratidza kuti uropi hunogona kudzivirira tsinga kubva mukukuvadzwa kunokonzerwa nekushushikana kwe oxidative uye kuzvimba, zvese izvi zvakabatana nezvirwere zvakaita seAlzheimer's neParkinson's disease.
Pamusoro pezvo, urume hunobatsira mukutapurirana kwetsinga dzeropa, zvichikanganisa kuburitswa kwema neurotransmitters, ayo akakosha pakutaurirana pakati pemasero etsinga. Nekutsigira hutano hwetsinga dzeropa uye mashandiro adzo, urume hunogona kubatsira kuvandudza mashandiro epfungwa uye kuderedza njodzi yezvirwere zvinokanganisa tsinga dzeropa.
Panyaya yekushandiswa kwembeu, spermine ine mashandisirwo akasiyana-siyana. Chekutanga, spermine chinhu chakakosha muchikamu chemishonga uye chinoshandiswa zvakanyanya mumishonga yekurwisa kenza uye mishonga yemwoyo. Kushanda kwayo zvakanaka, kuchengetedzeka uye kugadzikana zvinofarirwa neindasitiri yemishonga.
Chechipiri, spermine imhando yeanionic surfactant ine simba rakanaka re emulsification, kupinda uye kubvisa tsvina. Nokudaro, inoshandiswa zvakanyanya muindasitiri yemakemikari, mishonga yezvipembenene, fibers, mineral processing, electroplating nedzimwe nzvimbo, kunyanya muzvizoro, toothpaste, shampoo nezvimwe zvigadzirwa. Inoita basa rakakosha mukugadzira.
Pamusoro pezvo, mbeu yembeu inogona kushandiswawo senzira yekurapa zvipembenene zve organophosphorus, zvichiwedzera kushandiswa kwayo muindasitiri yemishonga yezvipembenene. Chekupedzisira, mbeu yembeu, sechinhu chakakosha chinokurudzira kuwanda kwemasero, inoshandiswawo mumunda wekurima. Inogona kuvandudza kupinza nekushandisa zvinovaka muviri nezvirimwa, uye kuwedzera goho uye mhando.
Sezvo misika ye biotechnology, hutano hwekurapa, uye hutano hwevanhu ichiramba ichikura, mikana yekushandisa spermine sechinhu chakakosha iri kutariswa zvakanyanya. Kunyanya munyaya dzekurapa, kugona kwayo mukutsvaga nekugadzira mishonga yekurwisa bundu, kurapwa nemasero uye kurapwa kwezvirwere zvemajini kuri kukwezva mari yakawanda mukutsvaga kwesainzi uye mabasa ekuvandudza, zvichiratidza kuti inogona kuva simba guru rekusimudzira kukura kweindasitiri mune ramangwana.
Panguva imwe chete, spermine iri kushandiswa zvakanyanya sechinhu chinoshanda zvikuru chekugadzirisa ganda muindasitiri yezvizoro, zvichiratidza kuti vatengi vari kuda zvigadzirwa zvekuchengetedza ganda zvechisikigo uye zvinoshanda zvikuru, zvichikonzera kudiwa kwespermine mumusika wezvigadzirwa zverunako zvepamusoro.
Pamusoro pezvo, mumunda wekurima, pasinei nekuderera kwekudiwa mumisika yechinyakare yakaita seacephate, kutsvaga spermine semutsigiri mutsva wekukura kwezvirimwa une hushamwari kune zvakatipoteredza kunotarisirwa kuvhura nzira itsva yekushandisa mukurima kwakasvibira uye kupindura kudiwa kwekurima kunochengetedza nharaunda pasi rose. Mhinduro dzinodiwa nekukurumidza.
Kubva pamaonero ekuvandudzwa kwetekinoroji, kufambira mberi kuri kuitwa kwetekinoroji yekugadzira mbeu dzembeu pamwe nekugadzirisa mitengo zvichavandudza kushanda zvakanaka kwekugadzira uye kukwikwidzana kwezvigadzirwa, uye zvichaunza nzvimbo yakakura yekuvandudza indasitiri. Pamwe chete nerutsigiro rwepamusoro-soro uye gwara rekutonga re biotechnology nekurima kwezvirimwa zvakasvibira, nharaunda yakanaka yekunze yakavakwa kuti indasitiri yembeu dzembeu ive neutano.
Muminda ye biochemistry uye mishonga, Spermine (polyamine), se biomolecule inokosha, yave ichinyanya kutariswa nekuda kwebasa rayo guru mukukura kwemasero, kuwanda uye maitiro akasiyana-siyana ehupenyu. Sezvo kutsvagurudza hutano, kukwegura uye mashandiro emasero kuri kuramba kuchienderera mberi, kudiwa kweSpermine kuri kuramba kuchiwedzera. Zvisinei, kune vagadziri vakawanda veSpermine vari pamusika, uye nzira yekuwana mugadziri weSpermine akavimbika yave basa rakakosha kune vaongorori nemabhizinesi.
Pakati pevagadziri vakawanda veSpermine, Suzhou Myland inoratidzika seyakanaka kwazvo nekuda kwemhando yepamusoro yechigadzirwa uye masevhisi ehunyanzvi. Spermine inopihwa naSuzhou Myland ineNhamba yeCAS ye71-44-3 uye kuchena kweinopfuura 98%.Chigadzirwa ichi chakachena kwazvo hachingosviki padanho repasi rose chete, asiwo chinoedzwa zvakanyanya kuti chive nechokwadi chekuti zvigadzirwa zvese zvinokwanisa kusangana nezvinodiwa nesainzi uye mashandisirwo emaindasitiri.
1. Kuvimbisa Hunhu
Suzhou Myland inonyatsoziva kuti mhando yechigadzirwa ndiyo musimboti wekurarama nekukura kwebhizinesi. Kambani iyi ine michina yekugadzira yepamusoro uye sisitimu yakasimba yekutarisira mhando kuti ive nechokwadi chekuti zvigadzirwa zvese zveSpermine zvinoedzwa uye kuongororwa kwakasimba. Ingave iri kutenga zvinhu zvisina kugadzirwa kana chikamu chega chega chemaitiro ekugadzira, Suzhou Myland inoedza kuwana hunhu hwakanaka kuti ive nechokwadi chekuchena kwakanyanya uye mhando yepamusoro yezvigadzirwa zvayo.
2. Rutsigiro rwehunyanzvi rwehunyanzvi
Pamusoro pekupa Spermine yemhando yepamusoro, Suzhou Myland inopawo vatengi rutsigiro rwehunyanzvi. Ingave kushandiswa kwechigadzirwa, mamiriro ekuchengetera, kana dhizaini yekuedza yakafanana, timu yehunyanzvi yekambani inogona kupa vatengi nhungamiro yakadzama uye mazano. Basa iri rekufunga zvakanaka haringogadzirisi kugutsikana kwevatengi chete, asiwo rinowedzera kuvimba kwevatengi nechigadzirwa.
3. Mutengo wemakwikwi
Nechinangwa chekuona kuti chigadzirwa chakanaka, Suzhou Myland yakazvipirawo kupa vatengi mitengo inokwikwidzana. Nekuvandudza maitiro ekugadzira uye manejimendi ezvekutengeswa, kambani inokwanisa kuderedza mitengo zvinobudirira, nokudaro ichidzosera mitengo inokwanisika kuvatengi. Izvi zvinoita kuti masangano akawanda ekutsvaga kwesainzi nemabhizinesi awane Spermine yemhando yepamusoro pamitengo inonzwisisika uye zvinosimudzira kufambira mberi kwekutsvaga kwakabatana.
Maitiro ekutenga
Kana uchitsvaga mugadziri weSpermine akavimbika, Suzhou Myland hapana mubvunzo kuti isarudzo yakavimbika. Unogona kuwana rumwe ruzivo kuburikidza newebhusaiti yepamutemo yekambani kana kubata timu yekutengesa zvakananga. Ingave iri yekuedza kudiki kana mashandisirwo makuru emaindasitiri, Suzhou Myland inogona kupa mhinduro dzinochinjika zvichienderana nezvinodiwa nevatengi.
Mubvunzo: Chii chinonzi spermine, uye inowanikwa kupi?
A:Urume chinhu chinogadzirwa nepolyamine chinowanikwa mumasero ese mapenyu. Chinonyanya kuwanikwa muzvikamu zvakawanda munyama dzakadai seuropi, chiropa, uye prostate. Urume hunobatanidzwa mumabasa akasiyana-siyana ehupenyu, kusanganisira kukura kwemasero, kusiyanisa, uye kugadzikana kweDNA.
Mubvunzo: Urume hunogona sei kuiswa mukudya kwangu?
A: Urume hunowanikwa muzvikafu zvakasiyana-siyana, kunyanya mu:
●Zvigadzirwa zvakaviriswa (senge chizi nesoya muto)
● Dzimwe nyama (dzakadai sehuku nenyama yemombe)
●Hove
● Zviyo zvakakwana
●Nyemba
Pamusoro pezvo, zvinowedzerwa zvespermine zvinowanikwa kune avo vanoda kuwedzera kudya kwavo.
Mubvunzo: Ko mbeu yemurume inobatsira pahutano hweganda here?
A: Ehe, urume hunozivikanwa nekuda kwekubatsira kwayo pahutano hweganda. Hunogona kubatsira kuvandudza kutwasuka kweganda, kuderedza kutaridzika kwemitsara midiki nemakwinya, uye kukurudzira kunyorova kweganda. Hunhu hwayo hwekuchengetedza mabhakitiriya hunobatsirawo kudzivirira ganda kubva mukukuvadzwa kwezvakatipoteredza, zvichiita kuti rive chinhu chinozivikanwa muzvigadzirwa zvekuchengetedza ganda.
Chiziviso: Chinyorwa ichi ndecheruzivo rwese chete uye hachifanirwe kutorwa semazano ekurapa. Mamwe emashoko eblog anobva paInternet uye haasi ehunyanzvi. Iyi webhusaiti ine basa rekugadzirisa, kuronga nekugadzirisa zvinyorwa chete. Chinangwa chekutumira rumwe ruzivo hazvirevi kuti unobvumirana nemaonero ayo kana kusimbisa chokwadi chezviri mukati mayo. Gara uchibvunza nyanzvi yehutano usati washandisa chero mishonga yekuwedzera kana kuita shanduko kuhurongwa hwako hwehutano.
Nguva yekutumira: Gumiguru-18-2024
